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3. A Geometric Approach to Solve Fuzzy Linear Systems

Author

Gasilov, N., Amrahov, Şahin Emrah, Fatullayev, A. Golayoglu, Karakas, H. I., and Akin, O.

Subjects
Computer Science - Numerical Analysis, Mathematics - Numerical Analysis, G.1.3, G.4, J.2
Abstract

In this paper, linear systems with a crisp real coefficient matrix and with a vector of fuzzy triangular numbers on the right-hand side are studied. A new method, which is based on the geometric representations of linear transformations, is proposed to find solutions. The method uses the fact that a vector of fuzzy triangular numbers forms a rectangular prism in n-dimensional space and that the image of a parallelepiped is also a parallelepiped under a linear transformation. The suggested method clarifies why in general case different approaches do not generate solutions as fuzzy numbers. It is geometrically proved that if the coefficient matrix is a generalized permutation matrix, then the solution of a fuzzy linear system (FLS) is a vector of fuzzy numbers irrespective of the vector on the right-hand side. The most important difference between this and previous papers on FLS is that the solution is sought as a fuzzy set of vectors (with real components) rather than a vector of fuzzy numbers. Each vector in the solution set solves the given FLS with a certain possibility. The suggested method can also be applied in the case when the right-hand side is a vector of fuzzy numbers in parametric form. However, in this case, -cuts of the solution can not be determined by geometric similarity and additional computations are needed.

Published
2009
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6. EVALUATION OF OXIDATIVE STRESS MARKERS IN GIRLS WITH PREMATURE THELARCHE AND PRECOCIOUS PUBERTY.

Author

Gunes, S. Odabasi, Akin, O., Durmaz, N., Erel, O., and Yavuz, S. T.

Subjects
*FOLLICLE-stimulating hormone, *RECEIVER operating characteristic curves, *OXIDATIVE stress, *LUTEINIZING hormone, *ETIOLOGY of diseases, *PRECOCIOUS puberty
Abstract

Context. Oxidative products take part in various physiological processes and overproduction of oxidative products is involved in the etiology of many diseases. Objectives. We aimed to evaluate thiol-disulfide homeostasis (TDH); one of the oxidative stress parameters, in girls with premature thelarche (PT) and precocious puberty (PP). Design. This case-control study was conducted between January 2022 and July 2022. Subjects and Methods. TDH parameters, involving native thiol (NT), disulfide, and total thiol (TT), were evaluated in 39 girls with PT, 41 girls with PP and 46 healthy prepubertal girls. The correlations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2) levels with the TDH parameters were determined and ROC curve analysis was performed. Results. NT, TT and NT/TT ratio were higher in the PT and PP groups compared to the control group (p<0.01). Disulfide/NT ratio and disulfide/TT ratio were lower in the PT and PP groups compared to the control group (p<0.05). All the TDH values did not statistically differ between the PP and PT group (p>0.05). There was a positive correlation between LH level, FSH level, and NT level, TT level, NT/TT ratio. The best parameter to discriminate PT or PT and control groups were NT and TT (p<0.01). Conclusion. TDH is altered in girls with PT and PP. NT and TT levels can be useful to discriminate prepubertal girls with lipomastia and girls with PP and PT in clinical practice. Further studies on larger cohorts of patients are required to clarify our results. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Turning waste to wealth: harnessing the potential of Cassava peels for nutritious animal feed

Author

Iheanacho Okike, Seerp Wigboldus, Anandan Samireddipalle, Diego Naziri, Akin O. K. Adesehinwa, Victor Attah Adejoh, Tunde Amole, Sunil Bordoloi, Peter Kulakow, Thiele, Graham, Friedmann, Michael, Campos, Hugo, Polar, Vivian, and Bentley, Jeff

