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In alternative medicine, Saw palmetto is used in the treatment of many diseases, as it is effective in treating urinary system diseases through anti-androgen effects and effects on involuntary receptors in the lower urinary tract, in addition to being used in the treatment of patients with benign prostatic hyperplasia and cancer Prostatitis, chronic prostatitis (CP) and erectile dysfunction (ED). Scientific research has proven that Saw palmetto is considered a herbal remedy because it contains 3 phytosterols, 14 fatty acids, and SRM3251 contains 3 phytosterols, 17 fatty acids, β-carotene, and γ-tocopherol. It also played an important role as an anti-androgen as 5a-dihydrotestosterone (DHT) is converted from testosterone by the action of 5a-reductase, and this helps in the development of male sexual characteristics, transcription of androgen-regulating genes, prostate enlargement. Also, it affects on enzymes and chemokines that effect on the inflammatory process. Saw palmetto is used in the treatment of Chronic Prostatitis (CP) and Chronic Pelvic Pain Syndrome (CPPS). In this review, the phytochemical content of Saw palmetto will be highlighted and the pharmacological effect on male hormones, urinary system diseases and infections will be studied. [ABSTRACT FROM AUTHOR]

The subject of disease management has undergone a revolution because to nanotechnology, which has created new instruments and unique tactics for focused therapies. The various roles that nanoparticles play in the treatment of diseases are thoroughly examined in this review paper. Nanoparticles have special physicochemical characteristics that make them useful platforms for therapeutic treatments, imaging, and drug administration. This study emphasises the uses of nanoparticles in diverse illness contexts, such as cancer, infectious diseases, neurodegenerative disorders, and cardiovascular ailments, through a methodical consideration of current developments. The research paper also explores challenges associated with nanoparticle-based medicines, including potential toxicity and regulatory barriers. This review contributes to the understanding of how nanoparticles can change the healthcare landscape by offering insights into the current status of nanoparticle research and its possible implications for future disease management techniques. [ABSTRACT FROM AUTHOR]

Healthcare service delivery is fundamentally difficult since it involves nuanced interactions between many different parties, cutting-edge technology, and complex clinical procedures. The vital necessity of patient safety and the reduction of potential dangers are becoming more and more obvious as the healthcare landscape changes. In order to promote a culture of safety within the realm of healthcare and nursing, this review paper critically analyses the function of risk management. In this comprehensive review, we examine the various facets of risk management and how critical it is to patient care. With a focus on patient-centeredness and on-going quality improvement, the transformation of healthcare systems from fragmented and episodic treatment models to integrated and preventative paradigms is the main objective of present study. Given their frontline presence and crucial role in patient care, the review clarifies the essential role of nursing professionals in risk management. It looks at how nurses' roles have evolved to include clinical practice, drug administration, infection control, and communication in detecting, assessing, and managing risks. The paper also emphasizes the need of interdisciplinary cooperation by demonstrating how effective risk management transcends conventional barriers and necessitates a group commitment to patient safety. Ultimately, the delivery of high-quality care is the cornerstone of the environment that healthcare organizations and nursing professionals may jointly establish by adopting a proactive approach to risk management. [ABSTRACT FROM AUTHOR]

Worldwide, Verbascum thapsus is used for the treatment of various ailments owing to the presence of bioactives of therapeutic potential. Current study was planned to extract bioactives from V thapsus roots using methanol and water as solvents under stimulated effect of ultrasonic waves and characterize them to evaluate their potential benefits. Proximate analysis explored the presence of significant contents of protein, fats, fiber, organic and inorganic minerals. Fourier transform infrared spectra and high-performance liquid chromatography chromatogram indicated the presence of different phytochemicals having antioxidant potential as evidenced by total phenolic contents, total flavonoids content and 2,2-diphenyl-1-picrylhydrazyl activity of both extracts. Both extracts displayed excellent antimicrobial potential against Staphylococcus aureus (S aureus) and Fusarium Solani (F solani). Aqueous and methanolic extracts exhibited higher inhibition of biofilm made by Bacillus subtilis (B subtilis) as 55.09 and 61.58%, respectively in comparison to biofilm of Escherichia coli (E coli) as 48.11 and 36.51%, respectively. Methanol extract exhibited anti-amylase activity (IC50 5.26 ±.31 μg/mL) with an inhibition rate of 68.11% whereas IC50 of aqueous extract was 6.59 ±.53 μg/mL with an inhibition rate of 63.53%. Inhibitory potential against α-glucosidase (IC50 3.70 ±.94 ppm) was demonstrated by methanol extract in comparison to aqueous extract (IC50 7.58 ±.15). The study concluded that V thapsus roots have significant medicinal potential due to the presence of variety of bioactive molecules and can be used in pharmaceutical preparations. [ABSTRACT FROM AUTHOR]

