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1. Treatment at Relapse for Synovial Sarcoma of Children, Adolescents and Young Adults: From the State of Art to Future Clinical Perspectives

Author

Ferrari A, Berlanga P, Gatz SA, Schoot RA, van Noesel MM, Hovsepyan S, Chiaravalli S, Bergamaschi L, Minard-Colin V, Corradini N, Alaggio R, Gasparini P, Brennan B, Casanova M, Pasquali S, and Orbach D

Subjects
synovial sarcoma, relapse, second line therapy, surgery, new agents, tcr-t cell therapy, children, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Andrea Ferrari,1 Pablo Berlanga,2 Susanne Andrea Gatz,3 Reineke A Schoot,4 Max M van Noesel,4,5 Shushan Hovsepyan,6 Stefano Chiaravalli,1 Luca Bergamaschi,1 Veronique Minard-Colin,2 Nadege Corradini,7 Rita Alaggio,8 Patrizia Gasparini,9 Bernadette Brennan,10 Michela Casanova,1 Sandro Pasquali,11,12 Daniel Orbach13 1Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; 2Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France; 3Cancer Research UK Clinical Trials Unit, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; 4Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; 5Division Imaging & Cancer, University Medical Center Utrecht, Utrecht, the Netherlands; 6Pediatric Cancer and Blood Disorders Center of Armenia, Yerevan, Armenia; 7Department of Pediatric Hematology and Oncology-IHOPe, Léon Bérard Center, Lyon, France; 8Pathology Department, Ospedale Pediatrico Bambino Gesù IRCCS, Roma, Italy; 9Tumor Genomics Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; 10Pediatric Oncology, Royal Manchester Children’s Hospital, Manchester, UK; 11Molecular Pharmacology Unit, Department of Applied Research and Technological Development, Molecular Pharmacology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; 12Sarcoma Service, Department of Surgery, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; 13SIREDO Oncology Center(Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer), Institut Curie, PSL University, Paris, FranceCorrespondence: Andrea Ferrari, Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G. Venezian, Milano, MI, 1 20133, Italy, Tel +39 02 23902588, Fax +39 02 23902648, Email andrea.ferrari@istitutotumori.mi.itAbstract: While the overall prognosis is generally quite satisfactory in children, adolescents and young adults with localised synovial sarcoma at first diagnosis, the outcome remains poor for patients after relapse. Conversely to the front-line standardised treatment options, patients with relapse generally have an individualised approach and to date, there is still a lack of consensus regarding standard treatment approaches. Studies on relapsed synovial sarcoma were able to identify some prognostic variables that influence post-relapse survival, in order to plan risk-adapted salvage protocols. Treatment proposals must consider previous first-line treatments, potential toxicities, and the possibility of achieving an adequate local treatment by new surgery and/or re-irradiation. Effective second-line drug therapies are urgently needed. Notably, experimental treatments such as adoptive engineered TCR-T cell immunotherapy seem promising in adults and are currently under validation also in paediatric patients.Keywords: synovial sarcoma, relapse, second line therapy, surgery, new agents, TCR-T cell therapy, children

Published
2023

3. Pediatric Non-Rhabdomyosarcoma Soft Tissue Sarcomas: Standard of Care and Treatment Recommendations from the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG)

Author

Ferrari A, Brennan B, Casanova M, Corradini N, Berlanga P, Schoot RA, Ramirez-Villar GL, Safwat A, Guillen Burrieza G, Dall'Igna P, Alaggio R, Lyngsie Hjalgrim L, Gatz SA, Orbach D, and van Noesel MM

