106 results on '"Aksöyek S"'
Search Results
2. A retrospective review of 228 episodes of infective endocarditis where rheumatic valvular disease is still common
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Çetinkaya, Y, Akova, M, Akalın, H.E, Aşçıoğlu, S, Hayran, M, Uzuns, Ö, Aksöyek, S, Tokgözoğlu, L, Oto, A, Kes, S, Paşaoğlu, İ, and Ünal, S
- Published
- 2001
- Full Text
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3. Case Image: Rare Cause Of Recurrent Pericardial Tamponade: Cardiac Angiosarcoma
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Şener, Y.Z, Okşul, M, Kıvrak, A, Canpolat, U, Aksöyek, S., and Kardiyoloji
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- 2017
4. Hepatoblastoma in Children
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Abbasoglu, L., primary, Gün, F., additional, Tansu Salman, F., additional, Çelik, A., additional, Saraç, F., additional, Ünüvar, A., additional, Görgün, Ö., additional, and Aksöyek, S., additional
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- 2004
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5. QT dynamicity and heart rate variability for prediction of adverse outcome during in hospital follow-up
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Sade, E., primary, Aytemir, K, additional, Özer, N, additional, Övünç, K, additional, Aksöyek, S, additional, Önalan, O., additional, Nazli, N., additional, Özmen, F., additional, Kes, S., additional, and Oto, A., additional
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- 2001
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6. Plasma CRP levels and QT dispersion in acute coronary syndromes
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Y⇔ld⇔rr, A., primary, Sade, E., additional, Kabakc⇔, G., additional, Batur, M.K., additional, Ünsal, İ., additional, Övünç, K., additional, Aksöyek, S., additional, Tokgözoğlu, L., additional, Oto, A., additional, Özmen, F., additional, and Kes, S., additional
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- 2000
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7. The effects of coronary artery disease and clinical stability on endothelial function parameters
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Yildirir, A., primary, Tokgödzoğlu, L., additional, Haznedaroğlu, İ., additional, Sinici, İ., additional, Ünsal, İ., additional, Kabakcı, G., additional, Övünç, K., additional, Aksöyek, S., additional, Oto, A., additional, Özmen, F., additional, Kirazlı, Ş., additional, and Kes, S., additional
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- 2000
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8. Assessment of autonomic nervous system function in patients with behçet's disease by heart rate variability
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Aytemir, K., primary, Batur, M.K., additional, Aksöyek, S., additional, Özcebe, O., additional, Özer, N., additional, and Oto, A., additional
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- 1998
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9. 1.P.315 Angiotensin converting enzyme gene polymorphism is not associated with the risk or extent of ischemic heart disease in Turkish patients
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Tokgözoǧlu, S.L., primary, Alikaşfoǧlu, M., additional, Atalar, E., additional, Tunçbilek, E., additional, Övünç, K., additional, Aksöyek, S., additional, Kabakçi, G., additional, and Kes, S., additional
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- 1997
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10. Wilms' Tumor and Associated Malformations; Report of Two Cases with WAGR and Drash Syndrome
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Özbey, H., primary, Boneval, C., additional, Kapran, Y., additional, Aksöyek, S., additional, Salman, T., additional, and Çelik, A., additional
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- 1996
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11. Prevalence of coronary artery disease before valvular surgery in patients with rheumatic valvular disease.
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Atalar E, Yorgun H, Canpolat U, Sunman H, Kepez A, Kocabas U, Ozer N, Ovünç K, Aksöyek S, Ozmen F, Atalar, Enver, Yorgun, Hikmet, Canpolat, Uğur, Sunman, Hamza, Kepez, Alper, Kocabaş, Uğur, Ozer, Necla, Ovünç, Kenan, Aksöyek, Serdar, and Ozmen, Ferhan
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- 2012
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12. Diagnostic accuracy and clinical utility of echocardiographic indices for detecting left ventricular diastolic dysfunction in patients with coronary artery disease and normal ejection fraction.
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Ozer N, Okutucu S, Kepez A, Aksoy H, Deveci OS, Atalar E, Ovünç K, Aksöyek S, Ozer, Necla, Okutucu, Sercan, Kepez, Alper, Aksoy, Hakan, Deveci, Onur Sinan, Atalar, Enver, Ovünç, Kenan, and Aksöyek, Serdar
- Abstract
Objective: The aim of present study was to assess the clinical utility and diagnostic accuracy of diastolic dysfunction criteria that were recommended in current American Society of Echocardiography and European Association of Echocardiography recommendations for prediction of increased LVEDP (>16 mmHg) in patients with coronary artery disease and normal EF.Methods: Forty-five consecutive patients (mean age=61.5±10.3 years) referred for cardiac catheterization were enrolled in this prospective study. All patients underwent transthoracic echocardiography and tissue Doppler imaging within 24 hours before cardiac catheterization. Patients were divided into 2 groups according to left ventricular end diastolic pressure (LVEDP) (LVEDP>16 mmHg, n=23; LVEDP≤16 mmHg, n=22). Receiver operating characteristics curve analyses were performed and sensitivity, specificity, positive predictive value and negative predictive value were calculated for indices to detect high LVEDP.Results: Among the indices, left atrial volume index (LAVI) ≥34 ml/m2 (sensitivity=60.0% and specificity=90.0%) and ratio of transmitral to septal annular velocities during early filling (septal E/e' ratio) ≥15 (sensitivity=30.4% and specificity=95.5%) had more reasonable sensitivity and specificity. Receiver operating characteristics curve analysis revealed that best predictors of high LVEDP were septal E/e' [area under curve (AUC)=0.694, standard error (SE)=0.66, p=0.01] and LAVI (AUC=0.669, SE=0.63, p=0.045]. There were statistically significant correlations between LVEDP and septal E/e' (r=0.541, p=0.001) and LAVI (r=0.461, p=0.002). A proposed algorithm consisting LAVI ≥34 ml/m2 and septal E/e' >8 could determine diastolic dysfunction with a 95.6% sensitivity and 54.5% specificity.Conclusion: Septal E/e' (≥15) and LAVI (≥ 34 ml/m2) were the better predictors of the increased LVEDP than the other echocardiographic parameters. There were statistically significant moderate positive correlations of LVEDP with septal E/ e' and LAVI. Combination of LAVI and septal E/e' is useful to detect diastolic dysfunction. [ABSTRACT FROM AUTHOR]- Published
- 2011
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13. Mean systolic annular velocity and strain score index: new and non-invasive parameters for the evaluation of acute myocardial infarction patients.
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Kaya EB, Ozer N, Aksoy H, Deveci OS, Tülümen E, Okutucu S, Yorgun H, Atalar E, Aksöyek S, Ozmen F, Ovünç K, Kes S, and Ozkutlu H
- Abstract
Copyright of Anatolian Journal of Cardiology / Anadolu Kardiyoloji Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2010
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14. The early predictors of ventricular remodeling after myocardial infarction: the role of tumor necrosis factor-alpha.
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Kaya EB, Ozer N, Deveci OS, Kepez A, Tülümen E, Aksöyek S, Atalar E, Ovünç K, Özmen F, and Özkutlu H
- Abstract
Copyright of Anatolian Journal of Cardiology / Anadolu Kardiyoloji Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2009
15. Effect of balloon-induced acute ischaemia on P wave dispersion during percutaneous transluminal coronary angioplasty.
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Özmen, F., Atalar, E., Aytemir, K., Özer, N., Açıl, T., Övünç, K., Aksöyek, S., and Kes, S.
- Abstract
Aims P wave dispersion is a recent ECG marker that reflects discontinuous and inhomogeneous conduction of sinus impulses, which has been studied in a limited number of cardiac conditions. The aim of our study was to investigate the effects of angioplasty induced-ischaemia on atrial conduction abnormalities as estimated by P maximum and P dispersion. Methods and Results The study consisted of 67 consecutive patients (41 men, mean age 58±11 years) with 1-vessel coronary artery disease who underwent elective single vessel coronary angioplasty (left anterior descending (LAD) coronary artery in 28 patients, the right coronary artery (RCA) in 22 patients and the left circumflex coronary artery (LCx) in 17 patients. All patients underwent 12-lead surface ECG before the first inflation (baseline) and then 60 s after intra-coronary balloon inflation. The maximum P wave duration, the minimumP wave duration, and P wave dispersion (Pd=Pmax−Pmin) were calculated from 12-lead surface ECGs. Conclusion The prolongation of P wave dispersion may be a useful and simple additional marker for myocardial ischaemia. [ABSTRACT FROM PUBLISHER]
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- 2001
16. VERAPAMIL SR AND TRANDOLAPRIL COMBINATION THERAPY IS SAFE AND EFFECTIVE IN HYPERTENSIVE PATIENTS WITH METABOLIC DISORDERS
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Aksöyek, S, Özer, N, Aytemir, K, and Kes, S
- Abstract
Verapamil SR (180 mg) plus Trandolapril (2 mg) is a potent antihypertensive combination but the efficacy and safety of this treatment has not been studied fully in hypertensive patients with metabolic disorders. We enrolled 298 patients with mild to moderate hypertension who had at least one of the following disorders: diabetes mellitus, hypercholesterolaemia or mild renal failure. The sitting systolic pressure and diastolic blood pressures were significantly decreased after 12 weeks of treatment. Blood pressure was inadequately controlled in only 24 patients (8.8%). Progressive decreases in blood glucose, total cholesterol, low‐density lipoprotein and triglyceride levels were observed during the study. There was no significant change in blood urea nitrogen, creatinine and transaminase levels (p>0.05). There was a significant decrease in microalbuminuria levels. There was no significant change in glycosylated haemoglobin levels in diabetic patients. Verapamil SR plus trandolapril is an effective drug combination in the treatment of hypertension. It may be used safely in patients with diabetes mellitus, hyperlipidaemia and mild renal failure.