Subjects
GE, S1
Abstract

In Nigeria, processing cassava for food and industry yields around 15 million tons of wet peels annually. These peels are usually dumped near processing centres to rot or dry enough to be burned. Rotting heaps release methane into the air and a stinking effluent that pollutes nearby streams and underground water, while burning produces clouds of acrid smoke. However, when properly dried, peels can be an ingredient in animal feed. Previous attempts over two decades to use peels in animal feed failed to yield profitable options for drying wet peels at commercial scale, but recent research suggests that cassava peels can be processed into high-quality cassava peel (HQCP) products to be used as nutritious, low-cost animal feed ingredients. The core innovation was to adopt the same steps and equipment used for processing cassava roots into gari, the main staple food in the country. When dried, 3 tons of wet peels yield a tonne of healthy and energy-rich animal feed, containing nearly 3,000 kilocalories per kilogram of dry matter (kcal/kgDM). Adopting this innovation at scale in Nigeria’s poultry and fish sectors alone has the potential to turn approximately 3.6 million tons of wet peels into 1.2 million tons of feed ingredients capable of replacing approximately 810,000 tons of largely imported maize. The innovation has great potential to increase feed availability and lower its cost while saving cereals for human consumption, reducing the import bill, creating new business opportunities, and protecting the environment. This research was initiated by CGIAR centres and taken up by the CGIAR Research Program on Roots, Tubers and Bananas (RTB) over the past decade with strategic input from the CGIAR Research Program on Livestock to accelerate development of the innovation, and this chapter documents the potential and progress in taking this innovation to scale.

Published
2022

13. Strategies to manage hepatitis C virus infection disease burden—Volume 4

Author

Chen, D. S., Hamoudi, W., Mustapha, B., Layden, J., Nersesov, A., Reic, T., Garcia, V., Rios, C., Mateva, L., Njoya, O., Al‐Busafi, S. A., Abdelmageed, M. K., Abdulla, M., Adda, D., Akin, O., Al Baqali, A., Al Dweik, N., Al Ejji, K., Al ghazzawi, I., Al Kaabi, S., Al Naamani, K., Al Qamish, J., Al Sadadi, M., Al Salman, J., AlBadri, M., Al‐Romaihi, H. E., Ampofo, W., Antonov, K., Anyaike, C., Arome, F., Bane, A., Blach, S., Borodo, M. M., Brandon, S. M., Bright, B., Butt, M. T., Cardenas, I., Chan, H. L. Y., Chen, C. J., Chen, P. J., Chien, R. N., Chuang, W. L., Cuellar, D., Derbala, M., Elbardiny, A. A., Estes, C., Farag, E., Fung, J., Gamkrelidze, I., Genov, J., Ghandour, Z., Ghuloom, M., Gomez, B., Gunter, J., Habeeb, J., Hajelssedig, O., Himatt, S. M., Hrstic, I., Hu, C. C., Huang, C. F., Hui, Y. T., Jahis, R., Jelev, D., John, A. K., Kaliaskarova, K. S., Kamel, Y., Kao, J. H., Khamis, J., Khattabi, H., Khoudri, I., Konysbekova, A., Kotzev, I., Lai, M. S., Lao, W. C., Lee, M. H., Lesi, O., Li, M., Lo, A., Loo, C. K., Lukšić, B., Maaroufi, A., Malu, A. O., Mitova, R., Mohamed, R., Morović, M., Murphy, K., Nde, H., Ngige, E., Njouom, R., Nonković, D., Obekpa, S., Oguche, S., Okolo, E. E., Omede, O., Omuemu, C., Ondoa, P., Opare‐Sem, O., Owusu‐Ofori, S., Phillips, R. O., Prokopenko, Y. N., Razavi, H., Razavi‐Shearer, D., Razavi‐Shearer, K., Redae, B., Rinke de Wit, T., Robbins, S., Roberts, L. R., Sanad, S. J., Sharma, M., Simonova, M., Su, T. H., Sultan, K., Tan, S. S., Tchernev, K., Tsang, O. T. Y., Tsang, S., Tzeuton, C., Ugoeze, S., Uzochukwu, B., Vi, R., Vince, A., Wani, H. U., Wong, V. W. S., Workneh, A., Yacoub, R., Yesmembetov, K. I., Youbi, M., Yuen, M. F., and Schmelzer, J. D.

