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1. Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a refined classification from the European society for blood and marrow transplantation (EBMT)

Author

Mohty, Mohamad, Malard, Florent, Alaskar, Ahmed S., Aljurf, Mahmoud, Arat, Mutlu, Bader, Peter, Baron, Frederic, Bazarbachi, Ali, Blaise, Didier, Brissot, Eolia, Ciceri, Fabio, Corbacioglu, Selim, Dalle, Jean-Hugues, Dignan, Fiona, Huynh, Anne, Kenyon, Michelle, Nagler, Arnon, Pagliuca, Antonio, Perić, Zinaida, Richardson, Paul G., Ruggeri, Annalisa, Ruutu, Tapani, Yakoub-Agha, Ibrahim, Duarte, Rafael F., and Carreras, Enric

Published
2023
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2. Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a position statement from an international expert group

Author

Mohty, Mohamad, Malard, Florent, Abecasis, Manuel, Aerts, Erik, Alaskar, Ahmed S., Aljurf, Mahmoud, Arat, Mutlu, Bader, Peter, Baron, Frederic, Basak, Grzegorz, Bazarbachi, Ali, Blaise, Didier, Ciceri, Fabio, Corbacioglu, Selim, Dalle, Jean-Hugues, Dignan, Fiona, Fukuda, Takahiro, Huynh, Anne, Kuball, Jurgen, Lachance, Silvy, Lazarus, Hillard, Masszi, Tamas, Michallet, Mauricette, Nagler, Arnon, NiChonghaile, Mairead, Okamoto, Shinichiro, Pagliuca, Antonio, Peters, Christina, Petersen, Finn B., Richardson, Paul G., Ruutu, Tapani, Saber, Wael, Savani, Bipin N., Soiffer, Robert, Styczynski, Jan, Wallhult, Elisabeth, Yakoub-Agha, Ibrahim, Duarte, Rafael F., and Carreras, Enric

Published
2020
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4. Artificial Intelligence in Laboratory Technologies for Early Detection and Prognostication of Sepsis: A Systematic Review.

Author

Bakouri, Mohsen, Alqahtani, Nasser M., Alhussain, Othman M., Alrashidi, Nawaf, Almutairi, Sulaiman N., Alabdulwahab, Ahmed O., Alaskar, Badr S., and Alqahtani, Megren A.

Subjects
ARTIFICIAL intelligence, SEPSIS, RECEIVER operating characteristic curves, MACHINE learning, NEONATAL sepsis
Abstract

Background: Sepsis a complex clinical syndrome represents life-threatening organ dysfunction instigated by an infection's dysregulated host response. Early detection and accurate prognostication of sepsis are crucial; they pave the way for timely intervention, ultimately enhancing patient outcomes. The rise in interest towards Artificial Intelligence (AI) applications within laboratory technologies is directly related to its potential for improving early detection and prognosis forecasting in sepsis cases; this interest comes as AI continues its advancement. Methods: We conducted a systematic review of studies utilizing AI algorithms in laboratory settings for early sepsis detection and prognostication: our methods entailed searching relevant databases for research published until October 2023. Our inclusion criteria spanned original articles; these applied machine learning (ML) and deep learning (DL) techniques to laboratory data with the aim being sepsis prediction. We assessed the quality of the studies, extracted and synthesized data on AI model performance metrics - including: area under receiver operating characteristic curve (AUROC), sensitivity, specificity, and accuracy. Results: The review encompassed eight studies meeting the inclusion criteria; AI models showcased exceptional predictive capabilities evidenced by a range of AUROC values from 0.799 to 0.9213, signifying noticeably acceptable performance. However, there was wide variation in sensitivity and specificity among these analyses; an indicator of heterogeneity in model performance. Superior prognostic accuracy and potential for real-time monitoring of patients' early sepsis signs emerged in several models; notably, within the first 12 hours of patient admission their highest predictive period. The models frequently outperformed traditional scoring systems. Conclusion: Laboratory technology's AI applications significantly promise sepsis' early detection and prognostication. Reviewed studies suggest AI models may surpass traditional methods, offering potential integration into clinical workflows for rapid sepsis identification aid. Nevertheless, we also acknowledged both the variability in model performance and necessity of additional validation across diverse clinical settings. Future research: it must concentrate on two key aspects-the refinement of AI algorithms to enhance sensitivity and precision; furthermore, it should delve into evaluating the clinical impact of tools for sepsis prediction that are assisted by AI. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Radiological outcome of bone disease in multiple myeloma patients pre- and post therapy