Subjects
non-rhabdomyosarcoma soft tissue sarcomas, nrsts, epssg, treatment, recommendations, pediatric, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Andrea Ferrari,1 Bernadette Brennan,2 Michela Casanova,1 Nadege Corradini,3 Pablo Berlanga,4 Reineke A Schoot,5 Gema L Ramirez-Villar,6 Akmal Safwat,7 Gabriela Guillen Burrieza,8 Patrizia Dall’Igna,9 Rita Alaggio,10 Lisa Lyngsie Hjalgrim,11 Susanne Andrea Gatz,12 Daniel Orbach,13 Max M van Noesel5 1Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy; 2Pediatric Oncology, Royal Manchester Children’s Hospital, Manchester, UK; 3Department of Pediatric Oncology, Institut d’Hematologie et d’Oncologie Pédiatrique/Centre, Léon Bérard, Lyon, France; 4Department of Pediatric and Adolescent Oncology, Gustave-Roussy, Cancer Campus, Université Paris-Saclay, Villejuif, France; 5Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; 6Pediatric Oncology Unit, Hospital Universitario Virgen del Rocío, Seville, Spain; 7Oncology Department and Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark; 8Surgical Oncology and Neonatal Surgery, Pediatric Surgery Department, Hospital Infantil Universitari Vall d’Hebron, Barcelona, Spain; 9Department of Emergencies and Organ Transplantation, Pediatric Surgery, University of Bari, Bari, Italy; 10Pathology Department, Ospedale Pediatrico Bambino Gesù IRCCS, Rome, Italy; 11Department of Pediatrics and Adolescent Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; 12Cancer Research UK Clinical Trials Unit, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; 13SIREDO Oncology Center, Institut Curie, PSL University, Paris, FranceCorrespondence: Andrea Ferrari, Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Via G. Venezian, 1, Milan, MI, 20133, Italy, Tel +39 02 23902588, Fax +39 02 23902648, Email andrea.ferrari@istitutotumori.mi.itAbstract: This paper describes the standard of care for patients with non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) and the therapeutic recommendations developed by the European paediatric Soft tissue sarcoma Study Group (EpSSG). NRSTS form a very mixed group of mesenchymal extraskeletal malignancies. Their rarity, heterogeneity, and aggressiveness make the management of children and adolescents with these tumors complex and challenging. The overall cure rate for patients with NRSTS is around 70%, but survival depends on several prognostic variables, such as histotype and tumor grade, extent of disease and stage, tumor size, and tumor site. While surgery remains the mainstay of treatment for most of these tumors, a multimodal therapeutic approach including radiotherapy and chemotherapy is required in many cases. The EpSSG NRSTS 2005 study was the first prospective protocol tailored specifically to NRSTS. Together with the ARST0332 study developed by the North-American Soft Tissue Sarcoma Committee of the Children’s Oncology Group (COG), the EpSSG NRSTS 2005 study currently represents the benchmark for these tumors, establishing risk-adapted standards of care. The EpSSG has developed common treatment recommendations for the large group of adult-type NRSTS (including synovial sarcoma), and specific treatment recommendations for other particular adult-type histologies (ie, alveolar soft-part sarcoma, clear cell sarcoma and dermatofibrosarcoma protuberans); other highly malignant tumors with a biology and clinical behavior differing from those of adult-type NRSTS (ie, rhabdoid tumors and desmoplastic small round cell tumor); and soft tissue tumors of intermediate malignancy (ie desmoid-type fibromatosis, inflammatory myofibroblastic tumors, and infantile fibrosarcoma). New effective drugs are needed for patients whose NRSTS carries the worst prognosis, ie, those with unresectable tumors, metastases at diagnosis, or relapsing disease. Progress in this area relies on our ability to develop international integrated prospective collaborations, both within existing pediatric oncology networks and, importantly, between the communities of specialists treating pediatric and adult sarcoma.Keywords: non-rhabdomyosarcoma soft tissue sarcomas, NRSTS, EpSSG, treatment, recommendations, pediatric

Published
2022

4. Infantile fibrosarcoma with an EGFR kinase domain duplication: Underlining a close relationship with congenital mesoblastic nephroma and highlighting a similar morphological spectrum

Author

van Spronsen, R., Kester, L.A., Knops, R.R.G., van de Sande, M.A.J., van Leenders, G.J.L.H., de Laat, P.C.J., Stortelder, E., Korpershoek, E., van Noesel, M.M., Meister, M.T., Koerkamp, M.J.A. Groot, de Graaf, N., Giovannoni, I., Tops, B.B.J., de Krijger, R.R., ter Horst, S.A.J., Flucke, U., Alaggio, R., and Hiemcke-Jiwa, L.S.