Brain-derived neurotrophic factor (BDNF) and serotonin transporter (SERT) is implicated in the adverse life events which lead to depression. The variation in genetic make-up of BDNF (Val66Met) and SERT (5'-HTTLPR) are potential biomarkers in the development of neuropsychiatric disorders including depression. The purpose of this study was to investigate the correlation of functional polymorphisms of BDNF and SERT genes with depression among Pakistani population. A total of 373 participants (204 cases with depressive episodes and 169 healthy controls) with age between 14 and 65yrs were recruited from Pakistani population. BDNF and SERT gene polymorphisms were genotyped using PCR-RFLP analysis. The result showed that lack of association of Val66Met (χ²: 3.596, p>0.05) and 5'-HTTLPR (χ²: 0.634, p>0.05) gene polymorphisms were found with depression. However, SERT 'SL' (OR: 1.150, 95%CI: 0.601- 2.201) and BDNF 'AA' (OR: 1.651, 95%CI: 0.585-4.660) and 'GA' (OR: 2.279, 95%CI: 0.825-6.298) genotypes might be a risk genotypes for depression. Hence, it is concluded that the functional BDNF (Val66Met) and SERT (5'-HTTLPR) gene polymorphisms may not be associated with depression. Replication studies on these polymorphisms with large sample size are needed. [ABSTRACT FROM AUTHOR]

Momardica charint seed as vegetable and folk medicine in Pakistan, India, China, Bangladesh and other Asian countries Momardica charinta also known as Kerala, bittergourd, balsam pear. It possesses many biological active constituents including glycosides, saponins, phenolic and flavonoids compound, protein, triterpenes, steroid, saponins, alkaloid. It also contain thiamine, beta carotene, folate, riboflavin, calcium, iron, potassium, zinc and fiber. Several studies have been done to show medicinal importance of its fruit which has different biological functions such as antidiabetes antihypertension, antiviral, antibacterial and antifungal infection, anti-tumorous as well as anti-carcinogenic effects. The present research is big contribution of Momardicacharinta activity as weight reducing plant through serotonergic neurotransmitter Decrease in body weight and food intake might be due to increased concentration of serotonin in their respective receptors in brain, which produce hypophagic effect in rats treated with water extract of Momardicacharinttia. More animal and human trials needed to confirm, the safety and antiobesity effect of MC and the role of neurotransmitter involve in reduction of body weight. [ABSTRACT FROM AUTHOR]

Obesity is a common disease of developing countries, including Pakistan. Obesity is a risk factor for many diseases which can be life threatening or making the person unable to perform daily routine work. In the current study, clinical trials were designed to evaluate the effects of medical intervention by comparing the effects of placebo control drug "Plasicure" with the herbal medicinal formulation "Obesecure". The test drug formulation was designed on the basis of the screening study for Leptogenic drugs. To evaluate the safety of the test drug, the toxicity index and the safety profile of test formulation was assessed on animal models. The drug was found safe for further clinical study. Randomized Controlled Clinical Trials were conducted. The statistical analysis was carried out by the application of Two-Way Repeated Analysis of Variance test. The clinical findings of randomized controlled trial revealed that the test drug was Leptogenic and effective in weight reduction as compared to control drug Plasicure therapy as the p-value deduced was 0.001 in leptin level and 0.000 in case of BMI after the conduction of Two-Way Repeated Analysis of Variance test. Hence it is concluded that obscure therapy is more significant than control drug Plasicure therapy in the management and treatment of obesity. [ABSTRACT FROM AUTHOR]

A novel series of 5-(3-Chlorophenyl)-2-((N-(substituted)-2-acetamoyl)sulfanyl)-1,3,4-oxadiazole derivatives was efficiently synthesized and screened for antibacterial, hemolytic and thrombolytic activities. The molecule 7c remained the best inhibitor of all selected bacterial strains and furthermore possessed very low toxicity, 8.52±0.31. Compound 7a 7b and 7f showed very good thrombolytic activity relative to Streptokinase employed as reference drug. In addition to low toxicity and moderately good thrombolytic activity, the synthesized compounds possessed excellent to moderate antibacterial activity, relative to ciprofloxacin. All compounds especially 7b and 7f can be consider for further clinical studies and might be helpful in synthesis of new drugs for treatment of cardiovascular diseases. [ABSTRACT FROM AUTHOR]