Published
2017
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14. The present and future disease burden of hepatitis C virus infections with todayʼs treatment paradigm: Volume 4

Author

Chan, H. L. Y., Chen, C. J., Omede, O., Al Qamish, J., Al Naamani, K., Bane, A., Tan, S. S., Simonova, M., Cardenas, I., Derbala, M., Akin, O., Phillips, R. O., Abdelmageed, M. K., Abdulla, M., Adda, D., Al Baqali, A., Al Dweik, N., Al Ejji, K., Al ghazzawi, I., Al Kaabi, S., Al Sadadi, M., Al Salman, J., AlBadri, M., Al‐Busafi, S. A., Al‐Romaihi, H. E., Ampofo, W., Antonov, K., Anyaike, C., Arome, F., Blach, S., Borodo, M. M., Brandon, S. M., Bright, B., Butt, M. T., Chen, D. S., Chen, P. J., Chien, R. N., Chuang, W. L., Cuellar, D., Elbardiny, A. A., Estes, C., Farag, E., Fung, J., Gamkrelidze, I., Garcia, V., Genov, J., Ghandour, Z., Ghuloom, M., Gomez, B., Gunter, J., Habeeb, J., Hajelssedig, O., Hamoudi, W., Himatt, S. M., Hrstic, I., Hu, C. C., Huang, C. F., Hui, Y. T., Jahis, R., Jelev, D., John, A. K., Kaliaskarova, K. S., Kamel, Y., Kao, J. H., Khamis, J., Khattabi, H., Khoudri, I., Konysbekova, A., Kotzev, I., Lai, M. S., Lao, W. C., Layden, J., Lee, M. H., Lesi, O., Li, M., Lo, A., Loo, C. K., Lukšić, B., Maaroufi, A., Malu, A. O., Mateva, L., Mitova, R., Mohamed, R., Morović, M., Murphy, K., Mustapha, B., Nersesov, A., Ngige, E., Njouom, R., Njoya, O., Nonković, D., Obekpa, S., Oguche, S., Okolo, E. E., Omuemu, C., Ondoa, P., Opare‐Sem, O., Owusu‐Ofori, S., Prokopenko, Y. N., Razavi, H., Razavi‐Shearer, D., Razavi‐Shearer, K., Redae, B., Reic, T., Rinke de Wit, T., Rios, C., Robbins, S., Roberts, L. R., Sanad, S. J., Schmelzer, J. D., Sharma, M., Su, T. H., Sultan, K., Tchernev, K., Tsang, O. T. Y., Tsang, S., Tzeuton, C., Ugoeze, S., Uzochukwu, B., Vi, R., Vince, A., Wani, H. U., Wong, V. W. S., Workneh, A., Yacoub, R., Yesmembetov, K. I., Youbi, M., Yuen, M. F., and Nde, H.

Published
2017
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15. Historical epidemiology of hepatitis C virus in select countries—volume 4

Author

Maaroufi, A., Vince, A., Himatt, S. M., Mohamed, R., Fung, J., Opare‐Sem, O., Workneh, A., Njouom, R., Al ghazzawi, I., Abdulla, M., Kaliaskarova, K. S., Owusu‐Ofori, S., Abdelmageed, M. K., Adda, D., Akin, O., Al Baqali, A., Al Dweik, N., Al Ejji, K., Al Kaabi, S., Al Naamani, K., Al Qamish, J., Al Sadadi, M., Al Salman, J., AlBadri, M., Al‐Busafi, S. A., Al‐Romaihi, H. E., Ampofo, W., Antonov, K., Anyaike, C., Arome, F., Bane, A., Blach, S., Borodo, M. M., Brandon, S. M., Bright, B., Butt, M. T., Cardenas, I., Chan, H. L. Y., Chen, C. J., Chen, D. S., Chen, P. J., Chien, R. N., Chuang, W. L., Cuellar, D., Derbala, M., Elbardiny, A. A., Estes, C., Farag, E., Gamkrelidze, I., Garcia, V., Genov, J., Ghandour, Z., Ghuloom, M., Gomez, B., Gunter, J., Habeeb, J., Hajelssedig, O., Hamoudi, W., Hrstic, I., Hu, C. C., Huang, C. F., Hui, Y. T., Jahis, R., Jelev, D., John, A. K., Kamel, Y., Kao, J. H., Khamis, J., Khattabi, H., Khoudri, I., Konysbekova, A., Kotzev, I., Lai, M. S., Lao, W. C., Layden, J., Lee, M. H., Lesi, O., Li, M., Lo, A., Loo, C. K., Lukšić, B., Malu, A. O., Mateva, L., Mitova, R., Morović, M., Murphy, K., Mustapha, B., Nde, H., Nersesov, A., Ngige, E., Njoya, O., Nonković, D., Obekpa, S., Oguche, S., Okolo, E. E., Omede, O., Omuemu, C., Ondoa, P., Phillips, R. O., Prokopenko, Y. N., Razavi, H., Razavi‐Shearer, D., Redae, B., Reic, T., Rinke de Wit, T., Rios, C., Robbins, S., Roberts, L. R., Sanad, S. J., Schmelzer, J. D., Sharma, M., Simonova, M., Su, T. H., Sultan, K., Tan, S. S., Tchernev, K., Tsang, O. T. Y., Tsang, S., Tzeuton, C., Ugoeze, S., Uzochukwu, B., Vi, R., Wani, H. U., Wong, V. W. S., Yacoub, R., Yesmembetov, K. I., Youbi, M., Yuen, M. F., and Razavi‐Shearer, K.

