1. Clinical profile, risk factors and outcomes of ric COVID-19: a retrospective cohort multicentre study in Saudi Arabia.
- Author
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Albuali WH, AlGhamdi AA, Aldossary SJ, AlHarbi SA, Al Majed SI, Alenizi A, Al-Qahtani MH, Lardhi AA, Al-Turki SA, AlSanea AS, Bubshait DK, Kobeisy SA, Herzallah NH, Alqarni WA, AlHarbi AH, Albuali HW, Aldossary BJ, AlQurashi FO, and Yousef AA
- Subjects
- Adolescent, Child, Child, Preschool, Hospitalization, Humans, Infant, Infant, Newborn, Retrospective Studies, Risk Factors, Saudi Arabia epidemiology, COVID-19 epidemiology
- Abstract
Objective: To describe the risk factors, clinical profile and outcomes of COVID-19 in the paediatric population., Design: Multicentre, retrospective observational study., Setting: Four tertiary hospitals in Saudi Arabia., Patients: We recruited 390 paediatric patients aged 0-18 years who presented from March to December 2020 and tested positive for COVID-19 on PCR., Main Outcome Measures: We retrospectively analysed medical records for sociodemographics, health indicators, clinical presentations, laboratory findings, clinical complications, and outcomes., Results: The mean participant age was 5.66±4.90 years, and the mean hospital stay was 2.17±3.48 days. Forty patients, mostly school-aged children (16, 40.00%; p=0.005) and children with comorbidities (25, 62.50%; p<0.001), received more than just supportive care. Complications were seen in 15 (3.9%) patients, bacterial infection being the most common (6, 40.00%). Patients presented with dyspnoea (OR 6.89; 95% CI 2.89 to 20.72), abnormal chest radiographs (OR 6.11; 95% CI 1.26 to 29.38), lethargy (OR 9.04; 95% CI 2.91 to 28.06) and elevated ferritin (OR 14.21; 95% CI 4.18 to 48.37) and D-dimer (OR 48.40; 95% CI 14.32 to 163.62), with higher odds of developing complications. The odds of paediatric intensive care unit (ICU) admission were higher for patients with dyspnoea (adjusted OR 4.66; 95% CI 1.24 to 17.50) and elevated white blood cell count (adjusted OR 3.54; 95% CI 1.02 to 12.30)., Conclusions: COVID-19 complications were limited among our patients. However, dyspnoea, abnormal chest radiographs, lethargy and elevated ferritin and D-dimer were associated with an increased risk of complications. Dyspnoea, leucocytosis, comorbidities and abnormal chest radiographs at presentation increased the risk of ICU admission., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2022
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