Search

Your search keyword '"Alaoui-Jamali, Moulay A."' showing total 528 results
Start Over Author "Alaoui-Jamali, Moulay A."
528 results on '"Alaoui-Jamali, Moulay A."'

1. Corrigendum

Author

Zhan, Yao, Guo, Jun, Yang, William, Goncalves, Christophe, Rzymski, Tomasz, Dreas, Agnieszka, Zylkiewicz, Eliza, Mikulski, Maciej, Brzozka, Krzysztof, Golas, Aniela, Kong, Yan, Ma, Meng, Huang, Fan, Huor, Bonnie, Guo, Qianyu, da Silva, Sabrina Daniela, Torres, Jose, Cai, Yutian, Topisirovic, Ivan, Su, Jie, Bijian, Krikor, Alaoui-Jamali, Moulay A., Huang, Sidong, Journe, Fabrice, Ghanem, Ghanem E., Miller, Wilson H., Jr., and del Rincon, Sonia V.

Subjects
Health care industry
Abstract

Original citation: J Clin Invest. 2017;127(11):4179-4192. https://doi.org/10.1172/JCI91258. Citation for this corrigendum: J Clin Invest. 2024;134(8):e181338. https://doi.org/10.1172/JCI181338. The authors recently became aware that in the original Figure 2, A and C, [...]

Published
2024
Full Text
View/download PDF

4. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Author

Klionsky, Daniel J, Abdel-Aziz, Amal Kamal, Abdelfatah, Sara, Abdellatif, Mahmoud, Abdoli, Asghar, Abel, Steffen, Abeliovich, Hagai, Abildgaard, Marie H, Abudu, Yakubu Princely, Acevedo-Arozena, Abraham, Adamopoulos, Iannis E, Adeli, Khosrow, Adolph, Timon E, Adornetto, Annagrazia, Aflaki, Elma, Agam, Galila, Agarwal, Anupam, Aggarwal, Bharat B, Agnello, Maria, Agostinis, Patrizia, Agrewala, Javed N, Agrotis, Alexander, Aguilar, Patricia V, Ahmad, S Tariq, Ahmed, Zubair M, Ahumada-Castro, Ulises, Aits, Sonja, Aizawa, Shu, Akkoc, Yunus, Akoumianaki, Tonia, Akpinar, Hafize Aysin, Al-Abd, Ahmed M, Al-Akra, Lina, Al-Gharaibeh, Abeer, Alaoui-Jamali, Moulay A, Alberti, Simon, Alcocer-Gómez, Elísabet, Alessandri, Cristiano, Ali, Muhammad, Al-Bari, M Abdul Alim, Aliwaini, Saeb, Alizadeh, Javad, Almacellas, Eugènia, Almasan, Alexandru, Alonso, Alicia, Alonso, Guillermo D, Altan-Bonnet, Nihal, Altieri, Dario C, Álvarez, Élida MC, Alves, Sara, da Costa, Cristine Alves, Alzaharna, Mazen M, Amadio, Marialaura, Amantini, Consuelo, Amaral, Cristina, Ambrosio, Susanna, Amer, Amal O, Ammanathan, Veena, An, Zhenyi, Andersen, Stig U, Andrabi, Shaida A, Andrade-Silva, Magaiver, Andres, Allen M, Angelini, Sabrina, Ann, David, Anozie, Uche C, Ansari, Mohammad Y, Antas, Pedro, Antebi, Adam, Antón, Zuriñe, Anwar, Tahira, Apetoh, Lionel, Apostolova, Nadezda, Araki, Toshiyuki, Araki, Yasuhiro, Arasaki, Kohei, Araújo, Wagner L, Araya, Jun, Arden, Catherine, Arévalo, Maria-Angeles, Arguelles, Sandro, Arias, Esperanza, Arikkath, Jyothi, Arimoto, Hirokazu, Ariosa, Aileen R, Armstrong-James, Darius, Arnauné-Pelloquin, Laetitia, Aroca, Angeles, Arroyo, Daniela S, Arsov, Ivica, Artero, Rubén, Asaro, Dalia Maria Lucia, Aschner, Michael, Ashrafizadeh, Milad, Ashur-Fabian, Osnat, Atanasov, Atanas G, Au, Alicia K, Auberger, Patrick, Auner, Holger W, and Aurelian, Laure

