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2. A new class of dimeric product isolated from the fungus Chaetomium globosum: evaluation of chemical structure and biological activity.

Author

Sarmales-Murga C, Akaoka F, Sato M, Takanishi J, Mino T, Miyoshi N, and Watanabe K

Subjects
Antineoplastic Agents chemistry, Antineoplastic Agents isolation & purification, Benzopyrans chemistry, Benzopyrans isolation & purification, Female, HeLa Cells, Humans, Inhibitory Concentration 50, Pigments, Biological chemistry, Pigments, Biological isolation & purification, Antineoplastic Agents pharmacology, Benzopyrans pharmacology, Chaetomium chemistry, Pigments, Biological pharmacology, Uterine Cervical Neoplasms drug therapy
Abstract

Chaetomium globosum is a filamentous fungus from which we have previously isolated a series of interesting natural products. Here, we isolated a previously unknown natural product from the culture of C. globosum. Through spectroscopic and crystallographic characterization, we determined the compound to be a new dimerized azaphilone-type product which we termed cochliodone J (1). Furthermore, our investigation into the biological activity of the natural product determined that 1 was cytotoxic to human cervix carcinoma HeLa cells with an IC 50 of 17.3 µM. Lastly, a plausible biosynthetic mechanism for 1 is suggested based on our previous study on the biosynthesis of a closely related compound, cochliodone A (2).

Published
2020
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