24 results on '"Al-Abdely, H."'
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2. Successful therapy of cerebral phaeopyphomycosis due to Ramichloridium mackenziei with the new triazole posaconazole (SCH56592)
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Al-Abdely, H., Alkhunaizi, A., Al-Tawfiq, J., Hassonah, M., Rinaldi, M., and Sutton, D.
- Published
- 2003
3. Antimicrobial usage in Saudi Ministry of Health Hospitals: Data from 2016 and 2017
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Al Matar, M., primary, Enani, M., additional, Al Abdely, H., additional, Roshdy, H., additional, and Binsaleh, G., additional
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- 2019
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4. Case characteristics among Middle East respiratory syndrome coronavirus outbreak and non-outbreak cases in Saudi Arabia from 2012 to 2015
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Alhamlan, F S, primary, Majumder, M S, additional, Brownstein, J S, additional, Hawkins, J, additional, Al-Abdely, H M, additional, Alzahrani, A, additional, Obaid, D A, additional, Al-Ahdal, M N, additional, and BinSaeed, A, additional
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- 2017
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5. An outbreak of Middle East Respiratory Syndrome (MERS) due to coronavirus in Al-Ahssa Region, Saudi Arabia, 2015
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El Bushra, Hassan, primary, Abdalla, Mohamed, additional, Al Arbash, Hussain, additional, Alshayeb, Z, additional, Al-Ali, S, additional, Al-Abdel LAtif, Zaki, additional, Al-Bahkit, Hussain, additional, Abdalla, O, additional, Mohammed, M, additional, Al-Abdely, H, additional, Chahed, Mohamed, additional, Lohiniva, Anna, additional, and Bin Saeed, Abdulaziz, additional
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- 2016
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6. Chronic Abdominal Pain and Intestinal Obstruction in a 24-Year-Old Woman
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Alhuraiji, A., primary, Alqaraawi, A., additional, Alaraj, A., additional, Al-Abdely, H. M., additional, and Alrajhi, A. A., additional
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- 2014
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7. Successful therapy of cerebral phaeohyphomycosis due toRamichloridium mackenzieiwith the new triazole posaconazole
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Al-abdely, H. M., primary, Alkhunaizi, A. M., additional, Al-tawfiq, J. A., additional, Hassounah, M., additional, Rinaldi, M. G., additional, and Sutton, D. A., additional
- Published
- 2005
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8. Fungal Endocarditis: Evidence in the World Literature, 1965-1995
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Ellis, M. E., primary, Al-Abdely, H., additional, Sandridge, A., additional, Greer, W., additional, and Ventura, W., additional
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- 2001
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9. Investigation and control of aspergillosis and other filamentous fungal infections in solid organ transplant recipients
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Patterson, J.E., primary, Peters, J., additional, Calhoon, J.H., additional, Levine, S., additional, Anzueto, A., additional, Al‐Abdely, H., additional, Sanchez, R., additional, Patterson, T.F., additional, Rech, M., additional, Jorgensen, J.H., additional, Rinaldi, M.G., additional, Sako, E., additional, Johnson, S., additional, Speeg, V., additional, Halff, G.A., additional, and Trinkle, J.K., additional
- Published
- 2000
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10. Markedly Elevated Serum Lactate Dehydrogenase Levels Are a Clue to the Diagnosis of Disseminated Histoplasmosis in Patients with AIDS
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Corcoran, G. R., primary, Al-Abdely, H., additional, Flanders, C. D., additional, Geimer, J., additional, and Patterson, T. F., additional
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- 1997
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11. Successful therapy of cerebral phaeohyphomycosis due to Ramichloridium mackenziei with the new triazole posaconazole.
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Al-Abdely, H. M., Alkhunaizi, A. M., Al-Tawfiq, J. A., Hassounah, M., Rinaldi, M. G., and Sutton, D. A.
