41 results on '"Al-Hajjaj, Mohamed S."'
Search Results
2. Altered respiratory microbiota composition and functionality associated with asthma early in life
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AL Bataineh, Mohammad T., Hamoudi, Rifat A., Dash, Nihar R., Ramakrishnan, Rakhee K., Almasalmeh, Mohamad A., Sharif, Hanan A., Al-Hajjaj, Mohamed S., and Hamid, Qutayba
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- 2020
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3. Differential expression of CCR2 and CX3CR1 on CD16+ monocyte subsets is associated with asthma severity
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Al-Rashoudi, Reem, Moir, Gillian, Al-Hajjaj, Mohamed S., Al-Alwan, Monther M., Wilson, Heather M., and Crane, Isabel J.
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- 2019
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4. The impact of environmental and climate parameters on the incidence and mortality of COVID-19 in the six Gulf Cooperation Council countries: A cross-country comparison study
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Saddik, Basema, primary, Awad, Manal A., additional, Al-Bluwi, Najlaa, additional, Hussein, Amal, additional, Shukla, Ankita, additional, Al-Shujairi, Arwa, additional, AlZubaidi, Hamzah, additional, Al-Hajjaj, Mohamed S., additional, Halwani, Rabih, additional, and Hamid, Qutayba, additional
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- 2022
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5. The prevalence and characteristics of water-pipe smoking among high school students in Saudi Arabia
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Al Moamary, Mohamed S., Al Ghobain, Mohamed A., Al Shehri, Sulieman N., Alfayez, Abdulrhman I., Gasmelseed, Ahmed Y., and Al-Hajjaj, Mohamed S.
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- 2012
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6. Asthma Associated Cytokines Regulate the Expression of SARS-CoV-2 Receptor ACE2 in the Lung Tissue of Asthmatic Patients
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Saheb Sharif-Askari, Fatemeh, primary, Goel, Swati, additional, Saheb Sharif-Askari, Narjes, additional, Hafezi, Shirin, additional, Al Heialy, Saba, additional, Hachim, Mahmood Yaseen, additional, Hachim, Ibrahim Yaseen, additional, Mahboub, Bassam, additional, Salameh, Laila, additional, Abdelrazig, Mawada, additional, Elzain, Eman Ibrahim, additional, Al-Muhsen, Saleh, additional, Al-Hajjaj, Mohamed S., additional, Ratemi, Elaref, additional, Hamid, Qutayba, additional, and Halwani, Rabih, additional
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- 2022
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7. Spirometric reference values for healthy nonsmoking Saudi adults
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Al Ghobain, Mohammed O., Alhamad, Esam H., Alorainy, Hassan S., Al Hazmi, Manal, Al Moamary, Mohamed S., Al-Hajjaj, Mohamed S., Idress, Majdy, Al-Jahdali, Hamdan, and Zeitouni, Mohammed
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- 2014
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8. Additional file 2 of Altered respiratory microbiota composition and functionality associated with asthma early in life
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Bataineh, Mohammad T. AL, Hamoudi, Rifat A., Nihar R. Dash, Ramakrishnan, Rakhee K., Almasalmeh, Mohamad A., Sharif, Hanan A., Al-Hajjaj, Mohamed S., and Qutayba Hamid
- Abstract
Additional file 2: Figure. S1. Analytical flowchart outlining data curation and metrics used for analysis. Figure. S2. Bacterial sequence curation and analysis. We sequenced 16Sv4 amplicons generated from DNA samples on a MiSeq. MiSeq-generated Fastq files were quality-filtered and clustered into 97% similarity operational taxonomic units (OTUs) using the mothur software package [ http://www.mothur.org ]. The per-base raw Q30 (Phred33) scores of the forward sequencing read are summarized (A). Sequencing quality for R1 and R2 was determined using FastQC 0.11.5, the per-sequence averaged raw Q30 (Phred33) scores of the forward sequencing read are summarized (B). Figure. S3. Fungal sequence curation and analysis. We sequenced ITS2 amplicons generated from DNA samples on a MiSeq. MiSeq-generated Fastq files were quality-filtered and clustered into 97% similarity operational taxonomic units (OTUs) using the mothur software package [ http://www.mothur.org ]. The per-base raw Q30 (Phred33) scores of the forward sequencing read are summarized (A). Sequencing quality for R1 and R2 was determined using FastQC 0.11.5, the per-sequence averaged raw Q30 (Phred33) scores of the forward sequencing read are summarized (B). Figure. S4. Aggregated taxonomic composition. High quality reads were classified using Greengenes v. 13_8 as the reference database for bactria and UNITE (v. 7.1) as the reference database for fungi. We aggregated OTUs into each taxonomic rank, the aggregated taxa were visualized at each taxanomic rank using taxanomic bar plots and plotted the relative abundance of the most abundant ones for bacteria (A) and Fungi (B). The unfilled portion of the bar plots represent lower-abundance taxa.
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- 2020
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9. The Saudi Thoracic Society guidelines for influenza vaccinations
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Zeitouni, Mohammed O., Al Barrak, Ali M., Al-Moamary, Mohamed S., Alharbi, Nasser S., Idrees, Majdy M., Al Shimemeri, Abdullah A., and Al-Hajjaj, Mohamed S.
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lcsh:RC705-779 ,lcsh:Diseases of the circulatory (Cardiovascular) system ,lcsh:RC666-701 ,Hajj ,Umrah ,Saudi Arabia ,lcsh:Diseases of the respiratory system ,Guidelines ,vaccination ,Influenza - Abstract
Influenza viruses are responsible for the influenza outbreaks that lead to significant burden and cause significant morbidity and mortality worldwide. Based on the core proteins, influenza viruses are classified into three types, A, B, and C, of which only A and B cause significant human disease and so the vaccine is directed against these two subtypes only. The effectiveness of the vaccine depends on boosting the immune system against the serotypes included within it. As influenza viruses undergo periodic changes in their antigen, the vaccine is modified annually to ensure susceptibility. In contrast to other countries, Saudi Arabia faces a unique and challenging situation due to Hajj and Umrah seasons, when millions of people gather at the holy places in Mecca and Madinah, during which influenza outbreaks are commonly found. Such challenges making the adoption of strict vaccination strategy in Saudi Arabia is of great importance. All efforts were made to develop this guideline in an easy-to-read form, making it very handy and easy to use by health care workers. The guideline was designed to provide recommendations for problems frequently encountered in real life, with special consideration for special situations such as Hajj and Umrah seasons and pregnancy.