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- 2001
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17. 35th Annual Meeting of the European Association for the Study of Diabetes
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Melander, A., Olsson, J., Lindberg, G., Salzman, A., Howard, T., Stang, P., Lydick, E., Emslie-Smith, A., Boyle, D. I. R., Evans, J. M. M., Macdonald, T. M., Bain, J., Sullivan, F., Juhl, C., Pørksen, N., Sturis, J., Hollingdal, M., Pincus, S., Veldhuis, J., Dejgaard, A., Schmitz, O., Kristensen, J. S., Frandsen, K. B., Bayer, Th., Müller, P., Dunning, B. E., Paladini, S., Gutierrez, C., Deacon, R., Valentin, M., Grunberger, G., Weston, W. M., Patwardhan, R., Rappaport, E. B., Sargeant, L. A., Wareham, N. J., Khaw, K. T., Zethelius, Björn, Lithell, Hans, Hales, C. Nicholas, Berne, Christian, Lakka, H.-M., Oksanen, L., Tuomainen, T.-P., Kontula, K., Salonen, J. T., Dekker, J. M., de Boks, P., de Vegt, F., Stehouwer, C. D. A., Nijpels, G., Bouter, L. M., Heine, R. J., Bruno, G., Cavallo-Perin, P., Bargero, G., D’Errico, N., Borra, M., Macchia, G., Pagano, G., Newton, R. W., Ruta, D. A., New, J. P., Wallace, C., Roxburgh, M. A., Young, R. J., Vaughan, N. J. A., Elliott, P., Brennan, G., Devers, M., MacAlpine, R., Steinke, D., Lawson, D. H., Decallonne, B., Casteels, K., Gysemans, C., Bouillon, R., Mathieu, C., Linn, Thomas, Strate, Christine, Schneider, Kerstin, Funda, D. P., Jirsa, M., Kozáková, H., Kaas, A., Kofronová, O., Tlaskalová-Hogenová, H., Buschard, K., Wanka, H., Hartmann, A., Kuttler, B., Rasmussen, S. B., Sørensen, T. S., Markholst, H., Petersen, J. S., Karounos, D., Dyrberg, T., Mabley, J. G., Haskó, G., Szabó, C., Seissler, J., Nguyen, T. B. T., Steinbrenner, H., Scherbaum, W. A., Cipriani, R., Gabriele, A., Sensi, M., Guidobaldi, L., Pantellini, F., Cerrito, M. G., Scarpa, S., Di Mario, U., Morano, S., Ceolotto, G., Iori, E., Baritono, E., Del Prato, S., Semplicini, A., Trevisan, R., Zerbini, G., Meregalli, G., Asnaghi, V., Tentori, F., Maestroni, A., Mangili, R., Marescotti, C., Vedovato, M., Tiengo, A., Tadjieva, J., Mankovsky, B. N., Van Aken, S., Raes, A., Vande Walle, J., Matthys, D., Craen, M., Hansen, H. P., Lund, S. S., Rossing, P., Jensen, T., Parving, H.-H., Andersen, S., Tarnow, L., Hansen, B. V., Trautner, C., Haastert, B., Ennenbach, N., Willich, S., Tabák, Á. Gy., Orchard, T. J., Spranger, J., Preissner, K. T., Schatz, H., Pfeiffer, A., Cantón, A., Burgos, R., Hernández, C., Lecube, A., Mesa, J., Segura, R. M., Mateo, C., Simó, R., Fathallah, L., Greene, D. A., Obrosova, I., Gilbert, R. E., Kelly, D. J., Cox, A. J., Berka-Wilkinson, J. L., Taylor, H. R., Panagiotopoulos, S., Lee, V., Jerums, G., Cooper, M. E., Hitman, G. A., Aganna, E., Ogunkolade, W. B., Rema, M., Deepa, R., Shanthi-Rani, C. S., Barakat, K., Kumarajeewa, T. R., Cassell, P. G., McDermott, M. F., Mohan, V., Ways, K., Bursell, S., Devries, T., Woodworth, J., Alatorre, C., King, G., Aiello, L. P., Karisen, A. E., Pavlovic, D., Nielsen, K., Jensen, J., Andersen, H. U., Pociot, F., Mandrup-Poulsen, T., Eizirik, D. L., Nerup, J., Lortz, S., Tiedge, M., Lenzen, S., Lally, F. J., Bone, A. J., Darville, M. I., Ho, Y.-S., Sternesjö, J., Sandler, S., Chen, M.-C., Schuit, F., Pipeleers, D. G., Merezak, S., Hardikar, A., Hoet, J. J., Remacle, C., Reusens, B., Bréant, B., Garofano, A., Czernichow, P., Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Nakano, R., Komeda, K., Eto, K., Tobe, K., Kimura, S., Kadowaki, T., Ide, T., Murakami, K., Tsunoda, M., Mochizuki, T., Ozanne, S. E., Nave, B. T., Wang, C. L., Dorling, M. W., Petry, C. J., Koopmans, S. J., van der Bent, C., Que, I., Radder, J. K., Sebokova, E., Sana, A. K., Klimes, I., Ruderman, N., Morviducci, L., Pastore, L., Morelli, S., Sagratella, E., Zorretta, D., Buongiomo, A., Tamburrano, G., Giaccari, A., Martinenghi, Sabina, De Angelis, Gabriella Cusella, Ravasi, Flavio, Bifari, Francesco, Bordignon, Claudio, Falqui, Luca, Kessler, A., Dransfeld, O., Sasson, S., Tomas, E., Zorzano, A., Eckel, J., Thorsby, P., Rosenfalck, A. M., Kjems, L., Hanssen, K. F., Madsbad, S., Birkeland, K. I., Hamilton-Wessler, M., Markussen, J., Bergman, R. N., Melki, V., Hanaire-Broutin, H., Bessières-Lacombe, S., Tauber, J.-P., Home, P. D., Lindholm, A., Riis, A., Rosenstock, J., Schwartz, S., Clark, C., Edwards, M., Donley, D., Swift, P., Mortensen, H. B., Lynggaard, H., Hougaard, P., Cull, C. A., Neil, H. A. W., Frighi, V., Manley, S. E., Holman, R. R., Turner, R. C., Steiner, G., Davis, W. A., Weeraratna, T., Bruce, D. G., Davis, T. M. E., Vergès, B., Duvillard, L., Pont, F., Florentin, E., Gambert, Ph., Benko, B., Ljubić, S., Turk, Z., Granić, M., März, W., Wollschläger, H., Klein, G., Neiss, A., Wehling, M., Huxtable, S. J., Saker, P. J., Walker, M., Frayling, T. M., Levy, J. C., O’Rahilly, S., Hattersley, A. T., McCarthy, M. I., Orecchio, A., Giacchini, A., Dominici, R., Canettieri, G., Trinti, B., Zani, M., Andreoli, M., Sciacchitano, S., de Silva, A. M., Whitecross, K., Pasco, J., Kotowicz, M., Nicholson, G., Zimmet, P., Boyko, E. J., Collier, G. R., Frittitta, L., Pizzuti, A., Argiolas, A., Graci, S., Goldfine, I. D., Bozzali, M., Ercolino, T., Costanzo, B., Iacoviello, L., Tassi, V., Trischitta, V., Wauters, M., Rankinen, T., Mertens, I., Chagnon, M., Bouchard, C., Van Gaal, L., Sivenius, K., Valve, R., Hakkarainen, V., Niskanen, L., Laakso, M., Uusitupa, M., Beridze, N., Japaridze, M., Kurashvili, R., Dundua, M., Kebuladze, G., Kazakhashvili, N., Offley-Shore, B., Thomas, B., Ghebremeskel, K., Crawford, M., Lowy, C., Eriksson, Ulf J., Martin Simán, C., Wisse, Bert, Gittenberger-de Groot, Adriana C., Wentzel, P., Eriksson, U. J., Wender-Ożegowska, E., Drews, K., Biczysko, R., Bronisz, A., Rość, D., Graczykowska-Koczorowska, A., Kotschy, M., Sokup, A., Kohnert, K. D., Besch, W., Strese, J., Frick, U., Zander, E., Kemer, W., Škrha, J., Kvasnička, J., Kalvodová, B., Hilgertová, J., Schatteman, K., Goossens, F., Scharpé, S., De Leeuw, I., Hendriks, D., Legakis, I. N., Panayiotou, D., Mountokalakis, Th. D., Enderle, M. D., Beckmann, P., Balletshofer, B., Rittig, K., Maerker, E., Volk, A., Meisner, C., Jacob, S., Matthaei, S., Häring, H. U., Rett, K., Ueda, K., Nakagawa, T., Shimajiri, Y., Kokawa, M., Matsumoto, E., Sasaki, H., Sanke, T., Nanjo, K., McKinnon, Caroline M., Macfarlane, Wendy M., Docherty, Kevin, Furukawa, N., Shirotani, T., Kishikawa, H., Kaneko, K., Araki, E., Shichiri, M., Prentki, M., Roduit, R., Susini, S., Buteau, J., Ejrnæs, A. M., Andersen, N. Aa., Osterhoff, M., Möhlig, M., Ortmann, J., Bikashaghi, F., Mayer, C., Bikashagi, F., Ackermans, M. T., Pereira Arias, A. M., Bisschop, P. H. L. T., Endert, E., Sauerwein, H. P., Romijn, J. A., Gastaldelli, A., Baldi, S., Pettiti, M., Natali, A., Frascerra, S., Camastra, S., Toschi, E., Ferrannini, E., Stingl, H., Krssak, M., Bischof, M. G., Krebs, M., Fürnsinn, C., Nowotny, P., Waldhäusl, W., Roden, M., Neeft, M., Meijer, A. J., Båvenholm, P., Pigon, J., Efendic, S., Kästenbauer, T., Sauseng, S., Sokol, G., Auinger, M., Irsigler, K., Abbott, C. A., Carrington, A. L., Faragher, B., Kulkarni, J., Van Ross, E. R. E., Boulton, A. J. M., Armstrong, D. G., Hadi, S., Nguyen, H. C., Harkless, L. B., Jirkovská, A., Kasalicky, P., Hosová, J., Skibova, J., Uccioli, L., Caselli, A., Giacomozzi, C., Macellari, V., Giurato, L., Lardieri, L., Menzinger, G., Pham, H. T., Rosenblum, B. I., Lyons, T. E., Giurini, J. M., Smakowski, P., Chrzan, J. S., Habershaw, G. M., Veves, A., Foster, A. M., Bates, M., Doxford, M., Edmonds, M. E., Kecha, O., Winkler, R., Martens, H., Collette, J., Lefèbvre, P. J., Greiner, D., Geenen, V., Atlan-Gepner, C., Naspetti, M., Valéro, R., Barad, M., Lepault, F., Vialettes, B., Naquet, P., de Galan, B., Netea, M. G., Hancu, N., Smits, P., Van der Meer, J. W. M., Osterbye, T., Jørgensen, K. H., Tranum-Jensen, J., Fredman, P., Høy, M., Bokvist, K., Olsen, H. L., Horn, T., Gromada, J., Laub, R., Lohmann, T., Hahn, H. J., Adler, T., Emmrich, F., Rabuazzo, A. M., Lupi, R., Dotta, F., Patanè, G., Marselli, L., Realacci, M., Piro, S., Del Guerra, S., Santangelo, C., Navalesi, R., Purrello, F., Marchetti, P., de Vos, P., Visser, L., de Haan, B. J., Klok, P., van Schilfgaarde, R., Poppema, S., Juang, J.-H., Kuo, C.-H., Hsu, B. R.-S., Nacher, V., Pérez, M., Biarnés, M., Raurell, M., Soler, J., Montanya, E., Ritzel, R., Maubach, J., Büsing, M., Becker, T., Klempnauer, J., Hücking, K., Schmiegel, W. H., Nauck, M. A., Bouček, P., Saudek, F., Adamec, M., Kožitarová, R., Jedináková, T., Vlasáková, Z., Skibová, J., Bartoš, V., Maffi, P., Bertuzzi, F., Aldrighetti, L., Taglietti, M. V., Castelnuovo, A., Pozza, G., Di Carlo, V., Secchi, A., Renier, G., Mamputu, J.-C., Gillespie, J. S., McMaster, D., Mercer, C., Trimble, E. R., Lecomte, M., Véricel, E., Paget, C., Ruggiero, D., Lagarde, M., Wiernsperger, N., Pricci, F., Leto, G., Amadio, L., Cordone, S., Iacobini, C., Catalano, S., Violi, F., Rotella, C. M., Pugliese, G., Zicari, A., Gradini, R., Sale, P., Pala, L., Cresci, B., Giannini, S., Manuelli, C., Dahlfors, G., Arnqvist, H. J., Gonelle-Gispert, C., Halnan, P. A., Sadoul, K., Wolter, S., Lang, J., Niwa, T., Yu, W., Hidaka, H., Senda, T., Niki, I., Fukasawa, T., Renstrom, E., Barg, S., Seward, E., Rorsman, P., Rutter, G. A., Molinete, M., Lilla, V., Ravazzola, M., Halban, P. A., Efanov, A. M., Bertorello, A. M., Zaitsev, S. V., Zwiller, J., Berggren, P.