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300 results on '"Ahotupa, Markku"'

17. Determinants of coronary flow velocity reserve in healthy young men

Author

Kiviniemi, Tuomas O., Snapir, Amir, Saraste, Markku, Toikka, Jyri O., Raitakari, Olli T., Ahotupa, Markku, Hartiala, Jaakko J., Scheinin, Mika, and Koskenvuo, Juha W.

Subjects
Blood flow -- Research, Coronary vessels -- Research, Biological sciences
Abstract

The objective of this study was to identify risk markers for attenuated coronary flow velocity reserve (CFVR) that exist in healthy young men without evident atherosclerotic risk factors. Coronary blood flow velocity was measured with transthoracic Doppler echocardiography at baseline and during adenosine infusion in 37 healthy nonsmoking men [mean age, 27 yr (SD 4.0)]. Body composition and distribution of fat tissue were assessed with anthropometric measures and regulation of fat metabolism by determination of adiponectin and leptin levels. Physical performance capacity was tested with ergospirometry. The mean body mass index was 23 kg/[m.sup.2] (SD 1.9), waist-to-hip ratio was 0.84 (SD 0.04), and CFVR was 3.5 (SD 0.61). Obesity indexes at study outset, leptin, adiponectin, maximal load (Max load in W/kg) and maximal oxygen consumption (V[O.sub.2] peak in ml x [kg.sup.-1] x [min.sup.-1]) in ergospirometry, ratepressure product, and heart rate at rest were significantly associated with CFVR. In multivariate analysis, Max load (in W/kg) and waistto-hip ratio were the only independent predictors of CFVR. We found no relationship between CFVR and serum lipids or body mass index. We conclude that abdominal fat accumulation and low aerobic fitness are independently associated with CFVR in men. transthoracic Doppler echocardiography; physical capacity in ergospirometry; visceral adipose tissue doi:10.1152/ajpheart.00915.2005

Published
2006

35. Increased serum and low-density-lipoprotein antioxidant potential after antioxidant supplementation in endurance athletes

Author

Vasankari, Tommi J., Kujala, Urho M., Vasankari, Tuula M., Vuorimaa, Timo, and Ahotupa, Markku

Subjects
Antioxidants -- Physiological aspects, Low density lipoproteins -- Health aspects, Lipid peroxidation -- Physiological aspects, Exercise -- Physiological aspects, Athletes -- Health aspects, Food/cooking/nutrition, Health
Abstract

We studied the effect of antioxidant supplementation on acute exercise-induced lipid peroxidation and antioxidant potential measured in serum and low-density-lipoprotein (LDL) samples. Eight endurance athletes repeated a 31-km running exercise twice with aD interval of 4 wk. During the 4 wk before the runs, the subjects took in a single-blind randomized order either a combination of antioxidant supplements (the antioxidant trial; 294 mg vitamin E, 1000 mg vitamin C, and 60 mg ubiquinone daily) or placebo (the placebo trial). Venous blood samples were taken before and immediately after the 31-km run in both trials. Anti-oxidant supplementation raised the LDL antioxidant potential (TRAP) (40% and 30%, P = 0.0031), serum TRAP (9% and 10%, P = 0.0037), and serum [alpha]-tocopherol concentration (by 59% and 66%, P = 0.0004), in both pre- and postexercise samples, respectively. The supplementation did not, however, affect the concentration of LDL diene conjugation (DC) or of serum DC. Physical exercise increased serum DC (by 18% and 10%, P = 0.0004) but not LDL-DC, and the quantity of the increment of serum DC was not affected by antioxidant intervention. The major cause for the increased LDL-TRAP and serum TRAP after antioxidant supplementation is apparently the elevation of the serum [alpha]-tocopherol concentration.

Published
1997

40. Young Men With Poor Cardiorespiratory Fitness Combined With lower Testosterone Have High Levels of Oxidized LDL Lipids-Being Fit Alters This Relationship.

Author

Kosola, Jussi, Ahotupa, Markku, Kyröläinen, Heikki, Santtila, Matti, and Vasankari, Tommi

Abstract

Purpose: We hypothesized that lower androgen status together with poor physical fitness associates with atherogenic lipid profile and oxidative stress. Methods: Volunteered young men (N = 846, mean age 25.1 ± 4.6 years) were categorized into unfit, average fit, and fit groups according to tertiles of maximal oxygen uptake, series of muscle endurance tests, and maximal upper and lower body strength. Furthermore, concentrations of serum testosterone (TT) and free testosterone (FT) were determined to divide participants into lower and higher testosterone (loTT, hiTT) and free testosterone (loFT, hiFT) subgroups, using medians as cut-off points. The participants were divided into subgroups according to Fitness à Testosterone (Unfit/Average Fit/ Fit à Low/High TT/FT), and the concentrations of serum lipids and ox-LDL were measured. Results: The loTT/unfit cardiorespiratory subgroup had 29% higher concentration of ox-LDL compared with the loTT/fit cardiorespiratory subgroup (p = .044). The loTT / unfit cardiorespiratory subgroup had a significantly higher ratio of ox-LDL/HDL-cholesterol compared with the other five TT subgroups (p < .05, in all). While ox-LDL showed a gradual form of decrease from unfit to fit in loTT cardiorespiratory subgroups, no differences were seen in muscular fitness or maximal strength (upper and lower body) subgroups. Conclusions: Young men with poor cardiorespiratory fitness together with lower levels of TT have higher concentrations of ox-LDL. Good cardiorespiratory fitness combined with lower androgen levels is not related to atherogenic lipid profile. The combination of poor muscular fitness, or maximal muscle strength, and lower TT levels does not cause atherogenic lipid profile. [ABSTRACT FROM AUTHOR]

Published
2013

46. Two weeks of moderate-intensity continuous training, but not high-intensity interval training, increases insulin-stimulated intestinal glucose uptake

Author

Motiani, Kumail K., primary, Savolainen, Anna M., additional, Eskelinen, Jari-Joonas, additional, Toivanen, Jussi, additional, Ishizu, Tamiko, additional, Yli-Karjanmaa, Minna, additional, Virtanen, Kirsi A., additional, Parkkola, Riitta, additional, Kapanen, Jukka, additional, Grönroos, Tove J., additional, Haaparanta-Solin, Merja, additional, Solin, Olof, additional, Savisto, Nina, additional, Ahotupa, Markku, additional, Löyttyniemi, Eliisa, additional, Knuuti, Juhani, additional, Nuutila, Pirjo, additional, Kalliokoski, Kari K., additional, and Hannukainen, Jarna C., additional

Published
2017
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49. Longitudinal study of circulating oxidized LDL and HDL and fatty liver: the Cardiovascular Risk in Young Finns Study

Author

Kaikkonen, Jari E., primary, Kresanov, Petri, additional, Ahotupa, Markku, additional, Jula, Antti, additional, Mikkilä, Vera, additional, Viikari, Jorma S. A., additional, Juonala, Markus, additional, Hutri-Kähönen, Nina, additional, Kähönen, Mika, additional, Lehtimäki, Terho, additional, Kangas, Antti J., additional, Soininen, Pasi, additional, Ala-Korpela, Mika, additional, and Raitakari, Olli T., additional

Published
2016
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