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Tahir dkk., 2012. Penggunaan Metode Semiempirik PM3 Untuk Evaluasi Interaksi Allopurinol–Asam MetakrilatUntuk Sintesis Polimer Tercetak Molekul. Polimer tercetak molekul untuk aplikasi sensor allopurinol berbasis Quartz Crystal Microbalance dapatdirancang dengan pemodelan molekul menggunakan metoda mekanika kuantum-semiempirik PM3. Kajianditentukan berdasarkan interaksi molekular antara allopurinol sebagai templat dan asam metakrilat sebagaimonomer fungsional, sehingga diperoleh rasio mol antara allopurinol dan asam metakrilat secara teoritik.Pemodelan molekul dilakukan dengan pendekatan perhitungan mekanika kuantum semi empirik PM3 padaperangkat lunak Hyperchem 8.0. Hasil penelitian menunjukkan interaksi yang terbentuk melibatkan interaksinon kovalen terutama ikatan hidrogen. Kestabilan struktur pre kompleks dari allopurinol – asam metakrilatpaling tinggi pada rasio mol 1:3 yang digunakan sebagai rekomendasi rasio mol untuk sintesis polimer tercetakallopurinol.Kata kunci : allopurinol, asam metakrilat, semiempirik PM3, polimer tercetak molekul, Quartz Crystal MicrobalanceTahir et al., 2012. Use of PM3 Semiempirical Method to Evaluate of Allopurinol-Methacrylic Acids Interactionfor Synthesis of Molecular Imprinted Polymer. Molecular imprinted polymer of allopurinol for sensing application based on Quartz Crystal Microbalance can bedesigned using molecular modeling applying quantum mechanics-PM3 semiempirical calculation. The study isperformed theoretically by evaluating of the molecular interaction between allopurinol as templat molecule andmethacrylic acids as functional monomer molecules. All of the calculation is run on PM3 semiempirical levelusing HyperChem Software. The result showed that the existences of interaction are formed by non covalentbinding especially hydrogen bonding. Structure stability of pre complex between allopurinol-methacrylic acid isrelatively optimum at ratio 1:3 and it can be used as the experimental mole ratio to synthesize of allopurinolimprinted polimer.Keywords : allopurinol, methacrylic acid, semiempirical PM3, molecular imprinted polymer, QuartzCrystal Microbalance

The use of biomimetic sensor has attracted attention due to its sensitivity and selectivity. Molecular imprinted polymer (MIP) among the best synthetic biomimetic interfaces to detect target molecules. However MIP has low electrical conductivity. Sensor fabricated using high conductive polymer will possess a good sensitivity and short response time. Therefore, it is important to enhance the conductivity of MIP, thus it would directly influence charge carrier mobility of the polymer itself. The resulting rGO-MIP OTFT exhibit electrical conductivity of 3.10×10−3 Sm−1 at 0.4wt/vol% and MIP exhibit electrical conductivity of 7.16×10−4 Sm−1. The electrical conductivity of rGO-MIP increased about one in magnitude order compared to MIP. Moreover, this work reports the electrical performance of reduce graphene oxide-molecular imprinted polymer organic thin film transistor (rGO-MIP OTFT) for serine detection. rGO was introduced into MIP, to allow a highly conductive sensing material thus enhanced selectivity and sensitivity of the sensor. By analyzing the electrical performance of the sensors, the performances of OTFT sensor enhanced with rGO-MIP interlayer and OTFT sensor with MIP interlayer when exposed to serine analyte were obtained. The results showed that there were remarkable shifts of drain current obtained from OTFT sensor with rGO-MIP interlayer after exposed to serine analyte. Moreover, the sensitivity of OTFT sensor with rGO-MIP interlayer was nearly higher than the OTFT sensor with MIP interlayer. Hence, it proved that rGO successfully enhanced the sensing performance of OTFT sensor.