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11 results on '"Al-Batanyeh, KM"'

1. Designing and Synthesis of Green Polymeric Nanomaterials for Pharmaceutical Applications

Author

Aljabali, AAA, Zoubi, MSA, Al-Batanyeh, KM, Alqudah, A, Obeid, MA, Prasher, P, Mishra, V, Gupta, G, Negi, P, Kapoor, DN, Dureja, H, Satija, S, Chellappan, DK, Dua, K, Tambuwala, MM, Aljabali, AAA, Zoubi, MSA, Al-Batanyeh, KM, Alqudah, A, Obeid, MA, Prasher, P, Mishra, V, Gupta, G, Negi, P, Kapoor, DN, Dureja, H, Satija, S, Chellappan, DK, Dua, K, and Tambuwala, MM

Abstract

Nanotechnology provides areas that vary from conventional chemistry innovations to medical and climate technologies with productive applications. In practice, NPs have been synthesized by physical and chemical processes, including hydrothermal pyrolysis, spray pyrolysis, sonochemical, sol-gel, coprecipitation, and so on, using different chemical agents to minimize and maintain the harsh conditions of different chemicals to control the properties of the generated nanomaterials. NPs have been used as toxic agents. Biological synthesis is emerging as a green and safe method for synthesizing metal/metal oxide NPs with precursor materials from plants and microbes. Green synthesis of nanomaterials has emerged as an eco-friendly and alternative approach for the synthesis of novel nano-materials with great potential in medical and pharmaceutical applications. The nanomaterials generated from biomolecules, plant extract, algae, and microorganisms have been given considerable appreciation. It is believed the phytochemicals, alkaloids, flavonoids, and sugar compounds content to act as reducing and stabilization agents to prevent the agglomeration of the nanoparticles.

Published
2022

2. Correction: Aljabali, A.A.A.; et al. Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer via down Regulation of Nuclear p65 and HIF-1α. Cancers 2020, 12, 113

Author

Aljabali, AAA, Bakshi, HA, Hakkim, FL, Haggag, YA, Al-Batanyeh, KM, Zoubi, MSA, Al-Trad, B, Nasef, MM, Satija, S, Mehta, M, Pabreja, K, Mishra, V, Khan, M, Abobaker, S, Azzouz, IM, Dureja, H, Pabari, RM, Dardouri, AAK, Kesharwani, P, Gupta, G, Dhar Shukla, S, Prasher, P, Charbe, NB, Negi, P, Kapoor, DN, Chellappan, DK, Webba da Silva, M, Thompson, P, Dua, K, McCarron, P, and Tambuwala, MM

Subjects
1112 Oncology and Carcinogenesis
Abstract

The authors wish to make the following corrections to this paper [...].

Published
2020

3. Bioinspired Nanomaterials for Improving Sensing and Imaging Spectroscopy

Author

Pal, K, Qar, J, Aljabali, AAA, Al-Zanati, T, Al Zoubi, MS, Al-Batanyeh, KM, Negi, P, Gupta, G, Pardhi, DM, Dua, K, Tambuwala, MM, Pal, K, Qar, J, Aljabali, AAA, Al-Zanati, T, Al Zoubi, MS, Al-Batanyeh, KM, Negi, P, Gupta, G, Pardhi, DM, Dua, K, and Tambuwala, MM

Published
2021

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Author

Aljabali, AAA, Bakshi, HA, Hakkim, FL, Haggag, YA, Al-Batanyeh, KM, Al Zoubi, MS, Al-Trad, B, Nasef, MM, Satija, S, Mehta, M, Pabreja, K, Mishra, V, Khan, M, Abobaker, S, Azzouz, IM, Dureja, H, Pabari, RM, Dardouri, AAK, Kesharwani, P, Gupta, G, Dhar Shukla, S, Prasher, P, Charbe, NB, Negi, P, Kapoor, DN, Chellappan, DK, Webba da Silva, M, Thompson, P, Dua, K, McCarron, P, Tambuwala, MM, Aljabali, AAA, Bakshi, HA, Hakkim, FL, Haggag, YA, Al-Batanyeh, KM, Al Zoubi, MS, Al-Trad, B, Nasef, MM, Satija, S, Mehta, M, Pabreja, K, Mishra, V, Khan, M, Abobaker, S, Azzouz, IM, Dureja, H, Pabari, RM, Dardouri, AAK, Kesharwani, P, Gupta, G, Dhar Shukla, S, Prasher, P, Charbe, NB, Negi, P, Kapoor, DN, Chellappan, DK, Webba da Silva, M, Thompson, P, Dua, K, McCarron, P, and Tambuwala, MM