-O., MŞengül, A., Salman, F., Sargrn, M., Özer, E., Karşidaǧ, K., Salman, S., Gedik, S., Satman, İ., Dinççaǧ, N., Yılmaz, M. T., Lloyd, A., Hopkinson, P. K., Testa, M. A., Blonde, L., Turner, R. R., Hayes, J., Simonson, D. C., van der Ven, N. C. W., Lubach, C. H. C., Snoek, F. J., Mollema, E. D., van der Ploeg, H. M., Danne, T., Hoey, H., McGee, H., Fitzgerald, H., Lernmark, B., Thernlund, G., Fredin, K., Hägglöf, B., Lugari, R., Dell’Anna, C., Ugolotti, D., Dei Cas, A., Barilli, A. L., Sard, L., Marani, B., Iotti, M., Zandomeneghi, R., Gnudi, A., Kjems, L. L., Volund, Aa., Toft-Nielsen, M., Damholt, M. B., Hilsted, L., Hughes, T. E., Krarup, T., Holst, J. J., Young, A., Gottlieb, A., Fineman, M., Kolterman, O., Cancelas, J., García-Martínez, J. A., Villanueva-Peñacarrillo, M. L., Valverde, I., Malaisse, W. J., Filipsson, K., Ahrén, B., Balkan, B., Kwasnik, L., Battle, B., Li, X., Egan, J. M., Clocquet, A. R., Elahi, D., Petrella, E., Pricket, K., Petersen, K. F., Sullivan, J. T., Amatruda, J. M., Livingston, J. N., Shulman, G. I., Freyse, E.-J., Knospe, S., Glund, K., Demuth, H.-U., Walker, D., Malik, R. A., Reljanovic, M., Barada, A., Milicevic, Z., Tack, Cees J., Goldstein, David S., Van Huysen, C., Stevens, M. 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L., Srivatsa, A., Anderson, S. G., Cruikshank, J. K., Florkowski, C. M., Scott, R. S., Graham, P. J., Moir, C. L., Flores, C., Ruggenenti, P., Dodesini, A. R., Vasile, B., Gaspari, F., Arnoldi, F., Ferrari, S., Ciocca, I., Spalluzzi, A., Remuzzi, G., Delvigne, C., Ballaux, D., Bosman, D. R., Winkler, A. S., Marsden, J., Watkins, P. J., Strutton, D., Erbey, J. R., Jacobsen, P., Rossing, K., Jensen, J. S., Mansfield, M. W., Kowalska, I., Telejko, B., Bachórzewska-Gajewska, A., Prokop, J., Kochman, W., Musiał, W., Naskręt, D., Oleksa, R., Zozulińska, D., Sowiński, J., Wierusz-Wysocka, B., Klamann, A., Jonas, M., Müller-Lung, U., Heuser, L., Launhardt, V., Valensi, P., Pariès, J., Torremocha, F., Brulport, V., Sachs, R. N., Vanzetto, G., Levy, M., Lormeau, B., Halimi, S., Perfornis, A., Boumal, D., Zimmermann, C., Bernard, Y., Sabbah, A., Meneveau, N., Gautier, S., Bassand, J. P., Anděl, M., Kraml, P., Potočková, J., Dvořáková, H., Trešlová, L., Nuttall, S. L., Martin, U., Kendall, M. 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E., Ramu, Y., Vidyullatha, Y., Strojek, K., Gorska, J., Morawin, E., Ritz, E., Ciavarella, A., Malini, P. L., Strocchi, E., Fiumi, N., Ambrosioni, E., Idzior-Waluś, B., Stevens, L., McEneny, J., O’Kane, M. J., Moles, K. W., McMaster, C., Young, I. S., Leonhardt, W., Konstadelou, E., Gürlek, Alper, Soedamah-Muthu, S., Taskinen, M. R., Ehnholm, C., Wägner, A., Bayen, Laia, Rigla, M., Ortega, E., Caixàs, A., Mestrón, A., Ordóñez, J., Pérez, A., Sotiropoulou, G., Servais, P. L., Bertolotto, A., Pilo, M., Suchánková, G., Andratschke, S., Tschöp, M., Strasburger, C.-J., Rizzo, L., Aerts, P., Vinckx, M., Ansquer, J. C., Ryan, M., Buter, H., Navis, G. J., de Jong, P. E., de Zeeuw, D., Carreras, G., Giménez, G., Pou, J. M., Howorka, K., Gabriel, M., Pumprla, J., Köves, A., Bhowmik, N. B., Haque, A., Rahman, A., Paleari, F., Gamba, P., Mauri, G., Rovaris, G., Giannattasio, C., Piatti, M. L., Zincone, A., Cavaletti, G., Mancia, G., Lan, S., Arezzo, J., Gerber, R. A., Klioze, S. S., Saponara, C., Tartaglione, T., Cercone, S., Caputo, S., Meloni, T., Brunetti, D., Di Lazzaro, V., Xu, G., Jiang, H. Y., Shy, M. E., Sugimoto, K., Zhang, W.-X., Kuchmerovskaya, T., Donchenko, G., Shymansky, I., Kuchmerovsky, N., Pakyrbaeva, L., Cameron, N. E., Keegan, A., Cotter, M. A., Mirrlees, D., Smale, S. E., Biessels, G. J., Duis, S. E. J., Kamal, A., Gispen, W. H., Carrington, A., Carman, S., Smiarowski, H., Lavoie, D., Sawicki, D., Sabetta, A., Litchfield, J., Van Zandt, M., Sredy, J., Smirnova, V., Strokov, I., Ivanova, L., Ichunina, A., Nakamura, J., Nakayama, M., Hamada, Y., Chaya, S., Kato, K., Kasuya, Y., Mizubayashi, R., Miwa, K., Yasuda, Y., Kamiya, H., Hotta, N., Bíró, K., Kukorelli, T., Szilágyi, N., Kürthy, M., Komáromy, A., Mogyorosi, T., Nagy, K., Çakir, M., Baskal, N., Güllü, S., Elhan, A. H., Erdogan, G., Ziegler, D., Piolot, R., Neubauer, J., Senesi, B., Bonetti, R., Napolitano, A., Canepa, F., Ottonello, P., Schabmann, A., Giménez-Pérez, G., Arroyo, J. A., López, T., Ponz, E., Mauricio, D., Diem, P., Zanchin, L., Suter, S. L., Lefrandt, J. D., Smit, A., van Roon, A. M., Dullaart, R., Voita, D., Mackevics, V., Vitols, A., Lengyel, Cs., Farkas, Gy., Török, T., Légrády, P., Várkonyi, T. T., Kardos, A., Gingl, Z., Kempler, P., Rudas, L., Lonovics, J., Marchand, M., Stevens, L. K., Tarnás, Gy., Estrella, F., Christensen, N. J., Keresztes, K., Barna, I., Hermányi, Zs., Vargha, P., Bonnevie, L., Chanudet, X., Larroque, P., Tutuncu, N. Bascil, Deger, A., Batur, M. K., Yildirir, A., Onalan, O., Aksöyek, S., Kabakçι, G., Erbaş, T., Galicka-Latała, D., Surdacki, A., Gerritsen, J., TenVoorde, B. J., Heethaar, R. M., Tagawa, T. S., Kodama, M., Yoshioka, R., Yamasaki, Y., Didangelos, T., Athyros, V., Kontopoulos, A., Papageorgiou, A., Karamitsos, D., Lacigová, S., Rušavý, Z., Kárová, R., Perrild, H., Kay, L., Jørgensen, T., Bień, A. I., Witek, P., Geraldes, Elizabete, Rodrigues, D., Pereira, L., Doménech, A., Leitão, P., Anagnostopoulos, D., Foster, A. V. M., Nag, S., Barsoum, M., Lewis, G., Dunlop, N., Connolly, V., Bilous, R., Kelly, W., Chantelau, E., Gede, A., Sharman, D., O’Halloran, D., Best, C., Abbas, Z. G., Lutale, J., Gill, G. V., Jarvis, W. R., Archibald, L. K., Corcoran, S., Mansell, J., Pibworth, L., Terada, H., Shiba, T., Utugi, N., Utugi, T., Blum, M., Strobel, J., Höffken, K., Razvi, F. M., Kritzinger, E. E., Taylor, K., Jones, S., Illahi, W., Grüβer, M., Hartmann, P., Hoffstadt, K., van Leiden, H. A., Moll, A. C., Polak, B. C. P., Pietragalla, G. B., Maurino, M., Montanaro, M., Karadeniz, Ş., Tommasini, P., Quadrini, C., Demiraj, V., Rispoli, E., Ota, A., Takama, H., Saito, N., Hemández, C., Lepore, D., Antico, L., Giardina, B., Franconi, F., Michoud, E., Chamot, S., Riva, Ch., Hammes, H.-P., Renner, O., Breier, G., Lin, J., Alt, A., Betzholtz, C., Bretzel, R. G., Manti, R., Gallo, M., Molinar Hin, A., Brignardello, E., Boccuzzi, G., Li, Shanfang, Xiang, Kunsan, Zhang, Rugeng, Shangguan, Xinhong, Wu, Jianrong, Donnan, P. T., Broomhall, J., Hunter, K., Morris, A. D., Ioannidis, G., Peppa, M., Rontogianni, E., Kallifronas, M., Lekatsas, I., Chrysanthopoulou, G., Anthopoulos, L., Kesse, M., Thalassinos, N., Neves, C., Medina, J. L., Lopes, F., Yılmaz, M., Güvener, N., Güvener, M., Kocagöz, T., Böke, E., Paşaoglu, I., Bascil Tutuncu, N., Oto, A., Karvonen, M. K., Koulu, M., Pesonen, U., Mercuri, M., Rauramaa, R., Rutter, M. K., Kestevan, P., McComb, J. M., Marshall, S. M., Sobieska, M., Wiktorowicz, K., Kanters, S. D. J. M., Banga, J. D., Algra, A., Frijns, C. J. M., Beutler, J. J., Fijnheer, R., Nicoloff, G., Baydanoff, S., Stanimirova, N., Petrova, Ch., Lario, S., Campistol, J. M., Cases, A., Clària, J., Iñigo, P., Esmatjcs, E., Sármán, B., Tóth, M., Kocsis, I., Somogyi, A., Bumbure, A., Jachimowicz, K., Samson, J., Tomasiak, M., Sobol, A., Stańczyk, L., Watala, C., Stradina, P., Wiśniewska-Jarosińska, M., Marciniak, D., Więcławska, B., Watała, C., Golański, J., Zinnat, R., Mahmud, I., Büyükasik, Yahya, Demiroğlu, H., Szczepanik, A., Skowroński, M., Murawska, A., Meeking, D. R., Allard, S., Munday, J., Chowienczyk, P., Shaw, K. M., Cummings, M. H., Šimková, R., Jirsa, M., Hadoke, P. W. F., McIntyre, C. A., Jones, G. C., Williams, B. C., Elliott, A. I., McKnight, J. A., Pernow, J., Bombonato, G. C., Finucci, G. F., Zotta, L., Senses, V., Ozyazgan, S., Ince, E., Tunçdemir, M., Oztürk, M., Sultuybek, G., Akkan, A. G., Özyazgan, S., Unlücerci, Y., Bekpınar, S., Meyer, M. F., Lee, B. C., Shore, A. C., Humphreys, J. M., Tooke, J. E., Dell’Omo, G., Giovannitti, G., Caricato, F., Mariani, M., Pedrinelli, R., Kiviet-Boehm, C., Schwelling, V., Matthäei, S., Pfohl, M., McInerney, D., Itoh, H., Ohno, T., Katoh, N., Baumgartner-Parzer, S., Artwohl, M., Graier, W., Ludwig, C., Tachi, Y., Bannai, C., Shinohara, M., Shimpuku, H., Ohura, K., Bertacca, A., Sasvári, M., Szaleczki, E., Pusztai, P., Boes, U., Klaus, E., Dittrich, P., Wagner, Z., Wittmann, I., Pótó, L., Wagner, L., Mazák, I., Nagy, J., Feletto, F., Taboga, C., Tonutti, L., Lizzio, S., Russo, A., Selmo, V., Ceriello, A., Lekakis, J., Papamichael, C. M., Stamatelopoulos, K., Stamatelopoulos, S., Yillar, D. O., Gay, M., Lillaz, E., Passaro, A., Vanini, A., Calzoni, F., D’Elia, K., Carantoni, M., Zuliani, G., Fellin, R., Solini, A., Chwatko, G., Bald, E., Dramais, A.-S., Wallemacq, P. E., Vandeleene, B., Ciaria, M. V., Ariano, M., Strom, R., Gibney, J., Weiss, U., Turner, B., O’Gorman, P., Watts, G., Powrie, J., Crook, M., Shaw, K., and Cummings, M.