- Subjects
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ANTIFUNGAL agents , *ANTI-infective agents , *FUNGICIDES , *MYCOLOGY , *MICROBIOLOGY - Abstract
Cerebral phaeohyphomycosis caused by Ramichloridium mackenziei is universally fatal. All reported cases with long-term follow-up have indicated 100% mortality despite antifungal therapy and surgical intervention. We describe the case of a 62-year-old patient who underwent renal transplantation and had a cerebral abscess caused by R. mackenziei . The infection progressed despite surgical evacuation and therapy with liposomal amphotericin B, itraconazole, and 5-flucytosine. The patient was subsequently treated with the investigational triazole posaconazole oral suspension, 800 mg/day, in divided doses. Treatment with posaconazole resulted in progressive clinical and radiologic improvement. The patient is alive four years after diagnosis and maintained on posaconazole therapy. This case supports the potential role of this extended-spectrum azole in the treatment of this serious fungal infection of the central nervous system. [ABSTRACT FROM AUTHOR]
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- 2005
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12. Disseminated Mycobacterium simiae Infection in Patients with AIDS
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Al-Abdely, H. M., Revankar, S. G., and Graybill, J. R.
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Objectives: To report our experience with disseminated Mycobacterium simiae disease in patients with AIDS, and review other cases reported in the literature. Methods: We retrospectively reviewed all cases of M. simiae that were isolated from sterile body sites over a 9-year period at the University Health System Hospital at San Antonio, Texas, U.S.A. Data included patient demographics, clinical features, other accompanying opportunistic infections, in vitro susceptibility, therapy and outcome. Results: Ten cases of M. simiae disseminated disease were identified. All of them were inpatients with AIDS. Another nine cases of disseminated infection in AIDS patients were reported in the literature. Advanced AIDS with absolute CD4 counts of less than 50 and an associated AIDS-defining illness characterized all cases. Persistent fever and debilitation without localizing signs were the most common clinical features. Our patients responded poorly to antimycobacterial drugs and died within 6 months of diagnosis. The only reported successful therapy was in patients who responded well to highly active antiretroviral therapy and antimycobacterial regimens containing clarithromycin, ethambutol and ciprofloxacin. Conclusions: Clinical presentation of M. simiae infection mimics Mycobacterium avium complex, with fever and progressive debilitation, but is less responsive to therapy. Immuno-reconstitution with potent antiretroviral therapy may be the best therapy for such resistant disease. Copyright 2000 The British Infection Society
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- 2000
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13. An outbreak of Middle East Respiratory Syndrome (MERS) due to coronavirus in Al-Ahssa Region, Saudi Arabia, 2015
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He, El Bushra, Mn, Abdalla, Al Arbash H, Alshayeb Z, Al-Ali S, Za, Latif, Al-Bahkit H, Abdalla O, Mohammed M, Al-Abdely H, Chahed M, Anna-Leena Lohiniva, and Ab, Saeed
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Interviews as Topic ,Medical Audit ,Incidence ,Middle East Respiratory Syndrome Coronavirus ,Saudi Arabia ,Humans ,Coronavirus Infections ,Qualitative Research ,Disease Outbreaks - Abstract