Author

Aljohani, Somaya A., primary, Saib, Israa H., additional, Syed, Ghulam Shah, additional, Alruwaili, Ahmed, additional, Numani, Shah P., additional, Almuthri, Sulaiman A., additional, Vishwakarm, Ramesh K., additional, Mendoza, May Anne C., additional, Alsalman, Mohammed J., additional, Ozair, Nabil M., additional, Alhejazi, Ayman Y., additional, Alaskar, Ahmed S., additional, and Gmati, Giamal E., additional

Published
2022
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10. Hematological indices in the adult saudi population: Reference intervals by gender, age, and region

Author

Shaheen, Naila A., primary, Rehan, Hina, additional, Moghairi, Areej, additional, Gmati, Giamal, additional, Damlaj, Moussab, additional, Salama, Hind, additional, Rather, Mushtaq, additional, Mendoza, May Anne, additional, Alanazi, Abeer, additional, Al Ahmari, Bader, additional, Al Zahrani, Mohsen, additional, Al-Hejazi, Ayman, additional, and Alaskar, Ahmed S., additional

Published
2022
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14. Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives—a position statement from the European Society for Blood and Marrow Transplantation (EBMT)

Author

Mohty, M, Malard, F, Abecassis, M, Aerts, E, Alaskar, A S, Aljurf, M, Arat, M, Bader, P, Baron, F, Bazarbachi, A, Blaise, D, Ciceri, F, Corbacioglu, S, Dalle, J-H, Duarte, R F, Fukuda, T, Huynh, A, Masszi, T, Michallet, M, Nagler, A, NiChonghaile, M, Pagluica, T, Peters, C, Petersen, F B, Richardson, P G, Ruutu, T, Savani, B N, Wallhult, E, Yakoub-Agha, I, and Carreras, E

Published
2015
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16. Favorable Fertility Outcome in a Large Cohort of Sickle Cell Disease Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Author

Abdulsalam, Mazin Mohamed, Alahmari, Bader, Alaskar, Ahmed S., Hejazi, Ayman, Salama, Hind, Al Raizah, Abdulrahman, Alsaleh, Abdullah, Ibrahim, Ayman, Bakkar, Mohammed, Yahya, Ayel, Ghori, Abdul Rauf, Aljubour, Zied, Almohammadi, Rawan, Alanazi, Tahani, Ahmed, Rasha, Alharbi, Amani, Shehabeddine, Inaam, Ballili, Maybelle, Alsadi, Husam Mazin, and Alzahrani, Mohsen

Published
2023
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20. Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a position statement from an international expert group

Author

CTI Kuball, MS Hematologie, Cancer, Regenerative Medicine and Stem Cells, Infection & Immunity, Mohty, Mohamad, Malard, Florent, Abecasis, Manuel, Aerts, Erik, Alaskar, Ahmed S, Aljurf, Mahmoud, Arat, Mutlu, Bader, Peter, Baron, Frederic, Basak, Grzegorz, Bazarbachi, Ali, Blaise, Didier, Ciceri, Fabio, Corbacioglu, Selim, Dalle, Jean-Hugues, Dignan, Fiona, Fukuda, Takahiro, Huynh, Anne, Kuball, Jurgen, Lachance, Silvy, Lazarus, Hillard, Masszi, Tamas, Michallet, Mauricette, Nagler, Arnon, NiChonghaile, Mairead, Okamoto, Shinichiro, Pagliuca, Antonio, Peters, Christina, Petersen, Finn B, Richardson, Paul G, Ruutu, Tapani, Saber, Wael, Savani, Bipin N, Soiffer, Robert, Styczynski, Jan, Wallhult, Elisabeth, Yakoub-Agha, Ibrahim, Duarte, Rafael F, Carreras, Enric, CTI Kuball, MS Hematologie, Cancer, Regenerative Medicine and Stem Cells, Infection & Immunity, Mohty, Mohamad, Malard, Florent, Abecasis, Manuel, Aerts, Erik, Alaskar, Ahmed S, Aljurf, Mahmoud, Arat, Mutlu, Bader, Peter, Baron, Frederic, Basak, Grzegorz, Bazarbachi, Ali, Blaise, Didier, Ciceri, Fabio, Corbacioglu, Selim, Dalle, Jean-Hugues, Dignan, Fiona, Fukuda, Takahiro, Huynh, Anne, Kuball, Jurgen, Lachance, Silvy, Lazarus, Hillard, Masszi, Tamas, Michallet, Mauricette, Nagler, Arnon, NiChonghaile, Mairead, Okamoto, Shinichiro, Pagliuca, Antonio, Peters, Christina, Petersen, Finn B, Richardson, Paul G, Ruutu, Tapani, Saber, Wael, Savani, Bipin N, Soiffer, Robert, Styczynski, Jan, Wallhult, Elisabeth, Yakoub-Agha, Ibrahim, Duarte, Rafael F, and Carreras, Enric