Subjects
Biochemistry and Cell Biology, Biological Sciences, Animals, Autophagosomes, Autophagy, Autophagy-Related Proteins, Biological Assay, Biomarkers, Humans, Lysosomes, English, grammar, spelling, writing, Autophagosome, cancer, flux, LC3, lysosome, macroautophagy, neurodegeneration, phagophore, stress, vacuole, Biochemistry & Molecular Biology, Biochemistry and cell biology
Abstract

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.

Published
2021

5. Correction: MNK1/NODAL Signaling Promotes Invasive Progression of Breast Ductal Carcinoma In Situ

Author

Guo, Qianyu, primary, Li, Vivian Z., additional, Nichol, Jessica N., additional, Huang, Fan, additional, Yang, William, additional, Preston, Samuel E.J., additional, Talat, Zahra, additional, Lefrère, Hanne, additional, Yu, Henry, additional, Zhang, Guihua, additional, Basik, Mark, additional, Gonçalves, Christophe, additional, Zhan, Yao, additional, Plourde, Dany, additional, Su, Jie, additional, Torres, Jose, additional, Marques, Maud, additional, Habyan, Sara Al, additional, Bijian, Krikor, additional, Amant, Frédéric, additional, Wichter, Michael, additional, Behbod, Fariba, additional, McCaffrey, Luke, additional, Alaoui-Jamali, Moulay, additional, Giannakopoulos, Nadia V., additional, Brackstone, Muriel, additional, Postovit, Lynne-Marie, additional, del Rincón, Sonia V., additional, and Miller, William H., additional

Published
2024
Full Text
View/download PDF

6. MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma

Author

Zhan, Yao, primary, Guo, Jun, additional, Yang, William, additional, Goncalves, Christophe, additional, Rzymski, Tomasz, additional, Dreas, Agnieszka, additional, Żyłkiewicz, Eliza, additional, Mikulski, Maciej, additional, Brzózka, Krzysztof, additional, Golas, Aniela, additional, Kong, Yan, additional, Ma, Meng, additional, Huang, Fan, additional, Huor, Bonnie, additional, Guo, Qianyu, additional, da Silva, Sabrina Daniela, additional, Torres, Jose, additional, Cai, Yutian, additional, Topisirovic, Ivan, additional, Su, Jie, additional, Bijian, Krikor, additional, Alaoui-Jamali, Moulay A., additional, Huang, Sidong, additional, Journe, Fabrice, additional, Ghanem, Ghanem E., additional, Miller, Wilson H., additional, and del Rincón, Sonia V., additional

Published
2024
Full Text
View/download PDF

7. Therapeutic Advances and Challenges for the Management of HPV-Associated Oropharyngeal Cancer

Author

Muniz, Isis de Araújo Ferreira, primary, Araujo, Megan, additional, Bouassaly, Jenna, additional, Farshadi, Fatemeh, additional, Atique, Mai, additional, Esfahani, Khashayar, additional, Bonan, Paulo Rogerio Ferreti, additional, Hier, Michael, additional, Mascarella, Marco, additional, Mlynarek, Alex, additional, Alaoui-Jamali, Moulay, additional, and Silva, Sabrina Daniela da, additional

