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2. Structure activity relationships of galabioside derivatives as inhibitors of E. coli and S. suis adhesins: nanomolar inhibitors of S. suis adhesins

Author

Ohlsson, Jörgen, Larsson, Andreas, Haataja, Sauli, Alajääski, Jenny, Stenlund, Peter, Pinkner, Jerome S, Hultgren, Scott J, Finne, Jukka, Kihlberg, Jan, Nilsson, Ulf J, Ohlsson, Jörgen, Larsson, Andreas, Haataja, Sauli, Alajääski, Jenny, Stenlund, Peter, Pinkner, Jerome S, Hultgren, Scott J, Finne, Jukka, Kihlberg, Jan, and Nilsson, Ulf J

Abstract

Four collections of Gal1-4Gal derivatives were synthesised and evaluated as inhibitors of the PapG class II adhesin of uropathogenic Escherichia coli and of the PN and PO adhesins of Streptococcus suis strains. Galabiosides carrying aromatic structures at C1, methoxyphenyl O-galabiosides in particular, were identified as potent inhibitors of the PapG adhesin. Phenylurea derivatisation at C3 and methoxymethylation at O2 of galabiose provided inhibitors of the S. suis strains type PN adhesin with remarkably high affinities (30 and 50 nM, respectively). In addition, quantitative structure–activity relationship models for E. coli PapG adhesin and S. suis adhesin type PO were developed using multivariate data analysis. The inhibitory lead structures constitute an advancement towards high-affinity inhibitors as potential anti-adhesion therapeutic agents targeting bacterial infections.

Published
2005
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5. Structure-activity relationships of galabioside derivatives as inhibitors of E. coli and S. suis adhesins: nanomolar inhibitors of S. suis adhesins.

Author

Ohlsson J, Larsson A, Haataja S, Alajääski J, Stenlund P, Pinkner JS, Hultgren SJ, Finne J, Kihlberg J, and Nilsson UJ

Subjects
Adhesins, Bacterial metabolism, Adhesins, Escherichia coli metabolism, Bacterial Proteins antagonists & inhibitors, Bacterial Proteins chemistry, Bacterial Proteins metabolism, Disaccharides chemistry, Disaccharides metabolism, Escherichia coli chemistry, Fimbriae Proteins metabolism, Galactose analogs & derivatives, Galactose chemistry, Galactose metabolism, Galactosides metabolism, Galactosides pharmacology, Hemagglutination Inhibition Tests, Models, Chemical, Models, Molecular, Molecular Structure, Multivariate Analysis, Protein Binding, Streptococcus suis chemistry, Surface Plasmon Resonance, Adhesins, Bacterial chemistry, Adhesins, Escherichia coli chemistry, Fimbriae Proteins chemistry, Galactosides chemistry, Quantitative Structure-Activity Relationship
Abstract

Four collections of Gal alpha1-4Gal derivatives were synthesised and evaluated as inhibitors of the PapG class II adhesin of uropathogenic Escherichia coli and of the P(N) and P(O) adhesins of Streptococcus suis strains. Galabiosides carrying aromatic structures at C1, methoxyphenyl O-galabiosides in particular, were identified as potent inhibitors of the PapG adhesin. Phenylurea derivatisation at C3' and methoxymethylation at O2' of galabiose provided inhibitors of the S. suis strains type P(N) adhesin with remarkably high affinities (30 and 50 nM, respectively). In addition, quantitative structure-activity relationship models for E. coli PapG adhesin and S. suis adhesin type P(O) were developed using multivariate data analysis. The inhibitory lead structures constitute an advancement towards high-affinity inhibitors as potential anti-adhesion therapeutic agents targeting bacterial infections.

Published
2005
Full Text
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