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6 results on '"Aigerim Aidarova"'

1. Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation

Author

Matouš Vobořil, Tomáš Brabec, Jan Dobeš, Iva Šplíchalová, Jiří Březina, Adéla Čepková, Martina Dobešová, Aigerim Aidarova, Jan Kubovčiak, Oksana Tsyklauri, Ondřej Štěpánek, Vladimír Beneš, Radislav Sedláček, Ludger Klein, Michal Kolář, and Dominik Filipp

Subjects
Science
Abstract

Immune tolerance is mediated by the deletion of autoreactive T cells via medullary thymic epithelial cells (mTEC) and dendritic cells (DC), and by the induction of regulatory T cells (Treg). Here the authors show that mTEC receiving toll-like receptor signaling control the recruitment of CD14+Sirpα+ DC population that is capable of inducing Treg for establishing tolerance.

Published
2020
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2. Genetic Influence on Frequencies of Myeloid-Derived Cell Subpopulations in Mouse

Author

Imtissal Krayem, Yahya Sohrabi, Eliška Javorková, Valeriya Volkova, Hynek Strnad, Helena Havelková, Jarmila Vojtíšková, Aigerim Aidarova, Vladimír Holáň, Peter Demant, and Marie Lipoldová

Subjects
myeloid-derived cells, genetic control, CD11b+Gr1+ subpopulation, neutrophils, relative spleen weight, spleen architecture, Immunologic diseases. Allergy, RC581-607
Abstract

Differences in frequencies of blood cell subpopulations were reported to influence the course of infections, atopic and autoimmune diseases, and cancer. We have discovered a unique mouse strain B10.O20 containing extremely high frequency of myeloid-derived cells (MDC) in spleen. B10.O20 carries 3.6% of genes of the strain O20 on the C57BL/10 genetic background. It contains much higher frequency of CD11b+Gr1+ cells in spleen than both its parents. B10.O20 carries O20-derived segments on chromosomes 1, 15, 17, and 18. Their linkage with frequencies of blood cell subpopulations in spleen was tested in F2 hybrids between B10.O20 and C57BL/10. We found 3 novel loci controlling MDC frequencies: Mydc1, 2, and 3 on chromosomes 1, 15, and 17, respectively, and a locus controlling relative spleen weight (Rsw1) that co-localizes with Mydc3 and also influences proportion of white and red pulp in spleen. Mydc1 controls numbers of CD11b+Gr1+ cells. Interaction of Mydc2 and Mydc3 regulates frequency of CD11b+Gr1+ cells and neutrophils (Gr1+Siglec-F- cells from CD11b+ cells). Interestingly, Mydc3/Rsw1 is orthologous with human segment 6q21 that was shown previously to determine counts of white blood cells. Bioinformatics analysis of genomic sequence of the chromosomal segments bearing these loci revealed polymorphisms between O20 and C57BL/10 that change RNA stability and genes’ functions, and we examined expression of relevant genes. This identified potential candidate genes Smap1, Vps52, Tnxb, and Rab44. Definition of genetic control of MDC can help to personalize therapy of diseases influenced by these cells.

Published
2022
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4. IL-17 driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum

Author

Tomas Brabec, Matouš Vobořil, Dagmar Schierova, Evgeny Valter, Iva Splichalova, Jan Dobeš, Jiri Brezina, Martina Dobesova, Aigerim Aidarova, Martin Jakubec, Jasper Manning, Richard Blumberg, Ari Waissman, Michal Kolar, Jan Kubovciak, Dagmar Srutkova, Tomas Hudcovic, Martin Schwarzer, Eva Fronkova, Tereza Pinkasova, Petr Jabandziev, and Dominik Filipp

Subjects
Immunology, Immunology and Allergy
Published
2023
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5. Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation

Author

Adéla Čepková, Radislav Sedlacek, Jan Kubovciak, Martina Dobešová, Aigerim Aidarova, Iva Splichalova, Dominik Filipp, Matouš Vobořil, Oksana Tsyklauri, Jan Dobeš, Vladimir Benes, Ludger Klein, Jiří Březina, Tomáš Brabec, Ondřej Štěpánek, and Michal Kolář

Subjects
0301 basic medicine, Central tolerance, Lipopolysaccharide Receptors, General Physics and Astronomy, Autoimmunity, Cell Separation, Dendritic cells, Autoantigens, T-Lymphocytes, Regulatory, Mice, 0302 clinical medicine, IL-2 receptor, Receptors, Immunologic, lcsh:Science, Antigen Presentation, Toll-like receptor, education.field_of_study, Multidisciplinary, Toll-Like Receptors, FOXP3, hemic and immune systems, Regulatory T cells, Colitis, Flow Cytometry, Adoptive Transfer, Up-Regulation, Cell biology, Self Tolerance, Chemokines, Single-Cell Analysis, Signal Transduction, CD14, Science, Population, Antigen presentation, chemical and pharmacologic phenomena, Thymus Gland, Biology, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Animals, education, Sequence Analysis, RNA, Epithelial Cells, General Chemistry, Dendritic cell, Disease Models, Animal, 030104 developmental biology, lcsh:Q, 030215 immunology
Abstract

The development of thymic regulatory T cells (Treg) is mediated by Aire-regulated self-antigen presentation on medullary thymic epithelial cells (mTECs) and dendritic cells (DCs), but the cooperation between these cells is still poorly understood. Here we show that signaling through Toll-like receptors (TLR) expressed on mTECs regulates the production of specific chemokines and other genes associated with post-Aire mTEC development. Using single-cell RNA-sequencing, we identify a new thymic CD14+Sirpα+ population of monocyte-derived dendritic cells (CD14+moDC) that are enriched in the thymic medulla and effectively acquire mTEC-derived antigens in response to the above chemokines. Consistently, the cellularity of CD14+moDC is diminished in mice with MyD88-deficient TECs, in which the frequency and functionality of thymic CD25+Foxp3+ Tregs are decreased, leading to aggravated mouse experimental colitis. Thus, our findings describe a TLR-dependent function of mTECs for the recruitment of CD14+moDC, the generation of Tregs, and thereby the establishment of central tolerance., Immune tolerance is mediated by the deletion of autoreactive T cells via medullary thymic epithelial cells (mTEC) and dendritic cells (DC), and by the induction of regulatory T cells (Treg). Here the authors show that mTEC receiving toll-like receptor signaling control the recruitment of CD14+Sirpα+ DC population that is capable of inducing Treg for establishing tolerance.

Published
2020

6. Determination of rational transformation coefficients of transformers distribution networks

Author

Dauren Akhmetbayev, Arman Akhmetbayev, and Aigerim Aidarova

Subjects
010302 applied physics, lcsh:GE1-350, Distribution networks, MathematicsofComputing_NUMERICALANALYSIS, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, law.invention, Nonlinear system, law, 0103 physical sciences, ComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATION, Applied mathematics, 0210 nano-technology, Transformer, lcsh:Environmental sciences, Mathematics, Voltage
Abstract

The thesis proposed a systematic approach to the determination of rational coefficients transformation of transformers distribution networks. Analytic expressions are obtained for transformation coefficient of transformer from the point of view of synthesis of distribution networks in the field of permissible voltage regimes. The Newton-Raphson method was used to solve nonlinear equations for transformation coefficients. This eliminates the need for calculation of steady distribution network modes.

Published
2017

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