Published
2024
Full Text
View/download PDF

10. Supplementary Data from MNK1/NODAL Signaling Promotes Invasive Progression of Breast Ductal Carcinoma In Situ

Author

Guo, Qianyu, primary, Li, Vivian Z., primary, Nichol, Jessica N., primary, Huang, Fan, primary, Yang, William, primary, Preston, Samuel E.J., primary, Talat, Zahra, primary, Lefrère, Hanne, primary, Yu, Henry, primary, Zhang, Guihua, primary, Basik, Mark, primary, Gonçalves, Christophe, primary, Zhan, Yao, primary, Plourde, Dany, primary, Su, Jie, primary, Torres, Jose, primary, Marques, Maud, primary, Habyan, Sara Al, primary, Bijian, Krikor, primary, Amant, Frédéric, primary, Witcher, Michael, primary, Behbod, Fariba, primary, McCaffrey, Luke, primary, Alaoui-Jamali, Moulay, primary, Giannakopoulos, Nadia V., primary, Brackstone, Muriel, primary, Postovit, Lynne-Marie, primary, del Rincón, Sonia V., primary, and Miller, Wilson H., primary

Published
2024
Full Text
View/download PDF

11. Data from MNK1/NODAL Signaling Promotes Invasive Progression of Breast Ductal Carcinoma In Situ

Author

Guo, Qianyu, primary, Li, Vivian Z., primary, Nichol, Jessica N., primary, Huang, Fan, primary, Yang, William, primary, Preston, Samuel E.J., primary, Talat, Zahra, primary, Lefrère, Hanne, primary, Yu, Henry, primary, Zhang, Guihua, primary, Basik, Mark, primary, Gonçalves, Christophe, primary, Zhan, Yao, primary, Plourde, Dany, primary, Su, Jie, primary, Torres, Jose, primary, Marques, Maud, primary, Habyan, Sara Al, primary, Bijian, Krikor, primary, Amant, Frédéric, primary, Witcher, Michael, primary, Behbod, Fariba, primary, McCaffrey, Luke, primary, Alaoui-Jamali, Moulay, primary, Giannakopoulos, Nadia V., primary, Brackstone, Muriel, primary, Postovit, Lynne-Marie, primary, del Rincón, Sonia V., primary, and Miller, Wilson H., primary

Published
2024
Full Text
View/download PDF

14. Genetic Mutations Associated with Inflammatory Response Caused by HPV Integration in Oropharyngeal Squamous Cell Carcinoma.

Author

Atique, Mai, Muniz, Isis, Farshadi, Fatemeh, Hier, Michael, Mlynarek, Alex, Macarella, Marco, Maschietto, Mariana, Nicolau, Belinda, Alaoui-Jamali, Moulay A., and da Silva, Sabrina Daniela

Subjects
SQUAMOUS cell carcinoma, HUMAN papillomavirus, GENETIC mutation, MOLECULAR mechanisms of immunosuppression, INFLAMMATION, HEAD & neck cancer, GENITAL warts
Abstract

(1) Background: Head and neck cancer (HNC) ranks as the sixth most prevalent cancer in the world. In addition to the traditional risk factors such as alcohol and tobacco consumption, the implication of the human papillomavirus (HPV) is becoming increasingly significant, particularly in oropharyngeal cancer (OPC). (2) Methods: This study is based on a review analysis of different articles and repositories investigating the mutation profile of HPV-related OPC and its impact on patient outcomes. (3) Results: By compiling data from 38 datasets involving 8311 patients from 12 countries, we identified 330 genes that were further analyzed. These genes were enriched for regulation of the inflammatory response (RB1, JAK2, FANCA, CYLD, SYK, ABCC1, SYK, BCL6, CEBPA, SRC, BAP1, FOXP1, FGR, BCR, LRRK2, RICTOR, IGF1, and ATM), among other biological processes. Hierarchical cluster analysis showed the most relevant biological processes were linked with the regulation of mast cell cytokine production, neutrophil activation and degranulation, and leukocyte activation (FDR < 0.001; p-value < 0.05), suggesting that neutrophils may be involved in the development and progression of HPV-related OPC. (4) Conclusions: The neutrophil infiltration and HPV status emerge as a potential prognostic factor for OPC. HPV-infected HNC cells could potentially lead to a decrease in neutrophil infiltration. By gaining a better molecular understanding of HPV-mediated neutrophil immunosuppression activity, it is possible to identify a meaningful target to boost antitumor immune response in HNC and hence to improve the survival of patients with HNC. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

15. RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells

Author

Krishnan, Rehna, primary, Lapierre, Mariah, additional, Gautreau, Brandon, additional, Nixon, Kevin C J, additional, El Ghamrasni, Samah, additional, Patel, Parasvi S, additional, Hao, Jun, additional, Yerlici, V Talya, additional, Guturi, Kiran Kumar Naidu, additional, St-Germain, Jonathan, additional, Mateo, Francesca, additional, Saad, Amine, additional, Algouneh, Arash, additional, Earnshaw, Rebecca, additional, Shili, Duan, additional, Seitova, Alma, additional, Miller, Joshua, additional, Khosraviani, Negin, additional, Penn, Adam, additional, Ho, Brandon, additional, Sanchez, Otto, additional, Hande, M Prakash, additional, Masson, Jean-Yves, additional, Brown, Grant W, additional, Alaoui-Jamali, Moulay, additional, Reynolds, John J, additional, Arrowsmith, Cheryl, additional, Raught, Brian, additional, Pujana, Miguel A, additional, Mekhail, Karim, additional, Stewart, Grant S, additional, Hakem, Anne, additional, and Hakem, Razqallah, additional

Published
2023
Full Text
View/download PDF

16. Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis

Author

Li, Li, Guturi, Kiran Kumar Naidu, Gautreau, Brandon, Patel, Parasvi S., Saad, Amine, Morii, Mayako, Mateo, Francesca, Palomero, Luis, Barbour, Haithem, Gomez, Antonio, Ng, Deborah, Kotlyar, Max, Pastrello, Chiara, Jackson, Hartland W., Khokha, Rama, Jurisica, Igor, Affar, El Bachir, Raught, Brian, Sanchez, Otto, Alaoui-Jamali, Moulay, Pujana, Miguel A., Hakem, Anne, and Hakem, Razq

Subjects
Ligases -- Health aspects, Cellular signal transduction -- Genetic aspects -- Health aspects, Breast cancer -- Genetic aspects -- Development and progression -- Care and treatment, Health care industry
Abstract

The E3 ubiquitin ligase RNF8 plays critical roles in maintaining genomic stability by promoting the repair of DNA double-strand breaks (DSBs) through ubiquitin signaling. Abnormal activation of Notch signaling and defective repair of DSBs promote breast cancer risk. Here, we found that low expression of the full- length RNF8 correlated with poor prognosis for breast cancer patients. Our data revealed that in addition to its role in the repair of DSBs, RNF8 regulated Notch1 signaling and cell-fate determination of mammary luminal progenitors. Mechanistically, RNF8 acted as a negative regulator of Notch signaling by ubiquitylating the active NOTCH1 protein (N1ICD), leading to its degradation. Consistent with abnormal activation of Notch signaling and impaired repair of DSBs in Rn/8-mutant mammary epithelial cells, we observed increased risk of mammary tumorigenesis in mouse models for RNF8 deficiency. Notably, deficiency of RNF8 sensitized breast cancer cells to combination of pharmacological inhibitors of Notch signaling and poly(ADP-ribose) polymerase (PARP), suggesting implications for treatment of breast cancer associated with impaired RNF8 expression or function., Introduction Regulation of Notch signaling and repair of double-strand breaks (DSBs) is critical for maintaining tissue homeostasis and suppression of cancer. Notch signaling is important for the control of cell-fate [...]