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- 2015
10. Thromboprophylaxis and mortality among patients who developed venous thromboembolism in seven major hospitals in Saudi Arabia.
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Al-Hameed, Fahad M., Al-Dorzi, Hasan M., Qadhi, Abdulelah I., Shaker, Amira, Al-Gahtani, Farjah H., Al-Jassir, Fawzi F., Zahir, Galila F., Al-Khuwaitir, Tarig S., Addar, Mohammed H., Al-Hajjaj, Mohamed S., Abdelaal, Mohamed A., and Aboelnazar, Essam Y.
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ANTICOAGULANTS ,CONFIDENCE intervals ,DRUG prescribing ,PROBABILITY theory ,PULMONARY embolism ,THROMBOEMBOLISM ,VENOUS thrombosis ,VEINS ,PHYSICIAN practice patterns ,DATA analysis software ,DESCRIPTIVE statistics - Abstract
INTRODUCTION: Venous thromboembolism (VTE) during hospitalization is a serious and potentially fatal condition. Despite its effectiveness, evidence-based thromboprophylaxis is still underutilized in many countries including Saudi Arabia. OBJECTIVE OF THE STUDY: Our objectives were to determine how often hospital-acquired VTE patients received appropriate thromboprophylaxis, VTE-associated mortality, and the percentage of patients given anticoagulant therapy and adherence to it after discharged. METHODS: This study was conducted in seven major hospitals in Saudi Arabia. From July 1, 2009, till June 30, 2010, all recorded deep vein thrombosis (DVT) and pulmonary embolism (PE) cases were noted. Only patients with confirmed VTE diagnosis were included in the analysis. RESULTS: A total of 1241 confirmed VTE cases occurred during the 12-month period. Most (58.3%) of them were DVT only, 21.7% were PE, and 20% were both DVT and PE. 21.4% and 78.6% of confirmed VTE occurred in surgical and medical patients, respectively. Only 40.9% of VTE cases received appropriate prophylaxis (63.2% for surgical patients and 34.8% for medical patients; P < 0.001). The mortality rate was 14.3% which represented 1.6% of total hospital deaths. Mortality was 13.5% for surgical patients and 14.5% for medical patients (P > 0.05). Appropriate thromboprophylaxis was associated with 4.11% absolute risk reduction in mortality (95% confidence interval: 0.24%–7.97%). Most (89.4%) of the survived patients received anticoagulation therapy at discharge and 71.7% of them were adherent to it on follow-up. CONCLUSION: Thromboprophylaxis was underutilized in major Saudi hospitals denoting a gap between guideline and practice. This gap was more marked in medical than surgical patients. Hospital-acquired VTE was associated with significant mortality. Efforts to improve thromboprophylaxis utilization are warranted. [ABSTRACT FROM AUTHOR]
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- 2017
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11. Joint statement for the diagnosis, management, and prevention of chronic obstructive pulmonary disease for Gulf Cooperation Council countries and Middle East-North Africa region, 2017.
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Mahboub, Bassam H., Vats, Mayank Gian, Al Zaabi, Ashraf, Iqbal, Mohammed Nizam, Safwat, Tarek, Al-Hurish, Fatma, Miravitlles, Marc, Singh, Dave, Asad, Khaled, Zeineldine, Salah, and Al-Hajjaj, Mohamed S.
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- 2017
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12. The Saudi Thoracic Society guidelines for diagnosis and management of noncystic fibrosis bronchiectasis.
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Al-Jahdali, Hamdan, Alshimemeri, Abdullah, Mobeireek, Abdullah, Albanna, Amr S., Shirawi, Nehad N. Al, Wali, Siraj, Alkattan, Khaled, Alrajhi, Abdulrahman A., Mobaireek, Khalid, Alorainy, Hassan S., Al-Hajjaj, Mohamed S., Chang, Anne B., and Aliberti, Stefano
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BRONCHIECTASIS ,MEDICAL personnel ,MEDICAL protocols ,PATIENTS ,GENERAL practitioners ,DISEASE management ,DIAGNOSIS ,THERAPEUTICS - Abstract
This is the first guideline developed by the Saudi Thoracic Society for the diagnosis and management of noncystic fibrosis bronchiectasis. Local experts including pulmonologists, infectious disease specialists, thoracic surgeons, respiratory therapists, and others from adult and pediatric departments provided the best practice evidence recommendations based on the available international and local literature. The main objective of this guideline is to utilize the current published evidence to develop recommendations about management of bronchiectasis suitable to our local health-care system and available resources. We aim to provide clinicians with tools to standardize the diagnosis and management of bronchiectasis. This guideline targets primary care physicians, family medicine practitioners, practicing internists and respiratory physicians, and all other health-care providers involved in the care of the patients with bronchiectasis. [ABSTRACT FROM AUTHOR]
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- 2017
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13. Factors leading to refractory asthma in patients from Saudi Arabia.
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Al-Moamary, Amal M., Al-Hajjaj, Mohamed S., and Al Moamary, Mohamed S.
