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16 results on '"Ajuria, Leiore"'

2. The role of SUMOylation during development

Author

Talamillo, Ana, primary, Barroso-Gomila, Orhi, additional, Giordano, Immacolata, additional, Ajuria, Leiore, additional, Grillo, Marco, additional, Mayor, Ugo, additional, and Barrio, Rosa, additional

Published
2020
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5. Generation of a versatile BiFC ORFeome library for analyzing protein-protein interactions in live

Author

Bischof, Johannes, Duffraisse, Marilyne, Furger, Edy, Ajuria, Leiore, Giraud, Guillaume, Vanderperre, Solene, Paul, Rachel, Björklund, Mikael, Ahr, Damien, Ahmed, Alexis W, Spinelli, Lionel, Brun, Christine, Basler, Konrad, Merabet, Samir, University of Zurich, and Merabet, Samir

Subjects
1300 General Biochemistry, Genetics and Molecular Biology, 2400 General Immunology and Microbiology, 570 Life sciences, biology, 2800 General Neuroscience, 10124 Institute of Molecular Life Sciences
Published
2018

6. Role of a versatile peptide motif controlling Hox nuclear export and autophagy in the Drosophila fat body.

Author

Duffraisse, Marilyne, Paul, Rachel, Carnesecchi, Julie, Hudry, Bruno, Banreti, Agnes, Reboulet, Jonathan, Ajuria, Leiore, Lohmann, Ingrid, and Merabet, Samir

Subjects
FAT, DROSOPHILA, AUTOPHAGY, EMBRYOLOGY, PROTEIN-protein interactions
Abstract

Hox proteins are major regulators of embryonic development, acting in the nucleus to regulate the expression of their numerous downstream target genes. By analyzing deletion forms of the Drosophila Hox protein Ultrabithorax (Ubx), we identified the presence of an unconventional nuclear export signal (NES) that overlaps with a highly conserved motif originally described as mediating the interaction with the PBC proteins, a generic and crucial class of Hox transcriptional cofactors that act in development and cancer. We show that this unconventional NES is involved in the interaction with the major exportin protein CRM1 (also known as Embargoed in flies) in vivo and in vitro. We find that this interaction is tightly regulated in the Drosophila fat body to control the autophagy-repressive activity of Ubx during larval development. The role of the PBC interaction motif as part of an unconventional NES was also uncovered in other Drosophila and human Hox proteins, highlighting the evolutionary conservation of this novel function. Together, our results reveal the extreme molecular versatility of a unique short peptide motif for controlling the context-dependent activity of Hox proteins both at transcriptional and non-transcriptional levels. [ABSTRACT FROM AUTHOR]

Published
2020
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7. Generation of a versatile BiFC ORFeome library for analyzing protein–protein interactions in live Drosophila

Author

Bischof, Johannes, primary, Duffraisse, Marilyne, additional, Furger, Edy, additional, Ajuria, Leiore, additional, Giraud, Guillaume, additional, Vanderperre, Solene, additional, Paul, Rachel, additional, Björklund, Mikael, additional, Ahr, Damien, additional, Ahmed, Alexis W, additional, Spinelli, Lionel, additional, Brun, Christine, additional, Basler, Konrad, additional, and Merabet, Samir, additional

Published
2018
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8. Author response: Generation of a versatile BiFC ORFeome library for analyzing protein–protein interactions in live Drosophila

Author

Bischof, Johannes, primary, Duffraisse, Marilyne, additional, Furger, Edy, additional, Ajuria, Leiore, additional, Giraud, Guillaume, additional, Vanderperre, Solene, additional, Paul, Rachel, additional, Björklund, Mikael, additional, Ahr, Damien, additional, Ahmed, Alexis W, additional, Spinelli, Lionel, additional, Brun, Christine, additional, Basler, Konrad, additional, and Merabet, Samir, additional

Published
2018
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10. Origins of Context-Dependent Gene Repression by Capicua

Author

Forés, Marta, primary, Ajuria, Leiore, additional, Samper, Núria, additional, Astigarraga, Sergio, additional, Nieva, Claudia, additional, Grossman, Rona, additional, González-Crespo, Sergio, additional, Paroush, Ze'ev, additional, and Jiménez, Gerardo, additional

Published
2015
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16. Mirror represses pipe expression in follicle cells to initiate dorsoventral axis formation in Drosophila.

Author

Andreu, María José, González-Pérez, Esther, Ajuria, Leiore, Samper, Núria, González-Crespo, Sergio, Campuzano, Sonsoles, and Jiménez, Gerardo

Subjects
DROSOPHILA as laboratory animals, EPIDERMAL growth factor receptors, PROTEIN-tyrosine kinases, OVARIAN follicle, SULFOTRANSFERASES, TRANSCRIPTION factors, CONSERVED sequences (Genetics), CELLULAR signal transduction
Abstract

Dorsoventral (DV) axis formation in Drosophila begins with selective activation of EGFR, a receptor tyrosine kinase (RTK), in dorsal-anterior (DA) ovarian follicle cells. A critical event regulated by EGFR signaling is the repression of the sulfotransferaseencoding gene pipe in dorsal follicle cells, but how this occurs remains unclear. Here we show that Mirror (Mirr), a homeodomain transcription factor induced by EGFR signaling in DA follicle cells, directly represses pipe expression by binding to a conserved element in the pipe regulatory region. In addition, we find that the HMG-box protein Capicua (Cic) supports pipe expression in ventral follicle cells by repressing Mirr in this region. Interestingly, this role of Cic resembles its function in regulating anteroposterior (AP) body patterning, where Cic supports gap gene expression in central regions of the embryo by repressing Tailless, a repressor induced by RTK signaling at the embryonic poles. Thus, related RTK-Cic repressor circuits regulate the early stages of Drosophila DV and AP body axis formation. [ABSTRACT FROM AUTHOR]

Published
2012
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