Published
2018
Full Text
View/download PDF

22. Data from A Unique Morphological Phenotype in Chemoresistant Triple-Negative Breast Cancer Reveals Metabolic Reprogramming and PLIN4 Expression as a Molecular Vulnerability

Author

Sirois, Isabelle, primary, Aguilar-Mahecha, Adriana, primary, Lafleur, Josiane, primary, Fowler, Emma, primary, Vu, Viet, primary, Scriver, Michelle, primary, Buchanan, Marguerite, primary, Chabot, Catherine, primary, Ramanathan, Aparna, primary, Balachandran, Banujan, primary, Légaré, Stéphanie, primary, Przybytkowski, Ewa, primary, Lan, Cathy, primary, Krzemien, Urszula, primary, Cavallone, Luca, primary, Aleynikova, Olga, primary, Ferrario, Cristiano, primary, Guilbert, Marie-Christine, primary, Benlimame, Naciba, primary, Saad, Amine, primary, Alaoui-Jamali, Moulay, primary, Saragovi, Horace Uri, primary, Josephy, Sylvia, primary, O'Flanagan, Ciara, primary, Hursting, Stephen D., primary, Richard, Vincent R., primary, Zahedi, René P., primary, Borchers, Christoph H., primary, Bareke, Eric, primary, Nabavi, Sheida, primary, Tonellato, Peter, primary, Roy, Josée-Anne, primary, Robidoux, André, primary, Marcus, Elizabeth A., primary, Mihalcioiu, Catalin, primary, Majewski, Jacek, primary, and Basik, Mark, primary

Published
2023
Full Text
View/download PDF

23. Supplementary Data S18 from A Unique Morphological Phenotype in Chemoresistant Triple-Negative Breast Cancer Reveals Metabolic Reprogramming and PLIN4 Expression as a Molecular Vulnerability

Author

Sirois, Isabelle, primary, Aguilar-Mahecha, Adriana, primary, Lafleur, Josiane, primary, Fowler, Emma, primary, Vu, Viet, primary, Scriver, Michelle, primary, Buchanan, Marguerite, primary, Chabot, Catherine, primary, Ramanathan, Aparna, primary, Balachandran, Banujan, primary, Légaré, Stéphanie, primary, Przybytkowski, Ewa, primary, Lan, Cathy, primary, Krzemien, Urszula, primary, Cavallone, Luca, primary, Aleynikova, Olga, primary, Ferrario, Cristiano, primary, Guilbert, Marie-Christine, primary, Benlimame, Naciba, primary, Saad, Amine, primary, Alaoui-Jamali, Moulay, primary, Saragovi, Horace Uri, primary, Josephy, Sylvia, primary, O'Flanagan, Ciara, primary, Hursting, Stephen D., primary, Richard, Vincent R., primary, Zahedi, René P., primary, Borchers, Christoph H., primary, Bareke, Eric, primary, Nabavi, Sheida, primary, Tonellato, Peter, primary, Roy, Josée-Anne, primary, Robidoux, André, primary, Marcus, Elizabeth A., primary, Mihalcioiu, Catalin, primary, Majewski, Jacek, primary, and Basik, Mark, primary

Published
2023
Full Text
View/download PDF

24. Supplementary Data - Tables S1-S17 from A Unique Morphological Phenotype in Chemoresistant Triple-Negative Breast Cancer Reveals Metabolic Reprogramming and PLIN4 Expression as a Molecular Vulnerability

Author

Sirois, Isabelle, primary, Aguilar-Mahecha, Adriana, primary, Lafleur, Josiane, primary, Fowler, Emma, primary, Vu, Viet, primary, Scriver, Michelle, primary, Buchanan, Marguerite, primary, Chabot, Catherine, primary, Ramanathan, Aparna, primary, Balachandran, Banujan, primary, Légaré, Stéphanie, primary, Przybytkowski, Ewa, primary, Lan, Cathy, primary, Krzemien, Urszula, primary, Cavallone, Luca, primary, Aleynikova, Olga, primary, Ferrario, Cristiano, primary, Guilbert, Marie-Christine, primary, Benlimame, Naciba, primary, Saad, Amine, primary, Alaoui-Jamali, Moulay, primary, Saragovi, Horace Uri, primary, Josephy, Sylvia, primary, O'Flanagan, Ciara, primary, Hursting, Stephen D., primary, Richard, Vincent R., primary, Zahedi, René P., primary, Borchers, Christoph H., primary, Bareke, Eric, primary, Nabavi, Sheida, primary, Tonellato, Peter, primary, Roy, Josée-Anne, primary, Robidoux, André, primary, Marcus, Elizabeth A., primary, Mihalcioiu, Catalin, primary, Majewski, Jacek, primary, and Basik, Mark, primary

