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273 results on '"Al-Ani, Mohammad"'

12. Patent Foramen Ovale and Hypoxemia

Author

Mojadidi, Mohammad K, Ruiz, Juan C, Chertoff, Jason, Zaman, Muhammad O, Elgendy, Islam Y, Mahmoud, Ahmed N, Al-Ani, Mohammad, Elgendy, Akram Y, Patel, Nimesh K, Shantha, Ghanshyam, Tobis, Jonathan M, and Meier, Bernhard

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Clinical Research, Heart Disease, Lung, Cardiovascular, 2.1 Biological and endogenous factors, Aetiology, Endovascular Procedures, Foramen Ovale, Patent, Humans, Hypoxia, patent foramen ovale, hypoxemia, right-to-left shunt, chronic obstructive pulmonary disease, sleep apnea, platypnea-orthodeoxia, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

Patent foramen ovale (PFO), an embryonic remnant of the fetal circulation, is present in 20-25% of adults. Although recent observational studies and clinical trials have established the link between PFO-mediated right-to-left shunting with cryptogenic stroke and migraine with aura, the role of a PFO in exacerbating hypoxemic medical conditions (ie, sleep apnea, chronic obstructive pulmonary disease, pulmonary hypertension, platypnea-orthodeoxia, pulmonary arteriovenous malformation, high-altitude pulmonary edema, and exercise desaturation) remains less understood. PFO-mediated hypoxemia occurs when deoxygenated venous blood from the right atrium enters and mixes with oxygenated arterial blood in the left atrium. Patients with an intracardiac right-to-left shunt may have profound hypoxemia out of proportion to underlying primary lung disease, even in the presence of normal right-sided pressures. The presence of right-to-left cardiac shunting can exacerbate the degree of hypoxemia in patients with underlying pulmonary disorders. In a subset of these patients, percutaneous PFO closure may result in marked improvement in dyspnea and hypoxemia. This review discusses the association between PFO-mediated right-to-left shunting with medical conditions associated with hypoxemia and explores the role of percutaneous PFO closure in alleviating the hypoxemia.

Published
2019

23. Reconsidering FDA Guidelines: A Single-Center Experience of Prolonged Impella 5.5 Support

Author

Valdes, Carlos Alberto, primary, Stinson, Griffin, additional, Sharaf, Omar M., additional, Jimenez Contreras, Fabian, additional, Bilgili, Ahmet, additional, Ahmed, Mustafa M., additional, Vilaro, Juan, additional, Parker, Alex M., additional, Al-Ani, Mohammad A. Z., additional, Demos, Daniel, additional, Aranda, Juan, additional, Bleiweis, Mark, additional, Beaver, Thomas M., additional, and Jeng, Eric I., additional

Published
2023
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40. Serpins, Viruses, and the Virome: New Directions in Therapy

Author

Ambadapadi, Sriram, Chen, Hao, Zheng, Donghang, Liu, Liying, Dai, Erbin, Munuswamy-Ramanujam, Ganesh, Morshed, Sufi, Fuentes, Jorge, Fortunel, Adisson, Al-Ani, Mohammad, Kesavalu, Lakshmyya, McFadden, Grant, Lucas, Alexandra, Geiger, Margarethe, editor, Wahlmüller, Felix, editor, and Furtmüller, Margareta, editor

Published
2015
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50. Quantitative Computed Tomography: What Clinical Questions Can it Answer in Chronic Lung Disease?

Author

Marcelo Cardoso Barros, Stephan Altmayer, Alysson Roncally Carvalho, Rosana Rodrigues, Matheus Zanon, Tan-Lucien Mohammed, Pratik Patel, Al-Ani Mohammad, Borna Mehrad, Jose Miguel Chatkin, and Bruno Hochhegger

Subjects
Pulmonary and Respiratory Medicine, Lung Diseases, Observer Variation, Humans, Tomography, X-Ray Computed, Lung, Respiratory Function Tests
Abstract

Quantitative computed tomography (QCT) has recently gained an important role in the functional assessment of chronic lung disease. Its capacity in diagnostic, staging, and prognostic evaluation in this setting is similar to that of traditional pulmonary function testing. Furthermore, it can demonstrate lung injury before the alteration of pulmonary function test parameters, and it enables the classification of disease phenotypes, contributing to the customization of therapy and performance of comparative studies without the intra- and inter-observer variation that occurs with qualitative analysis. In this review, we address technical issues with QCT analysis and demonstrate the ability of this modality to answer clinical questions encountered in daily practice in the management of patients with chronic lung disease.

Published
2022

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