Published
2022
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6. Pediatric BCOR-Altered Tumors From Soft Tissue/Kidney Display Specific DNA Methylation Profiles

Author

Salgado, C. M., Alaggio, R., Ciolfi, A., Zin, A., Diomedi Camassei, F., Pedace, L., Milano, G. M., Serra, A., Di Giannatale, A., Mastronuzzi, A., Gianatti, A., Bisogno, G., Ferrari, A., Tartaglia, M., Reyes-Mugica, M., Locatelli, Franco, Miele, E., Locatelli F. (ORCID:0000-0002-7976-3654), Salgado, C. M., Alaggio, R., Ciolfi, A., Zin, A., Diomedi Camassei, F., Pedace, L., Milano, G. M., Serra, A., Di Giannatale, A., Mastronuzzi, A., Gianatti, A., Bisogno, G., Ferrari, A., Tartaglia, M., Reyes-Mugica, M., Locatelli, Franco, Miele, E., and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

In the pediatric population, BCL6-correpresor gene (BCOR)-upregulated tumors include primitive myxoid mesenchymal tumors/undifferentiated sarcomas (PMMTI/UND), clear cell sarcomas of the kidney (CCSK), and high-grade neuroepithelial tumors (HG-NET). We investigated DNA methylation (DNAm) and copy number variation (CNV) profiling in these tumors (N = 34) using an Illumina EPIC BeadChip to better define the potential use of these tools to confirm diagnosis and predict outcomes. Twenty-seven tumors from 25 patients (age range, 0-10 years), showed molecular confirmation of genetic abnormalities as follows: BCOR internal tandem duplication in 14 PMMTI/UND, 8 CCSK, and 3 HG-NET and YWHAE fusions in 2 PMMTI/UND. The remaining 7 cases lacking informative molecular data were analyzed by immunophenotyping and were included in the study as a training cohort, clearly separated from the main study group. These were 4 PMMTI, 1 HG-NET, and 1 CCSK in which poor RNA preservation precluded the confirmation of BCOR rearrangements and 1 CCSK in which no rearrangements were found. DNAm data were compared with those of brain tumor and/or sarcoma classifier. Differentially methylated regions (DMRs) were analyzed in the 3 groups. Twenty-two cases of the 24 molecularly confirmed PMMTI/UND and CCSK and 3 of 6 of those with only immunophenotyping were classified within the methylation class "BCOR-altered sarcoma family" with optimal calibrated scores. PMMTI/UND and CCSK showed similar methylation profiles, whereas thousands of DMRs and significantly enriched pathways were evident between soft tissue/kidney tumors and HG-NET. The CNV analysis showed an overall flat profile in 19 of the 31 evaluable tumors (8/10 CCSK; 9/18 PMMTI/UND; 2/4 HG-NET). The most frequent CNVs were 1q gain and 9p and 10q loss. Follow-up time data were available for 20 patients: ≥2 CNV significantly correlated with a worse overall survival rate. In conclusion, soft tissue and kidney BCOR sarcomas matched with BCOR

Published
2023

14. Infantile fibrosarcoma with an EGFR kinase domain duplication: Underlining a close relationship with congenital mesoblastic nephroma and highlighting a similar morphological spectrum

Author

Spronsen, R. van, Kester, L.A., Knops, R.R., Sande, Marc van de, Leenders, G. van, Laat, P.C.J. de, Stortelder, E., Korpershoek, E., Noesel, M.M. van, Meister, M.T., Koerkamp, M., Graaf, N. De, Giovannoni, I., Tops, B.B.J., Krijger, R.R. de, Horst, S.A.J. Ter, Flucke, U.E., Alaggio, R., Hiemcke-Jiwa, L.S., Spronsen, R. van, Kester, L.A., Knops, R.R., Sande, Marc van de, Leenders, G. van, Laat, P.C.J. de, Stortelder, E., Korpershoek, E., Noesel, M.M. van, Meister, M.T., Koerkamp, M., Graaf, N. De, Giovannoni, I., Tops, B.B.J., Krijger, R.R. de, Horst, S.A.J. Ter, Flucke, U.E., Alaggio, R., and Hiemcke-Jiwa, L.S.