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- 1999
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18. 865 Hyperthomocysteinemia is associated with the presence of left atrial spontenous echo contrast and or thrombus in stroke patients with nonvalvular atrial fibrillation.
- Author
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Ozer, N., Kýlýc, H., Arsava, E. M., Atalar, E., Ay, H., Aksöyek, S., Övünç, K., TokgözoÖlu, L., Sarýbas, O., and Kes, S.
- Subjects
CEREBROVASCULAR disease patients ,HYPERHOMOCYSTEINEMIA ,ATRIAL fibrillation - Abstract
An abstract of the article "Hyperhomocysteinemia is associated with the presence of left atrial spontenous echo contrast and or thrombus in stroke patients with nonvalvular atrial fibrillation" by N. Ozer, E. M. Arsava, and colleagues is presented.
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- 2003
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19. QT dynamicity and heart rate variability for prediction of adverse outcome during in hospital follow-up.
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Sade, E., Aytemir, K, Özer, N, Övünç, K, Aksöyek, S, Önalan, O., Nazli, N., Özmen, F., Kes, S., and Oto, A.
- Published
- 2000
20. [Heart Failure with Reduced Ejection Fraction: A Historical and Theoretical Essay on Evaluation of Pharmacological Treatment].
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Aksöyek S
- Subjects
- Humans, Heart Failure drug therapy
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- 2023
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21. Case Image: Rare cause of recurrent pericardial tamponade: Cardiac angiosarcoma.
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Şener YZ, Okşul M, Kıvrak A, Canpolat U, and Aksöyek S
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- Humans, Male, Middle Aged, Cardiac Tamponade diagnostic imaging, Cardiac Tamponade etiology, Heart Neoplasms complications, Heart Neoplasms diagnostic imaging, Hemangiosarcoma complications, Hemangiosarcoma diagnostic imaging
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- 2017
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22. Porcelain thoracic aorta in a patient with rheumatoid arthritis.
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Canpolat U, Gürses KM, Sahiner L, and Aksöyek S
- Subjects
- Arthritis, Rheumatoid drug therapy, Coronary Angiography, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease drug therapy, Echocardiography, Female, Fluoroscopy, Humans, Middle Aged, Tomography, X-Ray Computed, Aorta, Thoracic diagnostic imaging, Aorta, Thoracic pathology, Arthritis, Rheumatoid complications, Hypertension complications, Vascular Calcification diagnostic imaging
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- 2013
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23. Case Images: Asymptomatic giant left ventricular psuedoaneurysm in a true aneurysm following anterior myocardial infarction.
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Canpolat U, Ozer N, Aksöyek S, and Ovünç K
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- Anterior Wall Myocardial Infarction, Humans, Heart Aneurysm, Heart Ventricles
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- 2012
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24. Pulmonary embolism presenting with evolving electrocardiographic abnormalities mimicking anteroseptal myocardial infarction: a case report.
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Özer N, Yorgun H, Canpolat U, Ateş AH, and Aksöyek S
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- Chest Pain, Diagnosis, Differential, Female, Humans, Middle Aged, Pulmonary Embolism pathology, Anterior Wall Myocardial Infarction pathology, Electrocardiography instrumentation, Pulmonary Embolism diagnosis
- Abstract
Objectives: To report a case with dynamic ST segment elevation suggestive of anteroseptal acute myocardial infarction (AMI) that proved to be bilateral pulmonary thromboembolism (PTE)., Clinical Presentation and Intervention: A 50-year-old woman with syncope was transferred to the emergency department. Findings from the admission electrocardiogram were suggestive of anteroseptal AMI; however, coronary angiography revealed that the patient had normal coronary arteries. On further evaluation, the patient was found to have massive bilateral PTE., Conclusion: This report emphasizes the role of evolving electrocardiographic changes in the diagnosis of PTE, particularly in patients with chest pain and ST segment elevation suggestive of acute coronary syndrome., (Copyright © 2011 S. Karger AG, Basel.)
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- 2011
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25. Coexistence of cor triatriatum and rheumatic mitral stenosis in an adult patient.
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Ozer N, Aksoy H, Deveci OS, Tülümen E, Atalar E, Ovünç K, and Aksöyek S
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- Cor Triatriatum complications, Cor Triatriatum diagnosis, Female, Humans, Incidental Findings, Middle Aged, Mitral Valve Stenosis complications, Mitral Valve Stenosis diagnosis, Rheumatic Heart Disease complications, Rheumatic Heart Disease diagnosis, Cor Triatriatum diagnostic imaging, Echocardiography, Mitral Valve Stenosis diagnostic imaging, Rheumatic Heart Disease diagnostic imaging
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- 2010
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26. Comparison of strain doppler echocardiography and radiologic left ventriculography for quantitative assessment of regional myocardial function.
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Ozer N, Kiliç H, Kepez A, Kaya EB, Deniz A, Atalar E, Aksöyek S, Ovünç K, Ozmen F, and Kes S
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- Coronary Disease physiopathology, Female, Humans, Male, Middle Aged, ROC Curve, Ventricular Dysfunction, Left physiopathology, Coronary Angiography methods, Coronary Disease diagnostic imaging, Echocardiography, Doppler methods, Myocardial Contraction physiology, Ventricular Dysfunction, Left diagnostic imaging
- Abstract
Objective: We aimed to study the comparison of strain and strain rate parameters with conventional left ventriculography derived regional function., Method: Forty patients were included in the study. The study group was selected from patients who had undergone left ventriculography and coronary angiography for clinical indications. Regional myocardial function was assessed using the centerline method via ACOM PC Quantcor LVA measurement system. Patients were also evaluated with echocardiography. Strain and strain rate Doppler echocardiographic measurements were compared with conventional left ventriculography at anterobasal, anterolateral, inferior and posterobasal segments., Results: Radiological left ventricular radial shortening was found to correlate with longitudinal strain shortening in all ventriculographic segments examined (anterobasal, r = 0.771, P < 0.0001; anterolateral, r = 0.790, P < 0.0001; posterobasal, r = 0.861, P < 0.0001; inferior, r = 0.815, P < 0.0001). Correlation was persistent both in patients with or without coronary artery disease. The sensitivity of a peak systolic longitudinal strain >12.5% for prediction of patients with radial shortening >or=20% was 75%, with a specificity of 100%. However, no relationship could be demonstrated between radiological left ventricular radial shortening and strain rate measurements., Conclusions: In our study it was shown that regional wall motion can be measured quantitatively via strain Doppler echocardiography with the left ventriculography as reference.
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- 2008
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27. Determination of left ventricular filling pressure by new echocardiographic methods in patients with coronary artery disease.
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Ozer N, Kepez A, Kaya B, Kiliç H, Deniz A, Arslan U, Atalar E, Ovünç K, and Aksöyek S
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- Cardiac Catheterization, Female, Humans, Male, Middle Aged, ROC Curve, Reproducibility of Results, Systole physiology, Time Factors, Coronary Disease diagnostic imaging, Coronary Disease physiopathology, Echocardiography, Mitral Valve diagnostic imaging, Mitral Valve physiopathology, Ventricular Dysfunction, Left diagnostic imaging, Ventricular Dysfunction, Left physiopathology
- Abstract
Aim: The present study was designed to determine the reliability of the analysis of the time difference between onset of mitral inflow and onset of early diastolic mitral annulus velocity and mean systolic strain index, and comparing them with E/E' in the detection of increased left ventricular end-diastolic pressure (LVEDP) in patients with coronary artery disease., Methods: Eighty patients (mean age: 57.2 +/- 11.5 years) referred for cardiac catheterization were studied. Patients were divided into 2 groups according to LVEDP (group 1: LVEDP > 20 mmHg, n = 39 patients; group 2: LVEDP < or = 20 mmHg, n = 41 patients). From the mitral inflow, peak E velocity was calculated. With tissue Doppler echocardiography, early diastolic velocity (E') measured from the septal, lateral, inferior and lateral mitral annulus and mean value of E' and E/E' ratio were calculated. The time difference between onset of mitral inflow and onset of early diastolic mitral annulus velocity (T(E'-E)) was calculated. From the apical chambers, the peak systolic strain value of 16 left ventricular (LV) segments was measured and the mean of these 16 segments was calculated and referred to as mean systolic strain index., Results: The patients with increased LVEDP (group 1) had a higher E/E' ratio (13.8 +/- 3.4 vs. 9.9 +/- 2.8, P < 0.001) and lower mean systolic strain index (11.8 +/- 3.4 % vs. 13.5 +/- 3.6 %, P = 0.038) than patients in group 2. The sensitivity of E/E' > 13.42 for identifying LVEDP > 20 mmHg was 71%, with a specificity of 89%. The sensitivity of a mean systolic strain index < 10.57% for identifying LVEDP > 20 mmHg was 44%, with a specificity of 83%. T(E'-E )was not significantly different between the two groups., Conclusion: The decreased longitudinal function of the left ventricle is related to increased LVEDP. The E/E' ratio, which in recent years has been used for the prediction of LV filling pressures, was a better predictor for increased LVEDP than the mean systolic strain score index and the time difference between onset of mitral inflow and onset of early diastolic mitral annulus velocity in patients with coronary artery disease.
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- 2008
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28. Renal cell carcinoma extending from superior vena cava into right atrium.