Published
2023
Full Text
View/download PDF

27. Suppl Figure 1-6, Suppl Table S0 and Suppl Methods from A Unique Morphological Phenotype in Chemoresistant Triple-Negative Breast Cancer Reveals Metabolic Reprogramming and PLIN4 Expression as a Molecular Vulnerability

Author

Sirois, Isabelle, primary, Aguilar-Mahecha, Adriana, primary, Lafleur, Josiane, primary, Fowler, Emma, primary, Vu, Viet, primary, Scriver, Michelle, primary, Buchanan, Marguerite, primary, Chabot, Catherine, primary, Ramanathan, Aparna, primary, Balachandran, Banujan, primary, Légaré, Stéphanie, primary, Przybytkowski, Ewa, primary, Lan, Cathy, primary, Krzemien, Urszula, primary, Cavallone, Luca, primary, Aleynikova, Olga, primary, Ferrario, Cristiano, primary, Guilbert, Marie-Christine, primary, Benlimame, Naciba, primary, Saad, Amine, primary, Alaoui-Jamali, Moulay, primary, Saragovi, Horace Uri, primary, Josephy, Sylvia, primary, O'Flanagan, Ciara, primary, Hursting, Stephen D., primary, Richard, Vincent R., primary, Zahedi, René P., primary, Borchers, Christoph H., primary, Bareke, Eric, primary, Nabavi, Sheida, primary, Tonellato, Peter, primary, Roy, Josée-Anne, primary, Robidoux, André, primary, Marcus, Elizabeth A., primary, Mihalcioiu, Catalin, primary, Majewski, Jacek, primary, and Basik, Mark, primary

Published
2023
Full Text
View/download PDF

30. MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma

Author

Zhan, Yao, Guo, Jun, Yang, William, Goncalves, Christophe, Rzymski, Tomasz, Dreas, Agnieszka, Zyfkiewicz, Eliza, Mikulski, Maciej, Brzozka, Krzysztof, Golas, Aniela, Kong, Yan, Ma, Meng, Huang, Fan, Huor, Bonnie, Guo, Qianyu, Daniela da Silva, Sabrina, Torres, Jose, Cai, Yutian, Topisirovic, Ivan, Su, Jie, Bijian, Krikor, Alaoui-Jamali, Moulay A., Huang, Sidong, Journe, Fabrice, Ghanem, Ghanem E., H. Miller Jr., Wilson, and del Rincon, Sonia V.

Subjects
Phosphorylation -- Research, Gene mutation -- Research, Cell migration -- Research, Melanoma -- Diagnosis -- Care and treatment, Health care industry
Abstract

Melanoma can be stratified into unique subtypes based on distinct pathologies. The acral/mucosal melanoma subtype is characterized by aberrant and constitutive activation of the proto-oncogene receptor tyrosine kinase C-KIT, which drives tumorigenesis. Treatment of these melanoma patients with C-KIT inhibitors has proven challenging, prompting us to investigate the downstream effectors of the C-KIT receptor. We determined that C-KIT stimulates MAP kinase-interacting serine/threonine kinases 1 and 2 (MNK1/2), which phosphorylate eukaryotic translation initiation factor 4E (eIF4E) and render it oncogenic. Depletion of MNK1/2 in melanoma cells with oncogenic C-KIT inhibited cell migration and mRNA translation of the transcriptional repressor SNA/1 and the cell cycle gene CCNE1. This suggested that blocking MNK1/2 activity may inhibit tumor progression, at least in part, by blocking translation initiation of mRNAs encoding cell migration proteins. Moreover, we developed an MNK1/2 inhibitor (SEL201), and found that SEL201-treated KIT-mutant melanoma cells had lower oncogenicity and reduced metastatic ability. Clinically, tumors from melanoma patients harboring K/T mutations displayed a marked increase in MNK1 and phospho-eIF4E. Thus, our studies indicate that blocking MNK1/2 exerts potent antimelanoma effects and support blocking MNK1/2 as a potential strategy to treat patients positive for K/T mutations., Introduction Early-stage melanoma can be cured by surgery, but patients often develop advanced disease that requires effective systemic treatment. Melanoma arising on acral and mucosal anatomical sites accounts for about [...]

