5 results on '"Aikeremu Aierken"'
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2. A review of chemotherapeutic drugs-induced arrhythmia and potential intervention with traditional Chinese medicines
- Author
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Weina Li, Xiaozhen Cheng, Guanghui Zhu, Ying Hu, Yunhan Wang, Yueyue Niu, Hongping Li, Aikeremu Aierken, Jie Li, Ling Feng, and Guifang Liu
- Subjects
chemotherapeutic drugs ,traditional Chinese medicine ,arrhythmia ,adverse effects ,review ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Significant advances in chemotherapy drugs have reduced mortality in patients with malignant tumors. However, chemotherapy-related cardiotoxicity increases the morbidity and mortality of patients, and has become the second leading cause of death after tumor recurrence, which has received more and more attention in recent years. Arrhythmia is one of the common types of chemotherapy-induced cardiotoxicity, and has become a new risk related to chemotherapy treatment, which seriously affects the therapeutic outcome in patients. Traditional Chinese medicine has experienced thousands of years of clinical practice in China, and has accumulated a wealth of medical theories and treatment formulas, which has unique advantages in the prevention and treatment of malignant diseases. Traditional Chinese medicine may reduce the arrhythmic toxicity caused by chemotherapy without affecting the anti-cancer effect. This paper mainly discussed the types and pathogenesis of secondary chemotherapeutic drug-induced arrhythmia (CDIA), and summarized the studies on Chinese medicine compounds, Chinese medicine Combination Formula and Chinese medicine injection that may be beneficial in intervention with secondary CDIA including atrial fibrillation, ventricular arrhythmia and sinus bradycardia, in order to provide reference for clinical prevention and treatment of chemotherapy-induced arrhythmias.
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- 2024
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3. Effect of individualized management on ART failure among HIV/AIDS patients: a follow-up study in Yili prefecture, Xinjiang Uygur Auto-nomous Region
- Author
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Meng SHAN, Arezu·Rouziniyazi, Xiaomin HU, Hao CHEN, Fuxiu YE, Aikeremu·Aierken, and Mingjian NI
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individualized management ,hiv/aids ,antiretroviral therapy ,immunological efficacy ,Public aspects of medicine ,RA1-1270 - Abstract
ObjectiveTo analyze the effect of individualized management on antiretroviral therapy (ART) failure among human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients for developing effective individualized management scheme for HIV/AIDS patients on ART.MethodsA total of 1 882 HIV/AIDS patients (≥ 16 years old) on ART and with baseline CD4+T lymphocytes (CD4+T) counts were recruited in the Second People′s Hospital of Yining City, Xinjiang Uygur Autonomous Region (Xinjiang) from 2018 through October 2020. Then the patients were randomly assigned into two gender- and age-matched groups (941 in each group): a group with ordinary management including routine follow-up interview and CD4+T count, free ART, psychological support, and health education and the other group with increased face-to-face follow-ups for comprehensive assessment on conditions relevant to ART by medical staff or community workers and the development of individualized management schemes. Mann-Whitney test was used to analyze the trend in CD4+T count change of the two groups over time; the cumulative incidence curve of ART failure of the two groups were plotted with Kaplan-Meier (K-M) method and Cox proportional hazard regression model was adopted to explore influencing factors of ART failure. ResultsCompared with those in the routine management group, significantly higher CD4+T counts were detected in follow-up laboratory tests in the individualized management group (P < 0.05 for all), especially for the patients with the baseline CD4+T count of < 350/μL after 6-month ART. The K-M analysis showed that at the end of follow-up, the cumulative ART failure rate (11.4%, 107/941) of the individualized management group was significantly lower than that (16.9%, 159/941) of the routine intervention group (P = 0.001 in Log-rank test). Multivariate Cox regression analysis revealed that the patients under individualized management (hazard risk [HR] = 0.733, 95% confidence interval [95%CI]: 0.572-0.939) and those with the CD4+T count of ≥ 350/μL at the first follow-up (HR = 0.271, 95%CI: 0.212 – 0.346) were at lower ART failure risk; but the patients with the interval of ≥ 366 days between the HIV infection confirmation and the beginning of ART were at a higher risk of ART failure (HR = 1.474, 95%CI: 1.059 – 2.050). ConclusionIndividualized management could reduce immunological failure among HIV/AIDS patients on ART; low CD4+T count and long interval between HIV infection confirmation and the beginning of ART are risk factors for ART failure for the patients on the treatment.
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- 2023
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4. [Transverse small incision intrathecal "loop" minimally invasive suture for treatment of acute Achilles tendon rupture].