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Ozer N, Deniz A, Pişkinpaşa S, Kiliçkap S, Kepez A, Hazirolan T, Atalar E, Ovünç K, and Aksöyek S
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- Carcinoma, Renal Cell diagnostic imaging, Carcinoma, Renal Cell pathology, Diagnosis, Differential, Echocardiography, Transesophageal, Follow-Up Studies, Heart Neoplasms diagnostic imaging, Heart Neoplasms pathology, Humans, Male, Middle Aged, Neoplasm Invasiveness, Vascular Neoplasms diagnostic imaging, Vascular Neoplasms pathology, Carcinoma, Renal Cell secondary, Heart Atria, Heart Neoplasms secondary, Kidney Neoplasms pathology, Vascular Neoplasms secondary, Vena Cava, Superior
- Abstract
Tumoral invasion of inferior vena cava by renal cell carcinoma is reported to be relatively frequent. Usually the tumor grows intraluminally into the renal vein and inferior vena cava as an extension of primary tumor. In this report, we present an unusual case of venous system involvement, invasion of renal cell carcinoma into superior vena cava.
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- 2007
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29. Plasma osteopontin levels are elevated in non-ST-segment elevation acute coronary syndromes.
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Coskun S, Atalar E, Ozturk E, Yavuz B, Ozer N, Goker H, Ovünç K, Aksöyek S, Kes S, Sivri B, Kirazli S, and Ozmen F
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- Aged, Angina Pectoris blood, Biomarkers blood, Female, Humans, Male, Middle Aged, Prognosis, Syndrome, Angina, Unstable blood, Coronary Stenosis blood, Myocardial Ischemia blood, Osteopontin blood
- Abstract
Background: The regions of ruptured atherosclerotic plaques have numerous macrophages. Osteopontin that modulates macrophage function has been shown in atherosclerotic plaques. We aimed to study the plasma levels of osteopontin in patients with unstable angina or non-ST-seg ment elevation myocardial infarction (NSTEMI) and the rela tionship between osteopontin and the extent of the coronary artery disease (CAD)., Methods: We studied 65 patients with unstable angina or NSTEMI, 25 patients with stable angina and 18 patients as the control group. The extent of coronary artery stenosis was determined by the number of vessels with >50% stenosis. Plasma osteopontin concentrations were measured from the blood samples that were drawn immediately after admission to the emergency department in unstable angina/NSTEMI patients and before the coronary angiograph in the stable angina and control groups., Results: The plasma osteopontin concentration was (495 118 ng/ml) significantly higher in the patients with unstable angina/NSTEMI compared to the stable angina group (319 106 ng/ml) and control group (125+/-54 ng/ml) (p=0.0001 The plasma osteopontin levels were lower in the patients with stable angina pectoris who had one-vessel disease compared to those with two-vessel disease (p=0.01). How ever, in the unstable angina/NSTEMI group, the plasma osteopontin levels were statistically not different among the patients with one-vessel, and two-vessel and three-vessel disease (p=NS). There was no correlation between the plasma osteopontin levels and the extent of coronary stenosis., Conclusions: The plasma osteopontin levels are elevatedin patients with unstable angina/NSTEMI, but there appears to be no correlation with the extent of CAD. These results ma suggest that osteopontin may have a role in the pathobiology of ACS.
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- 2006
30. Effects of trapidil on renal ischemia-reperfusion injury.
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Avlan D, Tamer L, Ayaz L, Polat A, Oztürk C, Ozturhan H, Camdeviren H, and Aksöyek S
- Subjects
- Animals, Kidney metabolism, Kidney pathology, Malondialdehyde metabolism, Peroxidase metabolism, Rats, Rats, Wistar, Reperfusion Injury pathology, Tumor Necrosis Factor-alpha metabolism, Tyrosine analogs & derivatives, Tyrosine metabolism, Kidney blood supply, Reperfusion Injury metabolism, Trapidil pharmacology, Vasodilator Agents pharmacology
- Abstract
There is increasing evidence to suggest that reactive oxygen and nitrogen species play a role in the pathogenesis of renal ischemia-reperfusion (I/R) injury. This study was designed to determine the possible protective effects of trapidil treatment against oxidative and nitrosative tissue injury of kidney induced by I/R. A renal I/R injury was induced by a left renal pedicle occlusion by ischemia for 45 minutes, followed by 1 hour of reperfusion with contralateral nephrectomy in I/R and I/R + trapidil groups. Trapidil (8 mg/kg intravenously) was administrated immediately before reperfusion phase. At the end of the reperfusion period, rats were killed. Then, renal tissue samples were taken for biochemical analysis and histopathological evaluation, and blood samples were obtained to determinate serum urea, aspartate aminotransferase (AST), and tumor necrosis factor-alpha (TNF-alpha) levels. Ischemia-reperfusion injury caused significant increases in myeloperoxidase activity and malondialdehyde and 3-nitrotyrosine levels in renal tissue and elevated serum urea, AST, and TNF-alpha levels. In addition, severe deterioration of renal morphology was seen in the I/R group. Trapidil treatment significantly reduced in biochemical parameters, as well as serum urea, AST, and TNF-alpha levels. Furthermore, renal tissue injury was markedly attenuated with trapidil treatment. These data suggest that reactive oxygen species and reactive nitrogen species play a causal role in I/R-induced renal tissue, and trapidil has a renoprotective effect against oxidative and nitrosative kidney damage.
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- 2006
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31. Impaired systemic endothelial function in patients with pseudoexfoliation syndrome.
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Atalar PT, Atalar E, Kilic H, Abbasoglu OE, Ozer N, Aksöyek S, Ovünç K, Ozmen F, and Gürsel E
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- Aged, Brachial Artery diagnostic imaging, Case-Control Studies, Endothelium, Vascular diagnostic imaging, Endothelium, Vascular drug effects, Exfoliation Syndrome diagnostic imaging, Female, Humans, Male, Middle Aged, Nitroglycerin pharmacology, Prospective Studies, Ultrasonography, Vasodilator Agents pharmacology, Endothelium, Vascular physiopathology, Exfoliation Syndrome physiopathology
- Abstract
Pseudoexfoliation syndrome (PEX) is the most common clinical precursor of open-angle glaucoma. Recent studies have shown that pseudoexfoliative material is widely distributed throughout the body, including blood vessels. The aim of our study was to evaluate endothelial function in the brachial artery of patients with pseudoexfoliation syndrome. We prospectively examined 23 patients with PEX (mean age, 70 +/- 8 years) and 20 healthy age- and sex-matched individuals (mean age, 68 +/- 9 years) as a control group. Brachial artery endothelial function was assessed by vascular response to reactive hyperemia (flow-mediated dilation (FMD) and sublingual nitroglycerin (NTG-mediated dilation) using high-resolution ultrasound. Flow-mediated and NTG-induced dilation were expressed as the percent change in diameter after reactive hyperemia and after NTG administration relative to the baseline value, respectively. Patients with cardiovascular disease and other conditions associated with endothelial dysfunction were excluded. When compared with controls, patients with PEX had significantly lower flow-mediated dilation (4.5 +/- 2.8 versus 8.2 +/- 3.7, P = 0.01) and NTG-mediated dilation (10.9 +/- 3.1 versus 15.8 +/- 3.8, P = 0.0001). Flow-mediated dilation and NTG-mediated dilation were similar in PEX patients with glaucoma (n = 11) and without glaucoma (n = 12). Flow-mediated and NTG-mediated dilation did not correlate with any measured parameter in any patient or control subject. The findings indicate that systemic endothelial function is impaired in PEX syndrome patients.
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- 2006
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32. Echocardiographic predictors of left atrial appendage spontaneous echocontrast in patients with stroke and atrial fibrillation.
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Ozer N, Kiliç H, Arslan U, Atalar E, Aksöyek S, Ovünç K, Ay H, Oztürk E, Karaagaoglu E, Tokgozoglu L, and Kes SS
- Subjects
- Aged, Atrial Fibrillation complications, Echocardiography, Female, Humans, Male, Reproducibility of Results, Risk Factors, Sensitivity and Specificity, Stroke etiology, Atrial Appendage diagnostic imaging, Atrial Fibrillation diagnostic imaging, Echocardiography, Transesophageal methods, Image Interpretation, Computer-Assisted methods, Risk Assessment methods, Stroke diagnostic imaging
- Abstract
Objective: The presence of spontaneous echocontrast (SEC) in the left atrium (LA) or LA appendage (LAA) has been associated with a higher risk of thromboembolism and cerebrovascular accidents. The purpose of this study was to define the new transesophageal echocardiographic predictors of SEC for patients with stroke and atrial fibrillation., Methods: We studied 47 patients with stroke and atrial fibrillation who were undergoing transesophageal echocardiography for the evaluation of source of cardiac emboli. Patients were divided into two groups based on the absence (group 1) or presence (group 2) of SEC in the LAA., Results: Compared with group 1, group 2 had larger LA, larger LAA minimum and maximum areas, and decreased LAA flow velocity, LAA wall velocity, LAA tissue intensity, and intensity ratio. In the stepwise discriminate analysis tissue intensity of LAA, minimum LAA area, LAA flow velocity, and LAA wall velocity were found as independent predictors of LAA SEC. LAA wall velocity had the greatest area under the receiver operating characteristic curve, indicating that the most powerful parameter for SEC is LAA wall velocity., Conclusion: Decreased LAA flow velocity and LA wall velocity, increased LAA size, and less negative LAA tissue intensity are associated with SEC in patients with nonvalvular atrial fibrillation. Strain and strain measurements of LAA give no more benefit.
- Published
- 2005
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33. Protective effect of trapidil against oxidative organ damage in burn injury.
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Avlan D, Taşkinlar H, Tamer L, Camdeviren H, Ozturhan H, Oztürk C, and Aksöyek S
- Subjects
- Animals, Burns metabolism, Lipid Peroxidation, Malondialdehyde metabolism, Peroxidase metabolism, Peroxynitrous Acid metabolism, Random Allocation, Rats, Rats, Wistar, Tumor Necrosis Factor-alpha metabolism, Tyrosine analogs & derivatives, Tyrosine metabolism, Burns drug therapy, Oxidative Stress drug effects, Protective Agents therapeutic use, Trapidil therapeutic use
- Abstract
Animal models of thermal injury indicate reactive oxygen species and inflammatory cytokines as causative agents in tissue injury on various organs distant from the original wound. Trapidil has various properties, such as inhibition of platelet aggregation and lipid peroxidation as well as reduction of the inflammatory response to injury. This study was designed to determine the possible protective effect of trapidil treatment against oxidative organ damage in lung, intestine and kidney induced by cutaneous thermal injury. Thirty Wistar rats were randomly divided into five groups. Sham group (n=6) was exposed to 21 degrees C water while burn-3 h group (n=6) and burn+trap-3h group (n=6), burn-24 h (n=6) and burn+trap-24 h groups were exposed to boiling water for 12s to produce a full thickness burn in 35-40% of total body surface area. In both burn+trap-3 h and burn-trap-24 h group, 8 mg/kg trapidil was given intravenously immediately after thermal injury. Three and 24 h later, tissue samples were taken for biochemical analysis from lung, intestine and kidney and blood samples were obtained to determinate serum TNF-alpha levels. Cutaneous thermal injury caused a significant increase in myeloperoxidase (MPO) activity and malondialdehyde (MDA) and 3-nitrotyrozine (3-NT) levels in all tissues and elevated serum TNF-alpha levels at post-burn 3 and 24 h. Trapidil treatment significantly reduced in biochemical parameters, as well as serum TNF-alpha levels. These data suggest that trapidil has a protective effect against oxidative organ damage in burn injury.
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- 2005
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34. [Does sepsis impair the healing of colonic anastomosis in splenectomized rats?].
