Search

Your search keyword '"Ahola-Olli, A. (Ari)"' showing total 13 results
Start Over Author "Ahola-Olli, A. (Ari)"
13 results on '"Ahola-Olli, A. (Ari)"'

1. The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study

Author

Karhunen, V. (Ville), Gill, D. (Dipender), Huang, J. (Jian), Bouras, E. (Emmanouil), Malik, R. (Rainer), Ponsford, M. J. (Mark J.), Ahola-Olli, A. (Ari), Papadopoulou, A. (Areti), Palaniswamy, S. (Saranya), Sebert, S. (Sylvain), Wielscher, M. (Matthias), Auvinen, J. (Juha), Veijola, J. (Juha), Herzig, K.-H. (Karl-Heinz), Timonen, M. (Markku), Keinänen-Kiukaanniemi, S. (Sirkka), Dichgans, M. (Martin), Salmi, M. (Marko), Jalkanen, S. (Sirpa), Lehtimäki, T. (Terho), Salomaa, V. (Veikko), Raitakari, O. (Olli), Jones, S. A. (Simon A.), Hovingh, G. K. (G. Kees), Tsilidis, K. K. (Konstantinos K.), Järvelin, M.-R. (Marjo-Riitta), Dehghan, A. (Abbas), Karhunen, V. (Ville), Gill, D. (Dipender), Huang, J. (Jian), Bouras, E. (Emmanouil), Malik, R. (Rainer), Ponsford, M. J. (Mark J.), Ahola-Olli, A. (Ari), Papadopoulou, A. (Areti), Palaniswamy, S. (Saranya), Sebert, S. (Sylvain), Wielscher, M. (Matthias), Auvinen, J. (Juha), Veijola, J. (Juha), Herzig, K.-H. (Karl-Heinz), Timonen, M. (Markku), Keinänen-Kiukaanniemi, S. (Sirkka), Dichgans, M. (Martin), Salmi, M. (Marko), Jalkanen, S. (Sirpa), Lehtimäki, T. (Terho), Salomaa, V. (Veikko), Raitakari, O. (Olli), Jones, S. A. (Simon A.), Hovingh, G. K. (G. Kees), Tsilidis, K. K. (Konstantinos K.), Järvelin, M.-R. (Marjo-Riitta), and Dehghan, A. (Abbas)

Abstract

Objective: To leverage large scale genetic association data to investigate the interplay between circulating cytokines and cardiometabolic traits, and thus identifying potential therapeutic targets. Design: Bi-directional Mendelian randomisation study. Setting: Genome-wide association studies from three Finnish cohorts (Northern Finland Birth Cohort 1966, Young Finns Study, or FINRISK study), and genetic association summary statistics pooled from observational studies for expression quantitative trait loci and cardiometabolic traits. Participants: Data for 47 circulating cytokines in 13 365 individuals from genome-wide association studies, summary statistic data for up to 21 735 individuals on circulating cytokines, summary statistic gene expression data across 49 tissues in 838 individuals, and summary statistic data for up to 1 320 016 individuals on cardiometabolic traits. Interventions: Relations between circulating cytokines and cardiovascular, anthropometric, lipid, or glycaemic traits (coronary artery disease, stroke, type 2 diabetes mellitus, body mass index, waist circumference, waist to hip ratio, systolic blood pressure, glycated haemoglobin, high density lipoprotein cholesterol, low density lipoprotein cholesterol, total cholesterol, triglycerides, C reactive protein, glucose, fasting insulin, and lifetime smoking). Main outcome methods: Genetic instrumental variables that are biologically plausible for the circulating cytokines were generated. The effects of cardiometabolic risk factors on concentrations of circulating cytokines, circulating cytokines on other circulating cytokines, and circulating cytokines on cardiometabolic outcomes were investigated. Results: Genetic evidence (mendelian randomisation P<0.0011) suggests that higher body mass index, waist circumference, smoking, higher concentrations of lipids, and systolic blood pressure increase circulating concentrations of several inflammatory cytokines and C reactive protein. Evidence

Published
2023

2. Cohort profile:SUPER-Finland – the Finnish study for hereditary mechanisms of psychotic disorders

Author

Lähteenvuo, M. (Markku), Ahola-Olli, A. (Ari), Suokas, K. (Kimmo), Holm, M. (Minna), Misiewicz, Z. (Zuzanna), Jukuri, T. (Tuomas), Männynsalo, T. (Teemu), Wegelius, A. (Asko), Haaki, W. (Willehard), Kajanne, R. (Risto), Kyttälä, A. (Aija), Tuulio-Henriksson, A. (Annamari), Lahdensuo, K. (Kaisla), Häkkinen, K. (Katja), Hietala, J. (Jarmo), Paunio, T. (Tiina), Niemi-Pynttäri, J. (Jussi), Kieseppä, T. (Tuula), Veijola, J. (Juha), Lönnqvist, J. (Jouko), Isometsä, E. (Erkki), Kampman, O. (Olli), Tiihonen, J. (Jari), Hyman, S. (Steven), Neale, B. (Benjamin), Daly, M. (Mark), Suvisaari, J. (Jaana), Palotie, A. (Aarno), Lähteenvuo, M. (Markku), Ahola-Olli, A. (Ari), Suokas, K. (Kimmo), Holm, M. (Minna), Misiewicz, Z. (Zuzanna), Jukuri, T. (Tuomas), Männynsalo, T. (Teemu), Wegelius, A. (Asko), Haaki, W. (Willehard), Kajanne, R. (Risto), Kyttälä, A. (Aija), Tuulio-Henriksson, A. (Annamari), Lahdensuo, K. (Kaisla), Häkkinen, K. (Katja), Hietala, J. (Jarmo), Paunio, T. (Tiina), Niemi-Pynttäri, J. (Jussi), Kieseppä, T. (Tuula), Veijola, J. (Juha), Lönnqvist, J. (Jouko), Isometsä, E. (Erkki), Kampman, O. (Olli), Tiihonen, J. (Jari), Hyman, S. (Steven), Neale, B. (Benjamin), Daly, M. (Mark), Suvisaari, J. (Jaana), and Palotie, A. (Aarno)