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ASTHMA treatment , *ASTHMA risk factors , *ASTHMA - Abstract
AIM: The aim of this study was to study the clinical characteristic of patient with refractory asthma (RA) from Saudi Arabia. METHODS: This paper prospectively studied in a university hospital factors leading to RA in a cohort of patients who have inadequately controlled asthma or with frequent exacerbations despite optimum controller therapy. It also studied patients with asthma that requires extended periods of oral steroids to control. RESULTS: The mean age was 45.1 years (±9.1) where 74 patients were enrolled in this study with the age group (37–48 years) is having the highest percentage (64.8%). Female patients represented 62.2%. The two major comorbid conditions were allergic rhinitis (54.1%) and gastroesophageal reflux (33.8%). The vast majority (72 patients) had at least one trigger factor for asthma (97.3%). The asthma control test showed that 86.4% had an uncontrolled status. Spirometry showed mild disease in 9.5%, moderate in 47.3%, and severe in 43.2%. Eosinophilia was seen in only 16.2%. Immunoglobulin E level between 70 and 700 μg/L was found in 58.1% of patients. CONCLUSION: RA has certain clinical characteristics and associated comorbid conditions as well as precipitating factors that facilitate the identifications of these cases. [ABSTRACT FROM AUTHOR]
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- 2017
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14. Spirometric reference values for healthy nonsmoking Saudi adults
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Al Ghobain, Mohammed O., primary, Alhamad, Esam H., additional, Alorainy, Hassan S., additional, Al Hazmi, Manal, additional, Al Moamary, Mohamed S., additional, Al-Hajjaj, Mohamed S., additional, Idress, Majdy, additional, Al-Jahdali, Hamdan, additional, and Zeitouni, Mohammed, additional
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- 2013
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15. The Saudi Thoracic Society pneumococcal vaccination guidelines-2016.
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Alharbi, N. S., Al-Barrak, A. M., Al-Moamary, M. S., Zeitouni, M. O., Idrees, M. M., Al-Ghobain, M. O., Al-Shimemeri, A. A., and Al-Hajjaj, Mohamed S.
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STREPTOCOCCAL disease diagnosis ,MEDICAL protocols ,CHEST diseases ,DIFFERENTIAL diagnosis ,ISLAM ,PNEUMOCOCCAL vaccines ,RESEARCH funding ,STREPTOCOCCAL diseases ,TIME ,TRAVEL hygiene ,SYSTEMATIC reviews ,RETROSPECTIVE studies ,INFECTIOUS disease transmission - Abstract
Streptococcus pneumoniae (pneumococcus) is the leading cause of morbidity and mortality worldwide. Saudi Arabia is a host to millions of pilgrims who travel annually from all over the world for Umrah and the Hajj pilgrimages and are at risk of developing pneumococcal pneumonia or invasive pneumococcal disease (IPD). There is also the risk of transmission of S. pneumoniae including antibiotic resistant strains between pilgrims and their potential global spread upon their return. The country also has unique challenges posed by susceptible population to IPD due to people with hemoglobinopathies, younger age groups with chronic conditions, and growing problem of antibiotic resistance. Since the epidemiology of pneumococcal disease is constantly changing, with an increase in nonvaccine pneumococcal serotypes, vaccination policies on the effectiveness and usefulness of vaccines require regular revision. As part of the Saudi Thoracic Society (STS) commitment to promote the best practices in the field of respiratory diseases, we conducted a review of S. pneumoniae infections and the best evidence base available in the literature. The aim of the present study is to develop the STS pneumococcal vaccination guidelines for healthcare workers in Saudi Arabia. We recommend vaccination against pneumococcal infections for all children <5 years old, adults ≥50 years old, and people ≥6 years old with certain risk factors. These recommendations are based on the presence of a large number of comorbidities in Saudi Arabia population <50 years of age, many of whom have risk factors for contracting pneumococcal infections. A section for pneumococcal vaccination before the Umrah and Hajj pilgrimages is included as well. [ABSTRACT FROM AUTHOR]
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- 2016
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16. The Saudi Initiative for Asthma - 2016 update: Guidelines for the diagnosis and management of asthma in adults and children.
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Al-Moamary, Mohamed S., Alhaider, Sami A., Idrees, Majdy M., Al Ghobain, Mohammed O., Zeitouni, Mohammed O., Al-Harbi, Adel S., Yousef, Abdullah A., Al-Matar, Hussain, Alorainy, Hassan S., and Al-Hajjaj, Mohamed S.
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ASTHMA treatment ,ASTHMA diagnosis ,ASTHMA ,MEDICAL protocols ,EVALUATION of human services programs - Abstract
This is an updated guideline for the diagnosis and management of asthma, developed by the Saudi Initiative for Asthma (SINA) group, a subsidiary of the Saudi Thoracic Society. The main objective of SINA is to have guidelines that are up to date, simple to understand and easy to use by nonasthma specialists, including primary care and general practice physicians. SINA approach is mainly based on symptom control and assessment of risk as it is the ultimate goal of treatment. The new SINA guidelines include updates of acute and chronic asthma management, with more emphasis on the use of asthma control in the management of asthma in adults and children, inclusion of a new medication appendix, and keeping consistency on the management at different age groups. The section on asthma in children is rewritten and expanded where the approach is stratified based on the age. The guidelines are constructed based on the available evidence, local literature, and the current situation in Saudi Arabia. There is also an emphasis on patient–doctor partnership in the management that also includes a self-management plan. [ABSTRACT FROM AUTHOR]
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- 2016
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17. Prevalence of chronic obstructive pulmonary disease among smokers attending primary healthcare clinics in Saudi Arabia
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Al Ghobain, Mohammed, primary, Al-Hajjaj, Mohamed S., additional, and Wali, Siraj Omar, additional
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- 2011
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18. The Saudi clinical practice guideline for the diagnosis of the first deep venous thrombosis of the lower extremity.
