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Your search keyword '"Aillon, Raul Piseaux"' showing total 6 results
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6 results on '"Aillon, Raul Piseaux"'

1. Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis

Author

Watanabe, Satoshi, Markov, Nikolay S., Lu, Ziyan, Aillon, Raul Piseaux, Soberanes, Saul, Runyan, Constance E., Ren, Ziyou, Grant, Rogan A., Maciel, Mariana, Abdala-Valencia, Hiam, Politanska, Yuliya, Nam, Kiwon, Sichizya, Lango, Kihshen, Hermon G., Joshi, Nikita, McQuattie-Pimentel, Alexandra C., Gruner, Katherine A., Jain, Manu, Sznajder, Jacob I., Morimoto, Richard I., Reyfman, Paul A., Gottardi, Cara J., Budinger, G. R. Scott, and Misharin, Alexander V.

Published
2021

3. The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging

Author

McQuattie-Pimentel, Alexandra C., Ren, Ziyou, Joshi, Nikita, Watanabe, Satoshi, Stoeger, Thomas, Chi, Monica, Lu, Ziyan, Sichizya, Lango, Aillon, Raul Piseaux, Chen, Ching-I, Soberanes, Saul, Chen, Zhangying, Reyfman, Paul A., Walter, James M., Anekalla, Kishore R., Davis, Jennifer M., Helmin, Kathryn A., Runyan, Constance E., Abdala-Valencia, Hiam, Nam, Kiwon, Meliton, Angelo Y., Winter, Deborah R., Morimoto, Richard I., Mutlu, Gokhan M., Bharat, Ankit, Perlman, Harris, Gottardi, Cara J., Ridge, Karen M., Chandel, Navdeep S., Sznajder, Jacob I., Balch, William E., Singer, Benjamin D., Misharin, Alexander V., and Budinger, G.R. Scott

Subjects
Lung diseases -- Genetic aspects -- Risk factors, Age factors in disease -- Genetic aspects, Macrophages -- Genetic aspects -- Health aspects, Health care industry
Abstract

Alveolar macrophages orchestrate the response to viral infections. Age-related changes in these cells may underlie the differential severity of pneumonia in older patients. We performed an integrated analysis of single-cell RNA-Seq data that revealed homogenous age-related changes in the alveolar macrophage transcriptome in humans and mice. Using genetic lineage tracing with sequential injury, heterochronic adoptive transfer, and parabiosis, we found that the lung microenvironment drove an age-related resistance of alveolar macrophages to proliferation that persisted during influenza A viral infection. Ligand-receptor pair analysis localized these changes to the extracellular matrix, where hyaluronan was increased in aged animals and altered the proliferative response of bone marrow-derived macrophages to granulocyte macrophage colony-stimulating factor (GM-CSF). Our findings suggest that strategies targeting the aging lung microenvironment will be necessary to restore alveolar macrophage function in aging., Introduction Advanced age is the most important risk factor for severe disease or death in patients with viral pneumonia, including coronavirus disease 2019 (COVID-19) (1,2). Alveolar macrophages play central roles [...]

Published
2021
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5. Lung Injury Induces Alveolar Type 2 Cell Hypertrophy and Polyploidy with Implications for Repair and Regeneration

Author

Weng, Anthea, primary, Maciel Herrerias, Mariana, additional, Watanabe, Satoshi, additional, Welch, Lynn C., additional, Flozak, Annette S., additional, Grant, Rogan A., additional, Aillon, Raul Piseaux, additional, Dada, Laura A., additional, Han, Seung Hye, additional, Hinchcliff, Monique, additional, Misharin, Alexander V., additional, Budinger, G. R. Scott, additional, and Gottardi, Cara J., additional

Published
2022
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6. Lung injury induces alveolar type 2 cell hypertrophy and polyploidy with implications for repair and regeneration

Author

Weng, Anthea, primary, Maciel-Herrerias, Mariana, additional, Watanabe, Satoshi, additional, Welch, Lynn, additional, Flozak, Annette S., additional, Grant, Rogan, additional, Aillon, Raul Piseaux, additional, Dada, Laura, additional, Han, Seung Hye, additional, Hinchcliff, Monique, additional, Misharin, Alexander, additional, Budinger, GR Scott, additional, and Gottardi, Cara J., additional

Published
2021
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