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Naycı A, Çömelekoğlu Ü, Çıngı E, Taşkınlar H, Avlan D, Renda N, and Aksöyek S
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- Animals, Colon chemistry, Disease Models, Animal, Hydroxyproline analysis, Pressure, Rats, Rats, Wistar, Tissue Adhesions, Anastomosis, Surgical, Colon surgery, Sepsis physiopathology, Splenectomy, Wound Healing physiology
- Abstract
Background: To investigate the effect of splenectomy on the healing of colonic anastomoses under normal and septic conditions., Methods: Forty Wistar rats were assigned into six groups: group 1: sham, group 2: colonic anastomose, group 3: splenectomy, group 4: colonic anastomose plus sepsis, group 5: colonic anastomose plus splenectomy, group 6: colonic anastomose plus splenectomy plus sepsis. The rats underwent a standardized left colonic resection and primary anastomosis and/or splenectomy. Sepsis was produced by cecal ligation and puncture. Wound healing was evaluated by bursting pressure and hydroxiproline estimates., Results: Bursting pressures were as follows: group 1: 173 +/- 14 mmHg, group 2: 186 +/- 7 mmHg, group 3: 168 +/- 6 mmHg, group 4: 113 +/- 14 mmHg, group 5: 167 +/- 10 mmHg, and group 6: 183 +/- 3 mmHg. Hidroksiprolin contents were: group 1: 3.5 +/- 0.2 microg/mg, group 2: 3.2 +/- 0.3 microg/mg, group 3: 3.4 +/- 0.2 microg/mg, group 4: 2.3 +/- 0.2 microg/mg, group 5: 3.0 +/- 0.2 microg/mg, grup 6 3.2 +/- 0.1 microg/mg. Statistical significance was found between group 4 and the other groups (p<0.05)., Conclusion: Sepsis impairs the healing of colonic anastomoses. However, sepsis does not impair the intestinal wound healing in splenectomized rats.
- Published
- 2005
35. Doppler tissue evaluation of intra-atrial and interatrial electromechanical delay and comparison with P-wave dispersion in patients with mitral stenosis.
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Ozer N, Yavuz B, Can I, Atalar E, Aksöyek S, Ovünç K, Ozmen F, and Kes S
- Subjects
- Adult, Atrial Fibrillation etiology, Female, Heart Conduction System, Humans, Male, Mitral Valve Stenosis complications, Mitral Valve Stenosis physiopathology, Myocardial Contraction, Reproducibility of Results, Sensitivity and Specificity, Ventricular Dysfunction, Left etiology, Atrial Fibrillation diagnostic imaging, Echocardiography, Doppler methods, Electrocardiography methods, Heart Atria diagnostic imaging, Mitral Valve Stenosis diagnostic imaging, Ventricular Dysfunction, Left diagnostic imaging
- Abstract
Objective: The aim of our study was to: (1) measure atrial electromechanical delay in patients with mitral stenosis (MS) and in a control group; (2) find the echocardiographic parameters that affect atrial electromechanical delay; and (3) examine the correlation between atrial electromechanical delay and P-wave dispersion (PWD)., Methods: A total of 25 patients with pure MS (age 43 +/- 10 years; 18 women, 7 men) and 16 control subjects (age 41 +/- 8 years; 9 women, 7 men) were studied. Interatrial and intra-atrial electromechanical delay was measured with Doppler tissue echocardiography. From the 12-lead electrocardiograms, PWD was calculated., Results: Interatrial electromechanical delay was 71.2 +/- 33 in the MS group and 40.5 +/- 21.0 in the control group (P = .01). In the MS group, PWD was 50 +/- 7 and in the control group it was 29 +/- 5 (P = .03). A positive correlation was detected between interatrial electromechanical delay and PWD (r = 0.6, P = .03)., Conclusion: This study shows that interatrial electromechanical delay gets longer in MS and is correlated with PWD. Atrial electromechanical delay is related with left atrial size but not with severity of MS.
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- 2005
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36. An unusual case of recurrent mass in the right atrium: intravenous leiomyomatosis.
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Ozer N, Engin H, Akgül E, Sahiner L, Atalar E, Aksöyek S, Ovünç K, Ozmen F, and Kes S
- Subjects
- Adult, Diagnosis, Differential, Echocardiography, Female, Heart Atria surgery, Heart Neoplasms secondary, Heart Neoplasms surgery, Humans, Leiomyomatosis surgery, Neoplasm Recurrence, Local, Heart Atria diagnostic imaging, Heart Neoplasms diagnostic imaging, Leiomyomatosis diagnostic imaging, Leiomyomatosis pathology, Uterine Neoplasms pathology
- Abstract
Intravenous leiomyomatosis with a cardiac extension is an extremely rare condition. In this report, a case of a 43-year-old female patient is described: she was operated for right atrial mass protruding into the inferior vena cava, which was later diagnosed as leiomyoma. After a 3-year symptom-free period, recurrence of the extension through the inferior vena cava was observed. After abdominal ultrasonographic examination, which revealed bilateral ovarian and retroperitoneal mass, bilateral oopherectomy, retroperitoneal, and right atrial mass excision was done. The retroperitoneal and right atrial mass was reported as leiomyoma. On her last admission, she had complaints of dizziness, abdominal pain, and bilateral leg edema; and right atrial mass extending through the common iliac vein was noted, but the patient did not accept any further treatment modality.
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- 2005
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37. Poly (adp-ribose) synthetase inhibition reduces oxidative and nitrosative organ damage after thermal injury.
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Avlan D, Unlü A, Ayaz L, Camdeviren H, Nayci A, and Aksöyek S
- Subjects
- Animals, Burns drug therapy, Lipid Peroxidation physiology, Malondialdehyde, Peroxidase metabolism, Rats, Rats, Wistar, Benzamides therapeutic use, Burns physiopathology, Poly(ADP-ribose) Polymerase Inhibitors
- Abstract
Poly (ADP-ribose) synthetase (PARS) is a nuclear enzyme activated by DNA single-strand breakage, which can be triggered by reactive oxygen and nitrogen species. Activation of this enzyme depletes the intracellular concentration of energetic substrates such as nicotinamide adenine dinucleotide (NAD). Eventually, this process results in cell dysfunction and cell death. PARS inhibitors have successfully shown benefits in several experimental models of ischemia-reperfusion injury, inflammation, and sepsis. In our experimental study, we investigated the role of 3-aminobenzamide (3-AB), a nonspecific PARS inhibitor, in systemic organ damage after burn. Twenty-four Wistar rats were randomly divided into three groups. The sham group (n=8) was exposed to 21 degrees C water, and the burn group (n=8) and the burn-plus-3-AB group (n=8) were exposed to boiling water for 12 s to produce a full-thickness burn of 35-40% of total body surface area. In the burn-plus-3-AB group, 3-AB 10 mg/kg was given intraperitoneally 10 min before thermal injury. Twenty-four hours later, tissue samples were obtained for biochemical analysis from lung, intestine, and kidney. In the burn group, tissue malondialdehyde, myeloperoxidase, and 3-nitrotyrosine levels in all organs were significantly increased compared with the sham group (p<0.05). Pretreatment with 3-AB significantly reduced burn-induced organ damage (p<0.05). These data provide evidence of the relationship between the PARS pathway and lipid peroxidation in systemic organ damage after thermal injury.
- Published
- 2005
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38. An unusual cause for massive upper gastrointestinal bleeding in children: Dieulafoy's lesion.
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Avlan D, Nayci A, Altintaş E, Cingi E, Sezgin O, and Aksöyek S
- Subjects
- Arteries abnormalities, Child, Preschool, Humans, Male, Epinephrine therapeutic use, Gastrointestinal Hemorrhage drug therapy, Gastrointestinal Hemorrhage etiology, Stomach blood supply, Stomach Diseases complications, Stomach Diseases drug therapy, Vasoconstrictor Agents therapeutic use
- Abstract
Dieulafoy's lesion is a rare cause of severe upper gastrointestinal hemorrhage in children and predominantly occurs in the proximal stomach. We report a case of massive upper gastrointestinal bleeding in a 3-year-old boy that originated from a Dieulafoy's lesion and was treated by epinephrine injection.
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- 2005
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39. Right ventricular outflow tract thrombus in a case of Behcet's disease.
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Ozer N, Ciftçi O, Demirci M, Atalar E, Ovünç K, Aksöyek S, Ozmen F, and Kes S
- Subjects
- Adult, Coronary Thrombosis surgery, Female, Heart Ventricles diagnostic imaging, Humans, Ultrasonography, Behcet Syndrome complications, Coronary Thrombosis diagnostic imaging, Coronary Thrombosis etiology
- Abstract
Behcet's disease is known as a chronic systemic vasculitic syndrome, the hallmark of which is recurrent oral aphthous and genital ulcerations and uveitis. Vascular involvement, mainly thrombosis, reportedly affects as many as one-third of patients. Cardiac involvement, however, is very rare. We present in this report a young female patient developing right ventricular thrombus while being treated medically.
- Published
- 2005
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40. The protective effect of selenium on ipsilateral and contralateral testes in testicular reperfusion injury.
- Author
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Avlan D, Erdouğan K, Cimen B, Düşmez Apa D, Cinel I, and Aksöyek S
- Subjects
- Animals, Humans, Lipid Peroxidation, Male, Malondialdehyde analysis, Random Allocation, Rats, Rats, Wistar, Reperfusion Injury physiopathology, Superoxide Dismutase analysis, Testis blood supply, Antioxidants therapeutic use, Reperfusion Injury prevention & control, Selenium therapeutic use, Spermatic Cord Torsion surgery
- Abstract
This study was designed to investigate the effect of selenium on ipsilateral and contralateral testicular damage after unilateral testicular torsion/detorsion (T/D). Thirty-two male rats were divided into four groups, each containing eight rats. Torsion was created by rotating the right testis 720 degrees in a clockwise direction. Group 1 underwent sham operation to determine basal values for biochemical and histopathological evaluation. Sham operation was performed in group 2, and sodium selenate (0.2 mg/kg) was given intraperitoneally. Group 3 served as a T/D group, receiving 4-h torsion and 4-h detorsion. Similarly, in group 4 sodium selenate (0.2 mg/kg) was injected intraperitoneally 20 min before detorsion. Bilateral orchiectomies were performed for measurement of tissue malondialdehyde (MDA) levels and superoxide dismutase (SOD) activities and histopathologic examination. The results were compared statistically. The highest MDA and the lowest SOD values were determined in both testes in group 3. There were statistically significant differences in MDA levels and SOD activities in group 3 compared with group 4. Specimens from group 3 had a significantly greater histologic injury than other groups. These results suggest that ischemia-reperfusion injury occurred in both testes after unilateral testicular T/D and that selenium administration before detorsion prevents reperfusion injury in testicular torsion.
- Published
- 2005
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41. The role of poly(ADP-ribose) synthetase inhibition on the intestinal mucosal barrier after thermal injury.