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Al-Hameed, Fahad, Al-Dorzi, Hasan M., Shamy, Abdulrahman, Qadi, Abdulelah, Bakhsh, Ebtisam, Aboelnazar, Essam, Abdelaal, Mohamad, Al Khuwaitir, Tarig, Al-Moamary, Mohamed S., Al-Hajjaj, Mohamed S., Brozek, Jan, Schünemann, Holger, Mustafa, Reem, and Falavigna, Maicon
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VENOUS thrombosis diagnosis ,THROMBOEMBOLISM ,VEINS ,DIFFERENTIAL diagnosis ,ENZYME-linked immunosorbent assay ,LEG ,MEDICAL protocols ,DIAGNOSIS - Abstract
The diagnosis of deep venous thrombosis (DVT) may be challenging due to the inaccuracy of clinical assessment and diversity of diagnostic tests. On one hand, missed diagnosis may result in life-threatening conditions. On the other hand, unnecessary treatment may lead to serious complications. As a result of an initiative of the Ministry of Health of the Kingdom of Saudi Arabia (KSA), an expert panel led by the Saudi Association for Venous Thrombo-Embolism (SAVTE; a subsidiary of the Saudi Thoracic Society) with the methodological support of the McMaster University Working Group, produced this clinical practice guideline to assist healthcare providers in evidence-based clinical decision-making for the diagnosis of a suspected first DVT of the lower extremity. Twenty-four questions were identified and corresponding recommendations were made following the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. These recommendations included assessing the clinical probability of DVT using Wells criteria before requesting any test and undergoing a sequential diagnostic evaluation, mainly using highly sensitive D-dimer by enzyme-linked immunosorbent assay (ELISA) and compression ultrasound. Although venography is the reference standard test for the diagnosis of DVT, its use was not recommended. [ABSTRACT FROM AUTHOR]
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- 2015
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19. Bronchiectasis and Mediastinal Neurofibroma in a Saudi Female with Ehlers-Danlos Syndrome
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Al-Hajjaj, Mohamed S., primary
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- 2000
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20. The Outcome of Tuberculosis Treatment after Implementation of the National Tuberculosis Control Program in Saudi Arabia
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Al-Hajjaj, Mohamed S., primary
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- 2000
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21. IL-4 receptor alpha single-nucleotide polymorphisms rs1805010 and rs1801275 are associated with increased risk of asthma in a Saudi Arabian population.
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Al-Muhsen, Saleh, Vazquez-Tello, Alejandro, Alzaabi, Ashraf, Al-Hajjaj, Mohamed S., Al-Jahdali, Hamdan H., and Halwani, Rabih
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ASTHMA risk factors ,CHI-squared test ,STATISTICAL correlation ,GENES ,GENETIC polymorphisms ,POLYMERASE chain reaction ,RESEARCH funding - Abstract
BACKGROUND: The IL-4 receptor alpha subunit (IL-4Rα), when associated with the common gamma chain receptor, or the IL-13Rα1 subunit, transduces signals to STAT6 in response to IL-4 and IL-13 stimulations. This results in a number of cell-specific responses including Th2 differentiation, lymphocyte proliferation and IgE production. Given the prominent role of IL-4Rα in allergic disorders, several single-nucleotide polymorphisms (SNPs) have been found associated with asthma and other atopic disorders, including rs1805010 (I75V) and rs1801275 (Q576R) SNPs; however, lack of significant association have also been reported for some ethnic groups. The objective of this study was to determine whether IL-4Rα rs1805010 and rs1801275 polymorphisms are associated with asthma in patients from Saudi Arabia. MATERIALS AND METHODS: One hundred and ninety severe asthmatic patients (11-70 years old) and 194 healthy subjects of equivalent age range were recruited for blood donation. DNA was purified and genotyping for rs1801275 and rs1805010 polymorphisms in the IL-4Rα gene was performed by PCR amplification, followed by cycle sequencing of the purified PCR fragments using BigDye chain terminator and capillary electrophoresis. RESULTS: Pearson's Chi-square tests showed that the minor alleles, G, for both rs1805010 and rs1801275 SNPs, were significantly more frequent in asthmatics than in the healthy group (Yates' P < 0.05); conversely, the major alleles, A, were significantly more frequent in healthy than in asthmatics (P < 0.05). Concerning association analysis, odds for A/G-G/G genotypes were significantly higher to be associated with asthma predisposition (rs1801275: OR = 2.12; 95% CI = 1.39-3.22; P < 0.001*; rs1805010: OR = 1.6; 95% CI = 1.01-2.53; P < 0.05*; dominant model). Analysis of gender-genotype interactions, with genders nested within A/G-G/G, indicated higher odds for females than males of significant association with asthma (rs1801275: OR = 5.19, 95% CI = 2.09-12.94*; rs1805010: OR = 3.73, 95% CI = 2.06-6.74*). Rs1805010 and rs1801275 were in linkage disequilibrium (D' = 0.27; P < 0.0004*), with G-G haplotype being more frequent in asthmatics than in healthy subjects (OR = 2.43, 95% CI = 1.59-3.71*). [ABSTRACT FROM AUTHOR]
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- 2014
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22. The Saudi Guidelines for the Diagnosis and Management of COPD.
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Khan, Javed H., S. Lababidi, Hani M., Al-Moamary, Mohamed S., Zeitouni, Mohammed O., AL-Jahdali, Hamdan H., Al-Amoudi, Omar S., Wali, Siraj O., Idrees, Majdy M., Al-Shimemri, Abdullah A., Al Ghobain, Mohammed O., Alorainy, Hassan S., and Al-Hajjaj, Mohamed S.
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OBSTRUCTIVE lung disease diagnosis ,MEDICAL protocols - Abstract
The Saudi Thoracic Society (STS) launched the Saudi Initiative for Chronic Airway Diseases (SICAD) to develop a guideline for the diagnosis and management of chronic obstructive pulmonary disease (COPD). This guideline is primarily aimed for internists and general practitioners. Though there is scanty epidemiological data related to COPD, the SICAD panel believes that COPD prevalence is increasing in Saudi Arabia due to increasing prevalence of tobacco smoking among men and women. To overcome the issue of underutilization of spirometry for diagnosing COPD, handheld spirometry is recommended to screen individuals at risk for COPD. A unique feature about this guideline is the simplified practical approach to classify COPD into three classes based on the symptoms as per COPD Assessment Test (CAT) and the risk of exacerbations and hospitalization. Those patients with low risk of exacerbation (<2 in the past year) can be classified as either Class I when they have less symptoms (CAT < 10) or Class II when they have more symptoms (CAT ≥ 10). High-risk COPD patients, as manifested with ≥2 exacerbation or hospitalization in the past year irrespective of the baseline symptoms, are classified as Class III. Class I and II patients require bronchodilators for symptom relief, while Class III patients are recommended to use medications that reduce the risks of exacerbations. The guideline recommends screening for co-morbidities and suggests a comprehensive management approach including pulmonary rehabilitation for those with a CAT score ≥10. The article also discusses the diagnosis and management of acute exacerbations in COPD. [ABSTRACT FROM AUTHOR]
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- 2014
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23. Outcome of pulmonary embolism and clinico-radiological predictors of mortality: Experience from a university hospital in Saudi Arabia.