Published
2017
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18. The Nigerian University System: Meeting the Challenges of Growth in a Depressed Economy.

Author

Adesola, Akin O.

Abstract

An overview of recent history of Nigerian higher education chronicles periods of phenomenal expansion, economic downturn and retrenchment, monitoring of efficiency and academic standards, continued uncontrolled expansion in the absence of basic facilities, recently improved fiscal management, revival of student aid, and proposals for the opening of private universities. (Author/MSE)

Published
1991

20. Challenges and Frugal Remedies for Lowering Facility Based Neonatal Mortality and Morbidity: A Comparative Study

Author

Hippolite O. Amadi, Akin O. Osibogun, Olateju Eyinade, Mohammed B. Kawuwa, Angela C. Uwakwem, Maryann U. Ibekwe, Peter Alabi, Chinyere Ezeaka, Dada G. Eleshin, and Mike O. Ibadin

Subjects
Pediatrics, RJ1-570
Abstract

Millennium development goal target on infant mortality (MDG4) by 2015 would not be realised in some low-resource countries. This was in part due to unsustainable high-tech ideas that have been poorly executed. Prudent but high impact techniques could have been synthesised in these countries. A collaborative outreach was initiated to devise frugal measures that could reduce neonatal deaths in Nigeria. Prevailing issues of concern that could militate against neonatal survival within care centres were identified and remedies were proffered. These included application of (i) recycled incubator technology (RIT) as a measure of providing affordable incubator sufficiency, (ii) facility-based research groups, (iii) elective training courses for clinicians/nurses, (iv) independent local artisans on spare parts production, (v) power-banking and apnoea-monitoring schemes, and (v) 1/2 yearly failure-preventive maintenance and auditing system. Through a retrospective data analyses 4 outreach centres and one “control” were assessed. Average neonatal mortality of centres reduced from 254/1000 to 114/1000 whilst control remained at 250/1000. There was higher relative influx of incubator-dependent-neonates at outreach centres. It was found that 43% of mortality occurred within 48 hours of presentation (d48) and up to 92% of d48 were of very-low birth parameters. The RIT and associated concerns remedies have demonstrated the vital signs of efficiency that would have guaranteed MDG4 neonatal component in Nigeria.

Published
2014
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25. Transcriptomic correlates of non-enhancing tumor volume on imaging in clear cell renal cell carcinoma

Author

Marcon, J., primary, Duzgol, C., additional, Kuo, F., additional, Weiss, K., additional, Di Natale, R.G., additional, Mano, R., additional, Silagy, A.W., additional, Blum, K.A., additional, Weng, S., additional, Attalla, K., additional, Reznik, E., additional, Coleman, J.A., additional, Russo, P., additional, Ahmed, F.S., additional, Akin, O., additional, and Hakimi, A.A., additional

Published
2020
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37. Flow structure in a radial flow pumping system using high-image-density particle image velocimetry

Author

Akin, O. and Rockwell, D.

Subjects
Pumping machinery -- Fluid dynamics, Impellers -- Analysis, Wakes (Aerodynamics) -- Analysis, Vortex-motion -- Analysis, Fluid dynamics -- Research, Engineering and manufacturing industries, Science and technology
Abstract

Use of high-image-density particle image velocimetry (PIV) allows characterization of the instantaneous structure of wake and wake-blade interactions in a simulated rotating machine. The distribution of vorticity over an entire plane within the pumping system is related to the instantaneous pressure source terms in the wake of the impeller. Comparison of instantaneous and ensemble-averaged vorticity contours shows that limited ensemble-averaging can produce a substantial reduction in vorticity levels associated with the instantaneous pressure source terms. When the wake from the impeller interacts with a stationary diffuser blade, the instantaneous processes of flow separation and reattachment can be effectively characterized using combinations of instantaneous streamline patterns and contours of constant vorticity. Moreover, active control of the inflow into the pumping system allows substantial modification of these vorticity distributions.