Published
2017
Full Text
View/download PDF

33. Data from MNK1/NODAL Signaling Promotes Invasive Progression of Breast Ductal Carcinoma In Situ

Author

Guo, Qianyu, primary, Li, Vivian Z., primary, Nichol, Jessica N., primary, Huang, Fan, primary, Yang, William, primary, Preston, Samuel E.J., primary, Talat, Zahra, primary, Lefrère, Hanne, primary, Yu, Henry, primary, Zhang, Guihua, primary, Basik, Mark, primary, Gonçalves, Christophe, primary, Zhan, Yao, primary, Plourde, Dany, primary, Su, Jie, primary, Torres, Jose, primary, Marques, Maud, primary, Habyan, Sara Al, primary, Bijian, Krikor, primary, Amant, Frédéric, primary, Witcher, Michael, primary, Behbod, Fariba, primary, McCaffrey, Luke, primary, Alaoui-Jamali, Moulay, primary, Giannakopoulos, Nadia V., primary, Brackstone, Muriel, primary, Postovit, Lynne-Marie, primary, del Rincón, Sonia V., primary, and Miller, Wilson H., primary

Published
2023
Full Text
View/download PDF

36. Supplementary Data from MNK1/NODAL Signaling Promotes Invasive Progression of Breast Ductal Carcinoma In Situ

Author

Guo, Qianyu, primary, Li, Vivian Z., primary, Nichol, Jessica N., primary, Huang, Fan, primary, Yang, William, primary, Preston, Samuel E.J., primary, Talat, Zahra, primary, Lefrère, Hanne, primary, Yu, Henry, primary, Zhang, Guihua, primary, Basik, Mark, primary, Gonçalves, Christophe, primary, Zhan, Yao, primary, Plourde, Dany, primary, Su, Jie, primary, Torres, Jose, primary, Marques, Maud, primary, Habyan, Sara Al, primary, Bijian, Krikor, primary, Amant, Frédéric, primary, Witcher, Michael, primary, Behbod, Fariba, primary, McCaffrey, Luke, primary, Alaoui-Jamali, Moulay, primary, Giannakopoulos, Nadia V., primary, Brackstone, Muriel, primary, Postovit, Lynne-Marie, primary, del Rincón, Sonia V., primary, and Miller, Wilson H., primary

Published
2023
Full Text
View/download PDF

37. Supplementary Figure 1 from A Novel Experimental Heme Oxygenase-1–Targeted Therapy for Hormone-Refractory Prostate Cancer

Author

Alaoui-Jamali, Moulay A., primary, Bismar, Tarek A., primary, Gupta, Ajay, primary, Szarek, Walter A., primary, Su, Jie, primary, Song, Wei, primary, Xu, Yingjie, primary, Xu, Bin, primary, Liu, Guoan, primary, Vlahakis, Jason Z., primary, Roman, Gheorghe, primary, Jiao, Jinsong, primary, and Schipper, Hyman M., primary

Published
2023
Full Text
View/download PDF

39. Supplementary Figure 4 from A Novel Experimental Heme Oxygenase-1–Targeted Therapy for Hormone-Refractory Prostate Cancer

Author

Alaoui-Jamali, Moulay A., primary, Bismar, Tarek A., primary, Gupta, Ajay, primary, Szarek, Walter A., primary, Su, Jie, primary, Song, Wei, primary, Xu, Yingjie, primary, Xu, Bin, primary, Liu, Guoan, primary, Vlahakis, Jason Z., primary, Roman, Gheorghe, primary, Jiao, Jinsong, primary, and Schipper, Hyman M., primary