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Al Otair, Hadil A. K., Al-Boukai, Ahmad A., Ibrahim, Gehan F., Al Shaikh, Mashael K., Mayet, Ahmed Y., and Al-Hajjaj, Mohamed S.
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THROMBOEMBOLISM ,VEINS ,OBESITY ,ACADEMIC medical centers ,ANGIOGRAPHY ,CHEST diseases ,CHI-squared test ,CONFIDENCE intervals ,DIAGNOSTIC imaging ,LONGITUDINAL method ,EVALUATION of medical care ,MEDICAL needs assessment ,MORTALITY ,PULMONARY embolism ,SERIAL publications ,COMORBIDITY ,DATA analysis ,DISCHARGE planning ,DATA analysis software ,ODDS ratio ,DIAGNOSIS - Abstract
OBJECTIVES: The objective of this study is to determine the outcome of pulmonary embolism (PE) and the clinico-radiological predictors of mortality in a university hospital setting. METHODS: A Prospective observational study conducted at King Khalid University Hospital, Riyadh Saudi Arabia between January 2009 and 2012. A total of 105 consecutive patients (49.9 ± 18.7 years) with PE diagnosed by computed tomography pulmonary angiography were followed until death or hospital discharge. RESULTS: Overall in hospital mortality rate was 8.6%, which is lower than other international reports. Two-thirds of patients developed PE during the hospitalization. The most common risk factors were surgery (35.2%), obesity (34.3%) and immobility (30.5%). The localization of the embolus was central in 32.4%, lobar in 19% and distal in 48.6%. A total of 26 patients (25%) had evidence of right ventricular strain and 14 (13.3%) were hypotensive. Multivariate analysis revealed that heart failure (Beta = −0.53, P < 0.001), palpitation (Beta = −0.24, P = 0.014) and high respiratory rate (Beta = −0.211, P < 0.036) were significant predictors of mortality. There was no significant difference in the localization of the embolus or obstruction score between survivors and non-survivors. CONCLUSION: The outcome of PE is improving; however, it remains an important risk factor for mortality in hospitalized patients. Congestive heart failure, tachypnea and tachycardia at presentation were associated with higher mortality. These factors need to be considered for risk stratification and management decisions of PE patients. Radiological quantification of clot burden was not a predictor of death. [ABSTRACT FROM AUTHOR]
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- 2014
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24. Pulmonary rehabilitation: A regional perspective evidenced-based review.
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Al Moamary, Mohamed S., Aloriny, Hassan, and AL-Hajjaj, Mohamed S.
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MEDICAL rehabilitation ,CHEST disease diagnosis ,LUNG disease diagnosis ,OBSTRUCTIVE lung disease diagnosis ,AIR travel ,BEHAVIOR modification ,CHRONIC diseases ,EXERCISE ,LUNG diseases ,MEDICAL care ,EVALUATION of medical care ,MEDICAL needs assessment ,NUTRITION ,OXYGEN ,PATIENTS ,EVIDENCE-based medicine - Abstract
Pulmonary rehabilitation (PR) is an integral component of the comprehensive management plan of patients with chronic lung diseases by addressing their functional and psychological deficits. PR is generally recommended to symptomatic patients with chronic lung diseases who develop shortness of breath on their own pace at level ground while receiving optimum therapy. From a regional perspective, this review covers the description of a PR program, its establishment and outcome assessment. [ABSTRACT FROM AUTHOR]
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- 2014
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25. Evaluation of the Teratogenic Potential of Pyrazinamide in Wistar Rats
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Al-Hajjaj, MS, primary, Al-Hajjaj, Mohamed S., additional, and Islam, MW, additional
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- 1999
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26. The Saudi initiative for asthma--2012 update: Guidelines for the diagnosis and management of asthma in adults and children.
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Al-Moamary, Mohamed S., Alhaider, Sami A., Al-Hajjaj, Mohamed S., Al-Ghobain, Mohammed O., Idrees, Majdy M., Zeitouni, Mohammed O., Al-Harbi, Adel S., Al Dabbagh, Maha M., Al-Matar, Hussain, and Alorainy, Hassan S.
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ASTHMA treatment ,ASTHMA diagnosis ,ASTHMA prevention ,DIAGNOSIS methods ,ASTHMA ,MEDICAL protocols - Abstract
This an updated guidelines for the diagnosis and management of asthma, developed by the Saudi Initiative for Asthma (SINA) group, a subsidiary of the Saudi Thoracic Society. The main objective of SINA is to have updated guidelines, which are simple to understand and easy to use by non-asthma specialists, including primary care and general practice physicians. This new version includes updates of acute and chronic asthma management, with more emphasis on the use of Asthma Control Test in the management of asthma, and a new section on "difficult-to-treat asthma." Further, the section on asthma in children was re-written to cover different aspects in this age group. The SINA panel is a group of Saudi experts with well-respected academic backgrounds and experience in the field of asthma. The guidelines are formatted based on the available evidence, local literature, and the current situation in Saudi Arabia. There was an emphasis on patient-doctor partnership in the management that also includes a self-management plan. The approach adopted by the SINA group is mainly based on disease control as it is the ultimate goal of treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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27. Predicting tobacco use among high school students by using the global youth tobacco survey in Riyadh, Saudi Arabia.
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Al Moamary, Mohamed S., Al Ghobain, Mohammed O., Al Shehri, Sulieman N., Gasmelseed, Ahmed Y., and Al-Hajjaj, Mohamed S.
