1. Inhibiting Effect of Zinc Oxide Nanoparticles on Advanced Glycation Products and Oxidative Modifications: a Potential Tool to Counteract Oxidative Stress in Neurodegenerative Diseases
- Author
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Mohammad Azam Ansari, Ahmed Jerah, Ghulam Md Ashraf, Saleh Mohammed Abdullah, George E. Barreto, Sana Fatma, Saheem Ahmad, Johar Iqbal, Jalaluddin M. Ashraf, Valentina Echeverria, Aymen M. Madkhali, and Al Hassan Hamali
- Subjects
0301 basic medicine ,Glycation End Products, Advanced ,Central nervous system ,Neuroscience (miscellaneous) ,Nanoparticle ,chemistry.chemical_element ,02 engineering and technology ,Oxidative phosphorylation ,Zinc ,Pharmacology ,Inhibitory postsynaptic potential ,medicine.disease_cause ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,X-Ray Diffraction ,Glycation ,medicine ,Humans ,Aloe ,Plant Extracts ,Neurodegenerative Diseases ,021001 nanoscience & nanotechnology ,Plant Leaves ,Oxidative Stress ,030104 developmental biology ,medicine.anatomical_structure ,Spectrometry, Fluorescence ,Neurology ,chemistry ,Nanoparticles ,Spectrophotometry, Ultraviolet ,Zinc Oxide ,0210 nano-technology ,Oxidation-Reduction ,Oxidative stress - Abstract
Advanced glycation end products (AGEs) are implicated in several central nervous system (CNS) pathologies including Alzheimer and Parkinson’s diseases. In the face-off of AGE menace, we have attempted to investigate the zinc oxide nanoparticle (ZnONP) role in inhibition of AGE formation. Synthesized ZnONPs were used to investigate the inhibitory effects on AGE formation. The inhibitory effects of ZnONPs on AGE formation were determined by biophysical immunological and biochemical techniques. The results showed that ZnONP is a potential anti-glycating agent inhibiting AGE formation as well as protecting the protein structure from change. Therefore, our findings suggest ZnONPs may be used as a therapeutic in resolving the AGE role in CNS-related complications.
- Published
- 2017