Published
1994

38. Actively controlled radial flow pumping system: manipulation of spectral content of wakes and wake-blade interactions

Author

Akin, O. and Rockwell, D.

Subjects
Pumping machinery -- Fluid dynamics, Impellers -- Analysis, Wakes (Aerodynamics) -- Analysis, Vortex-motion -- Analysis, Fluid dynamics -- Research, Engineering and manufacturing industries, Science and technology
Abstract

A unique, actively controlled pumping system allows independent control of inflow and impeller perturbations, as well as the phase shift between them. The basic configurations of an impeller and an impeller-diffuser blade system have been investigated with the objective of manipulating the spectral content of the unsteadiness of the near-wake at the impeller discharge. Substantial alteration of the discrete spectral components can be attained. A central feature is the generation of a number of nonlinear interaction components, corresponding to sum and difference frequencies, of the forcing- and blade passing-frequencies and their harmonics. With proper choice of perturbation conditions, it is possible to attenuate the inflow perturbation, as well as to alter the magnitudes of the blade passing component and its harmonics.

Published
1994

42. A Schematic Representation of the Designers’ Logic

Author

Akin, O., Chen, C.-C., Dave, B., Pithavadian, S., Bijl, A., Akin, O., Chen, C.-C., Dave, B., Pithavadian, S., Kalay, Y. E., Harfmann, A. C., Swerdloff, L. M., Krishnamurti, R., Schmitt, G., Robert, J.-C., Weeks, J., Flemming, U., Coyne, R., Glavin, T., Rychener, M., Koskela, L., Hynynen, R., Kallavuo, M., Kahkönen, K., Salokivi, J., Bridges, A. H., Polistina, A., Whittaker, W. L., Hasegawa, Y., Abel, C., Slocum, A. H., Kangari, R., Bandari, E., Wanner, M.-C., Skibniewski, M., Derrington, P., Hendrickson, C., Woodbury, R. F., Keirouz, W. T., Oppenheim, I. J., Rehak, D. R., Earl, C. F., Kano, N., Crowley, J. L., Drazan, P. J., Motazed, B., Oeser, H.-R., Tanaka, N., Saito, M., Arai, K., Banno, K., Ochi, T., Kikuchi, S., Ueno, T., Maeda, J., Yoshida, T., and Suzuki, S.

Published
1986
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43. The present and future disease burden of hepatitis C virus infections with today's treatment paradigm

Author

Chan, H. L. Y., Chen, C. J., Omede, O., Al Qamish, J., Al Naamani, K., Bane, A., Tan, S. S., Simonova, M., Cardenas, I., Derbala, M., Akin, O., Phillips, R. O., Abdelmageed, M. K., Abdulla, M., Adda, D., Al Baqali, A., Al Dweik, N., Al Ejji, K., Al ghazzawi, I., Al Kaabi, S., Al Sadadi, M., Al Salman, J., AlBadri, M., Al-Busafi, S. A., Al-Romaihi, H. E., Ampofo, W., Antonov, K., Anyaike, C., Arome, F., Blach, S., Borodo, M. M., Brandon, S. M., Bright, B., Butt, M. T., Chen, D. S., Chen, P. J., Chien, R. N., Chuang, W. L., Cuellar, D., Elbardiny, A. A., Estes, C., Farag, E., Fung, J., Gamkrelidze, I., Garcia, V., Genov, J., Ghandour, Z., Ghuloom, M., Gomez, B., Gunter, J., Habeeb, J., Hajelssedig, O., Hamoudi, W., Himatt, S. M., Hrstic, I., Hu, C. C., Huang, C. F., Hui, Y. T., Jahis, R., Jelev, D., John, A. K., Kaliaskarova, K. S., Kamel, Y., Kao, J. H., Khamis, J., Khattabi, H., Khoudri, I., Konysbekova, A., Kotzev, I., Lai, M. S., Lao, W. C., Layden, J., Lee, M. H., Lesi, O., Li, M., Lo, A., Loo, C. K., Lukšić, B., Maaroufi, A., Malu, A. O., Mateva, L., Mitova, R., Mohamed, R., Morović, M., Murphy, K., Mustapha, B., Nersesov, A., Ngige, E., Njouom, R., Njoya, O., Nonković, D., Obekpa, S., Oguche, S., Okolo, E. E., Omuemu, C., Ondoa, P., Opare- Sem, O., Owusu-Ofori, S., Prokopenko, Y. N., Razavi, H., Razavi-Shearer, D., Razavi-Shearer, K., Redae, B., Reic, T., Rinke de Wit, T., Rios, C., Robbins, S., Roberts, L. R., Sanad, S. J., Schmelzer, J. D., Sharma, M., Su, T. H., Sultan, K., Tchernev, K., Tsang, O. T. Y., Tsang, S., Tzeuton, C., Ugoeze, S., Uzochukwu, B., Vi, R., Vince, A., Wani, H. U., Wong, V. W. S., Workneh, A., Yacoub, R., Yesmembetov, K. I., Youbi, M., Yuen, M. F., and Nde, H.