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HIGH school students ,QUESTIONNAIRES ,SMOKING ,SURVEYS ,TIME ,TOBACCO ,CROSS-sectional method ,DESCRIPTIVE statistics - Abstract
OBJECTIVE: To identify the predictors that lead to cigarette smoking among high school students by utilizing the global youth tobacco survey in Riyadh, Kingdom of Saudi Arabia (KSA). METHODS: A cross-sectional study was conducted among high school students (grades 10-12) in Riyadh, KSA, between April 24, 2010, and June 16, 2010. RESULTS: The response rate of the students was 92.17%. The percentage of high school students who had previously smoked cigarettes, even just 1-2 puffs, was 43.3% overall. This behavior was more common among male students (56.4%) than females (31.3%). The prevalence of students who reported that they are currently smoking at least one cigarette in the past 30 days was 19.5% (31.3% and 8.9% for males and females, respectively). "Ever smoked" status was associated with male gender (OR = 2.88, confidence interval [CI]: 2.28-3.63), parent smoking (OR = 1.70, CI: 1.25-2.30) or other member of the household smoking (OR = 2.11, CI: 1.59-2.81) who smoked, closest friends who smoked (OR = 8.17, CI: 5.56-12.00), and lack of refusal to sell cigarettes (OR = 5.68, CI: 2.09-15.48). CONCLUSION: Several predictors of cigarette smoking among high school students were identified. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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28. Prevalence and characteristics of cigarette smoking among 16 to 18 years old boys and girls in Saudi Arabia.
- Author
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Al Ghobain, Mohammed O., Al Moamary, Mohamed S., Al Shehri, Sulieman N., and AL-Hajjaj, Mohamed S.
- Subjects
ANALYSIS of variance ,INTERVIEWING ,SMOKING ,SURVEYS ,LOGISTIC regression analysis ,RANDOMIZED controlled trials ,DISEASE prevalence ,CROSS-sectional method - Abstract
OBJECTIVE: To study the prevalence and characteristics of cigarette smoking among secondary school students (16- to 18-year-old boys and girls) in Riyadh city, Saudi Arabia. METHODS: We applied a standard two-stage, cross-sectional study design. Secondary schools for both boys and girls in Riyadh city were randomly selected using a cluster sampling method. We used the global youth tobacco survey (GYTS) tool to achieve our objectives. RESULTS: Among 1272 students (606 boys and 666 girls), the prevalence of those ever smoked cigarettes was 42.8% (55.6% of boys and 31.4% of girls). The prevalence of current smoking was 19.5% (31.2% of boys and 8.9% of girls). Despite the fact that the majority of students think smoking is harmful, most do not wish to stop smoking, and they had not tried to stop in the past year. Cigarette smoking is significantly associated with the male gender, having friends who smoke, and having parents who smoke, but is not significantly associated with the type of school attended. CONCLUSION: Smoking prevalence among secondary schools students in Saudi Arabia is high and alarming. There is a need to implement an education program about the risks of smoking and to include parents and friends as healthy models to prevent students from beginning to smoke. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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29. The Saudi Initiative for Asthma.
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Al-Moamary, Mohamed S., Al-Hajjaj, Mohamed S., Idrees, Majdy M., Zeitouni, Mohamed O., Alanezi, Mohammed O., Al-Jahdal, Hamdan H., and Dabbagh, Maha Al
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- *
ASTHMA treatment , *MEDICAL protocols , *ASTHMA in children , *MEDICAL care use , *PUBLIC health - Abstract
The Saudi Initiative for Asthma (SINA) provides up-to-date guidelines for healthcare workers managing patients with asthma. SINA was developed by a panel of Saudi experts with respectable academic backgrounds and longstanding experience in the field. SINA is founded on the latest available evidence, local literature, and knowledge of the current setting in Saudi Arabia. Emphasis is placed on understanding the epidemiology, pathophysiology, medications, and clinical presentation. SINA elaborates on the development of patient-doctor partnership, self-management, and control of precipitating factors. Approaches to asthma treatment in SINA are based on disease control by the utilization of Asthma Control Test for the initiation and adjustment of asthma treatment. This guideline is established for the treatment of asthma in both children and adults, with special attention to children 5 years and younger. It is expected that the implementation of these guidelines for treating asthma will lead to better asthma control and decrease patient utilization of the health care system. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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- View/download PDF
30. Differential expression of CCR2 and CX3CR1 on CD16+ monocyte subsets is associated with asthma severity.
- Author
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Al-Rashoudi, Reem, Moir, Gillian, Al-Hajjaj, Mohamed S., Al-Alwan, Monther M., Wilson, Heather M., and Crane, Isabel J.
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CHEMOKINE receptors ,ASTHMA ,SAUDI Arabians ,ASTHMATICS ,IMMUNOLOGIC diseases - Abstract
Background: Monocytes play an important role in immune and inflammatory diseases and monocyte subsets are predictors of disease in certain conditions. Expression of the chemokine receptors, CCR2 and CX
3 CR1 on monocyte subsets relates to their function and can be used in their characterization. Our objective was to determine whether CD14, CD16, CCR2 and CX3 CR1 on monocyte subsets are potential indicators of asthma severity. Methods: Blood samples were collected from Saudi Arabian patients with asthma and normal healthy individuals. Six-color flow-cytometry phenotypic analysis was used to identify human blood monocyte subsets, based on their expression of CD14 and CD16 following CD45 gating. Expression of CCR2 and CX3 CR1 was analysed on classical (CD14++ CD16− ), intermediate (CD14++ CD16+ ) and non-classical (CD14+ CD16++ ) subsets and correlated with disease severity. Results: We demonstrated a significant increase in percentage of total CD45-positive monocytes in the blood of patients with severe asthma, but the proportion of the individual monocyte subsets was not significantly changed when patients with mild, moderate and severe asthma were compared with healthy individuals. CD16 expression (mean fluorescence intensity, MFI) was decreased on intermediate and non-classical subsets in patients with severe asthma compared to healthy controls. CX3 CR1 expression was also lower, with a lower percentage of cells expressing CX3 CR1 in the non-classical CD14+ CD16++ subset in all patients with asthma and this was inversely related to the percentage of cells expressing CCR2. Conclusions: CCR2 expression on monocytes indicated a tendency toward more phagocytic monocytes in patients with asthma. The differential expression of CD16, CX3 CR1 and CCR2 on monocyte subsets in peripheral blood indicates modulation of the inflammatory response and suggests a role for monocytes in asthma pathogenesis. [ABSTRACT FROM AUTHOR]- Published
- 2019
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31. Management of chronic unexplained cough.
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Al-Hajjaj, Mohamed S.