Abstract

Purpose: SUPER-Finland is a large Finnish collection of psychosis cases. This cohort also represents the Finnish contribution to the Stanley Global Neuropsychiatric Genetics Initiative, which seeks to diversify genetic sample collection to include Asian, Latin American and African populations in addition to known population isolates, such as Finland. Participants: 10 474 individuals aged 18 years or older were recruited throughout the country. The subjects have been genotyped with a genome-wide genotyping chip and exome sequenced. A subset of 897 individuals selected from known population sub-isolates were selected for whole-genome sequencing. Recruitment was done between November 2015 and December 2018. Findings to date: 5757 (55.2%) had a diagnosis of schizophrenia, 944 (9.1%) schizoaffective disorder, 1612 (15.5%) type I or type II bipolar disorder, 532 (5.1 %) psychotic depression, 1047 (10.0%) other psychosis and for 530 (5.1%) self-reported psychosis at recruitment could not be confirmed from register data. Mean duration of schizophrenia was 22.0 years at the time of the recruitment. By the end of the year 2018, 204 of the recruited individuals had died. The most common cause of death was cardiovascular disease (n=61) followed by neoplasms (n=40). Ten subjects had psychiatric morbidity as the primary cause of death. Future plans: Compare the effects of common variants, rare variants and copy number variations (CNVs) on severity of psychotic illness. In addition, we aim to track longitudinal course of illness based on nation-wide register data to estimate how phenotypic and genetic differences alter it.

Published
2023

3. Does social intolerance vary according to cognitive styles, genetic cognitive capacity, or education?

Author

Saarinen, A. (Aino), Keltikangas-Järvinen, L. (Liisa), Dobewall, H. (Henrik), Cloninger, C. R. (C. Robert), Ahola-Olli, A. (Ari), Lehtimäki, T. (Terho), Hutri-Kähönen, N. (Nina), Raitakari, O. (Olli), Rovio, S. (Suvi), Ravaja, N. (Niklas), Saarinen, A. (Aino), Keltikangas-Järvinen, L. (Liisa), Dobewall, H. (Henrik), Cloninger, C. R. (C. Robert), Ahola-Olli, A. (Ari), Lehtimäki, T. (Terho), Hutri-Kähönen, N. (Nina), Raitakari, O. (Olli), Rovio, S. (Suvi), and Ravaja, N. (Niklas)

Abstract

Background: Low education, low cognitive abilities, and certain cognitive styles are suggested to predispose to social intolerance and prejudices. Evidence is, however, restricted by comparatively small samples, neglect of confounding variables and genetic factors, and a narrow focus on a single sort of prejudice. We investigated the relationships of education, polygenic cognitive potential, cognitive performance, and cognitive styles with social intolerance in adulthood over a 15-year follow-up. Methods: We used data from the prospective population-based Young Finns Study (n = 960‒1679). Social intolerance was evaluated with the Social Intolerance Scale in 1997, 2001, and 2011; cognitive performance with the Cambridge Neuropsychological Test Automated Battery in 2011; cognitive styles in 1997; and socioeconomic factors in 1980 (childhood) and 2011 (adulthood); and polygenic cognitive potential was calculated based on genome-wide association studies. Results: We found that nonrational thinking, polygenic cognitive potential, cognitive performance, or socioeconomic factors were not related to social intolerance. Regarding cognitive styles, low flexibility (B = –0.759, p < .001), high perseverance (B = 1.245, p < .001), and low persistence (B = –0.329, p < .001) predicted higher social intolerance consistently in the analyses. Discussion: When developing prejudice-reduction interventions, it should be considered that educational level or cognitive performance may not be crucial for development of social intolerance. Adopting certain cognitive styles may play more important roles in development of social intolerance.

Published
2022

4. The relationship between temperament, polygenic score for intelligence and cognition:a population-based study of middle-aged adults

Author

Tölli, P. (Pekka), Keltikangas-Järvinen, L. (Liisa), Lehtimäki, T. (Terho), Ravaja, N. (Niklas), Hintsanen, M. (Mirka), Ahola-Olli, A. (Ari), Pahkala, K. (Katja), Kähönen, M. (Mika), Hutri-Kähönen, N. (Nina), Laitinen, T. T. (Tomi T.), Tossavainen, P. (Päivi), Taittonen, L. (Leena), Dobewall, H. (Henrik), Jokinen, E. (Eero), Raitakari, O. (Olli), Cloninger, C. R. (C. Robert), Rovio, S. (Suvi), Saarinen, A. (Aino), Tölli, P. (Pekka), Keltikangas-Järvinen, L. (Liisa), Lehtimäki, T. (Terho), Ravaja, N. (Niklas), Hintsanen, M. (Mirka), Ahola-Olli, A. (Ari), Pahkala, K. (Katja), Kähönen, M. (Mika), Hutri-Kähönen, N. (Nina), Laitinen, T. T. (Tomi T.), Tossavainen, P. (Päivi), Taittonen, L. (Leena), Dobewall, H. (Henrik), Jokinen, E. (Eero), Raitakari, O. (Olli), Cloninger, C. R. (C. Robert), Rovio, S. (Suvi), and Saarinen, A. (Aino)

Abstract

We investigated whether temperament modifies an association between polygenic intelligence potential and cognitive test performance in midlife. The participants (n = 1647, born between 1962 and 1977) were derived from the Young Finns Study. Temperament was assessed with Temperament and Character Inventory over a 15-year follow-up (1997, 2001, 2007, 2012). Polygenic intelligence potential was assessed with a polygenic score for intelligence. Cognitive performance (visual memory, reaction time, sustained attention, spatial working memory) was assessed with CANTAB in midlife. The PGSI was significantly associated with the overall cognitive performance and performance in visual memory, sustained attention and working memory tests but not reaction time test. Temperament did not correlate with polygenic score for intelligence and did not modify an association between the polygenic score and cognitive performance, either. High persistence was associated with higher visual memory (B = 0.092; FDR-adj. p = 0.007) and low harm avoidance with higher overall cognitive performance, specifically better reaction time (B = −0.102; FDR-adj; p = 0.007). The subscales of harm avoidance had different associations with cognitive performance: higher “anticipatory worry,” higher “fatigability,” and lower “shyness with strangers” were associated with lower cognitive performance, while the role of “fear of uncertainty” was subtest-related. In conclusion, temperament does not help or hinder one from realizing their genetic potential for intelligence. The overall modest relationships between temperament and cognitive performance advise caution if utilizing temperament-related information e.g. in working-life recruitments. Cognitive abilities may be influenced by temperament variables, such as the drive for achievement and anxiety about test performance, but they involve distinct systems of learning and memory.