Published
2020

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Author

Aljabali, AAA, Bakshi, HA, Hakkim, FL, Haggag, YA, Al-Batanyeh, KM, Zoubi, MSA, Al-Trad, B, Nasef, MM, Satija, S, Mehta, M, Pabreja, K, Mishra, V, Khan, M, Abobaker, S, Azzouz, IM, Dureja, H, Pabari, RM, Dardouri, AAK, Kesharwani, P, Gupta, G, Dhar Shukla, S, Prasher, P, Charbe, NB, Negi, P, Kapoor, DN, Chellappan, DK, Webba da Silva, M, Thompson, P, Dua, K, McCarron, P, Tambuwala, MM, Aljabali, AAA, Bakshi, HA, Hakkim, FL, Haggag, YA, Al-Batanyeh, KM, Zoubi, MSA, Al-Trad, B, Nasef, MM, Satija, S, Mehta, M, Pabreja, K, Mishra, V, Khan, M, Abobaker, S, Azzouz, IM, Dureja, H, Pabari, RM, Dardouri, AAK, Kesharwani, P, Gupta, G, Dhar Shukla, S, Prasher, P, Charbe, NB, Negi, P, Kapoor, DN, Chellappan, DK, Webba da Silva, M, Thompson, P, Dua, K, McCarron, P, and Tambuwala, MM

Abstract

The authors wish to make the following corrections to this paper [...].

Published
2020

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Author

Aljabali, AAA, Bakshi, HA, Hakkim, FL, Haggag, YA, Al-Batanyeh, KM, Zoubi, MSA, Al-Trad, B, Nasef, MM, Satija, S, Mehta, M, Pabreja, K, Mishra, V, Khan, M, Abobaker, S, Azzouz, IM, Dureja, H, Pabari, RM, Dardouri, AAK, Kesharwani, P, Gupta, G, Dhar Shukla, S, Prasher, P, Charbe, NB, Negi, P, Kapoor, DN, Chellappan, DK, Webba da Silva, M, Thompson, P, Dua, K, McCarron, P, Tambuwala, MM, Aljabali, AAA, Bakshi, HA, Hakkim, FL, Haggag, YA, Al-Batanyeh, KM, Zoubi, MSA, Al-Trad, B, Nasef, MM, Satija, S, Mehta, M, Pabreja, K, Mishra, V, Khan, M, Abobaker, S, Azzouz, IM, Dureja, H, Pabari, RM, Dardouri, AAK, Kesharwani, P, Gupta, G, Dhar Shukla, S, Prasher, P, Charbe, NB, Negi, P, Kapoor, DN, Chellappan, DK, Webba da Silva, M, Thompson, P, Dua, K, McCarron, P, and Tambuwala, MM

Abstract

The authors wish to make the following corrections to this paper [...].

Published
2020

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Author

Aljabali, AAA, Bakshi, HA, Hakkim, FL, Haggag, YA, Al-Batanyeh, KM, Al Zoubi, MS, Al-Trad, B, Nasef, MM, Satija, S, Mehta, M, Pabreja, K, Mishra, V, Khan, M, Abobaker, S, Azzouz, IM, Dureja, H, Pabari, RM, Dardouri, AAK, Kesharwani, P, Gupta, G, Dhar Shukla, S, Prasher, P, Charbe, NB, Negi, P, Kapoor, DN, Chellappan, DK, Webba da Silva, M, Thompson, P, Dua, K, McCarron, P, Tambuwala, MM, Aljabali, AAA, Bakshi, HA, Hakkim, FL, Haggag, YA, Al-Batanyeh, KM, Al Zoubi, MS, Al-Trad, B, Nasef, MM, Satija, S, Mehta, M, Pabreja, K, Mishra, V, Khan, M, Abobaker, S, Azzouz, IM, Dureja, H, Pabari, RM, Dardouri, AAK, Kesharwani, P, Gupta, G, Dhar Shukla, S, Prasher, P, Charbe, NB, Negi, P, Kapoor, DN, Chellappan, DK, Webba da Silva, M, Thompson, P, Dua, K, McCarron, P, and Tambuwala, MM

Published
2020

8. Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage.

