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Objective: Cutaneous silent period (CSP) is an inhibitory spinal reflex and the afferent arm of this response involves A-delta nerve fibers. The aim of this study was to investigate CSP parameters in patients with type 2 diabetes mellitus (T2DM) and to examine the effects of alpha-lipoic acid (ALA) treatment on CSP. To the best of our knowledge, this investigation has not yet been carried out until date. Methods: Seventeen patients with T2DM and 23 healthy volunteers were studied. CSP latency and duration in the upper and lower extremities of both the groups were examined. In T2DM patients, the variables were examined before and after ALA treatment. Results: CSP latency in T2DM patients was longer than that in the controls. In the patient group, CSP latency in the upper and lower extremities and CSP Latency Differences (LD) shortened in the third month after treatment compared with the pre-treatment values. Conclusions: The results suggest that ALA treatment may alleviate small-fiber neuropathy in T2DM patients and that CSP may be a useful supportive tool to evaluate ALA treatment effectiveness.

The aim of this study is to assess whether the celecoxib has a radioprotective effect in the rat model of radiation-induced lung injury. Rats were given a single dose of 20 Gy to the right hemithorax and mediasten region from 80 cm distance and I cm depth by a (60)Co teletherapy unit. Histopathological evaluation was fulfilled using light microscope and the biochemical results were evaluated by considering membrane lipid peroxidation. Biochemical and histopathological results of 20 Gy irradiated lungs revealed significant tissue damage. In only radiation applied group (Group-3); macrophage clusters in alveolar structures, diffuse alveolar septum thickness, bronchial lymphocytes in groups and diffuse peribronchial edema were determined (radiation pneumonitis). It was seen that plasma MDA level was fairly elevated in irradiated lungs. But four dose of celecoxib precluded the radiotherapy induced lung damage significantly when compared to the control group (p < 0.05). It was thought that two dose of celecoxib alleviated the radiotherapy dependent lung damage. Biochemical and pathological evaluation of the animals in Group-4 showed that four dose of celecoxib lowered the radiotherapy induced lung damage significantly. In only celecoxib applied group (Group-5), biochemical and pathological results showed that celecoxib didn't cause any change in normal lung tissue.

Acute renal failure (ARF) is rarely reported after bowel preparation with sodium phosphate. We report a patient with mild Crohn disease (in remission), without history of renal disease, and with normal baseline renal function, who developed ARF 14 days after bowel preparation for colonoscopy with oral sodium phosphate. A renal biopsy showed multifocal calcium phosphate deposition in the renal tubules against a background of diffuse chronic tubulointerstitial injury. Review of the literature suggested 2 distinct patterns of ARF in the context of sodium phosphate bowel cleansing. One pattern is characterized by ARF, which develops a few hours or days after sodium phosphate administration, as a component of a systemic syndrome associated with severe hyperphosphatemia and hypocalcemia. Correction of these electrolyte abnormalities was frequently associated with rapid recovery of renal function. The cause of ARF in this context was not clear because the favorable outcome negated the need for renal biopsy. In the second pattern, exemplified by the current patient, ARF was identified incidentally. These patients did not have any features of an acute syndrome immediately after sodium phosphate administration and presented much later (usually weeks) with mild, nonspecific symptoms. At the time of presentation, the serum calcium and phosphate levels were normal. The renal biopsies in each of these patients showed nephrocalcinosis as the possible cause of ARF. The renal failure improved at least partially in most of these patients, but persisted in rare cases.

PubMedID: 16390223 Acute renal failure (ARF) is rarely reported after bowel preparation with sodium phosphate. We report a patient with mild Crohn disease (in remission), without history of renal disease, and with normal baseline renal function, who developed ARF 14 days after bowel preparation for colonoscopy with oral sodium phosphate. A renal biopsy showed multifocal calcium phosphate deposition in the renal tubules against a background of diffuse chronic tubulointerstitial injury. Review of the literature suggested 2 distinct patterns of ARF in the context of sodium phosphate bowel cleansing. One pattern is characterized by ARF, which develops a few hours or days after sodium phosphate administration, as a component of a systemic syndrome associated with severe hyperphosphatemia and hypocalcemia. Correction of these electrolyte abnormalities was frequently associated with rapid recovery of renal function. The cause of ARF in this context was not clear because the favorable outcome negated the need for renal biopsy. In the second pattern, exemplified by the current patient, ARF was identified incidentally. These patients did not have any features of an acute syndrome immediately after sodium phosphate administration and presented mocli later (usually weeks) with mild, nonspecific symptoms. At the time of presentation, the serum calcium and phosphate levels were normal. The renal biopsies in each of these patients showed nephrocalcinosis as the possible cause of ARF. The renal failure improved at least partially in most of these patients, but persisted in rare cases.

6th European Congress of Chemotherapy and Infection/24th Interdisciphinary Meeting of Chimiotherapie Anit-Infections -- DEC 01-03, 2004 -- Paris, FRANCE WOS: 000225734000193 …