Published
2022

5. Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis

Author

Bouras, E. (Emmanouil), Karhunen, V. (Ville), Gill, D. (Dipender), Huang, J. (Jian), Haycock, P. C. (Philip C.), Gunter, M. J. (Marc J.), Johansson, M. (Mattias), Brennan, P. (Paul), Key, T. (Tim), Lewis, S. J. (Sarah J.), Martin, R. M. (Richard M.), Murphy, N. (Neil), Platz, E. A. (Elizabeth A.), Travis, R. (Ruth), Yarmolinsky, J. (James), Zuber, V. (Verena), Martin, P. (Paul), Katsoulis, M. (Michail), Freisling, H. (Heinz), Nost, T. H. (Therese Haugdahl), Schulze, M. B. (Matthias B.), Dossus, L. (Laure), Hung, R. J. (Rayjean J.), Amos, C. I. (Christopher, I), Ahola-Olli, A. (Ari), Palaniswamy, S. (Saranya), Mannikko, M. (Minna), Auvinen, J. (Juha), Herzig, K.-H. (Karl-Heinz), Keinänen-Kiukaanniemi, S. (Sirkka), Lehtimäki, T. (Terho), Salomaa, V. (Veikko), Raitakari, O. (Olli), Salmi, M. (Marko), Jalkanen, S. (Sirpa), Järvelin, M.-R. (Marjo-Riitta), Dehghan, A. (Abbas), Tsilidis, K. K. (Konstantinos K.), Bouras, E. (Emmanouil), Karhunen, V. (Ville), Gill, D. (Dipender), Huang, J. (Jian), Haycock, P. C. (Philip C.), Gunter, M. J. (Marc J.), Johansson, M. (Mattias), Brennan, P. (Paul), Key, T. (Tim), Lewis, S. J. (Sarah J.), Martin, R. M. (Richard M.), Murphy, N. (Neil), Platz, E. A. (Elizabeth A.), Travis, R. (Ruth), Yarmolinsky, J. (James), Zuber, V. (Verena), Martin, P. (Paul), Katsoulis, M. (Michail), Freisling, H. (Heinz), Nost, T. H. (Therese Haugdahl), Schulze, M. B. (Matthias B.), Dossus, L. (Laure), Hung, R. J. (Rayjean J.), Amos, C. I. (Christopher, I), Ahola-Olli, A. (Ari), Palaniswamy, S. (Saranya), Mannikko, M. (Minna), Auvinen, J. (Juha), Herzig, K.-H. (Karl-Heinz), Keinänen-Kiukaanniemi, S. (Sirkka), Lehtimäki, T. (Terho), Salomaa, V. (Veikko), Raitakari, O. (Olli), Salmi, M. (Marko), Jalkanen, S. (Sirpa), Järvelin, M.-R. (Marjo-Riitta), Dehghan, A. (Abbas), and Tsilidis, K. K. (Konstantinos K.)

Abstract

Background: Epidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due to bias. In order to examine whether altered genetically predicted concentration of circulating cytokines are associated with cancer development, we performed a two-sample Mendelian randomisation (MR) analysis. Methods: Up to 31,112 individuals of European descent were included in genome-wide association study (GWAS) meta-analyses of 47 circulating cytokines. Single nucleotide polymorphisms (SNPs) robustly associated with the cytokines, located in or close to their coding gene (cis), were used as instrumental variables. Inverse-variance weighted MR was used as the primary analysis, and the MR assumptions were evaluated in sensitivity and colocalization analyses and a false discovery rate (FDR) correction for multiple comparisons was applied. Corresponding germline GWAS summary data for five cancer outcomes (breast, endometrial, lung, ovarian, and prostate), and their subtypes were selected from the largest cancer-specific GWASs available (cases ranging from 12,906 for endometrial to 133,384 for breast cancer). Results: There was evidence of inverse associations of macrophage migration inhibitory factor with breast cancer (OR per SD = 0.88, 95% CI 0.83 to 0.94), interleukin-1 receptor antagonist with endometrial cancer (0.86, 0.80 to 0.93), interleukin-18 with lung cancer (0.87, 0.81 to 0.93), and beta-chemokine-RANTES with ovarian cancer (0.70, 0.57 to 0.85) and positive associations of monokine induced by gamma interferon with endometrial cancer (3.73, 1.86 to 7.47) and cutaneous T-cell attracting chemokine with lung cancer (1.51, 1.22 to 1.87). These associations were similar in sensitivity analyses and supported in colocalization analyses. Conclusions: Our study adds to current knowledge on the role of specific inflammatory biomarker pathways in cancer aetiolog

Published
2022

6. Risky emotional family environment in childhood and depression-related cytokines in adulthood:the protective role of compassion

Author

Saarinen, A. (Aino), Keltikangas-Järvinen, L. (Liisa), Dobewall, H. (Henrik), Ahola-Olli, A. (Ari), Salmi, M. (Marko), Lehtimäki, T. (Terho), Raitakari, O. (Olli), Jalkanen, S. (Sirpa), and Hintsanen, M. (Mirka)

Subjects
inflammation, personality, family environment, childhood environment, emotional environment, cytokines
Abstract

Background: Previously, compassion has been found to protect against depressive symptoms, while emotional adversities in childhood are suggested to increase inflammatory responses. The current study investigated (a) whether emotional family environment in childhood predicts levels of such cytokines in adulthood that are previously found to be elevated in depression (interleukin [IL]-2, IL-6, IL-1b, monocyte chemoattractant protein-1, interferon-gamma [IFN-γ], and tumor necrosis factor alpha [TNF-α]) and (b) whether these associations are modified by compassion in adulthood. Methods: The participants (N = 1,198–1,523) came from the prospective population-based Young Finns data. Emotional family environment and parental socioeconomic factors were evaluated in 1980; participants’ compassion in 2001; and participants’ cytokine levels and adulthood covariates in 2007. Results: Risky emotional family environment in childhood predicted higher levels of IL-2, IL-6, IFN-γ, and TNF-α in adulthood. Additionally, there were significant interaction effects between compassion and emotional risk in childhood, when predicting IL-2, IL-6, and TNF-α. Specifically, individuals who grew up in a risky emotional family environment had on average higher levels of IL-2, IL-6, and TNF-α in adulthood when combined with low compassion. Conclusions: In individuals coming from risky emotional family environments, high compassion for others may protect against elevated levels of cytokines previously linked with depression.