Between 19 April and 23 June 2015, 52 laboratory-confirmed cases of Middle East Respiratory Syndrome due to coronavirus (MERS) were reported from Al-Ahssa region, eastern Saudi Arabia. The first seven cases occurred in one family; these were followed by 45 cases in three public hospitals. The objectives of this investigation were to describe the epidemiological characteristic of the cluster and identify potential risk factors and control measures to be instituted to prevent further occurrence of MERS. We obtained the medical records of all confirmed cases, interviewed the members of the affected household and reviewed the actions taken by the health authorities. All the cases were connected. The index case was a 62-year-old man with a history of close contact with dromedary camels; three of the seven infected family members and 18 people in hospitals died (case-fatality rate, 40.4%). The median incubation period was about 6 days. The cluster of cases appeared to be due to high exposure to MERS, delayed diagnosis, inadequate risk communication and inadequate compliance of hospital health workers and visitors with infection prevention and control measures.فاشية للمتلازمة التنفسية الشرق أوسطية بسبب فيروس كورونا في منطقة الأحساء بالمملكة العربية السعودية، 2015.حسن المهدي البرى، محمد نجيب عبد الله، حسن الأربش، زينب الشايب، سامي عبد الوهاب العي، زكي العبد اللطيف، حسن البخيت، عثان محمد عبد الله، معتز عبد الباقي محمد، هايل العبدلي، محمد شاهد، آنا لينا لوهينيفا، عبد العزيز عبد الله بن سعيد.ما بن 19 أبريل/نيسان و 23 يونيو/حزيران من عام 2015 تم الإباغ عن 52 حالة مؤكدة مختبرياً من المتلازمة التنفسية الرق أوسطية بسبب فروس كورونا من منطقة الأحساء، شرق المملكة العربية السعودية. حدثت الحالات السبعة الأولى في عائلة واحدة، وأعقب ذلك 45 حالة في ثلاثة مستشفيات عامة. وكانت أهداف هذا الاستقصاء وصف الخصائص الوبائية للعنقود وتحديد عوامل الخطر المحتملة وتدابر المكافحة التي يتعن وضعها للوقاية من حدوث مزيد من حالات المتلازمة التنفسية الرق أوسطية بن العاملن. حصلنا عى السجلات الطبية لجميع الحالات المؤكدة، وأجرينا مقابات مع أفراد الأسر المصابة، واستعرضنا الإجراءات التي اتخذتها السلطات الصحية. ووجدنا أن جميع الحالات كانت مرتبطة ببعضها. وكانت الحالة الدالة لرجل يبلغ من العمر 62 عاماً لديه تاريخ تماس وثيق مع جمال وحيدة السنام، توفي ثلاثة من أفراد الأسرة المصابن السبعة و 18 شخصاً في المستشفيات (معدل الوفيات ما بن الحالات، % 40.4 ). وكان متوسط فرة الحضانة حوالي 6 أيام. ويبدو أن عنقود الحالات يرجع إلى التعرض الكبر للفروس، وعدم كفاية الإباغ عن المخاطر، وعدم كفاية امتثال العاملن الصحين في المستشفيات والزوار لتدابر الوقاية من العدوى ومكافحتها.Arabie saoudite : flambée de syndrome respiratoire du Moyen-Orient (MERS) causé par le coronavirus dans la région d’Al-Ahssa en 2015.Entre le 19 avril et le 23 juin 2015, 52 cas confirmés en laboratoire de syndrome respiratoire du Moyen- Orient (MERS) causé par le coronavirus ont été notifiés dans la région d’Al-Ahssa, partie orientale de l’Arabie saoudite. Les sept premiers cas sont survenus dans une seule famille ; ils ont été suivis de 45 cas déclarés dans trois hôpitaux publics. Cette investigation avait pour objectifs de détailler les caractéristiques épidémiologiques de ce groupe de cas et d’identifier les facteurs de risque potentiels ainsi que les mesures de lutte à mettre en place afin d’empêcher la survenue de nouveaux cas de MERS. Nous avons consulté les dossiers médicaux de l’ensemble des cas confirmés, avons interrogé les membres des foyers touchés et passé en revue les interventions entreprises par les autorités sanitaires. Tous les cas étaient reliés entre eux. Le cas indicateur était un homme de 62 ans ayant eu des contacts étroits avec des dromadaires ; trois des sept membres infectés de la famille et 18 patients hospitalisés sont décédés (taux de létalité : 40,4 %). La période d’incubation médiane était d’environ 6 jours. Le groupe de cas était vraisemblablement dû à une forte exposition au MERS, associée à un diagnostic tardif, une communication sur les risques inappropriée et une mauvaise observance des mesures de prévention et de lutte contre les infections par les personnels de santé de l’hôpital et les visiteurs.
14. Molecular characterization of carbapenem-resistant Enterobacterales in thirteen tertiary care hospitals in Saudi Arabia.