Abstract

Item does not contain fulltext, Infantile fibrosarcoma (IFS) and congenital mesoblastic nephroma (CMN) are locally aggressive tumors primarily occurring in infants. Both IFS and the cellular subtype of CMN show overlapping morphological features and an ETV6-NTRK3 fusion, suggesting a close relationship. An activating alteration of EGFR, based on an EGFR kinase domain duplication (KDD), occurs in a subset of CMNs lacking an NTRK3 rearrangement, especially in the classic and mixed type. So far no EGFR-KDDs have been detected in IFS. We describe four pediatric tumors at the extremities (leg, n = 2; foot and arm n = 1) with histological features of IFS/CMN. Two cases showed classic IFS morphology while two were similar to classic/mixed type CMN. In all cases, an EGFR-KDD was identified without detection of a fusion gene. There were no abnormalities of the kidneys in any of the patients. This is the first description of IFS with an EGFR-KDD as driver mutation, supporting that IFS and CMN are similar lesions with the same morphological and genetic spectrum. Pathologists should be aware of the more fibrous variant of IFS, similar to classic/mixed type CMN. Molecular analyses are crucial to treat these lesions adequately, especially with regard to the administration of tyrosine kinase inhibitors.

Published
2022

15. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms

Author

Khoury, J.D., Solary, E., Abla, O., Akkari, Y., Alaggio, R., Apperley, J.F., Bejar, R., Berti, E., Busque, L., Chan, J.K.C., Chen, Weina, Chen, Xueyan, Chng, W.J., Choi, J.K., Colmenero, I., Coupland, S.E., Cross, N.C., Jong, Daphne de, Elghetany, M.T., Takahashi, E., Emile, J.F., Ferry, J., Fogelstrand, L., Fontenay, M., Germing, U., Gujral, S., Haferlach, T, Harrison, C., Hodge, J.C., Hu, S., Jansen, J.H., Kanagal-Shamanna, R., Kantarjian, H.M., Kratz, C.P., Li, X.Q., Lim, M.S.C., Loeb, K., Loghavi, S., Marcogliese, A., Meshinchi, S., Michaels, P., Naresh, K.N., Natkunam, Y., Nejati, R., Ott, G., Padron, E., Patel, K.P., Patkar, N., Picarsic, J., Platzbecker, U., Roberts, I., Schuh, A., Sewell, W., Siebert, R., Tembhare, P., Tyner, J., Verstovsek, S., Wang, W., Wood, B., Xiao, W., Yeung, C., Hochhaus, A., Khoury, J.D., Solary, E., Abla, O., Akkari, Y., Alaggio, R., Apperley, J.F., Bejar, R., Berti, E., Busque, L., Chan, J.K.C., Chen, Weina, Chen, Xueyan, Chng, W.J., Choi, J.K., Colmenero, I., Coupland, S.E., Cross, N.C., Jong, Daphne de, Elghetany, M.T., Takahashi, E., Emile, J.F., Ferry, J., Fogelstrand, L., Fontenay, M., Germing, U., Gujral, S., Haferlach, T, Harrison, C., Hodge, J.C., Hu, S., Jansen, J.H., Kanagal-Shamanna, R., Kantarjian, H.M., Kratz, C.P., Li, X.Q., Lim, M.S.C., Loeb, K., Loghavi, S., Marcogliese, A., Meshinchi, S., Michaels, P., Naresh, K.N., Natkunam, Y., Nejati, R., Ott, G., Padron, E., Patel, K.P., Patkar, N., Picarsic, J., Platzbecker, U., Roberts, I., Schuh, A., Sewell, W., Siebert, R., Tembhare, P., Tyner, J., Verstovsek, S., Wang, W., Wood, B., Xiao, W., Yeung, C., and Hochhaus, A.