Published
2021

7. Childhood Exposure to Parental Smoking and Midlife Cognitive Function The Young Finns Study

Author

Rovio, S. P. (Suvi P.), Pihlman, J. (Jukka), Pahkala, K. (Katja), Juonala, M. (Markus), Magnussen, C. G. (Costan G.), Pitkänen, N. (Niina), Ahola-Olli, A. (Ari), Salo, P. (Pia), Kähönen, M. (Mika), Hutri-Kähönen, N. (Nina), Lehtimäki, T. (Terho), Jokinen, E. (Eero), Laitinen, T. (Tomi), Taittonen, L. (Leena), Tossavainen, P. (Päivi), Viikari, J. S. (Jorma S. A.), Raitakari, O. T. (Olli T.), Institute for Molecular Medicine Finland, Genomics of Neurological and Neuropsychiatric Disorders, University of Helsinki, HUS Children and Adolescents, Lastentautien yksikkö, and Children's Hospital

Subjects
SECONDHAND SMOKE, parental smoking, passive smoking, NICOTINE EXPOSURE, Cambridge Neuropsychological Test Automated Battery, ADULTHOOD, PERFORMANCE, 3142 Public health care science, environmental and occupational health, COTININE, AGE, CIGARETTE-SMOKE, SELF-REPORTED SMOKING, CARDIOVASCULAR RISK-FACTORS, OXIDATIVE STRESS, tobacco smoke, cognitive function, secondhand smoke
Abstract

We studied whether exposure to parental smoking in childhood/adolescence is associated with midlife cognitive function, leveraging data from the Cardiovascular Risk in Young Finns Study. A population-based cohort of 3,596 children/adolescents aged 3–18 years was followed between 1980 and 2011. In 2011, cognitive testing was performed on 2,026 participants aged 34–49 years using computerized testing. Measures of secondhand smoke exposure in childhood/adolescence consisted of parental self-reports of smoking and participants’ serum cotinine levels. Participants were classified into 3 exposure groups: 1) no exposure (nonsmoking parents, cotinine

Published
2020

8. Reaction time and visual memory in connection to alcohol use in persons with bipolar disorder

Author

Mazumder, A. H. (Atiqul Haq), Barnett, J. (Jennifer), Isometsä, E. T. (Erkki Tapio), Lindberg, N. (Nina), Torniainen-Holm, M. (Minna), Lähteenvuo, M. (Markku), Lahdensuo, K. (Kaisla), Kerkelä, M. (Martta), Ahola-Olli, A. (Ari), Hietala, J. (Jarmo), Kampman, O. (Olli), Kieseppä, T. (Tuula), Jukuri, T. (Tuomas), Häkkinen, K. (Katja), Cederlöf, E. (Erik), Haaki, W. (Willehard), Kajanne, R. (Risto), Wegelius, A. (Asko), Männynsalo, T. (Teemu), Niemi-Pynttäri, J. (Jussi), Suokas, K. (Kimmo), Lönnqvist, J. (Jouko), Tiihonen, J. (Jari), Paunio, T. (Tiina), Vainio, S. J. (Seppo Juhani), Palotie, A. (Aarno), Niemelä, S. (Solja), Suvisaari, J. (Jaana), Veijola, J. (Juha), Mazumder, A. H. (Atiqul Haq), Barnett, J. (Jennifer), Isometsä, E. T. (Erkki Tapio), Lindberg, N. (Nina), Torniainen-Holm, M. (Minna), Lähteenvuo, M. (Markku), Lahdensuo, K. (Kaisla), Kerkelä, M. (Martta), Ahola-Olli, A. (Ari), Hietala, J. (Jarmo), Kampman, O. (Olli), Kieseppä, T. (Tuula), Jukuri, T. (Tuomas), Häkkinen, K. (Katja), Cederlöf, E. (Erik), Haaki, W. (Willehard), Kajanne, R. (Risto), Wegelius, A. (Asko), Männynsalo, T. (Teemu), Niemi-Pynttäri, J. (Jussi), Suokas, K. (Kimmo), Lönnqvist, J. (Jouko), Tiihonen, J. (Jari), Paunio, T. (Tiina), Vainio, S. J. (Seppo Juhani), Palotie, A. (Aarno), Niemelä, S. (Solja), Suvisaari, J. (Jaana), and Veijola, J. (Juha)

Abstract

The purpose of this study was to explore the association of cognition with hazardous drinking and alcohol-related disorder in persons with bipolar disorder (BD). The study population included 1268 persons from Finland with bipolar disorder. Alcohol use was assessed through hazardous drinking and alcohol-related disorder including alcohol use disorder (AUD). Hazardous drinking was screened with the Alcohol Use Disorders Identification Test for Consumption (AUDIT-C) screening tool. Alcohol-related disorder diagnoses were obtained from the national registrar data. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on A tablet computer: the 5-choice serial reaction time task, or reaction time (RT) test and the Paired Associative Learning (PAL) test. Depressive symptoms were assessed with the Mental Health Inventory with five items (MHI-5). However, no assessment of current manic symptoms was available. Association between RT-test and alcohol use was analyzed with log-linear regression, and eβ with 95% confidence intervals (CI) are reported. PAL first trial memory score was analyzed with linear regression, and β with 95% CI are reported. PAL total errors adjusted was analyzed with logistic regression and odds ratios (OR) with 95% CI are reported. After adjustment of age, education, housing status and depression, hazardous drinking was associated with lower median and less variable RT in females while AUD was associated with a poorer PAL test performance in terms of the total errors adjusted scores in females. Our findings of positive associations between alcohol use and cognition in persons with bipolar disorder are difficult to explain because of the methodological flaw of not being able to separately assess only participants in euthymic phase.