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Al-Abdely H, AlHababi R, Dada HM, Roushdy H, Alanazi MM, Alessa AA, Gad NM, Alasmari AM, Radwan EE, Al-Dughmani H, Koura B, Bader MM, Deen HMA, Bueid A, Elgaher KM, Alghoribi MF, Albarrag AM, and Somily AM
- Subjects
- Anti-Bacterial Agents pharmacology, Bacterial Proteins, Cross-Sectional Studies, Humans, Klebsiella pneumoniae genetics, Microbial Sensitivity Tests, Saudi Arabia epidemiology, Tertiary Care Centers, Carbapenems pharmacology, beta-Lactamases genetics
- Abstract
Background: Carbapenems are the antibiotics of last-resort for the treatment of bacterial infections caused by multidrug-resistant organisms. The emergence of resistance is a critical and worrisome problem for clinicians and patients. Carbapenem-resistant Enterobacterales (CRE) are spreading globally, are associated with an increased frequency of reported outbreaks in many regions, and are becoming endemic in many others., Objectives: Determine the molecular epidemiology of CRE isolates from various regions of Saudi Arabia to identify the genes encoding resistance and their clones for a better understanding of the epidemio-logical origin and national spread., Design: Multicenter, cross-sectional, laboratory-based study., Setting: Samples were collected from 13 Ministry of Health tertiary-care hospitals from five different regions of Saudi Arabia., Methods: Isolates were tested using the GeneXpert molecular platform to classify CRE., Main Outcome Measures: Prevalence of various types of CRE in Saudi Arabia., Sample Size: 519 carbapenem-resistant isolates., Result: Of 519 isolates, 440 (84.7%) were positive for CRE, with Klebsiella pneumoniae (410/456, 90%) being the most commonly isolated pathogen. The distribution of the CRE-positive K pneumoniae resistance genes was as follows: OXA-48 (n=292, 71.2%), NDM-1 (n=85, 20.7%), and NDM+OXA-48 (n=33, 8%). The highest percentage of a single blaOXA-48 gene was detected in the central and eastern regions (77%), while the bla
NDM -gene was the predominant type in the northern region (27%). The southern regions showed the lowest percentages for harboring both blaOXA-48 and blaNDM genes (4%), while the western region isolates showed the highest percentage of harboring both genes (14%)., Conclusion: The results illustrate the importance of molecular characterization of CRE isolates for patient care and infection prevention and control. Larger multicenter studies are needed to critically evaluate the risk factors and trends over time to understand the dynamics of spread and effective methods of control., Limitations: Lack of phenotypic susceptibility and clinical data., Conflict of Interest: None.- Published
- 2021
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15. Acquisition of respiratory and gastrointestinal pathogens among health care workers during the 2015 Hajj season.
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Yezli S, Alotaibi B, Al-Abdely H, Balkhy HH, Yassin Y, Mushi A, Maashi F, Pezzi L, Benkouiten S, Charrel R, Raoult D, and Gautret P
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- Adult, Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Male, Middle Aged, Multiplex Polymerase Chain Reaction, Religion, Saudi Arabia, Young Adult, Carrier State epidemiology, Crowding, Gastroenteritis epidemiology, Health Personnel, Infectious Disease Transmission, Patient-to-Professional, Occupational Exposure statistics & numerical data, Respiratory Tract Infections epidemiology
- Abstract
Background: Data on the risk of transmission of infection to health care workers (HCWs) serving ill pilgrims during the Hajj is scarce., Methods: Two cohorts of HCWs, the first serving Hajj pilgrims in Mecca and the second serving patients in Al-Ahsa, were investigated for respiratory and gastrointestinal symptoms and pathogen carriage using multiplex polymerase chain reaction before and after the 2015 Hajj., Results: A total of 211 HCWs were enrolled of whom 92 were exposed to pilgrims (Mecca cohort), whereas 119 were not exposed (Al-Ahsa cohort). Symptoms were observed only in HCWs from the Mecca cohort, with 29.3% experiencing respiratory symptoms during the Hajj period or in the subsequent days and 3.3% having gastrointestinal symptoms. Acquisition rates of at least 1 respiratory virus were 14.7% in the Mecca cohort and 3.4% in the Al-Ahsa cohort (P = .003). Acquisition rates of at least 1 respiratory bacterium were 11.8% and 18.6% in the Mecca and Al-Ahsa cohorts, respectively (P = .09). Gastrointestinal pathogens were rarely isolated in both cohorts of HCWs and acquisition of pathogens after the Hajj was documented in only a few individuals., Conclusions: HCWs providing care for pilgrims both acquire pathogens and present symptoms (especially respiratory symptoms) more frequently than those not working during Hajj., (Copyright © 2019 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.)
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- 2019
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16. The emerging pathogen Candida auris: A focus on the Middle-Eastern countries.
