1. Effect of pertussis toxin on the adrenergic regulation of plasma renin activity
- Author
-
JoséCarlos Peña, Alatorre-González Mc, García-Sáinz Ja, María Elena Ibarra-Rubio, and José Pedraza-Chaverri
- Subjects
Male ,Bordetella pertussis ,medicine.medical_specialty ,animal structures ,Epinephrine ,Adrenergic receptor ,Bacterial Toxins ,Adrenergic ,urologic and male genital diseases ,Pertussis toxin ,Plasma renin activity ,Clonidine ,General Biochemistry, Genetics and Molecular Biology ,Internal medicine ,Adrenal Glands ,Renin ,Renin–angiotensin system ,medicine ,Animals ,Virulence Factors, Bordetella ,General Pharmacology, Toxicology and Pharmaceutics ,biology ,Chemistry ,Isoproterenol ,Yohimbine ,Rats, Inbred Strains ,General Medicine ,biology.organism_classification ,Propranolol ,female genital diseases and pregnancy complications ,Rats ,Kinetics ,Endocrinology ,Pertussis Toxin ,hormones, hormone substitutes, and hormone antagonists ,circulatory and respiratory physiology ,medicine.drug - Abstract
Basal plasma renin activity (PRA) was not modified by pertussis toxin administration. On the contrary, the modulation of PRA by adrenergic amines was markedly affected by the toxin. Administration of epinephrine did not modified PRA in the controls but markedly increased it in toxin-treated rats. This effect of epinephrine was reproduced in control rats when yohimbine was given before the catecholamine. Clonidine decreased PRA to a much more significant extent in control rats than in animals treated with the toxin. Isoproterenol stimulated PRA to a greater level in toxin-treated rats. Our data indicates that pertussis toxin blocks the alpha2-adrenergic modulation of renin release and magnifies the ability of beta adrenergic activation to stimulate PRA.
- Published
- 1984
- Full Text
- View/download PDF