Subjects
parasitic diseases, hepatitis C, incidence, mortality, prevalence, treatment, geographic locations
Abstract

Factors influencing the morbidity and mortality associated with viremic hepatitis C virus (HCV) infection change over time and place, making it difficult to compare reported estimates. Models were developed for 17 countries (Bahrain, Bulgaria, Cameroon, Colombia, Croatia, Dominican Republic, Ethiopia, Ghana, Hong Kong, Jordan, Kazakhstan, Malaysia, Morocco, Nigeria, Qatar and Taiwan) to quantify and characterize the viremic population as well as forecast the changes in the infected population and the corresponding disease burden from 2015 to 2030. Model inputs were agreed upon through expert consensus, and a standardized methodology was followed to allow for comparison across countries. The viremic prevalence is expected to remain constant or decline in all but four countries (Ethiopia, Ghana, Jordan and Oman) ; however, HCV-related morbidity and mortality will increase in all countries except Qatar and Taiwan. In Qatar, the high-treatment rate will contribute to a reduction in total cases and HCV- related morbidity by 2030. In the remaining countries, however, the current treatment paradigm will be insufficient to achieve large reductions in HCV- related morbidity and mortality.

Published
2017

44. Strategies to manage hepatitis C virus infection disease burden

Author

Chen, D. S., Hamoudi, W., Mustapha, B., Layden, J., Nersesov, A., Reic, T., Garcia, V., Rios, C., Mateva, L., Njoya, O., Al-Busafi, S. A., Abdelmageed, M. K., Abdulla, M., Adda, D., Akin, O., Al Baqali, A., Al Dweik, N., Al Ejji, K., Al ghazzawi, I., Al Kaabi, S., Al Naamani, K., Al Qamish, J., Al Sadadi, M., Al Salman, J., AlBadri, M., Al-Romaihi, H. E., Ampofo, W., Antonov, K., Anyaike, C., Arome, F., Bane, A., Blach, S., Borodo, M. M., Brandon, S. M., Bright, B., Butt, M. T., Cardenas, I., Chan, H. L. Y., Chen, C. J., Chen, P. J., Chien, R. N., Chuang, W. L., Cuellar, D., Derbala, M., Elbardiny, A. A., Estes, C., Farag, E., Fung, J., Gamkrelidze, I., Genov, J., Ghandour, Z., Ghuloom, M., Gomez, B., Gunter, J., Habeeb, J., Hajelssedig, O., Himatt, S. M., Hrstic, I., Hu, C. C., Huang, C. F., Hui, Y. T., Jahis, R., Jelev, D., John, A. K., Kaliaskarova, K. S., Kamel, Y., Kao, J. H., Khamis, J., Khattabi, H., Khoudri, I., Konysbekova, A., Kotzev, I., Lai, M. S., Lao, W. C., Lee, M. H., Lesi, O., Li, M., Lo, A., Loo, C. K., Lukšić, B., Maaroufi, A., Malu, A. O., Mitova, R., Mohamed, R., Morović, M., Murphy, K., Nde, H., Ngige, E., Njouom, R., Nonković, D., Obekpa, S., Oguche, S., Okolo, E. E., Omede, O., Omuemu, C., Ondoa, P., Opare-Sem, O., Owusu-Ofori, S., Phillips, R. O., Prokopenko, Y. N., Razavi, H., Razavi-Shearer, D., Razavi-Shearer, K., Redae, B., Rinke de Wit, T., Robbins, S., Roberts, L. R., Sanad, S. J., Sharma, M., Simonova, M., Su, T. H., Sultan, K., Tan, S. S., Tchernev, K., Tsang, O. T. Y., Tsang, S., Tzeuton, C., Ugoeze, S., Uzochukwu, B., Vi, R., Vince, A., Wani, H. U., Wong, V. W. S., Workneh, A., Yacoub, R., Yesmembetov, K. I., Youbi, M., Yuen, M. F., and Schmelzer, J. D.