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Alfouzan W, Dhar R, Albarrag A, and Al-Abdely H
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- Antifungal Agents pharmacology, Candida drug effects, Candida genetics, Candidiasis blood, Cross Infection microbiology, Humans, Microbial Sensitivity Tests, Middle East epidemiology, Public Health, Virulence, Candida pathogenicity, Candidiasis epidemiology, Cross Infection epidemiology
- Abstract
Recent emergence of Candida auris as a multidrug resistant fungal pathogen, associated with difficult-to-control nosocomial transmission and high mortality, raises serious concerns for public health. Since it was first reported from Japan in 2009, C. auris infections have been diagnosed in several countries from all over the world. However, there is a paucity of reported cases from the Middle East. Literature search resulted in finding only six countries (Kuwait, Israel, Oman, KSA, UAE and Iran) reporting C. auris infections in the past three years. All patients were adults with several underlying comorbidities. Majority of the cases presented with bloodstream infection with crude mortality rate of 60%. All isolates were misidentified as C. haemulonii by commercial systems requiring specialized methods for identification. In vitro antifungal susceptibility testing showed 100% strains to be resistant to fluconazole (MIC 32 ≥ 256 mg/L) while variable resistance against other antifungal agents., (Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2019
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17. Point prevalence survey of antibiotic use in 26 Saudi hospitals in 2016.
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Al Matar M, Enani M, Binsaleh G, Roushdy H, Alokaili D, Al Bannai A, Khidir Y, and Al-Abdely H
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- Adult, Anti-Bacterial Agents administration & dosage, Antimicrobial Stewardship, Cephalosporins administration & dosage, Cross-Sectional Studies, Female, Health Care Surveys, Hospitalization statistics & numerical data, Humans, Inpatients, Intensive Care Units statistics & numerical data, Male, Practice Patterns, Physicians' statistics & numerical data, Prevalence, Respiratory Tract Infections drug therapy, Saudi Arabia, Surgery Department, Hospital supply & distribution, Anti-Bacterial Agents therapeutic use, Drug Prescriptions statistics & numerical data, Drug Utilization statistics & numerical data, Hospitals statistics & numerical data, Practice Patterns, Physicians' trends
- Abstract
Objective: To evaluate the antibiotic prescribing trends, qualitatively and quantitatively, among Saudi Ministry of Health (MOH) hospitals., Method and Materials: In May 2016, information about the hospitals and patients was collected for all inpatients from 26 MOH hospitals in Saudi Arabia. Additional information about antibiotic treatment and infections was gathered. Data collection was done using Global Point Prevalence Survey (PPS) tool designed by University of Antwerp, Belgium., Results: A total of 3240 antibiotic doses were administrated to 2182 patients who represented 46.9% of the total eligible admitted patients. Of those patients on antibiotics, 510 (24%) patients were in the Intensive Care Unit (ICU), 646 (30.4%) patients were medically treated, and 972 (45.7%) patients were in surgical departments. The most commonly prescribed antibiotic group was third-generation cephalosporin (17.2%) and the most frequent indication was respiratory ract infectiont (n=597; 18.2%). Antibiotics for surgical prophylaxis represented 23.4% of the total antibiotic doses. Of those, 78% were administrated for more than 24hs. The rate of adherence to antibiotic guidelines was 48.1%. The indications for antibiotics were not documented in the patients' notes for 51.1% of the prescriptions., Conclusion: This national PPS provided a useful tool to identify targets for quality improvement in order to enhance the prudent use of antibiotics in hospital settings. This survey can provide a background to assess the quality of antibiotic utilisation after any intervention by administering it regularly., (Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2019
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18. Middle Eastern Respiratory Syndrome Corona Virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia.