This study was aimed to investigate the antioxidant effects of Syzygium cumini (S. cumini) seeds extract along with wound healing score in correlation to glutathione and blood glucose levels in diabetic rats. Sprague-Dawley rats were divided into 8 groups (n=6) and diabetes was induced by a single intraperitoneal injection of streptozotocin (40 mg kg-1 body weight). An alcoholic extract of S. cumini was administered to punch plier induced wounded rats and changes in serum glutathione levels, wound healing score and blood glucose levels were examined. Laser treatment of 500 mW for 5 minutes was given once a day for 12 days at 810 and 630 nm respectively. Statistical analysis was performed using one way ANOVA. A p-value <0.05 was considered significant and p-value <0.001 was considered highly significant. There was significant increase in glutathione levels and wound healing score when S. cumini extract was administered oral and topical along with topical laser therapy. There was significant reduction in the blood glucose levels upon administration of S. cumini extract in diabetic rats. This study concludes that there was a positive relation between the glutathione levels and wound healing score, since there was increase in wound healing score with the increase in the glutathione levels. [ABSTRACT FROM AUTHOR]

Context: Rosa damascena Mill. is prescribed for the management of chest and abdominal pain, constipation, digestive disorders, menstrual bleeding and liver ailments. Objective: The current review compiles up to date and complete information of whole plant of R. damascena with particular emphasis on its numerous scientifically proved pharmacological effects, traditional and folk medicinal uses. Key finding: The data on the pharmacological effects of R. damascena were collected from various databases such as PubMed, Wiley Online Library, Elsevier and Web of Science using the keywords like phytoconstituents, pharmacology, medicinal uses and biological activity of R. damascene. Rosa damascena has a wide spectrum of bio‐pharmacological activity like antidepressant, hypoglycaemic, anti‐inflammatory, analgesic, antioxidant and antimicrobial. The main ingredients of R. damascena essential oil responsible for pharmacological activity are geraniol and citronellol. Its uses have been widely accepted in traditional system of medicines for the management of numerous diseases of human beings in different dosage forms. Summary: Rosa damascena has a significant place in traditional system of medicine. It is cost‐effective and an important plant with curative application in contemporary medicine. Further studies on the characterization of chemical constituents and scientific basis of pharmacological activity of R. damascena should be carried out to evaluate its impact on traditional system of medicines. Large‐scale preclinical and clinical trials will be beneficial in investigating the mechanism of the therapeutic potential of R. damascene to explore its uses in pharmaceutical industries. [ABSTRACT FROM AUTHOR]

Mushrooms can be used in diet as nutraceutical or functional food for promoting and maintaining health quality and health longevity. Mushrooms just like medicinal plants can be utilized in the form of powder or extract as curative agents of several diseases and in providing a healthy diet. In the current study, ten different mushroom species were collected from Azad Jammu and Kashmir. The selected mushrooms were assessed for their nutritional value, biological activities and fatty acid profiling. Before extraction, proximate analysis of all selected mushrooms was performed. Protein, fat, ash and total carbohydrate contents ranged from 10-30%, 0.43-8.08%, 1.1-9.14%, 12.47-92.52%, respectively. Then mushrooms were extracted with three different solvents n-hexane, ethyl acetate and methanol for the assessment of their antioxidant potential through different antioxidant assays like total phenolics, total flavonoid contents and DPPH inhibition assay. The order of antioxidant potential in different solvents is methanol > ethyl acetate > n-hexane. Quantification of fatty acids by GC/MS analysis revealed that stearic acid, palmitic acid, oleic acid, linolenic acid were present in significant quantity in different mushrooms and unsaturated fatty acids were found abundant over saturated fatty acids in all the selected mushrooms. So the presence of fatty acids in studied samples is one of the main biologically active ingredients from mushrooms. The study concluded that the selected mushrooms from different regions of Azad Jammu and Kashmir are of nutritional importance having significant antioxidant potential and contain several unsaturated fatty acids that contribute to the nutritional value of mushrooms. [ABSTRACT FROM AUTHOR]