Subjects
diagnosis, disease burden, elimination, epidemiology, hepatitis C, scenarios, strategy
Abstract

The hepatitis C virus (HCV) epidemic was forecasted through 2030 for 17 countries in Africa, Asia, Europe, Latin America and the Middle East, and interventions for achieving the Global Health Sector Strategy on viral hepatitis targets —“WHO Targets” (65% reduction in HCV-related deaths, 90% reduction in new infections and 90% of infections diagnosed by 2030) were considered. Scaling up treatment and diagnosis rates over time would be required to achieve these targets in all but one country, even with the introduction of high SVR therapies. The scenarios developed to achieve the WHO Targets in all countries studied assumed the implementation of national policies to prevent new infections and to diagnose current infections through screening.

Published
2017

50. The feasibility of epidemiological research on prostate cancer in African men in Ibadan, Nigeria

Author

Suvam Paul, Olufemi Ogunbiyi, Ilir Agalliu, Olayiwola B. Shittu, Olukemi K. Amodu, Thomas E. Rohan, Oluwafemi Popoola, Michael C. Asuzu, Adebola Adedimeji, David W. Lounsbury, Chioma C. Asuzu, Kola Jinadu, and Akin O Adebiyi

Subjects
Adult, Male, Gerontology, medicine.medical_specialty, Case–control study, Nigeria, Feasibility study, urologic and male genital diseases, Body Mass Index, Prostate cancer, Risk Factors, Environmental health, Epidemiology, Humans, Medicine, Body Weights and Measures, Genetic Predisposition to Disease, Epidemiologic study, Life Style, Aged, Aged, 80 and over, business.industry, Incidence, Mortality rate, Incidence (epidemiology), Public health, Public Health, Environmental and Occupational Health, Case-control study, Prostatic Neoplasms, Middle Aged, Prostate-Specific Antigen, medicine.disease, African men, Prostate-specific antigen, Logistic Models, Socioeconomic Factors, Case-Control Studies, Feasibility Studies, Biostatistics, business, Research Article
Abstract

Background Men of African descent have the highest incidence and mortality rates of prostate cancer (PrCa) worldwide. Notably, PrCa is increasing in Africa with Nigerian men being mostly affected. Thus, it is important to understand risk factors for PrCa in Nigeria and build capacity for cancer research. The goals of this study were to determine the feasibility of conducting an epidemiological study of PrCa and to obtain preliminary data on risk factors for PrCa in Nigeria. Methods A case–control study (50 cases/50 controls) was conducted at the University College Hospital (UCH) in Ibadan, Nigeria, between October 2011 and December 2012. Men aged 40 to 80 years were approached for the study and asked to provide informed consent and complete the research protocol. Logistic regression models were used to examine associations between demographic, social and lifestyle characteristics and risk of PrCa. Results The participation rate among cases and controls was 98% and 93%, respectively. All participants completed a questionnaire and 99% (50 cases/49 controls) provided blood samples. Cases had a median serum diagnostic PSA of 73 ng/ml, and 38% had a Gleason score 8–10 tumor. Family history of PrCa was associated with a 4.9-fold increased risk of PrCa (95% CI 1.0 - 24.8). There were statistically significant inverse associations between PrCa and height, weight and waist circumference, but there was no association with body mass index (kg/m2). There were no associations between other socio-demographic and lifestyle characteristics and PrCa risk. Conclusion This feasibility study demonstrated the ability to ascertain and recruit participants at UCH and collect epidemiological, clinical and biospecimen data. Our results highlighted the advanced clinical characteristics of PrCa in Nigerian men, and that family history of PrCa and some anthropometric factors were associated with PrCa risk in this population. However, larger studies are needed to better understand the epidemiological risk factors of PrCa in Nigeria.

Published
2015
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