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13 results on '"Alaaeddine, Rana A."'

6. Challenging inflammatory process at molecular, cellular and in vivo levels via some new pyrazolyl thiazolones

Author

Elzahhar, Perihan A., Alaaeddine, Rana A., Nassra, Rasha, Ismail, Azza, Labib, Hala F., Temraz, Mohamed G., Belal, Ahmed S. F., and El-Yazbi, Ahmed F.

Abstract

The work reported herein describes the synthesis of a new series of anti-inflammatory pyrazolyl thiazolones. In addition to COX-2/15-LOX inhibition, these hybrids exerted their anti-inflammatory actions through novel mechanisms. The most active compounds possessed COX-2 inhibitory activities comparable to celecoxib (IC50 values of 0.09–0.14 µM) with significant 15-LOX inhibitory activities (IC50s 1.96 to 3.52 µM). Upon investigation of their in vivo anti-inflammatory activities and ulcerogenic profiles, these compounds showed activity patterns equivalent or more superior to diclofenac and/or celecoxib. Intriguingly, the most active compounds were more effective than diclofenac in suppressing monocyte-to-macrophage differentiation and inflammatory cytokine production by activated macrophages, as well as their ability to induce macrophage apoptosis. The latter finding potentially adds a new dimension to the previously reported anti-inflammatory mechanisms of similar compounds. These compounds were effectively docked into COX-2 and 15-LOX active sites. Also, in silico predictions confirmed the appropriateness of these compounds as drug-like candidates.

Published
2021
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12. Synthesis, Docking Studies and Biological Evaluation of Triazole‐Thiazolidinedione/Rhodanine Hybrids Targeting Cyclooxygenase‐2, 5‐Lipoxygenase and Peroxisome proliferator‐activated receptor

Author

Alaaeddine, Rana, primary, Elzahhar, Perihan, additional, Belal, Ahmed, additional, Nassra, Rasha, additional, Ibrahim, Tamer, additional, Wallner, Nadja, additional, Knape, Tilo, additional, Von Knethen, Andreas, additional, and El‐Yazbi, Ahmed F., additional

Published
2018
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13. Neuropathic Pain: Literature Review and Recommendations of Potential Phytotherapies

Author

Raafat, Karim, primary, El-Haj, Rawan, additional, Shoumar, Dania, additional, Alaaeddine, Rana, additional, Fakhro, Yousra, additional, Tawil, Natalie, additional, Shaer, Farah, additional, Daher, Amani, additional, Awada, Natalie, additional, Sabra, Ali, additional, Atwi, Khouloud, additional, Khaled, Malak, additional, Messi, Raneem, additional, Abouzaher, Nour, additional, Houri, Mohamed, additional, and Al Jallad, Samer, additional

Published
2017
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