Abstract

Contains fulltext : 282922.pdf (Publisher’s version ) (Open Access)

Published
2022

16. Infantile fibrosarcoma with an EGFR kinase domain duplication:Underlining a close relationship with congenital mesoblastic nephroma and highlighting a similar morphological spectrum

Author

van Spronsen, R., Kester, L. A., Knops, R. R.G., van de Sande, M. A.J., van Leenders, G. J.L.H., de Laat, P. C.J., Stortelder, E., Korpershoek, E., van Noesel, M. M., Meister, M. T., Koerkamp, M. J.A.Groot, de Graaf, N., Giovannoni, I., Tops, B. B.J., de Krijger, R. R., ter Horst, S. A.J., Flucke, U., Alaggio, R., Hiemcke-Jiwa, L. S., van Spronsen, R., Kester, L. A., Knops, R. R.G., van de Sande, M. A.J., van Leenders, G. J.L.H., de Laat, P. C.J., Stortelder, E., Korpershoek, E., van Noesel, M. M., Meister, M. T., Koerkamp, M. J.A.Groot, de Graaf, N., Giovannoni, I., Tops, B. B.J., de Krijger, R. R., ter Horst, S. A.J., Flucke, U., Alaggio, R., and Hiemcke-Jiwa, L. S.

Abstract

Infantile fibrosarcoma (IFS) and congenital mesoblastic nephroma (CMN) are locally aggressive tumors primarily occurring in infants. Both IFS and the cellular subtype of CMN show overlapping morphological features and an ETV6-NTRK3 fusion, suggesting a close relationship. An activating alteration of EGFR, based on an EGFR kinase domain duplication (KDD), occurs in a subset of CMNs lacking an NTRK3 rearrangement, especially in the classic and mixed type. So far no EGFR-KDDs have been detected in IFS. We describe four pediatric tumors at the extremities (leg, n = 2; foot and arm n = 1) with histological features of IFS/CMN. Two cases showed classic IFS morphology while two were similar to classic/mixed type CMN. In all cases, an EGFR-KDD was identified without detection of a fusion gene. There were no abnormalities of the kidneys in any of the patients. This is the first description of IFS with an EGFR-KDD as driver mutation, supporting that IFS and CMN are similar lesions with the same morphological and genetic spectrum. Pathologists should be aware of the more fibrous variant of IFS, similar to classic/mixed type CMN. Molecular analyses are crucial to treat these lesions adequately, especially with regard to the administration of tyrosine kinase inhibitors.

Published
2022

17. Infantile fibrosarcoma with an EGFR kinase domain duplication: Underlining a close relationship with congenital mesoblastic nephroma and highlighting a similar morphological spectrum

Author

Cancer, PMC Medisch specialisten, Onderzoek Beeld, Pathologie Pathologen staf, MS Radiologie, van Spronsen, R, Kester, L A, Knops, R R G, van de Sande, M A J, van Leenders, G J L H, de Laat, P C J, Stortelder, E, Korpershoek, E, van Noesel, M M, Meister, M T, Koerkamp, M J A Groot, de Graaf, N, Giovannoni, I, Tops, B B J, de Krijger, R R, Ter Horst, S A J, Flucke, U, Alaggio, R, Hiemcke-Jiwa, L S, Cancer, PMC Medisch specialisten, Onderzoek Beeld, Pathologie Pathologen staf, MS Radiologie, van Spronsen, R, Kester, L A, Knops, R R G, van de Sande, M A J, van Leenders, G J L H, de Laat, P C J, Stortelder, E, Korpershoek, E, van Noesel, M M, Meister, M T, Koerkamp, M J A Groot, de Graaf, N, Giovannoni, I, Tops, B B J, de Krijger, R R, Ter Horst, S A J, Flucke, U, Alaggio, R, and Hiemcke-Jiwa, L S

Published
2022

19. Infantile fibrosarcoma with an EGFR kinase domain duplication: Underlining a close relationship with congenital mesoblastic nephroma and highlighting a similar morphological spectrum

Author

Spronsen, R. van, Kester, L.A., Knops, R.R.G., Sande, M.A.J. van de, Leenders, G.J.L.H. van, Laat, P.C.J. de, Stortelder, E., Korpershoek, E., Noesel, M.M. van, Meister, M.T., Koerkamp, M.J.A.G., Graaf, N. de, Giovannoni, I., Tops, B.B.J., Krijger, R.R. de, Horst, S.A.J. ter, Flucke, U., Alaggio, R., Hiemcke-Jiwa, L.S., Pathology, Pediatrics, and Radiology & Nuclear Medicine