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Khalid M, Khan B, Al Rabiah F, Alismaili R, Saleemi S, Rehan-Khaliq AM, Weheba I, Al Abdely H, Halim M, Nadri QJ, Al Dalaan AM, Zeitouni M, Butt T, and Al Mutairy E
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- Adolescent, Aged, Aged, 80 and over, Asymptomatic Infections, Coronavirus Infections diagnosis, Delayed Diagnosis, Drug Therapy, Combination, Female, Humans, Interferon alpha-2, Male, Middle Aged, Pneumonia virology, Recombinant Proteins therapeutic use, Respiratory Insufficiency virology, Saudi Arabia epidemiology, Tertiary Care Centers, Time-to-Treatment, Antiviral Agents therapeutic use, Coronavirus Infections drug therapy, Interferon-alpha therapeutic use, Middle East Respiratory Syndrome Coronavirus, Polyethylene Glycols therapeutic use, Ribavirin therapeutic use
- Abstract
Background and Objectives: Middle Eastern respiratory syndrome caused by novel coronavirus (MERS CoV) has been a major public health challenge since it was first described in 2012 in Saudi Arabia. So far, there is no effective treatment for this serious illness, which features a high mortality rate. We report an initial experience of the use of ribavirin and interferon (IFN)-a2b in the management of MERS CoV at a tertiary care hospital., Design and Settings: A case series of 6 patients admitted with a confirmed diagnosis of MERS CoV were treated with ribavirin and IFN-a2b in addition to supportive management. The patients' demographics, clinical parameters, and outcomes were recorded. Fifty-four close contacts of these patients were screened for MERS CoV., Methods: Six patients with MERS CoV infection were included in this study. Four cases featured symptomatic disease, including pneumonia and respiratory failure, while 2 were asymptomatic close contacts of the MERS CoV patients. The MERS CoV infection was confirmed by reverse transcription-polymerase chain reaction detection of the consensus viral RNA targets upstream of the E gene (UPE) and open reading frame (ORF1b) on a sputum sample. The patients' demographics, comorbid conditions, time to diagnosis and initiation of treatment, and clinical outcomes were recorded., Results: Three out of 6 patients who had comorbid conditions died during the study period, while 3 had suc.cessful outcomes. The diagnosis and treatment was delayed by an average of 15 days in those patients who died. Only 2 close contacts out of the 54 screened (3.7%) were positive for MERS CoV., Conclusion: Treatment with ribavirin and IFN-a2b may be effective in patients infected with MERS CoV. There appears to be a low infectivity rate among close contacts of MERS CoV patients.
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- 2014
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19. High efficacy and low toxicity of short-course oral valganciclovir as pre-emptive therapy for hematopoietic stem cell transplant cytomegalovirus infection.
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Saleh AJ, Al Mohareb F, Al Rabiah F, Chaudhri N, Al Sharif F, Al Zahrani H, Mohamed SY, Patel M, Rasheed W, Nurgat Z, Bakr M, Ahmed S, Zaidi S, Nasser A, Ibrahim K, Al Abdely H, and Aljurf M
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- Administration, Oral, Adolescent, Adult, Antigens, Viral blood, Antiviral Agents administration & dosage, Antiviral Agents adverse effects, Antiviral Agents therapeutic use, Cytomegalovirus drug effects, Cytomegalovirus immunology, Cytomegalovirus Infections etiology, Drug Administration Schedule, Female, Ganciclovir adverse effects, Ganciclovir therapeutic use, Humans, Kidney Diseases chemically induced, Male, Middle Aged, Neutropenia chemically induced, Treatment Outcome, Valganciclovir, Young Adult, Cytomegalovirus Infections drug therapy, Ganciclovir analogs & derivatives, Hematopoietic Stem Cell Transplantation adverse effects
- Abstract
Background: Cytomegalovirus (CMV) infection is a major infectious complication post-allogeneic hematopoietic stem cell transplantation (HSCT). CMV seropositivity in Eastern Mediterranean and certain Asian countries is reported to be close to 100%; hence, the need for effective pre-emptive treatment strategy that has low toxicity. Valganciclovir (VGC) is a prodrug of ganciclovir with high bioavailability., Patients and Methods: HSCT patients with documented CMV infection (as defined by positive CMV antigenemia) were treated as outpatients with VGC at a starting dose of 900 mg twice daily for 1 week. Those who were antigenemia negative after one week received 900 mg once daily for another week and treatment was subsequently discontinued. Those who were positive after one week of therapy continued on the twice-daily treatment schedule for another week and changed to a daily schedule once they converted to antigenemia negativity., Results: From January 2004 to December 2007, 47 HSCT patients received preemptive treatment with VGC for 61 episodes of CMV infection. The antigenemia range was 1 to 700 infected cells/slide. Complete responses were observed in 92% and 97% after the 1st and 2nd week of treatment, respectively. Three percent of the episodes were considered refractory, requiring alternative therapy. No CMV disease was observed in this cohort., Conclusion: Neutropenia was the main observed toxicity, requiring granulocyte-colony stimulating factor in 8 episodes. Outpatient treatment of CMV infection with "short-course oral VGC" given as a one-week twice-daily treatment and one week once daily maintenance is a highly effective therapy with minimal toxicity. These results require validation in a larger, randomized study.