- Author
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Aikeremu Aierken, Zhang Y, Gao W, Qin J, Jiang Q, and Chen D
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- Humans, Male, Adult, Middle Aged, Retrospective Studies, Rupture surgery, Treatment Outcome, Operative Time, Length of Stay, Wound Healing, Sutures, Blood Loss, Surgical, Athletic Injuries surgery, Achilles Tendon injuries, Achilles Tendon surgery, Minimally Invasive Surgical Procedures methods, Suture Techniques, Tendon Injuries surgery
- Abstract
Objective: To evaluate the effectiveness and feasibility of a transverse small incision intrathecal "loop" minimally invasive suture for acute Achilles tendon rupture., Methods: The clinical data of 30 patients with acute Achilles tendon rupture treated with transverse small incision intrathecal "loop" minimally invasive suture between January 2022 and October 2023 was retrospectively analyzed. The patients were all male, aged from 29 to 51 years, with an average of 39.8 years. The cause of injury was acute sports injury, and the time from injury to operation was 1-14 days, with an average of 3.4 days. The operation time, incision length, intraoperative blood loss, intraoperative complications, wound healing, and hospital stay were recorded. Postoperative appearance and function of ankle were evaluated by American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot score, Vancouver Scar Scale (VSS) score, and Arner-Lindholm score., Results: The operation time ranged from 30 to 90 minutes, with an average of 54.2 minutes; the incision length ranged from 1.3 to 3.5 cm, with an average of 2.2 cm; the intraoperative blood loss ranged from 5 to 70 mL, with an average of 22.3 mL; and the hospital stay ranged from 2 to 6 days, with an average of 3.7 days. All incisions healed by first intention, and there was no incision infection, poor healing, and deep venous thrombosis. All patients were followed up 5.3-22.0 months (mean, 14.7 months). During the follow-up, all the 30 patients had returned to exercise, and there was no complication such as Achilles tendon re-rupture, postoperative infection, and gastrocnemius muscle injury. At last follow-up, the AOFAS ankle-hindfoot score was 82-100, with an average of 95.1; the VSS score was 1-4, with an average of 2.1; according to the Arner-Lindholm score, 24 cases were rated as excellent and 6 cases as good., Conclusion: Transverse small incision intrathecal "loop" minimally invasive suture for the treatment of acute Achilles tendon rupture has the advantages of simple instrument, convenient operation, small trauma, quick recovery, and satisfactory effectiveness.
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- 2024
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5. [Effectiveness analysis of "tail compression fixation+suture bridge" technology under shoulder arthroscopy for treating primary tear in medial enthesis of rotator cuff].
- Author
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Aikeremu Aierken, Li Q, Fu K, Chen D, Yao Y, Shen Y, Jiang Q, and Qin J
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- Male, Female, Humans, Rotator Cuff surgery, Shoulder, Arthroscopy, Retrospective Studies, Treatment Outcome, Rupture, Sutures, Range of Motion, Articular, Rotator Cuff Injuries surgery, Shoulder Joint surgery
- Abstract
Objective: To investigate the feasibility and effectiveness of "tail compression fixation+suture bridge" technology under shoulder arthroscopy for treating primary tear in medial enthesis of rotator cuff., Methods: The clinical data of 11 patients with primary tear in medial enthesis of rotator cuff who met the selection criteria between October 2020 and October 2022 were retrospectively analyzed, including 3 males and 8 females, aged 39-79 years, with an average of 61.0 years. Rotator cuff injury was caused by traumatic fall in 8 cases, and the time from injury to admission was 1-4 months, with an average of 2.0 months; the remaining 3 cases had no obvious inducement. The active range of motion of the affected shoulder was limited, with an active forward flexion range of motion of (64.1±10.9)°, abduction of (78.1±6.4)°, internal rotation of (48.2±6.6)°, and external rotation of (41.8±10.5)°; 5 cases had shoulder stiffness. The preoperative visual analogue scale (VAS) score was 7.8±0.8 and the American Society of Shoulder and Elbow Surgeons (ASES) score was 23.9±6.4. The patients were treated with "tail compression fixation+suture bridge" technology under shoulder arthroscopy, and the pain and functional recovery were evaluated by VAS score, ASES score, and active range of motion of shoulder joint at last follow-up; MRI was performed after operation, and the integrity of rotator cuff was evaluated by Sugaya classification system., Results: All the 11 patients were followed up 2-22 months, with an average of 13.5 months. All incisions healed by first intention, and there was no complication such as infection, rotator cuff re-tear, and anchor falling off. At last follow-up, the VAS score was 0.8±0.7 and the ASES score was 93.5±4.2, which significantly improved when compared with those before operation ( P <0.05). All 11 patients had no significant swelling in the shoulders, and the active range of motion was (165.1±8.8)° in flexion, (75.3±8.4)° in abduction, (56.6±5.5)° in internal rotation, and (51.8±4.0)° in external rotation, which significantly improved when compared with those before operation ( P <0.05). Shoulder MRI showed adequate tendon thickness and good continuity in 9 cases, including 4 cases with partial high signal area; and 2 cases with inadequate tendon thickness but high continuity and partial high signal area. According to Sugaya classification system, there were 4 cases of type 1 (36.4%), 5 cases of type 2 (45.5%), and 2 cases of type 3 (18.1%)., Conclusion: For the patients with primary tear in medial enthesis of rotator cuff, the "tail compression fixation+suture bridge" technology under shoulder arthroscopy is simple and effective.
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- 2023
- Full Text
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