Published
2020

28. Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a position statement from an international expert group

Author

Mohty, Mohamad, primary, Malard, Florent, additional, Abecasis, Manuel, additional, Aerts, Erik, additional, Alaskar, Ahmed S., additional, Aljurf, Mahmoud, additional, Arat, Mutlu, additional, Bader, Peter, additional, Baron, Frederic, additional, Basak, Grzegorz, additional, Bazarbachi, Ali, additional, Blaise, Didier, additional, Ciceri, Fabio, additional, Corbacioglu, Selim, additional, Dalle, Jean-Hugues, additional, Dignan, Fiona, additional, Fukuda, Takahiro, additional, Huynh, Anne, additional, Kuball, Jurgen, additional, Lachance, Silvy, additional, Lazarus, Hillard, additional, Masszi, Tamas, additional, Michallet, Mauricette, additional, Nagler, Arnon, additional, NiChonghaile, Mairead, additional, Okamoto, Shinichiro, additional, Pagliuca, Antonio, additional, Peters, Christina, additional, Petersen, Finn B., additional, Richardson, Paul G., additional, Ruutu, Tapani, additional, Saber, Wael, additional, Savani, Bipin N., additional, Soiffer, Robert, additional, Styczynski, Jan, additional, Wallhult, Elisabeth, additional, Yakoub-Agha, Ibrahim, additional, Duarte, Rafael F., additional, and Carreras, Enric, additional

Published
2019
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29. Decidua Basalis Mesenchymal Stem Cells Favor Inflammatory M1 Macrophage Differentiation In Vitro

Author

Abumaree, Mohamed H., primary, Al Harthy, Seham, additional, Al Subayyil, Abdullah M., additional, Alshabibi, Manal A., additional, Abomaray, Fawaz M., additional, Khatlani, Tanvier, additional, Kalionis, Bill, additional, El-Muzaini, Mohammed F., additional, Al Jumah, Mohammed A., additional, Jawdat, Dunia, additional, Alawad, Abdullah O., additional, and AlAskar, Ahmed S., additional

Published
2019
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33. Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients

Author

University of Helsinki, Department of Medicine, Mohty, M., Malard, F., Abecassis, M., Aerts, E., Alaskar, A. S., Aljurf, M., Arat, M., Bader, P., Baron, F., Bazarbachi, A., Blaise, D., Ciceri, F., Corbacioglu, S., Dalle, J-H, Dignan, F., Fukuda, T., Huynh, A., Masszi, T., Michallet, M., Nagler, A., NiChonghaile, M., Okamoto, S., Pagliuca, A., Peters, C., Petersen, F. B., Richardson, P. G., Ruutu, T., Savani, B. N., Wallhult, E., Yakoub-Agha, I., Duarte, R. F., Carreras, E., University of Helsinki, Department of Medicine, Mohty, M., Malard, F., Abecassis, M., Aerts, E., Alaskar, A. S., Aljurf, M., Arat, M., Bader, P., Baron, F., Bazarbachi, A., Blaise, D., Ciceri, F., Corbacioglu, S., Dalle, J-H, Dignan, F., Fukuda, T., Huynh, A., Masszi, T., Michallet, M., Nagler, A., NiChonghaile, M., Okamoto, S., Pagliuca, A., Peters, C., Petersen, F. B., Richardson, P. G., Ruutu, T., Savani, B. N., Wallhult, E., Yakoub-Agha, I., Duarte, R. F., and Carreras, E.