Subjects
EGFR kinase domain duplication, Proto-Oncogene Proteins c-ets, Fibrosarcoma, Infant, RNA sequencing, General Medicine, Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9], Kidney Neoplasms, Pathology and Forensic Medicine, ErbB Receptors, Repressor Proteins, Infantile fibrosarcoma, Congenital mesoblastic nephroma, Humans, Nephroma, Mesoblastic, Child
Abstract

Contains fulltext : 249903.pdf (Publisher’s version ) (Open Access) Infantile fibrosarcoma (IFS) and congenital mesoblastic nephroma (CMN) are locally aggressive tumors primarily occurring in infants. Both IFS and the cellular subtype of CMN show overlapping morphological features and an ETV6-NTRK3 fusion, suggesting a close relationship. An activating alteration of EGFR, based on an EGFR kinase domain duplication (KDD), occurs in a subset of CMNs lacking an NTRK3 rearrangement, especially in the classic and mixed type. So far no EGFR-KDDs have been detected in IFS. We describe four pediatric tumors at the extremities (leg, n = 2; foot and arm n = 1) with histological features of IFS/CMN. Two cases showed classic IFS morphology while two were similar to classic/mixed type CMN. In all cases, an EGFR-KDD was identified without detection of a fusion gene. There were no abnormalities of the kidneys in any of the patients. This is the first description of IFS with an EGFR-KDD as driver mutation, supporting that IFS and CMN are similar lesions with the same morphological and genetic spectrum. Pathologists should be aware of the more fibrous variant of IFS, similar to classic/mixed type CMN. Molecular analyses are crucial to treat these lesions adequately, especially with regard to the administration of tyrosine kinase inhibitors.

Published
2021

21. Nationwide central diagnosis review for childhood solid tumors: From concept to realization of an Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) integrated project

Author

Spreafico, F, Quarello, P, Alaggio, R, Collini, P, Haupt, R, Mastronuzzi, A, Prete, A, Rabusin, M, Rizzari, C, Schumacher, F, Zecca, M, Pession, A, Fagioli, F, Spreafico F., Quarello P., Alaggio R., Collini P., Haupt R., Mastronuzzi A., Prete A., Rabusin M., Rizzari C., Schumacher F., Zecca M., Pession A., Fagioli F., Spreafico, F, Quarello, P, Alaggio, R, Collini, P, Haupt, R, Mastronuzzi, A, Prete, A, Rabusin, M, Rizzari, C, Schumacher, F, Zecca, M, Pession, A, Fagioli, F, Spreafico F., Quarello P., Alaggio R., Collini P., Haupt R., Mastronuzzi A., Prete A., Rabusin M., Rizzari C., Schumacher F., Zecca M., Pession A., and Fagioli F.

Published
2019

22. OP04.03: Placental vascular malperfusion in fetuses with congenital heart diseases: distinction based on pathophysiology.

Author

Toscano, A., Colucci, M., Masci, M., Stracuzzi, A., Alaggio, R., Campanale, C., Viggiano, M., Moras, P., Fabietti, I., and Pasquini, L.

Subjects
TRANSPOSITION of great vessels, FETAL heart, CONGENITAL heart disease, FETAL abnormalities, PLACENTA, HEART failure
Abstract

This article explores the relationship between placental malperfusion (PM) and congenital heart disease (CHD) in pregnancies. The study analyzed 95 fetal placentas affected by CHD and categorized placental pathology as maternal placental malperfusion (MPM), fetal placental malperfusion (FPM), and combined maternal-fetal placental malperfusion (MFPM). The results showed a higher prevalence of PM in patients with pathologies involving pulmonary overflow volume (OV) and transposition of great arteries (TGA). The study confirms an association between placental vascular anomalies and fetal CHD, but notes that the higher prevalence of PM in patients with OV may be influenced by comorbidities. [Extracted from the article]