Published
2023
Full Text
View/download PDF

40. Supplementary Figure 3 from A Novel Experimental Heme Oxygenase-1–Targeted Therapy for Hormone-Refractory Prostate Cancer

Author

Alaoui-Jamali, Moulay A., primary, Bismar, Tarek A., primary, Gupta, Ajay, primary, Szarek, Walter A., primary, Su, Jie, primary, Song, Wei, primary, Xu, Yingjie, primary, Xu, Bin, primary, Liu, Guoan, primary, Vlahakis, Jason Z., primary, Roman, Gheorghe, primary, Jiao, Jinsong, primary, and Schipper, Hyman M., primary

Published
2023
Full Text
View/download PDF

41. Supplementary Figure 2 from A Novel Experimental Heme Oxygenase-1–Targeted Therapy for Hormone-Refractory Prostate Cancer

Author

Alaoui-Jamali, Moulay A., primary, Bismar, Tarek A., primary, Gupta, Ajay, primary, Szarek, Walter A., primary, Su, Jie, primary, Song, Wei, primary, Xu, Yingjie, primary, Xu, Bin, primary, Liu, Guoan, primary, Vlahakis, Jason Z., primary, Roman, Gheorghe, primary, Jiao, Jinsong, primary, and Schipper, Hyman M., primary

Published
2023
Full Text
View/download PDF

42. Supplementary Methods, Figure Legends 1-4 from A Novel Experimental Heme Oxygenase-1–Targeted Therapy for Hormone-Refractory Prostate Cancer

Author

Alaoui-Jamali, Moulay A., primary, Bismar, Tarek A., primary, Gupta, Ajay, primary, Szarek, Walter A., primary, Su, Jie, primary, Song, Wei, primary, Xu, Yingjie, primary, Xu, Bin, primary, Liu, Guoan, primary, Vlahakis, Jason Z., primary, Roman, Gheorghe, primary, Jiao, Jinsong, primary, and Schipper, Hyman M., primary

Published
2023
Full Text
View/download PDF

44. Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer

Author

Carnielli, Carolina Moretto, Macedo, Carolina Carneiro Soares, De Rossi, Tatiane, Granato, Daniela Campos, Rivera, César, Domingues, Romênia Ramos, Pauletti, Bianca Alves, Yokoo, Sami, Heberle, Henry, Busso-Lopes, Ariane Fidelis, Cervigne, Nilva Karla, Sawazaki-Calone, Iris, Meirelles, Gabriela Vaz, Marchi, Fábio Albuquerque, Telles, Guilherme Pimentel, Minghim, Rosane, Ribeiro, Ana Carolina Prado, Brandão, Thaís Bianca, de Castro, Jr, Gilberto, González-Arriagada, Wilfredo Alejandro, Gomes, Alexandre, Penteado, Fabio, Santos-Silva, Alan Roger, Lopes, Márcio Ajudarte, Rodrigues, Priscila Campioni, Sundquist, Elias, Salo, Tuula, da Silva, Sabrina Daniela, Alaoui-Jamali, Moulay A., Graner, Edgard, Fox, Jay W., Coletta, Ricardo Della, and Paes Leme, Adriana Franco

Published
2018
Full Text
View/download PDF

45. Identification of R-Spondin Gene Signature Predictive of Metastatic Progression in BRAFV600E-Positive Papillary Thyroid Cancer

Author

da Silva, Sabrina Daniela, primary, Morand, Grégoire B., additional, Diesel, Luciana, additional, de Lima, Jefferson Muniz, additional, Bijian, Krikor, additional, Kailasam, Senthilkumar, additional, Lefebvre, Francois, additional, Bourque, Guillaume, additional, Hier, Michael, additional, and Alaoui-Jamali, Moulay A., additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results