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Your search keyword '"Aitoku, Yasuko"' showing total 14 results
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14 results on '"Aitoku, Yasuko"'

5. A Multicenter, Randomized, Controlled, Single-Blind Comparison Phase III Study to Determine the Efficacy and Safety of Gadobutrol 1.0 M Versus Gadopentetate Dimeglumine Following Single Injection in Patients Referred for Contrast-Enhanced MRI of the Body Regions or Extremities

Author

Kuwatsuru, Ryohei, Takahashi, Satoru, Umeoka, Shigeaki, Sugihara, Ryo, Zeng, Mengsu, Huan, Yi, Peng, Weijun, Ma, Lin, Guo, Liang, Teng, Gaojun, Yao, Weiwu, Tozaki, Mitsuhiro, Endo, Masahiro, Kaji, Shuichiro, Ro, Tokugen, Hahn, Seong Tae, Kang, Byung Chul, Nishimura, Hiroshi, Sugawara, Yoshifumi, Katakami, Nobuyuki, Breuer, Josy, and Aitoku, Yasuko

Published
2015
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6. Erratum to: Patient preferences for treatment of castration-resistant prostate cancer in Japan: a discrete-choice experiment

Author

Uemura, Hiroji, primary, Matsubara, Nobuaki, additional, Kimura, Go, additional, Yamaguchi, Akito, additional, Ledesma, Dianne Athene, additional, DiBonaventura, Marco, additional, Mohamed, Ateesha F., additional, Basurto, Enrique, additional, McKinnon, Ian, additional, Wang, Ed, additional, Concialdi, Kristen, additional, Narimatsu, Aya, additional, and Aitoku, Yasuko, additional

Published
2017
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8. Patient preferences for treatment of castration-resistant prostate cancer in Japan: a discrete-choice experiment

Author

Uemura, Hiroji, primary, Matsubara, Nobuaki, additional, Kimura, Go, additional, Yamaguchi, Akito, additional, Ledesma, Dianne Athene, additional, DiBonaventura, Marco, additional, Mohamed, Ateesha F., additional, Basurto, Enrique, additional, McKinnon, Ian, additional, Wang, Ed, additional, Concialdi, Kristen, additional, Narimatsu, Aya, additional, and Aitoku, Yasuko, additional

Published
2016
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9. Ethnic comparison of pharmacokinetics of 18F-florbetaben, a PET tracer for beta-amyloid imaging, in healthy Caucasian and Japanese subjects

Author

Senda, Michio, primary, Sasaki, Masahiro, additional, Yamane, Tomohiko, additional, Shimizu, Keiji, additional, Patt, Marianne, additional, Barthel, Henryk, additional, Sattler, Bernhard, additional, Nagasawa, Toshiki, additional, Schultze-Mosgau, Marcus, additional, Aitoku, Yasuko, additional, Dinkelborg, Ludger, additional, and Sabri, Osama, additional

Published
2014
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10. A multicenter, randomized, controlled, single‐blind comparison phase III study to determine the efficacy and safety of gadobutrol 1.0 M versus gadopentetate dimeglumine following single injection in patients referred for contrast‐enhanced MRI of the body regions or extremities

Author

Kuwatsuru, Ryohei, primary, Takahashi, Satoru, additional, Umeoka, Shigeaki, additional, Sugihara, Ryo, additional, Zeng, Mengsu, additional, Huan, Yi, additional, Peng, Weijun, additional, Ma, Lin, additional, Guo, Liang, additional, Teng, Gaojun, additional, Yao, Weiwu, additional, Tozaki, Mitsuhiro, additional, Endo, Masahiro, additional, Kaji, Shuichiro, additional, Ro, Tokugen, additional, Tae Hahn, Seong, additional, Chul Kang, Byung, additional, Nishimura, Hiroshi, additional, Sugawara, Yoshifumi, additional, Katakami, Nobuyuki, additional, Breuer, Josy, additional, and Aitoku, Yasuko, additional

Published
2014
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11. Magnetic Resonance Evaluation of Brain Metastases From Systemic Malignances With Two Doses of Gadobutrol 1.0 M Compared With Gadoteridol

Author

Katakami, Nobuyuki, primary, Inaba, Yoshitaka, additional, Sugata, Shigenori, additional, Tsurusaki, Masakatsu, additional, Itoh, Takashi, additional, Machida, Toru, additional, Tanaka, Hisashi, additional, Nakayama, Tetsuo, additional, Morikawa, Tsutomu, additional, Breuer, Josy, additional, and Aitoku, Yasuko, additional

Published
2011
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12. IC-P-121: Inter-Ethnic Comparability of Pharmacokinetics of Florbetaben (BAY 94-9172), a Beta-Amyloid Imaging PET agent, as a Basis of Global Development of a Diagnostics for Alzheimer's Disease

Author

Senda, Michio, primary, Yamane, Tomohiko, additional, Sasaki, Masahiro, additional, Shimizu, Keiji, additional, Barthel, Henryk, additional, Sattler, Bernhard, additional, Patt, Marianne, additional, Nagasawa, Toshiki, additional, Schultze-Mosgau, Marcus, additional, Aitoku, Yasuko, additional, and Sabri, Osama, additional

Published
2010
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13. Ethnic comparison of pharmacokinetics of F-florbetaben, a PET tracer for beta-amyloid imaging, in healthy Caucasian and Japanese subjects.

Author

Senda, Michio, Sasaki, Masahiro, Yamane, Tomohiko, Shimizu, Keiji, Patt, Marianne, Barthel, Henryk, Sattler, Bernhard, Nagasawa, Toshiki, Schultze-Mosgau, Marcus, Aitoku, Yasuko, Dinkelborg, Ludger, and Sabri, Osama

Subjects
POSITRON emission tomography, PHARMACOKINETICS, ALZHEIMER'S disease diagnosis, AMYLOID beta-protein, CAUCASIAN race, JAPANESE people, HEALTH
Abstract

Purpose: F-Florbetaben is a positron emission tomography (PET) tracer indicated for imaging cerebral beta-amyloid deposition in adult patients with cognitive impairment who are being evaluated for Alzheimer's disease and other causes of cognitive decline. The present study examined ethnic comparability of the plasma pharmacokinetics, which is the input to the brain, between Caucasian and Japanese subjects. Methods: Two identical phase I trials were performed in 18 German and 18 Japanese healthy volunteers to evaluate the plasma pharmacokinetics of a single dose of 300 MBq F-florbetaben, either of low (≤5 μg, LD) or high (50-55 μg, HD) mass dose. Pharmacokinetic parameters were evaluated based on the total F radioactivity measurements in plasma followed by metabolite analysis using radio-HPLC. Results: The pharmacokinetics of F-florbetaben was characterized by a rapid elimination from plasma. The dose-normalized areas under the curve of F-florbetaben in plasma as an indicator of the input to the brain were comparable between Germans (LD: 0.38 min/l, HD: 0.55 min/l) and Japanese (LD: 0.35 min/l, HD: 0.45 min/l) suggesting ethnic similarity, and the mass dose effect was minimal. A polar metabolite fraction was the main radiolabelled degradation product in plasma and was also similar between the doses and the ethnic groups. Conclusion: Absence of a difference in the pharmacokinetics of F-florbetaben in Germans and Japanese has warranted further global development of the PET imaging agent. [ABSTRACT FROM AUTHOR]

Published
2015
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