Published
2024
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27. Melanotic neuroectodermal tumor of infancy (Mnti) and pineal anlage tumor (pat) harbor a medulloblastoma signature by dna methylation profiling

Author

Lopez-Nunez, O., Alaggio, R., John, I., Ciolfi, A., Pedace, L., Mastronuzzi, A., Gianno, F., Giangaspero, F., Rossi, S., Donofrio, V., Cinalli, G., Surrey, L. F., Tartaglia, M., Locatelli, Franco, Miele, E., Locatelli F. (ORCID:0000-0002-7976-3654), Lopez-Nunez, O., Alaggio, R., John, I., Ciolfi, A., Pedace, L., Mastronuzzi, A., Gianno, F., Giangaspero, F., Rossi, S., Donofrio, V., Cinalli, G., Surrey, L. F., Tartaglia, M., Locatelli, Franco, Miele, E., and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

no abstract

Published
2021

29. The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx)

Author

Ciarapica, R, De Salvo, M, Carcarino, E, Bracaglia, G, Adesso, L, Leoncini, P P, DallʼAgnese, A, Walters, Z S, Verginelli, F, De Sio, L, Boldrini, R, Inserra, A, Bisogno, G, Rosolen, A, Alaggio, R, Ferrari, A, Collini, P, Locatelli, M, Stifani, S, Screpanti, I, Rutella, S, Yu, Q, Marquez, V E, Shipley, J, Valente, S, Mai, A, Miele, L, Puri, P L, Locatelli, F, Palacios, D, and Rota, R

Published
2014
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31. Il Principato durante la lotta dinastica angioino-durazzesca fino agli anni di Giovanni Antonio del Balzo Orsini

Author

Alaggio, R.

Subjects
Il saggio ricostruisce il ruolo svolto dal Principato di Taranto e dai suoi titolari durante le lotte dinastiche angioino-durazzesche che segnarono la storia del trono di Napoli tra la fine del 300 e la prima metà del 400. Sono evidenziati aspetti inediti ed indirizzi politici della feudalità regnicola rimasti fino ad ora inediti o poco valorizzati nell'influenza che esercitarono sul consolidamento della corona e negli equilibri internazionali
Published
2020

36. Immunofluorescence mapping, electron microscopy and genetics in the diagnosis and sub‐classification of inherited epidermolysis bullosa: a single‐centre retrospective comparative study of 87 cases with long‐term follow‐up

Author

Rossi, S., primary, Castiglia, D., additional, Pisaneschi, E., additional, Diociaiuti, A., additional, Stracuzzi, A., additional, Cesario, C., additional, Mariani, R., additional, Floriddia, G., additional, Zambruno, G., additional, Boldrini, R., additional, Abeni, D., additional, Novelli, A., additional, Alaggio, R., additional, and El Hachem, M., additional

Published
2021
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40. A clinical, histopathological and laboratory study of 19 consecutive Italian paediatric patients with chilblain‐like lesions: lights and shadows on the relationship with COVID‐19 infection

Author

El Hachem, M., primary, Diociaiuti, A., additional, Concato, C., additional, Carsetti, R., additional, Carnevale, C., additional, Ciofi Degli Atti, M., additional, Giovannelli, L., additional, Latella, E., additional, Porzio, O., additional, Rossi, S., additional, Stracuzzi, A., additional, Zaffina, S., additional, Onetti Muda, A., additional, Zambruno, G., additional, and Alaggio, R., additional

Published
2020
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50. La construcción de embarcaciones en el reino de Nápoles: dos ejemplos de industria naval en el Mediterráneo occidental en época aragonesa

Author

Colesanti G.T. and Alaggio R.

Subjects
Navigazione, Flotte, Regno di Napoli, Mediterraneo
Abstract

Nuestro trabajo tiene como objetivo mostrar los distintos enclaves del reino de Nápoles en los que se construían barcos entre los siglos xv y xvi. Se evidenciarán las diferencias, las conexiones y las complementariedades entre la política real y arsenales privados como el de Francesco Coppola o el del príncipe de Taranto, ambos muy activos en el siglo xv

Published
2018

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