- Subjects
- *
CHRONIC disease treatment , *COUGH treatment , *TREATMENT effectiveness - Abstract
The article focuses on managing chronic cough without clear presence of etiology. Topics discussed include three phases of cough, upper airway cough syndrome (UACS) includes nasopharyngeal conditions like allergic rhinitis (AR), and diagnosis of cough-variant asthma (C-VA) using pre- and post-bronchodilator spirometry. It also explains nonasthmatic eosinophilic bronchitis (NAEB), use of Chest X-ray (CXR), and gastroesophageal reflux disease (GERD) as it triggers cough.
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- 2017
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32. Difficult-to-treat asthma, is it really difficult?
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Al-Hajjaj, Mohamed S.
- Subjects
- *
ASTHMA , *ETIOLOGY of diseases , *ASTHMATICS , *LUNG diseases - Abstract
The author considers the severity of difficult-to-treat asthma (DTA). He cites some of the terminologies of DTA. He enumerates the genuine and nongenuine etiologies of DTA. He emphasizes the need for asthmatics under adequate maintenance therapy with persistent symptoms to be systematically evaluated in order to determine factors contributing to poor control.
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- 2011
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- View/download PDF
33. Saudi Thoracic Society annual award for achievement.
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Al-Hajjaj, Mohamed S.
- Subjects
- *
AWARDS , *MEDICAL societies , *RESEARCH , *ENDOWMENTS , *WINNERS - Abstract
The article focuses on the annual award for achievement given to the members of the Saudi Thoracic Society (STS). The areas of activities in which the award can be given, include scientific research, organizational activity, and securing donations and financial support for the society. Award winners will receive a plaque and certificate of recognition. The conditions associated with the award, procedures for awarding and the grounds for cancellation of the awards are detailed.
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- 2009
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34. Bronchial asthma in developing countries: A major social and economic burden.
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Al-Hajjaj, Mohamed S.
- Subjects
- *
ASTHMA , *LUNG diseases , *AIR pollution ,DEVELOPING countries - Abstract
The article focuses on bronchial asthma as a social and economic burden in developing countries. It mentions some of the factors that have contributed to the increase of the problem of bronchial asthma such as air pollution and fast modernization. Accordingly, there have not been reliable epidemiological studies to define the magnitude of the problem in many developing countries. Meanwhile, J.P. Watson and colleagues examined the applicability of therapeutic aspects of published international asthma management guidelines in these countries.
- Published
- 2008
- Full Text
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35. The Saudi initiative for asthma - 2024 update: Guidelines for the diagnosis and management of asthma in adults and children.
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Al-Moamary MS, Alhaider SA, Allehebi R, Idrees MM, Zeitouni MO, Al Ghobain MO, Alanazi AF, Al-Harbi AS, Yousef AA, Alorainy HS, and Al-Hajjaj MS
- Abstract
The Saudi Initiative for Asthma 2024 (SINA-2024) is the sixth version of asthma guidelines for the diagnosis and management of asthma for adults and children that was developed by the SINA group, a subsidiary of the Saudi Thoracic Society. The main objective of the SINA is to have guidelines that are up-to-date, simple to understand, and easy to use by healthcare workers dealing with asthma patients. To facilitate achieving the goals of asthma management, the SINA Panel approach is mainly based on the assessment of symptom control and risk for both adults and children. The approach to asthma management is aligned for age groups: adults, adolescents, children aged 5-12 years, and children aged <5 years. SINA guidelines have focused more on personalized approaches reflecting a better understanding of disease heterogeneity with the integration of recommendations related to biologic agents, evidence-based updates on treatment, and the role of immunotherapy in management. The medication appendix has also been updated with the addition of recent evidence, new indications for existing medication, and new medications. The guidelines are constructed based on the available evidence, local literature, and the current situation at national and regional levels. There is also an emphasis on patient-doctor partnership in the management that also includes a self-management plan., Competing Interests: The SINA is fully sponsored by the Saudi Thoracic Society., (Copyright: © 2023 Annals of Thoracic Medicine.)
- Published
- 2024
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- View/download PDF
36. The Saudi Initiative for Asthma - 2021 Update: Guidelines for the diagnosis and management of asthma in adults and children.
- Author
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Al-Moamary MS, Alhaider SA, Alangari AA, Idrees MM, Zeitouni MO, Al Ghobain MO, Alanazi AF, Al-Harbi AS, Yousef AA, Alorainy HS, and Al-Hajjaj MS
- Abstract
The Saudi Initiative for Asthma 2021 (SINA-2021) is the fifth version of asthma guidelines for the diagnosis and management of asthma for adults and children, which is developed by the SINA group, a subsidiary of the Saudi Thoracic Society. The main objective of the SINA is to have guidelines that are up to date, simple to understand, and easy to use by healthcare workers dealing with asthma patients. To facilitate achieving the goals of asthma management, the SINA panel approach is mainly based on the assessment of symptom control and risk for both adults and children. The approach to asthma management is aligned for age groups: adults, adolescents, children aged 5-12 years, and children aged less than 5 years. SINA guidelines have focused more on personalized approaches reflecting better understanding of disease heterogeneity with the integration of recommendations related to biologic agents, evidence-based updates on treatment, and the role of immunotherapy in management. Medication appendix has also been updated with the addition of recent evidence, new indications for existing medication, and new medications. The guidelines are constructed based on the available evidence, local literature, and the current situation at national and regional levels. There is also an emphasis on patient-doctor partnership in the management that also includes a self-management plan., Competing Interests: The SINA is fully sponsored by the STS., (Copyright: © 2021 Annals of Thoracic Medicine.)
- Published
- 2021
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- View/download PDF
37. Role of long-term azithromycin therapy for severe bronchial asthma.
- Author
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Al-Hajjaj MS and Al Moamary MS
- Abstract
Competing Interests: There are no conflicts of interest.
- Published
- 2020
- Full Text
- View/download PDF
38. The Saudi Initiative for Asthma - 2019 Update: Guidelines for the diagnosis and management of asthma in adults and children.
