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Your search keyword '"Al-Choboq, Joëlle"' showing total 13 results
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13 results on '"Al-Choboq, Joëlle"'

2. When Chromatin Decondensation Affects Nuclear γH2AX Foci Pattern and Kinetics and Biases the Assessment of DNA Double-Strand Breaks by Immunofluorescence.

Author

Granzotto, Adeline, El Nachef, Laura, Restier-Verlet, Juliette, Sonzogni, Laurène, Al-Choboq, Joëlle, Bourguignon, Michel, and Foray, Nicolas

Subjects
DOUBLE-strand DNA breaks, IMMUNOFLUORESCENCE, SODIUM butyrate, DNA repair, CELL cycle, BUTYRATES
Abstract

Immunofluorescence with antibodies against phosphorylated forms of H2AX (γH2AX) is revolutionizing our understanding of repair and signaling of DNA double-strand breaks (DSBs). Unfortunately, the pattern of γH2AX foci depends upon a number of parameters (nature of stress, number of foci, radiation dose, repair time, cell cycle phase, gene mutations, etc...) whose one of the common points is chromatin condensation/decondensation. Here, we endeavored to demonstrate how chromatin conformation affects γH2AX foci pattern and influences immunofluorescence signal. DSBs induced in non-transformed human fibroblasts were analyzed by γH2AX immunofluorescence with sodium butyrate treatment of chromatin applied after the irradiation that decondenses chromatin but does not induce DNA breaks. Our data showed that the pattern of γH2AX foci may drastically change with the experimental protocols in terms of size and brightness. Notably, some γH2AX minifoci resulting from the dispersion of the main signal due to chromatin decondensation may bias the quantification of the number of DSBs. We proposed a model called "Christmas light models" to tentatively explain this diversity of γH2AX foci pattern that may also be considered for any DNA damage marker that relocalizes as nuclear foci. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Influence of the Hypersensitivity to Low Dose Phenomenon on the Tumor Response to Hypofractionated Stereotactic Body Radiation Therapy

Author

Le Reun, Eymeric, primary, Granzotto, Adeline, additional, Pêtre, Adeline, additional, Bodgi, Larry, additional, Beldjoudi, Guillaume, additional, Lacornerie, Thomas, additional, Vallet, Véronique, additional, Bouchet, Audrey, additional, Al-Choboq, Joëlle, additional, Bourguignon, Michel, additional, Thariat, Juliette, additional, Bourhis, Jean, additional, Lartigau, Eric, additional, and Foray, Nicolas, additional

Published
2023
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6. Toward an Early Diagnosis for Alzheimer’s Disease Based on the Perinuclear Localization of the ATM Protein

Author

Berthel, Elise, primary, Pujo-Menjouet, Laurent, additional, Le Reun, Eymeric, additional, Sonzogni, Laurène, additional, Al-Choboq, Joëlle, additional, Chekroun, Abdennasser, additional, Granzotto, Adeline, additional, Devic, Clément, additional, Ferlazzo, Mélanie L., additional, Pereira, Sandrine, additional, Bourguignon, Michel, additional, and Foray, Nicolas, additional

Published
2023
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7. X-rays-Induced Bystander Effect Consists in the Formation of DNA Breaks in a Calcium-Dependent Manner: Influence of the Experimental Procedure and the Individual Factor

Author

Restier-Verlet, Juliette, primary, Joubert, Aurélie, additional, Ferlazzo, Mélanie L., additional, Granzotto, Adeline, additional, Sonzogni, Laurène, additional, Al-Choboq, Joëlle, additional, El Nachef, Laura, additional, Le Reun, Eymeric, additional, Bourguignon, Michel, additional, and Foray, Nicolas, additional

Published
2023
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8. Molecular Influence of the ATM Protein in the Treatment of Human Cells with Different Radioprotective Drugs: Comparisons between Antioxidative and Pro-Episkevic Strategies

Author

Restier-Verlet, Juliette, primary, Drouet, Michel, additional, Pras, Pauline, additional, Ferlazzo, Mélanie L., additional, Granzotto, Adeline, additional, Sonzogni, Laurène, additional, Al-Choboq, Joëlle, additional, El Nachef, Laura, additional, François, Sabine, additional, Bourguignon, Michel, additional, and Foray, Nicolas, additional

Published
2023
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9. Molecular and Cellular Responses to Ionization Radiation in Untransformed Fibroblasts from the Rothmund–Thomson Syndrome: Influence of the Nucleo-Shuttling of the ATM Protein Kinase

Author

Al-Choboq, Joëlle, primary, Nehal, Myriam, additional, Sonzogni, Laurène, additional, Granzotto, Adeline, additional, El Nachef, Laura, additional, Restier-Verlet, Juliette, additional, Maalouf, Mira, additional, Berthel, Elise, additional, Aral, Bernard, additional, Corradini, Nadège, additional, Bourguignon, Michel, additional, and Foray, Nicolas, additional

Published
2023
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10. Quantitative Correlations between Radiosensitivity Biomarkers Show That the ATM Protein Kinase Is Strongly Involved in the Radiotoxicities Observed after Radiotherapy

Author

Le Reun, Eymeric, primary, Bodgi, Larry, additional, Granzotto, Adeline, additional, Sonzogni, Laurène, additional, Ferlazzo, Mélanie L., additional, Al-Choboq, Joëlle, additional, El-Nachef, Laura, additional, Restier-Verlet, Juliette, additional, Berthel, Elise, additional, Devic, Clément, additional, Bouchet, Audrey, additional, Bourguignon, Michel, additional, and Foray, Nicolas, additional

Published
2022
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12. Individual Response to Radiation of Individuals with Neurofibromatosis Type I: Role of the ATM Protein and Influence of Statins and Bisphosphonates

Author

Combemale, Patrick, primary, Sonzogni, Laurène, additional, Devic, Clément, additional, Bencokova, Zuzana, additional, Ferlazzo, Mélanie Lydia, additional, Granzotto, Adeline, additional, Burlet, Steven Franck, additional, Pinson, Stéphane, additional, Amini-Adle, Mona, additional, Al-Choboq, Joëlle, additional, Bodgi, Larry, additional, Bourguignon, Michel, additional, Balosso, Jacques, additional, Bachelet, Jean-Thomas, additional, and Foray, Nicolas, additional

Published
2021
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