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1. The derivation and numerical solution of equations relating to stresses round mining roadways

Author

Airey, E. M.

Subjects
518
Abstract

It is a longstanding problem of the coalmining industry that alter a roadway has been driven, the surrounding rock will gradually be forced into the opening. The problem is being studied by the National Coal Board, using experimental and mathematical methods. This study is intended to evolve a mathematical method that is able to take into account the properties of the failed rock, and at the same time be faster in execution time and easier to run than the Finite Element Method, which is most commonly used for this type of work. The method described is based on analytic solutions to the equations for elastic and failed solids, the two regions being treated separately in the analysis. A boundary separating the two regions is defined, and the equations for the stresses are used to derive the shape of the boundary so that the failure criteria are satisfied on the boundary. This calculation of the boundary shape is performed by correcting an estimate of the boundary shape in an iteration procedure. When the shape of the boundary is finally derived the stresses in the whole region can be calculated. These calculations have been used in two computer programs, one being written for roadways which are symmetric, the second for roadways with no symmetry. Three modes of failure have been assumed in the computer programs: plastic, granular and shear failure, and in addition a pattern of failure which assumes a region of granular material surrounded by shear-failed rock has been studied. The results quoted cover a range of roadways, but this study does not attempt to provide comprehensive solutions to all relevant problems.

Published
1974

2. Identifying Genotype-Phenotype Correlations via Integrative Mutation Analysis.

Author

Airey E, Portelli S, Xavier JS, Myung YC, Silk M, Karmakar M, Velloso JPL, Rodrigues CHM, Parate HH, Garg A, Al-Jarf R, Barr L, Geraldo JA, Rezende PM, Pires DEV, and Ascher DB

Subjects
Exome genetics, Genotype, Humans, Phenotype, Exome Sequencing methods, DNA Mutational Analysis methods, Genetic Association Studies methods, Mutation genetics
Abstract

Mutations in protein-coding regions can lead to large biological changes and are associated with genetic conditions, including cancers and Mendelian diseases, as well as drug resistance. Although whole genome and exome sequencing help to elucidate potential genotype-phenotype correlations, there is a large gap between the identification of new variants and deciphering their molecular consequences. A comprehensive understanding of these mechanistic consequences is crucial to better understand and treat diseases in a more personalized and effective way. This is particularly relevant considering estimates that over 80% of mutations associated with a disease are incorrectly assumed to be causative. A thorough analysis of potential effects of mutations is required to correctly identify the molecular mechanisms of disease and enable the distinction between disease-causing and non-disease-causing variation within a gene. Here we present an overview of our integrative mutation analysis platform, which focuses on refining the current genotype-phenotype correlation methods by using the wealth of protein structural information.

Published
2021
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