Search

Your search keyword '"Akazawa, Hitoshi"' showing total 24 results
Start Over Author "Akazawa, Hitoshi"
24 results on '"Akazawa, Hitoshi"'

5. Efficacy of tokishakuyakusan and mecobalamin on post-infectious olfactory dysfunction: A prospective multicenter study

Author

Kobayashi, Masayoshi, primary, Miwa, Takaki, additional, Mori, Eri, additional, Shiga, Hideaki, additional, Tsuzuki, Kenzo, additional, Okutani, Fumino, additional, Hayama, Masaki, additional, Akazawa, Hitoshi, additional, Nakamura, Yosuke, additional, Suzuki, Motohiko, additional, Matsuwaki, Yoshinori, additional, Ogino, Eriko, additional, Shikina, Takashi, additional, Ikeda, Katsuhisa, additional, Hyo, Yukiyoshi, additional, Kashiwagi, Takashi, additional, Kondo, Kenji, additional, Shibata, Minori, additional, and Ueno, Takayoshi, additional

Published
2023
Full Text
View/download PDF

8. SEMA4A promotes eosinophil survival and contributes to eosinophil-mediated allergic diseases

Author

Maeda, Yohei, Tsuda, Takeshi, Takeda, Yoshito, Koyama, Shohei, Hayama, Yoshitomo, Nojima, Satoshi, Kimura, Tetsuya, Ito, Daisuke, Takamatsu, Hyota, Kang, Sujin, Nishide, Masayuki, Morimoto, Keiko, Hosokawa, Takashi, Kinehara, Yuhei, Kato, Yasuhiro, Nakatani, Takeshi, Takeda, Kazuya, Hayama, Masaki, Obata, Sho, Akazawa, Hitoshi, Shikina, Takashi, Inohara, Hidenori, and Kumanogoh, Atsushi

Published
2019
Full Text
View/download PDF

16. Eosinophil-derived neurotoxin enhances airway remodeling in eosinophilic chronic rhinosinusitis and correlates with disease severity

Author

Tsuda, Takeshi, primary, Maeda, Yohei, additional, Nishide, Masayuki, additional, Koyama, Shohei, additional, Hayama, Yoshitomo, additional, Nojima, Satoshi, additional, Takamatsu, Hyota, additional, Okuzaki, Daisuke, additional, Kinehara, Yuhei, additional, Kato, Yasuhiro, additional, Nakatani, Takeshi, additional, Obata, Sho, additional, Akazawa, Hitoshi, additional, Shikina, Takashi, additional, Takeda, Kazuya, additional, Hayama, Masaki, additional, Inohara, Hidenori, additional, and Kumanogoh, Atsushi, additional

Published
2018
Full Text
View/download PDF

19. Eosinophil-derived neurotoxin enhances airway remodeling in eosinophilic chronic rhinosinusitis and correlates with disease severity.

Author

Tsuda, Takeshi, Maeda, Yohei, Nishide, Masayuki, Koyama, Shohei, Hayama, Yoshitomo, Nojima, Satoshi, Takamatsu, Hyota, Okuzaki, Daisuke, Kinehara, Yuhei, Kato, Yasuhiro, Nakatani, Takeshi, Obata, Sho, Akazawa, Hitoshi, Shikina, Takashi, Takeda, Kazuya, Hayama, Masaki, Inohara, Hidenori, and Kumanogoh, Atsushi

Subjects
NASAL polyps, SINUSITIS, EPITHELIUM, NUCLEOTIDE sequence
Abstract

Eosinophilic chronic rhinosinusitis (ECRS) is a subtype of chronic rhinosinusitis (CRS) that is characterized by intractable nasal polyp formation. Eosinophil-derived neurotoxin (EDN) is an eosinophil granule protein that is closely related to allergic inflammation, but the pathological implications of EDN in ECRS remain unknown. In this study, we evaluated the function of EDN in ECRS pathogenesis and assessed its potential as a disease activity marker. Serum EDN levels were significantly higher in patients with ECRS than in those with other nasal and paranasal diseases, and were positively correlated with clinical disease activity. Production of EDN from isolated human eosinophils was induced by stimulation with IL-5 in vitro. Human nasal epithelial cells were stimulated with EDN, and the resultant changes in gene expression were detected by RNA sequencing. Pathway analysis revealed that the major canonical pathway affected by EDN stimulation was 'regulation of the epithelial–mesenchymal transition pathway'; the only gene in this pathway to be up-regulated was matrix metalloproteinase 9 (MMP-9). Consistent with this, immunostaining analysis revealed intense staining of both EDN and MMP-9 in nasal polyps from patients with ECRS. In conclusion, our data demonstrate that serum EDN level is a useful marker for the evaluation of ECRS severity. Furthermore, EDN induces production of MMP-9 from the nasal epithelium, which may be involved in the pathogenesis of ECRS. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

24. Prognostic predictors of sudden sensorineural hearing loss in defibrinogenation therapy.

Author

Oya, Ryohei, Horii, Arata, Akazawa, Hitoshi, Osaki, Yasuhiro, and Inohara, Hidenori

Subjects
RISK of deafness, ADRENOCORTICAL hormones, ANALYSIS of variance, ANTIFIBRINOLYTIC agents, BIOMARKERS, BLOOD testing, CHI-squared test, BLOOD coagulants, FIBRINOGEN, STATISTICS, DATA analysis, DATA analysis software, DESCRIPTIVE statistics, MANN Whitney U Test
Abstract

Conclusions: Defibrinogenation therapy rather than corticosteroids therapy should be chosen for patients specifically with profound hearing loss and with initial high fibrinogen.Objectives: Corticosteroids therapy is the standard treatment for sudden sensorineural hearing loss (SSNHL) and prognostic factors by this therapy were reported. Defibrinogenation therapy is one of the treatment options for SSNHL. Aims of this study were to identify prognostic factors and correlative markers with hearing improvement in treating SSNHL by defibrinogenation therapy.Methods: During the early phase of the study, consecutive 61 patients were treated by defibrinogenation therapy with batroxobin (50 units), whereas corticosteroids (500 mg/day of hydrocortisone tapered by 9 days) were used for consecutive 64 patients during the late phase. Blood data that could predict a complete recovery were identified. Coagulation/fibrinolysis markers correlated with hearing improvement by defibrinogenation therapy were investigated.Results: Although there were no overall differences in hearing improvement between the two therapies, recovery rate in profound hearing loss patients was better in defibrinogenation therapy. In patients who showed complete recovery, serum fibrinogen level before treatment was significantly higher in the defibrinogenation group than the corticosteroid group. Responses of several fibrinolysis markers to defibrinogenation therapy evaluated by post-/pre-values were negatively correlated with hearing improvement. [ABSTRACT FROM PUBLISHER]

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results