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13 results on '"Al Shweiki, Mhd Rami"'

6. Prodynorphin and Proenkephalin in Cerebrospinal Fluid of Sporadic Creutzfeldt–Jakob Disease

Author

Abu-Rumeileh, Samir, primary, Barschke, Peggy, additional, Oeckl, Patrick, additional, Baiardi, Simone, additional, Mammana, Angela, additional, Mastrangelo, Andrea, additional, Al Shweiki, Mhd Rami, additional, Steinacker, Petra, additional, Ladogana, Anna, additional, Capellari, Sabina, additional, Otto, Markus, additional, and Parchi, Piero, additional

Published
2022
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8. Cerebrospinal Fluid Levels of Prodynorphin‐Derived Peptides are Decreased in Huntington's Disease

Author

Al Shweiki, MHD Rami, primary, Oeckl, Patrick, additional, Pachollek, Adrian, additional, Steinacker, Petra, additional, Barschke, Peggy, additional, Halbgebauer, Steffen, additional, Anderl‐Straub, Sarah, additional, Lewerenz, Jan, additional, Ludolph, Albert C., additional, Bernhard Landwehrmeyer, Georg, additional, and Otto, Markus, additional

Published
2020
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9. Reshaping of the Arabidopsis thaliana proteome landscape and co-regulation of proteins in development and immunity

Author

Bassal, Mona, primary, Majovsky, Petra, additional, Thieme, Domenika, additional, Herr, Tobias, additional, Abukhalaf, Mohammad, additional, Ayash, Mohamed, additional, Al Shweiki, MHD Rami, additional, Proksch, Carsten, additional, Hmedat, Ali, additional, Ziegler, Jörg, additional, Neumann, Steffan, additional, and Hoehenwarter, Wolfgang, additional

Published
2020
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10. Different CSF protein profiles in amyotrophic lateral sclerosis and frontotemporal dementia with C9orf72 hexanucleotide repeat expansion

Author

Barschke, Peggy, primary, Oeckl, Patrick, additional, Steinacker, Petra, additional, Al Shweiki, MHD Rami, additional, Weishaupt, Jochen H, additional, Landwehrmeyer, G Bernhard, additional, Anderl-Straub, Sarah, additional, Weydt, Patrick, additional, Diehl-Schmid, Janine, additional, Danek, Adrian, additional, Kornhuber, Johannes, additional, Schroeter, Matthias L, additional, Prudlo, Johannes, additional, Jahn, Holger, additional, Fassbender, Klaus, additional, Lauer, Martin, additional, van der Ende, Emma Louise, additional, van Swieten, John Cornelis, additional, Volk, Alexander E, additional, Ludolph, Albert C, additional, and Otto, Markus, additional

Published
2020
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11. Cerebrospinal Fluid Levels of Prodynorphin‐Derived Peptides are Decreased in Huntington's Disease.

Author

Al Shweiki, MHD Rami, Oeckl, Patrick, Pachollek, Adrian, Steinacker, Petra, Barschke, Peggy, Halbgebauer, Steffen, Anderl‐Straub, Sarah, Lewerenz, Jan, Ludolph, Albert C., Bernhard Landwehrmeyer, Georg, and Otto, Markus

Abstract

RESULTS: Huntingtonʼs disease (HD) is a devastating neurodegenerative disorder characterized by a selective loss of striatal medium spiny projection neurons (MSNs). Prodynorphin (PDYN) is enriched in a subpopulation of striatal MSNs. Postmortem brains of HD patients and rodent models have been demonstrated to have reduced levels of PDYN transcripts and the neuropeptide dynorphin. RESULTS: Given the unmet need for novel pharmacodynamic HD biomarkers in the context of experimental huntingtin (htt)‐lowering therapies, we investigated the levels of PDYN‐derived peptides and neurofilament light (NfL) chain in the cerebrospinal fluid (CSF) from HD patients (n = 16), matched controls (n = 55), and patients with other neurodegenerative disorders (n = 70). Results: PDYN‐derived peptide levels were found to be substantially decreased in HD patients (P < 0.0001 in comparison to controls), whereas the NfL levels were elevated in all neurodegenerative disorders. Conclusions: Our study suggests decreased PDYN‐derived peptide levels in the CSF as a more specific biomarker for HD in comparison to NfL. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]

Published
2021
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