1. Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: The TREAT-OA consortium
- Author
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Kerkhof, J.M. (Hanneke), Meulenbelt, I. (Ingrid), Akune, T. (Toru), Arden, N.K. (Nigel), Aromaa, A. (Arpo), Bierma-Zeinstra, S.M. (Sita), Cooper, C. (Charles), Dai, J., Doherty, M. (Michael), Doherty, S. (Sally), Felson, D., Gonzalez, A. (Antonio), Gordon, A., Harilainen, A. (Arsi), Hart, D.J., Hauksson, V.B. (Valdimar), Heliovaara, M. (Markku), Hofman, A. (Albert), Ikegawa, S., Ingvarsson, T. (Torvaldur), Jiang, Q., Jonsson, H., Jonsdottir, I. (Ingileif), Kawaguchi, H., Kloppenburg, M. (Margreet), Kujala, U.M. (Urho), Lane, N.E., Leino-Arjas, P. (Päivi I.), Lohmander, L.S. (Stefan), Luyten, F.P. (Frank), Malizos, K.N. (Konstantinos), Nakajima, M., Nevitt, M.C. (Michael), Pols, H.A.P. (Huib), Rivadeneira Ramirez, F. (Fernando), Shi, D., Slagboom, P.E. (Eline), Spector, T.D. (Timothy), Stefansson, K. (Kari), Sudo, A. (Akihiro), Tamm, A., Tamm, A.E. (Aile), Tsezou, A. (Aspasia), Uchida, A., Uitterlinden, A.G. (André), Wilkinson, J.M. (Mark), Yoshimura, N., Valdes, A.M. (Ana Maria), Meurs, J.B.J. (Joyce) van, Carr, A.J. (Andrew Jonathan), Kerkhof, J.M. (Hanneke), Meulenbelt, I. (Ingrid), Akune, T. (Toru), Arden, N.K. (Nigel), Aromaa, A. (Arpo), Bierma-Zeinstra, S.M. (Sita), Cooper, C. (Charles), Dai, J., Doherty, M. (Michael), Doherty, S. (Sally), Felson, D., Gonzalez, A. (Antonio), Gordon, A., Harilainen, A. (Arsi), Hart, D.J., Hauksson, V.B. (Valdimar), Heliovaara, M. (Markku), Hofman, A. (Albert), Ikegawa, S., Ingvarsson, T. (Torvaldur), Jiang, Q., Jonsson, H., Jonsdottir, I. (Ingileif), Kawaguchi, H., Kloppenburg, M. (Margreet), Kujala, U.M. (Urho), Lane, N.E., Leino-Arjas, P. (Päivi I.), Lohmander, L.S. (Stefan), Luyten, F.P. (Frank), Malizos, K.N. (Konstantinos), Nakajima, M., Nevitt, M.C. (Michael), Pols, H.A.P. (Huib), Rivadeneira Ramirez, F. (Fernando), Shi, D., Slagboom, P.E. (Eline), Spector, T.D. (Timothy), Stefansson, K. (Kari), Sudo, A. (Akihiro), Tamm, A., Tamm, A.E. (Aile), Tsezou, A. (Aspasia), Uchida, A., Uitterlinden, A.G. (André), Wilkinson, J.M. (Mark), Yoshimura, N., Valdes, A.M. (Ana Maria), Meurs, J.B.J. (Joyce) van, and Carr, A.J. (Andrew Jonathan)
- Abstract
Objective: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. Methods: Descriptions of OA phenotypes of the 28 studies involved in the TREAT-OA consortium were collected. We investigated whether different OA definitions result in different association results by creating various hip OA definitions in one large population based cohort (the Rotterdam Study I
- Published
- 2011
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