Author

Bakshi HA, Zoubi MSA, Faruck HL, Aljabali AAA, Rabi FA, Hafiz AA, Al-Batanyeh KM, Al-Trad B, Ansari P, Nasef MM, Charbe NB, Satija S, Mehta M, Mishra V, Gupta G, Abobaker S, Negi P, Azzouz IM, Dardouri AAK, Dureja H, Prasher P, Chellappan DK, Dua K, Silva MWD, Tanani ME, McCarron PA, M Tambuwala M, Bakshi HA, Zoubi MSA, Faruck HL, Aljabali AAA, Rabi FA, Hafiz AA, Al-Batanyeh KM, Al-Trad B, Ansari P, Nasef MM, Charbe NB, Satija S, Mehta M, Mishra V, Gupta G, Abobaker S, Negi P, Azzouz IM, Dardouri AAK, Dureja H, Prasher P, Chellappan DK, Dua K, Silva MWD, Tanani ME, McCarron PA, and M Tambuwala M

Abstract

Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer.

Published
2020

9. Correction: Aljabali, A.A.A.; et al. Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer via down Regulation of Nuclear p65 and HIF-1α. Cancers 2020, 12 , 113.

Author

Aljabali AAA, Bakshi HA, Hakkim FL, Haggag YA, Al-Batanyeh KM, Zoubi MSA, Al-Trad B, Nasef MM, Satija S, Mehta M, Pabreja K, Mishra V, Khan M, Abobaker S, Azzouz IM, Dureja H, Pabari RM, Dardouri AAK, Kesharwani P, Gupta G, Dhar Shukla S, Prasher P, Charbe NB, Negi P, Kapoor DN, Chellappan DK, Webba da Silva M, Thompson P, Dua K, McCarron P, and Tambuwala MM

Abstract

The authors wish to make the following corrections to this paper [...].

Published
2020
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10. Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer Via Downregulation of Nuclear p65 and HIF-1α.

Author

Aljabali AAA, Bakshi HA, Hakkim FL, Haggag YA, Al-Batanyeh KM, Al Zoubi MS, Al-Trad B, Nasef MM, Satija S, Mehta M, Pabreja K, Mishra V, Khan M, Abobaker S, Azzouz IM, Dureja H, Pabari RM, Dardouri AAK, Kesharwani P, Gupta G, Dhar Shukla S, Prasher P, Charbe NB, Negi P, Kapoor DN, Chellappan DK, Webba da Silva M, Thompson P, Dua K, McCarron P, and Tambuwala MM

Abstract

Piceatannol (PIC) is known to have anticancer activity, which has been attributed to its ability to block the proliferation of cancer cells via suppression of the NF-kB signaling pathway. However, its effect on hypoxia-inducible factor (HIF) is not well known in cancer. In this study, PIC was loaded into bovine serum albumin (BSA) by desolvation method as PIC-BSA nanoparticles (NPs). These PIC-BSA nanoparticles were assessed for in vitro cytotoxicity, migration, invasion, and colony formation studies and levels of p65 and HIF-1α. Our results indicate that PIC-BSA NPs were more effective in downregulating the expression of nuclear p65 and HIF-1α in colon cancer cells as compared to free PIC. We also observed a significant reduction in inflammation induced by chemical colitis in mice by PIC-BSA NPs. Furthermore, a significant reduction in tumor size and number of colon tumors was also observed in the murine model of colitis-associated colorectal cancer, when treated with PIC-BSA NPs as compared to free PIC. The overall results indicate that PIC, when formulated as PIC-BSA NPs, enhances its therpautice potential. Our work could prompt further research in using natural anticancer agents as nanoparticels with possiable human clinical trails. This could lead to the development of a new line of safe and effective therapeutics for cancer patients., Competing Interests: The authors declare no conflicts of interest.

Published
2020
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11. Gold-coated plant virus as computed tomography imaging contrast agent.

Author

Aljabali AAA, Zoubi MSA, Al-Batanyeh KM, Al-Radaideh A, Obeid MA, Al Sharabi A, Alshaer W, AbuFares B, Al-Zanati T, Tambuwala MM, Akbar N, and Evans DJ

Abstract

Chemical modification of the surface of viruses, both the interior and the exterior, imparts new functionalities, that have potential applications in nanomedicine. In this study, we developed novel virus-based nanomaterials as a contrast agent for computed tomography (CT) imaging in vitro. The gold-coated cowpea mosaic virus (Au-CPMV) particles were generated by the electrostatic adsorption of positively charged electrolyte on the virus capsid with the subsequent incubation and reduction of anionic gold complexes. Au-CPMV particles as a CT contrast agent offer a fast scan time (less than 2 min), low cost, and biocompatibility and allow for high-resolution imaging with ca. 150 Hounsfield units (HU). The Au-CPMV surface was further modified allowing for the incorporation of targeting molecules of specific cell types., (Copyright © 2019, Aljabali et al.; licensee Beilstein-Institut.)

Published
2019
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