Published
2021

9. Reaction time and visual memory in connection to hazardous drinking polygenic scores in schizophrenia, schizoaffective disorder and bipolar disorder

Author

Mazumder, A. H. (Atiqul Haq), Barnett, J. (Jennifer), Isometsä, E. T. (Erkki Tapio), Lindberg, N. (Nina), Torniainen-Holm, M. (Minna), Lähteenvuo, M. (Markku), Lahdensuo, K. (Kaisla), Kerkelä, M. (Martta), Ahola-Olli, A. (Ari), Hietala, J. (Jarmo), Kampman, O. (Olli), Kieseppä, T. (Tuula), Jukuri, T. (Tuomas), Häkkinen, K. (Katja), Cederlöf, E. (Erik), Haaki, W. (Willehard), Kajanne, R. (Risto), Wegelius, A. (Asko), Männynsalo, T. (Teemu), Niemi-Pynttäri, J. (Jussi), Suokas, K. (Kimmo), Lönnqvist, J. (Jouko), Tiihonen, J. (Jari), Paunio, T. (Tiina), Vainio, S. J. (Seppo Juhani), Palotie, A. (Aarno), Niemelä, S. (Solja), Suvisaari, J. (Jaana), Veijola, J. (Juha), Mazumder, A. H. (Atiqul Haq), Barnett, J. (Jennifer), Isometsä, E. T. (Erkki Tapio), Lindberg, N. (Nina), Torniainen-Holm, M. (Minna), Lähteenvuo, M. (Markku), Lahdensuo, K. (Kaisla), Kerkelä, M. (Martta), Ahola-Olli, A. (Ari), Hietala, J. (Jarmo), Kampman, O. (Olli), Kieseppä, T. (Tuula), Jukuri, T. (Tuomas), Häkkinen, K. (Katja), Cederlöf, E. (Erik), Haaki, W. (Willehard), Kajanne, R. (Risto), Wegelius, A. (Asko), Männynsalo, T. (Teemu), Niemi-Pynttäri, J. (Jussi), Suokas, K. (Kimmo), Lönnqvist, J. (Jouko), Tiihonen, J. (Jari), Paunio, T. (Tiina), Vainio, S. J. (Seppo Juhani), Palotie, A. (Aarno), Niemelä, S. (Solja), Suvisaari, J. (Jaana), and Veijola, J. (Juha)

Abstract

The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder.

Published
2021

10. Polygenic burden has broader impact on health, cognition, and socioeconomic outcomes than most rare and high-risk copy number variants

Author

Saarentaus, E. C. (Elmo Christian), Havulinna, A. S. (Aki Samuli), Mars, N. (Nina), Ahola-Olli, A. (Ari), Kiiskinen, T. T. (Tuomo Tapio Johannes), Partanen, J. (Juulia), Ruotsalainen, S. (Sanni), Kurki, M. (Mitja), Urpa, L. M. (Lea Martta), Chen, L. (Lei), Perola, M. (Markus), Salomaa, V. (Veikko), Veijola, J. (Juha), Männikkö, M. (Minna), Hall, I. M. (Ira M.), Pietiläinen, O. (Olli), Kaprio, J. (Jaakko), Ripatti, S. (Samuli), Daly, M. (Mark), Palotie, A. (Aarno), Saarentaus, E. C. (Elmo Christian), Havulinna, A. S. (Aki Samuli), Mars, N. (Nina), Ahola-Olli, A. (Ari), Kiiskinen, T. T. (Tuomo Tapio Johannes), Partanen, J. (Juulia), Ruotsalainen, S. (Sanni), Kurki, M. (Mitja), Urpa, L. M. (Lea Martta), Chen, L. (Lei), Perola, M. (Markus), Salomaa, V. (Veikko), Veijola, J. (Juha), Männikkö, M. (Minna), Hall, I. M. (Ira M.), Pietiläinen, O. (Olli), Kaprio, J. (Jaakko), Ripatti, S. (Samuli), Daly, M. (Mark), and Palotie, A. (Aarno)

Abstract

Copy number variants (CNVs) are associated with syndromic and severe neurological and psychiatric disorders (SNPDs), such as intellectual disability, epilepsy, schizophrenia, and bipolar disorder. Although considered high-impact, CNVs are also observed in the general population. This presents a diagnostic challenge in evaluating their clinical significance. To estimate the phenotypic differences between CNV carriers and non-carriers regarding general health and well-being, we compared the impact of SNPD-associated CNVs on health, cognition, and socioeconomic phenotypes to the impact of three genome-wide polygenic risk score (PRS) in two Finnish cohorts (FINRISK, n = 23,053 and NFBC1966, n = 4895). The focus was on CNV carriers and PRS extremes who do not have an SNPD diagnosis. We identified high-risk CNVs (DECIPHER CNVs, risk gene deletions, or large [>1 Mb] CNVs) in 744 study participants (2.66%), 36 (4.8%) of whom had a diagnosed SNPD. In the remaining 708 unaffected carriers, we observed lower educational attainment (EA; OR = 0.77 [95% CI 0.66–0.89]) and lower household income (OR = 0.77 [0.66–0.89]). Income-associated CNVs also lowered household income (OR = 0.50 [0.38–0.66]), and CNVs with medical consequences lowered subjective health (OR = 0.48 [0.32–0.72]). The impact of PRSs was broader. At the lowest extreme of PRS for EA, we observed lower EA (OR = 0.31 [0.26–0.37]), lower-income (OR = 0.66 [0.57–0.77]), lower subjective health (OR = 0.72 [0.61–0.83]), and increased mortality (Cox’s HR = 1.55 [1.21–1.98]). PRS for intelligence had a similar impact, whereas PRS for schizophrenia did not affect these traits. We conclude that the majority of working-age individuals carrying high-risk CNVs without SNPD diagnosis have a modest impact on morbidity and mortality, as well as the limited impact on income and educational attainment, compared to individuals at the extreme end of common genetic variation. Our findings highlight that the contribution of trad

Published
2021

11. Childhood exposure to parental smoking and midlife cognitive function:the Young Finns Study

Author

Rovio, S. P. (Suvi P.), Pihlman, J. (Jukka), Pahkala, K. (Katja), Juonala, M. (Markus), Magnussen, C. G. (Costan G.), Pitkänen, N. (Niina), Ahola-Olli, A. (Ari), Salo, P. (Pia), Kähönen, M. (Mika), Hutri-Kähönen, N. (Nina), Lehtimäki, T. (Terho), Jokinen, E. (Eero), Laitinen, T. (Tomi), Taittonen, L. (Leena), Tossavainen, P. (Päivi), Viikari, J. S. (Jorma S. A.), Raitakari, O. T. (Olli T.), Rovio, S. P. (Suvi P.), Pihlman, J. (Jukka), Pahkala, K. (Katja), Juonala, M. (Markus), Magnussen, C. G. (Costan G.), Pitkänen, N. (Niina), Ahola-Olli, A. (Ari), Salo, P. (Pia), Kähönen, M. (Mika), Hutri-Kähönen, N. (Nina), Lehtimäki, T. (Terho), Jokinen, E. (Eero), Laitinen, T. (Tomi), Taittonen, L. (Leena), Tossavainen, P. (Päivi), Viikari, J. S. (Jorma S. A.), and Raitakari, O. T. (Olli T.)