Abstract

Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (480%). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity-grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation.

Published
2016

38. Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation

Author

Mohty, M, primary, Malard, F, additional, Abecassis, M, additional, Aerts, E, additional, Alaskar, A S, additional, Aljurf, M, additional, Arat, M, additional, Bader, P, additional, Baron, F, additional, Bazarbachi, A, additional, Blaise, D, additional, Ciceri, F, additional, Corbacioglu, S, additional, Dalle, J-H, additional, Dignan, F, additional, Fukuda, T, additional, Huynh, A, additional, Masszi, T, additional, Michallet, M, additional, Nagler, A, additional, NiChonghaile, M, additional, Okamoto, S, additional, Pagliuca, A, additional, Peters, C, additional, Petersen, F B, additional, Richardson, P G, additional, Ruutu, T, additional, Savani, B N, additional, Wallhult, E, additional, Yakoub-Agha, I, additional, Duarte, R F, additional, and Carreras, E, additional

Published
2016
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39. Phenotypic and Functional Characterization of Mesenchymal Stem/Multipotent Stromal Cells fromDecidua Basalisof Human Term Placenta

Author

Abomaray, F. M., primary, Al Jumah, M. A., additional, Alsaad, K. O., additional, Jawdat, D., additional, Al Khaldi, A., additional, AlAskar, A. S., additional, Al Harthy, S., additional, Al Subayyil, A. M., additional, Khatlani, T., additional, Alawad, A. O., additional, Alkushi, A., additional, Kalionis, B., additional, and Abumaree, M. H., additional

Published
2016
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40. Preconditioning by Hydrogen Peroxide Enhances Multiple Properties of Human Decidua Basalis Mesenchymal Stem/Multipotent Stromal Cells.

Author

Khatlani, T., Algudiri, D., Alenzi, R., Al Subayyil, A. M., Abomaray, F. M., Bahattab, E., AlAskar, A. S., Kalionis, B., El-Muzaini, M. F., and Abumaree, M. H.

Subjects
HYDROGEN peroxide, MESENCHYMAL stem cells, STEM cell treatment, OXIDATIVE stress, CELL proliferation, CELL migration
Abstract

Stem cell-based therapies rely on stem cell ability to repair in an oxidative stress environment. Preconditioning of mesenchymal stem cells (MSCs) to a stress environment has beneficial effects on their ability to repair injured tissues. We previously reported that MSCs from the decidua basalis (DBMSCs) of human placenta have many important cellular functions that make them potentially useful for cell-based therapies. Here, we studied the effect of DBMSC preconditioning to a stress environment. DBMSCs were exposed to various concentrations of hydrogen peroxide (H2O2), and their functions were then assessed. DBMSC expression of immune molecules after preconditioning was also determined. DBMSC preconditioning with H2O2 enhanced their proliferation, colonogenicity, adhesion, and migration. In addition, DBMSCs regardless of H2O2 treatment displayed antiangiogenic activity. H2O2 preconditioning also increased DBMSC expression of genes that promote cellular functions and decreased the expression of genes, which have opposite effect on their functions. Preconditioning also reduced DBMSC expression of IL-1β, but had no effects on the expression of other immune molecules that promote proliferation, adhesion, and migration. These data show that DBMSCs resist a toxic environment, which adds to their potential as a candidate stem cell type for treating various diseases in hostile environments. [ABSTRACT FROM AUTHOR]

Published
2018
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44. Health-related quality of life in patients with sickle cell disease in Saudi Arabia

Author

Ahmed, Anwar E., primary, Alaskar, Ahmed S., additional, Al-Suliman, Ahmad M., additional, Jazieh, Abdul-Rahman, additional, McClish, Donna K., additional, Al Salamah, Majid, additional, Ali, Yosra Z., additional, Malhan, Hafiz, additional, Mendoza, May Anne, additional, Gorashi, Abdulrahman O., additional, El-toum, Mohamed E., additional, and El-toum, Wala E., additional

Published
2015
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46. Public awareness of blood donation in Central Saudi Arabia