- Author
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Avlan D, Taşkinlar H, Unlü A, Oztürk C, Cinel L, Nayci A, Cinel I, and Aksöyek S
- Subjects
- Animals, Bacterial Translocation drug effects, Burns microbiology, Burns pathology, Intestine, Small drug effects, Intestine, Small metabolism, Intestine, Small pathology, Liver microbiology, Lymph Nodes microbiology, Malondialdehyde analysis, Mesentery microbiology, Random Allocation, Rats, Rats, Wistar, Spleen microbiology, Tyrosine analysis, Benzamides pharmacology, Burns metabolism, Enzyme Inhibitors pharmacology, Intestinal Mucosa drug effects, Poly(ADP-ribose) Polymerase Inhibitors, Tyrosine analogs & derivatives
- Abstract
Oxidative and nitrosative stressor agents can trigger DNA strand breakage, which then activates the nuclear enzyme poly(ADP-ribose) synthetase (PARS). Activation of the enzyme depletes the intracellular concentration of energetic substrates such as nicotinamide adenine dinucleotide (NAD). This process can result in cell dysfunction and cell death. PARS inhibitors have been successfully used in ischemia-reperfusion injury, inflammation and sepsis in several experimental models. In our experimental study, we investigated the role of 3-aminobeanzamide (3-AB), a non-specific PARS inhibitor, on the intestinal mucosal barrier after burn injury. Twenty-four Wistar rats were randomly divided into three groups. The sham group (n = 8) was exposed to 21 degrees C water while the burn group (n = 8) and the burn + 3-AB group (n = 9) were exposed to boiling water for 12s to produce a full thickness burn in 35-40% of total body surface area. In the burn + 3-AB group, 10mg/kg of 3-AB was given intraperitoneally 10min before thermal injury. Twenty-four hours later, tissue samples from mesenteric lymph nodes (MLN), spleen and liver were obtained under sterile conditions for microbiological analysis and ileum samples were obtained for biochemical and histopathological analysis. In burn group, the incidence of bacteria isolated from MLN and spleen was significantly higher than other groups (P < 0.05). 3-AB pre-treatment prevented burn induced bacterial translocation and it significantly reduced burn induced intestinal injury. Tissue malondialdehyde and 3-nitrotyrozine levels were found significantly lower than that of the burn group. These data suggest that the relationship between PARS pathway and lipid peroxidation in intestinal tissue and PARS has a role in intestinal injury caused by thermal injury.
- Published
- 2004
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42. Left ventricular long-axis function is reduced in patients with rheumatic mitral stenosis.
- Author
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Ozer N, Can I, Atalar E, Sade E, Aksöyek S, Ovünç K, Aytemir K, Tokgözoğlu L, Ozmen F, and Kes S
- Subjects
- Adult, Female, Humans, Linear Models, Male, Mitral Valve Stenosis complications, Reference Values, Rheumatic Heart Disease complications, Echocardiography, Doppler methods, Mitral Valve Stenosis diagnostic imaging, Mitral Valve Stenosis physiopathology, Rheumatic Heart Disease physiopathology, Ventricular Dysfunction, Left diagnostic imaging
- Abstract
Left ventricular long-axis function evaluated by M-mode or tissue Doppler echocardiography has been shown to be useful indexes of left ventricular systolic function; however it has not been evaluated in patients with mitral stenosis. We examined the left ventricular long-axis function of the patients with pure mitral stenosis and normal global systolic function as assessed by fractional shortening of the left ventricle (LV). Fifty-two patients with pure mitral stenosis and twenty-two healthy controls were evaluated by echocardiography. Although there was no statistically significant difference in global systolic function, M-mode derived systolic motion of the septal side and (12 +/- 3 vs 14.4 +/- 1.5 mm, P = 0.016) the lateral side of mitral annulus (13.2 +/- 3 vs 16.8 +/- 2 mm, P = 0.001) were both significantly lower in the patients with mitral stenosis than control subjects. Similarly tissue Doppler systolic velocity of the septal annulus (7.6 +/- 1.1 vs 10.4 +/- 3.2 cm/s, P = 0.03) and lateral mitral annulus (7.6 +/- 1.1 vs 10.4 +/- 3.2 cm/s, P = 0.003) were also significantly lower in patients with mitral stenosis than in controls. There was a statistically significant correlation between septal annular motion and annular velocity (r = 0.643, P = 0.002). Septal annular motion and annular velocity were also correlated with left atrial ejection fraction (r = 0.338, P = 0.005 and r = 0.676, P = 0.001, respectively). Thus, patients with mitral stenosis had significantly impaired long-axis function evaluated by M-mode or tissue Doppler echocardiography despite normal global systolic function.
- Published
- 2004
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43. Detection of patients with hypertrophic cardiomyopathy at risk for paroxysmal atrial fibrillation during sinus rhythm by P-wave dispersion.
- Author
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Köse S, Aytemir K, Sade E, Can I, Ozer N, Amasyali B, Aksöyek S, Ovünç K, Ozmen F, Atalar E, Işik E, Kes S, Demirtaş E, and Oto A
- Subjects
- Adult, Echocardiography, Female, Heart Atria diagnostic imaging, Heart Atria pathology, Heart Atria physiopathology, Heart Conduction System physiopathology, Heart Ventricles diagnostic imaging, Heart Ventricles pathology, Heart Ventricles physiopathology, Humans, Hypertrophy, Left Ventricular diagnosis, Hypertrophy, Left Ventricular epidemiology, Male, Middle Aged, Mitral Valve Insufficiency diagnosis, Mitral Valve Insufficiency epidemiology, Multivariate Analysis, Predictive Value of Tests, Retrospective Studies, Risk Factors, Sensitivity and Specificity, Severity of Illness Index, Statistics as Topic, Stroke Volume physiology, Atrial Fibrillation diagnosis, Atrial Fibrillation epidemiology, Cardiomyopathy, Hypertrophic diagnosis, Cardiomyopathy, Hypertrophic epidemiology, Electrocardiography, Heart Conduction System pathology
- Abstract
Background: Paroxysmal atrial fibrillation (PAF) in hypertrophic cardiomyopathy (HCM) is associated with poor prognosis. Previous studies have shown good correlation between P-wave dispersion (Pd) and occurrence of PAF. However, Pd in patients with HCM for predicting PAF has not been studied., Hypothesis: The aim of the study was to determine whether Pd could identify patients with HCM who are likely to suffer from PAF., Methods: Twenty-two patients with HCM with a history of PAF (Group 1) and 26 patients with HCM without a history of PAF (Group 2) were studied. Maximum (Pmax) and minimum (Pmin) P-wave durations, as well as P-wave dispersion (Pd = Pmax - Pmin) were calculated from 12-lead surface electrocardiograms (ECG)., Results: P-wave dispersion was significantly different between the groups (Group 1: 55 +/- 6 ms vs. Group 2: 37 +/- 8 ms; p<0.001), while Pmax (Group 1: 134 +/- 11 ms vs. Group 2: 128 +/- 13 ms; p = 0.06) and Pmin (Group 1: 78 +/- 9 ms vs. Group 2: 81 +/- 7 ms; p = 0.07) was not significantly different. Patients with a history of PAF had higher left atrial diameter than the patients without PAF (Group 1: 52 +/- 8 mm vs. Group 2: 48 +/- 10 mm; p = 0.02). A cut-off value of 46 ms for Pd had a sensitivity of 76% and a specificity of 82% in discriminating between patients with and without PAF., Conclusion: This study suggests that P-wave dispersion could identify patients with HCM who are likely to develop PAF.
- Published
- 2003
- Full Text
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44. Assessment of heart rate turbulence in the acute phase of myocardial infarction for long-term prognosis.
- Author
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Sade E, Aytemir K, Oto A, Nazli N, Ozmen F, Ozkutlu H, Tokgözoglu L, Aksöyek S, Ovünç K, Kabakçi G, Ozer N, and Kes S
- Subjects
- Case-Control Studies, Diabetes Mellitus epidemiology, Echocardiography, Electrocardiography, Ambulatory, Female, Humans, Male, Middle Aged, Multivariate Analysis, Predictive Value of Tests, Prognosis, Regression Analysis, Risk Factors, Sensitivity and Specificity, Stroke Volume physiology, Time Factors, Ventricular Premature Complexes epidemiology, Ventricular Premature Complexes physiopathology, Heart Rate physiology, Myocardial Infarction mortality, Myocardial Infarction physiopathology
- Abstract
This study is designed to assess the value of heart rate turbulence (HRT) in the acute phase of MI for prediction of long-term mortality risk. The study included 128 consecutive acute MI patients with 24-hour Holter recordings to evaluate HRT (turbulence onset and slope), SDNN, mean RR interval, and ventricular premature beat frequency. LVEF was evaluated by two-dimensional echocardiography. Data from 117 patients (mean age 58 +/- 11 years) were available for further analysis. Twelve patients died during follow-up (mean 312 +/- 78 days). Although SDNN < 70 ms was the most powerful predictor of mortality among all presumed risk factors (hazard ratio 20 [95% CI 2.6-158]; P = 0.004) in univariate Cox regression analysis, in multivariate analysis LVEF < or = 0.40 and turbulence slope < or = 2.5 ms/RR interval were the only independent predictors of mortality (hazard ratio 6.9 [95% CI 1.8-26]; P = 0.006, hazard ratio 7.3 [95% CI 1.4-37]; P = 0.016, respectively). Addition of HRT parameters for LVEF increased remarkably the positive predictive value (60%) without any decrease in the negative predictive value (92%). Blunted HRT reaction within the first 24 hours of acute MI is an independent predictor of long-term mortality. Furthermore, its predictive power is comparable and also additive to that of LVEF.
- Published
- 2003
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45. Angiotensin-converting enzyme genotype predicts valve damage in acute rheumatic fever.
- Author
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Atalar E, Tokgözoglu SL, Alikasifoglu M, Ovünç K, Aksöyek S, Kes S, and Tunçbilek E
- Subjects
- Adolescent, Adult, Aortic Valve, Female, Genotype, Humans, Male, Mitral Valve, Polymerase Chain Reaction, Genetic Predisposition to Disease, Heart Valve Diseases genetics, Peptidyl-Dipeptidase A genetics, Rheumatic Heart Disease genetics
- Abstract
Background and Aim of the Study: The genetic basis for host susceptibility to subsequent valve damage and scarring is not well defined in patients with a history of acute rheumatic fever (ARF). A high angiotensin-converting enzyme (ACE) activity has been demonstrated in valve tissue; hence, the study aim was to determine whether the ACE-DD genotype was a predisposing factor to heart valve damage after ARF attack., Methods: A total of 165 patients diagnosed previously (16 +/- 5 years ago) with ARF was evaluated. Diagnoses were conducted according to Jones' criteria, and all received similar treatment and remain on regular penicillin prophylaxis. The ACE genotype was determined using polymerase chain reaction methods., Results: Echocardiography showed that 39 patients (11 males, 28 females; mean age 25 +/- 6 years) had completely normal valves, and 126 patients (38 males, 88 females; mean age 21 +/- 6 years) had valve disease. The mitral valve was involved in 93% of patients (stenosis 86%, regurgitation 69%), and the aortic valve in 50% (stenosis 19%, regurgitation 48%). The ACE-DD genotype is associated with a significantly greater risk of valve involvement (risk ratio 2.7, 95% CI 1.15-6.5, p = 0.02). The distribution of genotypes was similar between aortic and mitral valve involvement., Conclusion: In patients with acute rheumatic fever the ACE-DD genotype is associated with an increased risk of subsequent heart valve damage.