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- 2010
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20. SCH 56592, amphotericin B, or itraconazole therapy of experimental murine cerebral phaeohyphomycosis due to Ramichloridium obovoideum ("Ramichloridium mackenziei").
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Al-Abdely HM, Najvar L, Bocanegra R, Fothergill A, Loebenberg D, Rinaldi MG, and Graybill JR
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- Animals, Central Nervous System Fungal Infections microbiology, Disease Models, Animal, Female, Mice, Mice, Inbred BALB C, Mice, Inbred ICR, Mycoses microbiology, Amphotericin B therapeutic use, Antifungal Agents therapeutic use, Ascomycota drug effects, Central Nervous System Fungal Infections drug therapy, Itraconazole therapeutic use, Mycoses drug therapy, Triazoles therapeutic use
- Abstract
Ramichloridium obovoideum ("Ramichloridium makenziei") is a rare cause of lethal cerebral phaeohyphomycosis. It has been, so far, geographically restricted to the Middle East. BALB/c mice were inoculated with two strains of R. obovoideum intracranially. Therapy with amphotericin B, itraconazole, or the investigational triazole SCH 56592 was conducted for 10 days. Half the mice were monitored for survival and half were killed for determination of the fungal load in brain tissue. Recipients of SCH 56592 had significantly prolonged survival and lower brain fungal burden, and this result was found for mice infected with both of the fungal strains tested. Itraconazole reduced the brain fungal load in mice infected with one strain but not the other, while amphotericin B had no effect on brain fungal concentrations. This study indicates a possible role of SCH 56592 in the treatment of the serious cerebral phaeohyphomycosis due to R. obovoideum.
- Published
- 2000
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21. Efficacy of the triazole SCH 56592 against Leishmania amazonensis and Leishmania donovani in experimental murine cutaneous and visceral leishmaniases.
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Al-Abdely HM, Graybill JR, Loebenberg D, and Melby PC
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- Amphotericin B pharmacology, Animals, Fluconazole pharmacology, Leishmaniasis, Cutaneous parasitology, Leishmaniasis, Visceral parasitology, Liver parasitology, Lymph Nodes parasitology, Male, Mice, Mice, Inbred BALB C, Spleen parasitology, Time Factors, Leishmania donovani, Leishmaniasis, Cutaneous drug therapy, Leishmaniasis, Visceral drug therapy, Triazoles therapeutic use, Trypanocidal Agents therapeutic use
- Abstract
Current therapy for leishmaniasis is unsatisfactory. Efficacious and safe oral therapy would be ideal. We examined the efficacy of SCH 56592, an investigational triazole antifungal agent, against cutaneous infection with Leishmania amazonensis and visceral infection with Leishmania donovani in BALB/c mice. Mice were infected in the ear pinna and tail with L. amazonensis promastigotes and were treated with oral SCH 56592 or intraperitoneal amphotericin B for 21 days. At doses of 60 and 30 mg/kg/day, SCH 56592 was highly efficacious in treating cutaneous disease, and at a dose of 60 mg/kg/day, it was superior to amphotericin B at a dose of 1 mg/kg/day. The means of tail lesion sizes were 0.32 +/- 0.12, 0.11 +/- 0.06, 0.17 +/- 0.07, and 0.19 +/- 0.08 mm for controls, SCH 56592 at 60 and 30 mg/kg/day, and amphotericin B recipients, respectively (P = 0.0003, 0.005, and 0.01, respectively). Parasite burden in draining lymph nodes confirmed these efficacy findings. In visceral leishmaniasis due to L. donovani infection, mice treated with SCH 56592 showed a 0.5- to 1-log-unit reduction in parasite burdens in the liver and the spleen compared to untreated mice. Amphotericin B at 1 mg/kg/day was superior to SCH 56592 in the treatment of visceral infection, with a 2-log-unit reduction in parasite burdens in both the liver and spleen. These studies indicate very good activity of SCH 56592 against cutaneous leishmaniasis due to L. amazonensis infection and, to a lesser degree, against visceral leishmaniasis due to L. donovani infection in susceptible BALB/c mice.