- Author
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Al-Moamary MS, Alhaider SA, Alangari AA, Al Ghobain MO, Zeitouni MO, Idrees MM, Alanazi AF, Al-Harbi AS, Yousef AA, Alorainy HS, and Al-Hajjaj MS
- Abstract
This is the fourth version of the updated guidelines for the diagnosis and management of asthma, developed by the Saudi Initiative for Asthma (SINA) group, a subsidiary of the Saudi Thoracic Society. The main objective of the SINA is to have guidelines that are up to date, simple to understand, and easy to use by healthcare workers dealing with asthma patients. To facilitate achieving the goals of asthma management, the SINA panel approach is mainly based on the assessment of symptom control and risk for both adults and children. The approach to asthma management is now more aligned for different age groups. The guidelines have focused more on personalized approaches reflecting better understanding of disease heterogeneity with integration of recommendations related to biologic agents, evidence-based updates on treatment, and role of immunotherapy in management. The medication appendix has also been updated with the addition of recent evidence, new indications for existing medication, and new medications. The guidelines are constructed based on the available evidence, local literature, and current situation at national and regional levels. There is also an emphasis on patient-doctor partnership in the management that also includes a self-management plan., Competing Interests: The SINA is fully sponsored by the STS.
- Published
- 2019
- Full Text
- View/download PDF
39. The reliability of an Arabic translation of the chronic obstructive pulmonary disease assessment test.
- Author
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Al-Moamary MS, Al-Hajjaj MS, Tamim HM, Al-Ghobain MO, Al-Qahtani HA, and Al-Kassimi FA
- Subjects
- Aged, Female, Humans, Male, Middle Aged, Prospective Studies, Reproducibility of Results, Saudi Arabia, Language, Pulmonary Disease, Chronic Obstructive physiopathology
- Abstract
Objective: To produce a conceptually equivalent Arabic version of the Chronic Obstructive Pulmonary Disease (COPD) Assessment Test (CAT), and to assess its reliability., Methods: A prospective observational study was carried out from June 2010 to September 2010 at King Abdulaziz Medical City and King Khalid University Hospital, Riyadh, Saudi Arabia. We conducted this study in 2 phases. Phase 1: the translation of the CAT from English to Arabic, through forward and backward translation, as well as pilot testing. Phase 2: assessment of the test-retest reliability of the CAT for 45 patients with COPD who received optimal care by their pulmonologist., Results: This study was conducted on 45 participants. The CAT mean total (+/- SD) score at the test session was 10.7+/-5.8, and 9.2+/-4.5 at the re-test session. The interclass correlation of the total score was 0.9 (p=0.000076). The strongest correlation was for the item of confidence in leaving home with a value of 0.92 (p=0.000082), whereas the weakest was for the item related to sleep with a value of 0.53 (p=0.007)., Conclusion: The Arabic version of the CAT was found to be easy to administer, reliable, and had a strong interclass correlation reflecting stability over time and across the items.
- Published
- 2011
40. Levels of acceptance of Asthma Control Test questionnaire among Saudi patients attending 5 tertiary care hospitals in Saudi Arabia.
- Author
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Alanezi M, Al-Jahdali HH, Al-Hajjaj MS, Zeitoni MO, and Al-Tasan TH
- Subjects
- Adolescent, Adult, Aged, Cross-Sectional Studies, Educational Status, Female, Humans, Male, Middle Aged, Saudi Arabia, Asthma therapy, Patient Acceptance of Health Care, Patient Compliance, Surveys and Questionnaires
- Abstract
Objective: To explore the levels of acceptance of asthma control test (ACT) among Saudi patients., Methods: A cross-sectional survey was carried out in 5 hospitals in Riyadh, Kingdom of Saudi Arabia, namely; Security Forces Hospital, King Abdul-Aziz Medical City, King Khalid University Hospital, King Faisal Specialist Hospital, and Riyadh Armed Forces Hospital, from the first of September to the 30th of November 2006. Patients attending the pulmonary clinic were asked to answer the ACT. This was followed by an interview to assess their view on the questions and their level of difficulty., Results: The total number of patients was 1060. Males constituted 41%. A third of the patients were uneducated. The majority of patients (94%) found the ACT questions easy. The younger patients found the ACT questions easier to answer than the older patients. Ninety-five percent of males found the ACT easy, while only 92% of females found the ACT easy. Educated patients found the ACT questions easy to perform more often than uneducated patients. There are no significant differences for age and gender, and for the question on whether the test helped to understand the patient's condition. There are no significant differences for age and education, and for the question on whether the patient is willing to perform the test in each clinic visit., Conclusion: The majority of Saudi patients found the ACT easy, and they are willing to repeat the test every clinic visit.
- Published
- 2009
41. Asthma control assessment using asthma control test among patients attending 5 tertiary care hospitals in Saudi Arabia.
- Author
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Al-Jahdali HH, Al-Hajjaj MS, Alanezi MO, Zeitoni MO, and Al-Tasan TH
- Subjects
- Adolescent, Adult, Aged, Asthma epidemiology, Chi-Square Distribution, Female, Humans, Interviews as Topic, Male, Middle Aged, Saudi Arabia epidemiology, Asthma physiopathology
- Abstract
Objective: Evaluation of asthma control using the Asthma Control Test (ACT)., Methods: The ACT was used to assess asthma control among patients with bronchial asthma visiting pulmonary clinics in 5 major tertiary care hospitals in Riyadh, Kingdom of Saudi Arabia. Each hospital had a target of 300 patients to recruit over the period of the study from the 1st September to 30th November 2006., Results: The total number of patients studied was 1,060 patients. Males constituted 442 (42%) and females constituted 618 (58%), the median age was 38.56 years (range 15-75). One third of patients had no formal education. The ACT score revealed uncontrolled asthma in 677 (64%), well-controlled asthma in 328 (31%), and complete controlled in 55 (5%). There are no significant correlations between the age below 40 and above 40 years and level of asthma control (p=0.12). However, the younger age group less than 20 had better control of asthma in comparison with older patients (p=0.0001). There was a significant correlation between level of asthma control and gender, males (44%) had better asthma control than females (30%) (p=0.0001)., Conclusion: Control of bronchial asthma is still a major concern in our population. Further studies are needed to explore the factors leading to poor asthma control.
- Published
- 2008
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