- Published
- 2003
46. Intestinal ischemic preconditioning protects the intestine and reduces bacterial translocation.
- Author
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Aksöyek S, Cinel I, Avlan D, Cinel L, Oztürk C, Gürbüz P, Nayci A, and Oral U
- Subjects
- Animals, Escherichia coli isolation & purification, Intestine, Small metabolism, Intestine, Small microbiology, Intestine, Small pathology, Male, Nitric Oxide metabolism, Nitric Oxide Synthase metabolism, Nitric Oxide Synthase Type II, Rats, Rats, Wistar, Sepsis metabolism, Sepsis microbiology, Sepsis pathology, Sepsis prevention & control, Intestine, Small blood supply, Ischemic Preconditioning
- Abstract
Ischemic preconditioning (IPC) was first demonstrated in the heart, but this protective effect has been also recently described in the intestine. The aim of this study was to determine the effects of intestinal ischemic preconditioning on the morphology of intestine and bacterial translocation. Twenty-four male Wistar rats weighting 250 to 300 g were randomized into three groups. A control group of rats (n = 8) were subjected laparotomy. In an ischemic group (n = 8), laparotomy was performed and the superior mesenteric artery was occluded by an atraumatic clamp for 30 min. In the preconditioned group (n = 8), before the ischemia-reperfusion (I/R) period (as in ischemic group), rats were subjected to an initial 10 min of intestinal ischemia and 10 min of reperfusion. Twenty-four hours later, to evaluate whether the I/R induced intestinal injury and bacterial translocation (BT), tissue and blood samples were collected, and liver, spleen, and mesenteric lymph node specimens were obtained under sterile conditions for microbiological analysis. Samples of ileum were removed for both biochemical and histopathological evaluation. In the I/R group, the incidence of bacteria-isolated mesenteric lymph nodes, spleen, liver, and blood was significantly higher than other groups (P < 0.05). IPC prevented I/R-induced BT and it significantly reduced the I/R-induced intestinal injury (P < 0.05). Increased inducible nitric oxide (NO) synthase (iNOS) expression observed on the ileal specimens of the I/R group was found to be prevented by IPC. Our data suggest IPC as a key factor that reduces BT and iNOS activation in intestinal I/R. This is the first study showing that intestinal IPC blocks the cascade of events that causes BT and intestinal injury that may lead to sepsis.
- Published
- 2002
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47. Thrombopoietin inside the pulmonary vessels in patients with and without pulmonary hypertension.
- Author
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Haznedaroğlu IC, Atalar E, Oztürk MA, Ozer N, Ovünç K, Aksöyek S, Kes S, Kirazli S, and Ozmen F
- Subjects
- Adult, Aged, Cardiac Catheterization, Female, Heart Ventricles chemistry, Humans, Hypertension, Pulmonary etiology, Male, Middle Aged, Pulmonary Artery chemistry, Pulmonary Circulation, Blood Vessels chemistry, Hypertension, Pulmonary metabolism, Lung blood supply, Thrombopoietin blood
- Abstract
There is substantial evidence that platelet production and release take place in the lungs. Thrombopoietin (Tpo) stimulation can cause platelet release in the pulmonary vasculature. On the other hand, myelofibrosis can occur in Tpo-overexpressing transgenic mice models, and there is unexplained pulmonary hypertension in chronic myeloproliferative disorders including primary myelofibrosis. In this study, we aimed to assess local Tpo concentrations inside the pulmonary artery and associated vessels in humans. We measured Tpo concentrations in plasma samples taken concurrently from the right ventricle, the pulmonary artery, and the left ventricle during cardiac catheterization in patients with and without pulmonary hypertension. The study group comprised 10 patients with normal pulmonary arterial pressure (Group A, male/female 4/6, mean age 48 +/- 19) and 14 patients with pulmonary hypertension (Group B, male/female 9/5, mean age 57 +/- 16). The Tpo levels inside the right ventricle, the pulmonary artery and the left ventricle were 33.3 +/- 15.6, 47.2 +/- 33.9, and 34.4 +/- 18.6 pg/ml, respectively, in Group A; and 85.0 +/- 39.8, 128.4 +/- 50.4, and 81.5 +/- 35.5 pg/ml, respectively, in Group B. Levels of the Tpo were significantly higher in all three localizations in Group B compared to Group A. Moreover, the Tpo concentration inside the pulmonary artery is significantly higher than the Tpo concentrations in the right and left ventricles in Group B patients. There were positive correlations between the Tpo levels and pulmonary artery systolic pressure over the whole patient group. In conclusion, there could be an association between pulmonary hypertension and Tpo level. Moreover, lung vasculature holding the major regulatory thrombopoietic hormone, Tpo, may be an important place for megakaryocytopoiesis.
- Published
- 2002
- Full Text
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48. Impaired fibrinolytic capacity in rheumatic mitral stenosis with or without atrial fibrillation and nonrheumatic atrial fibrillation.
- Author
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Atalar E, Ozmen F, Haznedaroğlu I, Ozer N, Aksöyek S, Ovünç K, Nazli N, Kirazli S, and Kes S
- Subjects
- Adult, Aged, Analysis of Variance, Atrial Fibrillation etiology, Blood Coagulation physiology, Case-Control Studies, Chronic Disease, Echocardiography, Doppler, Female, Humans, Male, Middle Aged, Mitral Valve Stenosis complications, Rheumatic Heart Disease blood, Rheumatic Heart Disease complications, Atrial Fibrillation blood, Fibrinolysis physiology, Mitral Valve Stenosis blood
- Abstract
Chronic atrial fibrillation (AF) has often been associated with systemic embolization, and patients with mitral stenosis (MS) have the highest thromboembolic risk. Increased risk of thromboembolism could be in part due to impaired fibrinolytic function. Global fibrinolytic capacity (GFC) is an innovative technique for evaluating the entire fibrinolytic system. The aim of our study was to evaluate fibrinolytic activity in patients with rheumatic and nonrheumatic chronic AE To investigate fibrinolytic activity, we assessed GFC in peripheral blood samples of 32 patients with nonrheumatic AF (14 women; mean age, 56 +/- 1 years), 30 patients with rheumatic MS and AF (23 women; mean age, 35 +/- 9 years), and 32 patients with rheumatic MS and sinus rhythm (24 women; mean age, 36 +/- 8 years). The control group comprised 30 healthy adult subjects in normal sinus rhythm. Patients with chronic AF (rheumatic and nonrheumatic) had lower GFC than did the controls (P = .0001). The rheumatic AF group also showed decreased levels of GFC compared with the nonrheumatic AF group, with the rheumatic MS and sinus rhythm group, and with controls (P = .03, P = .02, P = .0001, respectively). GFC was lower in patients with rheumatic MS and sinus rhythm than in controls (P = .003). Although there were correlations between GFC and mitral valve area, transmitral mean gradient, left atrial diameter, and mitral calcification in patients with rheumatic MS, multivariate analysis showed only transmitral gradient as an independent factor affecting GFC. Patients with AF have decreased GFC, a finding that suggests the presence of a hypofibrinolytic state. Fibrinolytic dysfunction was more pronounced in rheumatic MS patients with AF than in those with nonrheumatic AF. Moreover, patients with rheumatic MS and sinus rhythm had decreased global fibrinolytic activity. Hypofibrinolysis documented by decreased GFC can be one of the important causes of increased risk of embolism in patients with AF and rheumatic MS.
- Published
- 2002
- Full Text
- View/download PDF
49. Effects of short-term atorvastatin treatment on global fibrinolytic capacity, and sL-selectin and sFas levels in hyperlipidemic patients with coronary artery disease.
- Author
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Atalar E, Ozmen F, Haznedaroglu I, Açil T, Ozer N, Ovünç K, Aksöyek S, and Kes S
- Subjects
- Adult, Apoptosis drug effects, Atorvastatin, Cholesterol blood, Female, Humans, Lipoproteins, HDL blood, Lipoproteins, HDL drug effects, Lipoproteins, LDL blood, Lipoproteins, LDL drug effects, Male, Middle Aged, Time Factors, Treatment Outcome, Triglycerides blood, Anticholesteremic Agents therapeutic use, Coronary Artery Disease complications, Coronary Artery Disease drug therapy, Fatty Acids blood, Fibrinolysis drug effects, Heptanoic Acids therapeutic use, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Hyperlipidemias complications, Hyperlipidemias drug therapy, L-Selectin blood, L-Selectin drug effects, Pyrroles therapeutic use
- Abstract
Background: The beneficial effects of HMG-CoA reductase inhibitors (statins) in patients with coronary artery disease (CAD) appear to be attributable not only to their lipid-lowering properties, but also to their therapeutic effects on the coagulation system, and anti-inflammatory effect. Furthermore, statins mitigate the apoptosis of vascular smooth muscle cells (VSMC) and macrophages in atherosclerotic plaques., Hypothesis: The purpose of this study was to evaluate the effects of short-term atorvastatin treatment on the fibrinolytic system and systemic inflammatory status, and on apoptosis in hyperlipidemic patients with CAD., Methods: The study population consisted of 36 hyperlipidemic patients (14 women and 22 men, mean age 53+/-9 years) with stable CAD, untreated with lipid-lowering medications. Serum lipoproteins, fibrinogen levels, sFas and sL-selectin, and global fibrinolytic capacity (GFC) were measured at baseline and after 12 weeks of treatment with atorvastatin, 10 mg/day., Results: Atorvastatin treatment decreased serum low-density lipoprotein (-39%, P=0.0001), total cholesterol (-32%, P=0.0001), and triglycerides (-22%, P=0.0001), and increased high-density lipoprotein (+13%, P=0.0001) at 12 weeks compared to baseline. These effects were associated with a decrease in plasma fibrinogen from 331+/-73 to 298+/-58 mg/dl (P=0.0001), and sL-selectin levels from 666+/-201 to 584+/-162 ng/ml (P=0.0001). sFas levels and GFC increased from 3754+/-1264 to 4873+/-1835 pg/ml and from 3.5+/-2.4 to 5.6+/-2.9 microg/ml, respectively (both P=0.0001)., Conclusions: These results suggest that lipid lowering with atorvastatin therapy significantly increases GFC, decreases fibrinogen levels, and causes leukocyte deactivation. Our findings also suggest that atorvastatin treatment mitigates apoptosis of VSMC in the atherosclerotic plaque. These effects of atorvastatin may, in part, explain the early decrease in cardiovascular events observed in clinical trials of statins.
- Published
- 2002
- Full Text
- View/download PDF
50. Does menstrual flow exclude hematometra? A rare case of uterine anomaly presenting with anorectal malformation.
- Author
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Nayci A, Avlan D, Oz U, Toktaş S, and Aksöyek S
- Subjects
- Abdominal Pain diagnosis, Abdominal Pain etiology, Abnormalities, Multiple diagnosis, Abnormalities, Multiple surgery, Adolescent, Anal Canal surgery, Female, Hematometra complications, Hematometra surgery, Humans, Magnetic Resonance Imaging, Rectum surgery, Treatment Outcome, Uterus surgery, Anal Canal abnormalities, Hematometra diagnosis, Menstruation physiology, Rectum abnormalities, Uterus abnormalities
- Abstract
Hematometra, which is defined as accumulation of menstrual secretions in the uterine cavity, may not be diagnosed until the maturating adolescent fails to menstruate. Clinically, a lower abdominal mass and periodic abdominal pain may develop in these children after puberty. Here, a 13-year-old girl with menstrual flow who presented with symptoms of genital outflow tract obstruction is described., (Copyright 2002, Elsevier Science (USA). All rights reserved.)
- Published
- 2002
- Full Text
- View/download PDF
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