- Published
- 1999
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22. Efficacies of KY62 against Leishmania amazonensis and Leishmania donovani in experimental murine cutaneous leishmaniasis and visceral leishmaniasis.
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Al-Abdely HM, Graybill JR, Bocanegra R, Najvar L, Montalbo E, Regen SL, and Melby PC
- Subjects
- Amphotericin B administration & dosage, Amphotericin B therapeutic use, Animals, Female, Leishmaniasis, Cutaneous pathology, Leishmaniasis, Visceral pathology, Mice, Mice, Inbred BALB C, Amphotericin B analogs & derivatives, Antifungal Agents therapeutic use, Leishmania donovani, Leishmania mexicana, Leishmaniasis, Cutaneous drug therapy, Leishmaniasis, Visceral drug therapy
- Abstract
Current therapy for leishmaniasis is unsatisfactory because parenteral antimonial salts and pentamidine are associated with significant toxicity and failure rates. We examined the efficacy of KY62, a new, water-soluble, polyene antifungal, against cutaneous infection with Leishmania amazonensis and against visceral infection with Leishmania donovani in susceptible BALB/c mice. Mice were infected with L. amazonensis promastigotes in the ear pinna and in the tail and were treated with KY62 or amphotericin B. The cutaneous lesions showed a remarkable response to therapy with KY62 at a dose of 30 mg per kg of body weight per day. At this dose, the efficacy of KY62 was equivalent to or better than that of amphotericin B at 1 to 5 mg/kg/day. Mice infected intravenously with 10(7) L. donovani promastigotes and treated with KY62 showed a 4-log reduction in the parasite burden in the liver and spleen compared to untreated mice. These studies indicate potent activity of KY62 against experimental cutaneous leishmaniasis caused by L. amazoniensis and against experimental visceral leishmaniasis caused by L. donovani.
- Published
- 1998
- Full Text
- View/download PDF
23. Breast abscess caused by Brucella melitensis.
- Author
-
Al Abdely HM, Halim MA, and Amin TM
- Subjects
- Abscess drug therapy, Adult, Anti-Bacterial Agents therapeutic use, Breast Diseases drug therapy, Brucellosis drug therapy, Doxycycline therapeutic use, Drug Therapy, Combination, Female, Humans, Saudi Arabia, Trimethoprim, Sulfamethoxazole Drug Combination therapeutic use, Abscess microbiology, Breast Diseases microbiology, Brucella melitensis isolation & purification, Brucellosis microbiology
- Abstract
Cutaneous and soft tissue lesions are uncommon manifestations of brucellosis. Though breast involvement in animal brucellosis is not uncommon, involvement of the breast in human brucellosis is extremely rare. We report a case of breast abscess in a 39-year-old female caused by Brucella melitensis. Treatment with combination of trimethoprim/sulphamethoxazole (TMP/ SMX; cotrimoxazole) and doxycycline for 3 months resulted in clinical cure.
- Published
- 1996
- Full Text
- View/download PDF
24. Impaired elimination of atenolol in a nephropathic patient with self-medication overdose.
- Author
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el-Yazigi A, Bouchama A, al-Abdely H, Yusuf A, and Sieck JO
- Subjects
- Atenolol adverse effects, Atenolol blood, Diabetes Mellitus, Type 2 complications, Drug Overdose, Female, Humans, Hypertension metabolism, Metabolic Clearance Rate, Middle Aged, Renal Insufficiency complications, Atenolol metabolism, Hypertension drug therapy, Renal Insufficiency metabolism, Self Medication
- Abstract
A case of intoxication with atenolol (plasma concentration of 2.71 mg/L) caused by an improper self-medication combined with impaired renal function is presented. The patient was supported with atropine, isoproterenol, dopamine, and dobutamine, and a thorough pharmacokinetic monitoring of atenolol was conducted. As the serum creatinine concentration returned slowly to baseline with good diuresis, the concentration of atenolol decreased (biologic half-life = 2.95 days) and the blood pressure gradually recovered. The patient improved and was subsequently discharged in good health. Had pharmacokinetic monitoring of atenolol not been performed, hemodialysis would have been indicated.
- Published
- 1993
- Full Text
- View/download PDF
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