Abstract

We studied whether exposure to parental smoking in childhood/adolescence is associated with midlife cognitive function, leveraging data from the Cardiovascular Risk in Young Finns Study. A population-based cohort of 3,596 children/adolescents aged 3–18 years was followed between 1980 and 2011. In 2011, cognitive testing was performed on 2,026 participants aged 34–49 years using computerized testing. Measures of secondhand smoke exposure in childhood/adolescence consisted of parental self-reports of smoking and participants’ serum cotinine levels. Participants were classified into 3 exposure groups: 1) no exposure (nonsmoking parents, cotinine <1.0 ng/mL); 2) hygienic parental smoking (1–2 smoking parents, cotinine <1.0 ng/mL); and 3) nonhygienic parental smoking (1–2 smoking parents, cotinine ≥1.0 ng/mL). Analyses adjusted for sex, age, family socioeconomic status, polygenic risk score for cognitive function, adolescent/adult smoking, blood pressure, and serum total cholesterol level. Compared with the nonexposed, participants exposed to nonhygienic parental smoking were at higher risk of poor (lowest quartile) midlife episodic memory and associative learning (relative risk (RR) = 1.38, 95% confidence interval (CI): 1.08, 1.75), and a weak association was found for short-term and spatial working memory (RR = 1.25, 95% CI: 0.98, 1.58). Associations for those exposed to hygienic parental smoking were nonsignificant (episodic memory and associative learning: RR = 1.19, 95% CI: 0.92, 1.54; short-term and spatial working memory: RR = 1.10, 95% CI: 0.85, 1.34). We conclude that avoiding childhood/adolescence secondhand smoke exposure promotes adulthood cognitive function.

Published
2020

12. Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns

Author

Sliz, E. (Eeva), Kalaoja, M. (Marita), Ahola-Olli, A. (Ari), Raitakari, O. (Olli), Perola, M. (Markus), Salomaa, V. (Veikko), Lehtimäki, T. (Terho), Karhu, T. (Toni), Viinamäki, H. (Heimo), Salmi, M. (Marko), Santalahti, K. (Kristiina), Jalkanen, S. (Sirpa), Jokelainen, J. (Jari), Keinänen-Kiukaanniemi, S. (Sirkka), Männikkö, M. (Minna), Herzig, K.-H. (Karl-Heinz), Järvelin, M.-R. (Marjo-Riitta), Sebert, S. (Sylvain), and Kettunen, J. (Johannes)

Abstract

Background: Inflammatory processes contribute to the pathophysiology of multiple chronic conditions. Genetic factors play a crucial role in modulating the inflammatory load, but the exact mechanisms are incompletely understood. Objective: To assess genetic determinants of 16 circulating cytokines and cell adhesion molecules (inflammatory phenotypes) in Finns. Methods: Genome-wide associations of the inflammatory phenotypes were studied in Northern Finland Birth Cohort 1966 (N=5284). A subsequent meta-analysis was completed for 10 phenotypes available in a previous genome-wide association study, adding up to 13 577 individuals in the study. Complementary association tests were performed to study the effect of the ABO blood types on soluble adhesion molecule levels. Results: We identified seven novel and six previously reported genetic associations (p