Author

Abolfotouh,Mostafa A, Al-Assiri,Mohammed H, Al-Omani,Manar, Al Johar,Alwaleed, Al Hakbani,Abdulaziz, Alaskar,Ahmed S, Abolfotouh,Mostafa A, Al-Assiri,Mohammed H, Al-Omani,Manar, Al Johar,Alwaleed, Al Hakbani,Abdulaziz, and Alaskar,Ahmed S

Abstract

Mostafa A Abolfotouh,1,2 Mohammed H Al-Assiri,1 Manar Al-Omani,2 Alwaleed Al Johar,3 Abdulaziz Al Hakbani,3 Ahmed S Alaskar1,2 1King Abdullah International Medical Research Center, 2King Saud bin-Abdulaziz University for Health Sciences, 3College of Medicine, King Saud University, Riyadh, Saudi Arabia Introduction: In Saudi Arabia, voluntary donors are the only source of blood donation. The aim of this study was to assess the level of public knowledge and attitude toward blood donation in Saudi Arabia. Methods: Using a previously validated questionnaire that comprises 38 questions to assess the levels of knowledge, attitudes, and motivations towards blood donation, 469 Saudi adults who attended different shopping malls in Riyadh, Saudi Arabia were surveyed. Multiple regression analyses were used to identify the significant predictors of blood donation, with the significance set at P<0.05. Results: Approximately half of all subjects (53.3%) reported that they had previously donated blood, 39% of whom had donated more than once. The knowledge percentage mean score was 58.07%, denoting a poor level of knowledge, with only 11.9% reporting a good level of knowledge. The attitude percentage mean score towards donation was 75.45%, reflecting a neutral attitude towards donating blood, with 31.6% reporting a positive attitude. Donation was significantly more prevalent among males than females (66% versus 13.3%; P<0.001). After adjustment for confounders, a higher knowledge score (t=2.59; P=0.01), a higher attitude score (t=3.26; P=0.001), and male sex (t=10.45; P<0.001) were significant predictors of blood donation. An inability to reach the blood donation centers and a fear of anemia were the main reasons for females not donating blood (49.9% and 35.7%, respectively), whereas a lack of time was the main reason for males (59.5%). Conclusion: Prevalence of blood donation was less than satisfactory among the Saudi public, probably due to misconceptions, po

Published
2014

50. Phenotypic and Functional Characterization of Mesenchymal Stem/Multipotent Stromal Cells from Decidua Basalis of Human Term Placenta.

Author

Abomaray, F. M., Al Jumah, M. A., Alsaad, K. O., Jawdat, D., Al Khaldi, A., AlAskar, A. S., Al Harthy, S., Al Subayyil, A. M., Khatlani, T., Alawad, A. O., Alkushi, A., Kalionis, B., and Abumaree, M. H.

Subjects
MESENCHYMAL stem cells, STROMAL cells, PHENOTYPES, PLACENTA, INFLAMMATION treatment, OXIDATIVE stress
Abstract

Mesenchymal stem cell (MSC) therapies for the treatment of diseases associated with inflammation and oxidative stress employ primarily bone marrow MSCs (BMMSCs) and other MSC types such as MSC from the chorionic villi of human term placentae (pMSCs). These MSCs are not derived from microenvironments associated with inflammation and oxidative stress, unlike MSCs from the decidua basalis of the human term placenta (DBMSCs). DBMSCs were isolated and then extensively characterized. Differentiation of DBMSCs into three mesenchymal lineages (adipocytes, osteocytes, and chondrocytes) was performed. Real-time polymerase chain reaction (PCR) and flow cytometry techniques were also used to characterize the gene and protein expression profiles of DBMSCs, respectively. In addition, sandwich enzyme-linked immunosorbent assay (ELISA) was performed to detect proteins secreted by DBMSCs. Finally, the migration and proliferation abilities of DBMSCs were also determined. DBMSCs were positive for MSC markers and HLA-ABC. DBMSCs were negative for hematopoietic and endothelial markers, costimulatory molecules, and HLA-DR. Functionally, DBMSCs differentiated into three mesenchymal lineages, proliferated, and migrated in response to a number of stimuli. Most importantly, these cells express and secrete a distinct combination of cytokines, growth factors, and immune molecules that reflect their unique microenvironment. Therefore, DBMSCs could be attractive, alternative candidates for MSC-based therapies that treat diseases associated with inflammation and oxidative stress. [ABSTRACT FROM AUTHOR]

Published
2016
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