Published
2019

13. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Author

Davies, G. (Gail), Lam, M. (Max), Harris, S.E. (Sarah), Trampush, J.W. (Joey W.), Luciano, M. (Michelle), Hill, W.D. (W. David), Hagenaars, S. (Saskia), Ritchie, S.J. (Stuart J.), Marioni, R.E. (Riccardo), Fawns-Ritchie, C., Liewald, D.C.M. (David C. M.), Okely, J.A. (Judith A.), Ahola-Olli, A.V. (Ari V.), Barnes, C.L.K. (Catriona L. K.), Bertram, L. (Lars), Bis, J.C. (Joshua), Burdick, K.E. (Katherine E.), Christoforou, A. (Andrea), Derosse, P. (Pamela), Djurovic, S. (Srdjan), Espeseth, T. (Thomas), Giakoumaki, S. (Stella), Giddaluru, S. (Sudheer), Gustavson, D.E. (Daniel E.), Hayward, C. (Caroline), Hofer, E. (Edith), Ikram, M.A. (Arfan), Karlsson, R. (Robert), Knowles, E. (Emma), Lahti, J. (Jari), Leber, I. (Isabelle), Li, S. (Shuo), Mather, R., Melle, I. (Ingrid), Morris, D. (Derek), Oldmeadow, C. (Christopher), Palviainen, T. (Teemu), Payton, A. (Antony), Pazoki, R. (Raha), Petrovic, K. (Katja), Reynolds, C.A. (C.), Sargurupremraj, M. (Muralidharan), Scholz, M. (Markus), Smith, J.A. (Jennifer A), Smith, A.V. (Albert), Terzikhan, N. (Natalie), Thalamuthu, A. (Anbupalam), Trompet, S. (Stella), Lee, S.J. (Sven) van der, Ware, E.B. (Erin B.), Windham, B.G. (Gwen), Wright, M.J. (Margaret J.), Yang, J. (Jingyun), Yu, J. (Jin), Ames, D.J. (David), Amin, N. (Najaf), Amouyel, P. (Philippe), Andreassen, O.A. (Ole), Armstrong, N.J. (Nicola J.), Assareh, A.A., Attia, J. (John), Attix, D. (Deborah), Avramopoulos, D. (Dimitrios), Bennett, D.A. (David), Böhmer, M.R. (Marcel), Boyle, P.A. (Patricia A.), Brodaty, H. (Henry), Campbell, H. (Harry), Cannon, T.D. (Tyrone D.), Cirulli, E.T. (Elizabeth T.), Congdon, E. (Eliza), Conley, E.D. (Emily Drabant), Corley, J. (Janie), Cox, S.R. (Simon R.), Dale, A.M. (Anders), Dehghan, A. (Abbas), Dick, D. (Danielle), Dickinson, D. (Dwight), Hagen, K. (Knut), Evangelou, E. (Evangelos), Faul, J.D. (Jessica D.), Ford, I. (Ian), Freimer, N.A. (Nelson A.), Gao, H. (He), Giegling, I. (Ina), Gillespie, N.A. (Nathan A.), Gordon, S.D. (Scott D.), Gottesman, R.F. (Rebecca), Griswold, M.D. (Michael), Gudnason, V. (Vilmundur), Harris, T.B. (Tamara), Hartmann, A.M. (Annette M), Hatzimanolis, A. (Alex), Heiss, G. (Gerardo), Holliday, E.G. (Elizabeth), Joshi, P.K. (Peter), Kähönen, M. (Mika), Kardia, S.L.R. (Sharon L. R.), Karlsson, I. (Ida), Kleineidam, L. (Luca), Knopman, D.S. (David), Kochan, N.A. (Nicole A.), Konte, B. (Bettina), Kwok, J.B.J. (John), Le Hellard, S. (Stephanie), Lee, T. (Teresa), Lehtimäki, T. (Terho), Li, S.-C. (Shu-Chen), Liu, T. (Tian), Koini, M. (Marisa), London, E. (Edythe), Longstreth Jr, W.T., Lopez, O.L. (Oscar), Loukola, A. (Anu), Luck, T. (Tobias), Lundervold, A.J. (Astri), Lundquist, A. (Anders), Lyytikäinen, L.-P. (Leo-Pekka), Martin, N.G. (Nicholas), Montgomery, G.W. (Grant W.), Murray, A.D. (Alison D.), Need, A.C. (Anna C.), Noordam, R. (Raymond), Nyberg, L. (Lisa), Ollier, W.E.R. (William), Papenberg, G., Pattie, A. (Alison), Polasek, O. (Ozren), Poldrack, R.A. (Russell A.), Psaty, B.M. (Bruce M.), Reppermund, S., Riedel-Heller, S. (Steffi), Rose, R.J. (Richard), Rotter, J.I. (Jerome I.), Roussos, A. (Alexandra), Rovio, S.P. (Suvi P.), Saba, Y. (Yasaman), Sabb, F.W. (Fred W.), Sachdev, P.S. (Perminder), Satizabal, C.L. (Claudia), Schmid, M. (Matthias), Scott, R.J. (Rodney J.), Scult, M.A. (Matthew A.), Simino, J. (Jeannette), Slagboom, P.E. (Eline), Smyrnis, N. (Nikolaos), Soumaré, A. (Aicha), Stefanis, N.C. (Nikos C.), Stott, D.J. (David. J.), Straub, R.E. (Richard), Sundet, K. (Kjetil), Taylor, A.M. (Adele M.), Taylor, K.D. (Kent), Tzoulaki, I., Tzourio, C. (Christophe), Uitterlinden, A.G. (André), Vitart, V. (Veronique), Voineskos, A.N. (Aristotle N.), Kaprio, J. (Jaakko), Wagner, M. (Michael), Wagner, H. (Hermann), Weinhold, L. (Leonie), Wen, K.H. (K. Hoyan), Widen, E., Yang, Q. (Qiong Fang), Zhao, W. (Wei), Adams, H.H.H. (Hieab), Arking, D.E. (Dan), Bilder, R.M. (Robert M.), Bitsios, P. (Panos), Boerwinkle, E. (Eric), Chiba-Falek, O. (Ornit), Corvin, A. (Aiden), Jager, P.L. (Philip) de, Debette, S. (Stéphanie), Donohoe, D.J. (Dennis), Elliott, P. (Paul), Fitzpatrick, A.L. (Annette), Gill, M. (Michael), Glahn, D.C. (David), Hägg, S. (Sara), Hansell, N.K. (Narelle), Hariri, A.R. (Ahmad), Ikram, M.K. (Kamran), Jukema, J.W. (Jan Wouter), Vuoksimaa, E. (Eero), Keller, M.C. (Matthew C), Kremen, W.S. (William S.), Launer, L.J. (Lenore), Lindenberger, U. (Ulman), Palotie, A. (Aarno), Pedersen, N.L. (Nancy), Pendleton, N. (Neil), Porteous, D.J. (David J.), Räikkönen, K. (Katri), Raitakari, O.T. (Olli T.), Ramirez, A. (Alfredo), Reinvang, I. (Ivar), Rudan, I. (Igor), Rujescu, D. (Dan), Schmidt, R. (Reinhold), Schmidt, H. (Helena), Schofield, P.W. (Peter W.), Schofield, C.J. (Christopher), Starr, J.M. (John), Steen, V.M. (Vidar), Trollor, J., Turner, S.T. (Steven T.), Duijn, C.M. (Cornelia) van, Villringer, A. (Arno), Weinberger, D.R. (Daniel), Weir, D.R. (David R.), Wilson, J.F. (James F.), Malhotra, A.K. (Anil K), McIntosh, A.M. (Andrew), Gale, C.R. (Catharine R.), Seshadri, S. (Sudha), Mosley, T.H. (Thomas H.), Bressler, J. (Jan), Lencz, T. (Todd), Deary, I.J. (Ian), Davies, G. (Gail), Lam, M. (Max), Harris, S.E. (Sarah), Trampush, J.W. (Joey W.), Luciano, M. (Michelle), Hill, W.D. (W. David), Hagenaars, S. (Saskia), Ritchie, S.J. (Stuart J.), Marioni, R.E. (Riccardo), Fawns-Ritchie, C., Liewald, D.C.M. (David C. M.), Okely, J.A. (Judith A.), Ahola-Olli, A.V. (Ari V.), Barnes, C.L.K. (Catriona L. K.), Bertram, L. (Lars), Bis, J.C. (Joshua), Burdick, K.E. (Katherine E.), Christoforou, A. (Andrea), Derosse, P. (Pamela), Djurovic, S. (Srdjan), Espeseth, T. (Thomas), Giakoumaki, S. (Stella), Giddaluru, S. (Sudheer), Gustavson, D.E. (Daniel E.), Hayward, C. (Caroline), Hofer, E. (Edith), Ikram, M.A. (Arfan), Karlsson, R. (Robert), Knowles, E. (Emma), Lahti, J. (Jari), Leber, I. (Isabelle), Li, S. (Shuo), Mather, R., Melle, I. (Ingrid), Morris, D. (Derek), Oldmeadow, C. (Christopher), Palviainen, T. (Teemu), Payton, A. (Antony), Pazoki, R. (Raha), Petrovic, K. (Katja), Reynolds, C.A. (C.), Sargurupremraj, M. (Muralidharan), Scholz, M. (Markus), Smith, J.A. (Jennifer A), Smith, A.V. (Albert), Terzikhan, N. (Natalie), Thalamuthu, A. (Anbupalam), Trompet, S. (Stella), Lee, S.J. (Sven) van der, Ware, E.B. (Erin B.), Windham, B.G. (Gwen), Wright, M.J. (Margaret J.), Yang, J. (Jingyun), Yu, J. (Jin), Ames, D.J. (David), Amin, N. (Najaf), Amouyel, P. (Philippe), Andreassen, O.A. (Ole), Armstrong, N.J. (Nicola J.), Assareh, A.A., Attia, J. (John), Attix, D. (Deborah), Avramopoulos, D. (Dimitrios), Bennett, D.A. (David), Böhmer, M.R. (Marcel), Boyle, P.A. (Patricia A.), Brodaty, H. (Henry), Campbell, H. (Harry), Cannon, T.D. (Tyrone D.), Cirulli, E.T. (Elizabeth T.), Congdon, E. (Eliza), Conley, E.D. (Emily Drabant), Corley, J. (Janie), Cox, S.R. (Simon R.), Dale, A.M. (Anders), Dehghan, A. (Abbas), Dick, D. (Danielle), Dickinson, D. (Dwight), Hagen, K. (Knut), Evangelou, E. (Evangelos), Faul, J.D. (Jessica D.), Ford, I. (Ian), Freimer, N.A. (Nelson A.), Gao, H. (He), Giegling, I. (Ina), Gillespie, N.A. (Nathan A.), Gordon, S.D. (Scott D.), Gottesman, R.F. (Rebecca), Griswold, M.D. (Michael), Gudnason, V. (Vilmundur), Harris, T.B. (Tamara), Hartmann, A.M. (Annette M), Hatzimanolis, A. (Alex), Heiss, G. (Gerardo), Holliday, E.G. (Elizabeth), Joshi, P.K. (Peter), Kähönen, M. (Mika), Kardia, S.L.R. (Sharon L. R.), Karlsson, I. (Ida), Kleineidam, L. (Luca), Knopman, D.S. (David), Kochan, N.A. (Nicole A.), Konte, B. (Bettina), Kwok, J.B.J. (John), Le Hellard, S. (Stephanie), Lee, T. (Teresa), Lehtimäki, T. (Terho), Li, S.-C. (Shu-Chen), Liu, T. (Tian), Koini, M. (Marisa), London, E. (Edythe), Longstreth Jr, W.T., Lopez, O.L. (Oscar), Loukola, A. (Anu), Luck, T. (Tobias), Lundervold, A.J. (Astri), Lundquist, A. (Anders), Lyytikäinen, L.-P. (Leo-Pekka), Martin, N.G. (Nicholas), Montgomery, G.W. (Grant W.), Murray, A.D. (Alison D.), Need, A.C. (Anna C.), Noordam, R. (Raymond), Nyberg, L. (Lisa), Ollier, W.E.R. (William), Papenberg, G., Pattie, A. (Alison), Polasek, O. (Ozren), Poldrack, R.A. (Russell A.), Psaty, B.M. (Bruce M.), Reppermund, S., Riedel-Heller, S. (Steffi), Rose, R.J. (Richard), Rotter, J.I. (Jerome I.), Roussos, A. (Alexandra), Rovio, S.P. (Suvi P.), Saba, Y. (Yasaman), Sabb, F.W. (Fred W.), Sachdev, P.S. (Perminder), Satizabal, C.L. (Claudia), Schmid, M. (Matthias), Scott, R.J. (Rodney J.), Scult, M.A. (Matthew A.), Simino, J. (Jeannette), Slagboom, P.E. (Eline), Smyrnis, N. (Nikolaos), Soumaré, A. (Aicha), Stefanis, N.C. (Nikos C.), Stott, D.J. (David. J.), Straub, R.E. (Richard), Sundet, K. (Kjetil), Taylor, A.M. (Adele M.), Taylor, K.D. (Kent), Tzoulaki, I., Tzourio, C. (Christophe), Uitterlinden, A.G. (André), Vitart, V. (Veronique), Voineskos, A.N. (Aristotle N.), Kaprio, J. (Jaakko), Wagner, M. (Michael), Wagner, H. (Hermann), Weinhold, L. (Leonie), Wen, K.H. (K. Hoyan), Widen, E., Yang, Q. (Qiong Fang), Zhao, W. (Wei), Adams, H.H.H. (Hieab), Arking, D.E. (Dan), Bilder, R.M. (Robert M.), Bitsios, P. (Panos), Boerwinkle, E. (Eric), Chiba-Falek, O. (Ornit), Corvin, A. (Aiden), Jager, P.L. (Philip) de, Debette, S. (Stéphanie), Donohoe, D.J. (Dennis), Elliott, P. (Paul), Fitzpatrick, A.L. (Annette), Gill, M. (Michael), Glahn, D.C. (David), Hägg, S. (Sara), Hansell, N.K. (Narelle), Hariri, A.R. (Ahmad), Ikram, M.K. (Kamran), Jukema, J.W. (Jan Wouter), Vuoksimaa, E. (Eero), Keller, M.C. (Matthew C), Kremen, W.S. (William S.), Launer, L.J. (Lenore), Lindenberger, U. (Ulman), Palotie, A. (Aarno), Pedersen, N.L. (Nancy), Pendleton, N. (Neil), Porteous, D.J. (David J.), Räikkönen, K. (Katri), Raitakari, O.T. (Olli T.), Ramirez, A. (Alfredo), Reinvang, I. (Ivar), Rudan, I. (Igor), Rujescu, D. (Dan), Schmidt, R. (Reinhold), Schmidt, H. (Helena), Schofield, P.W. (Peter W.), Schofield, C.J. (Christopher), Starr, J.M. (John), Steen, V.M. (Vidar), Trollor, J., Turner, S.T. (Steven T.), Duijn, C.M. (Cornelia) van, Villringer, A. (Arno), Weinberger, D.R. (Daniel), Weir, D.R. (David R.), Wilson, J.F. (James F.), Malhotra, A.K. (Anil K), McIntosh, A.M. (Andrew), Gale, C.R. (Catharine R.), Seshadri, S. (Sudha), Mosley, T.H. (Thomas H.), Bressler, J. (Jan), Lencz, T. (Todd), and Deary, I.J. (Ian)

Abstract

General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the c

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results