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36 results on '"Albano, Pia Marie"'

1. Blood-Based FTIR Spectroscopy as a Minimally Invasive Diagnostic Method for Colorectal Cancer: A Meta-Analysis

Author

Magno, Gerard Mathew, primary, Lotilla, Gianna Erika, additional, Ambrosio, Enzo Rafael, additional, Nagera, Francis Louie, additional, Grino, Maria Isabel, additional, Castro, Mikaela Rosette, additional, Millan, Javier Alfonso, additional, Manzano, Joe Anthony, additional, Tiongco, Raphael Enrique, additional, and Albano, Pia Marie, additional

Published
2024
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13. Predicting the Likelihood of Colorectal Cancer with Artificial Intelligence Tools Using Fourier Transform Infrared Signals Obtained from Tumor Samples

Author

Villamanca, John Jerald, primary, Hermogino, Lemuel John, additional, Ong, Katherine Denise, additional, Paguia, Brian, additional, Abanilla, Lorenzo, additional, Lim, Antonio, additional, Angeles, Lara Mae, additional, Espiritu, Bernadette, additional, Isais, Maura, additional, Tomas, Rock Christian, additional, and Albano, Pia Marie, additional

Published
2022
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14. Artificial neural network in the discrimination of lung cancer based on infrared spectroscopy

Author

Lugtu, Eiron John, primary, Ramos, Denise Bernadette, additional, Agpalza, Alliah Jen, additional, Cabral, Erika Antoinette, additional, Carandang, Rian Paolo, additional, Dee, Jennica Elia, additional, Martinez, Angelica, additional, Jose, Julius Eleazar, additional, Santillan, Abegail, additional, Bangaoil, Ruth, additional, Albano, Pia Marie, additional, and Tomas, Rock Christian, additional

Published
2022
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16. Supplemental Material - Predicting the Likelihood of Colorectal Cancer with Artificial Intelligence Tools Using Fourier Transform Infrared Signals Obtained from Tumor Samples

Author

Villamanca, John Jerald, Hermogino, Lemuel John, Ong, Katherine Denise, Paguia, Brian, Abanilla, Lorenzo, Lim, Antonio, Angeles, Lara Mae, Espiritu, Bernadette, Isais, Maura, Tomas, Rock Christian, and Albano, Pia Marie

Subjects
FOS: Other engineering and technologies, 99999 Engineering not elsewhere classified
Abstract

Supplemental Material for Predicting the Likelihood of Colorectal Cancer with Artificial Intelligence Tools Using Fourier Transform Infrared Signals Obtained from Tumor Samples by John Jerald Villamanca, Lemuel John Hermogino, Katherine Denise Ong, Brian Paguia, Lorenzo Abanilla, Antonio Lim, Lara Mae Angeles, Bernadette Espiritu, Maura Isais, Rock Christian Tomas, and Pia Marie Albano in Applied Spectroscopy

Published
2022
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17. Meta-Analysis on the Association of Colibactin-Producing pks+ Escherichia coli with the Development of Colorectal Cancer.

Author

Gaab, Marcianne Elaine, Lozano, Prim Olivette, Ibañez, Danica, Manese, Korina Diane, Riego, Fatima May, Tiongco, Raphael Enrique, and Albano, Pia Marie

Subjects
ESCHERICHIA coli, COLON tumors, ONLINE information services, MEDICAL databases, DISEASE progression, META-analysis, CONFIDENCE intervals, CARCINOGENESIS, SYSTEMATIC reviews, ORGANIC compounds, COLORECTAL cancer, DESCRIPTIVE statistics, MICROBIAL virulence, MEDLINE, DATA analysis software
Abstract

Objective Previous studies on the association between pks + Escherichia coli and colorectal cancer (CRC) demonstrated conflicting results. Hence, we performed a meta-analysis to obtain more precise estimates. Methods Related literature was obtained from PubMed, ScienceDirect, Google Scholar, and Cochrane Library. Data were then extracted, summarized, and subjected to analysis using Review Manager 5.4 by computing for the pooled odds ratios at the 95% confidence interval. Results Overall analysis showed that individuals carrying pks + E coli had a greater risk of developing CRC. Subgroup analysis further showed that individuals from Western countries carrying pks + E coli and individuals with pks + E coli in their tissue samples had increased risk of developing CRC. Conclusion Results of this meta-analysis suggest that individuals with pks + E coli have a greater risk of developing CRC. However, more studies are needed to confirm our claims. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Diagnostic Efficiency of Serum-Based Infrared Spectroscopy in Detecting Breast Cancer: A Meta-Analysis.

Author

Pabico, Louise Julie, Jaron, Jennica Naiomi, Mosqueda, Marc Erickson, Wu, Jorge Jaesen, Tiongco, Raphael Enrique, and Albano, Pia Marie

Subjects
BREAST tumor diagnosis, ONLINE information services, MEDICAL databases, BIOPSY, META-analysis, SYSTEMATIC reviews, DESCRIPTIVE statistics, RESEARCH funding, BLOOD testing, INFRARED spectroscopy, DATA analysis software, SENSITIVITY & specificity (Statistics), RECEIVER operating characteristic curves, MEDLINE, ODDS ratio
Abstract

Background The advancement of Fourier transform infrared (FTIR) spectroscopy as a potential diagnostic tool in the clinical setting has been studied over the years, particularly its application in cancer diagnostics. Objective To summarize previous research on FTIR spectroscopy in detecting breast cancer using serum specimens. Methods Related literature was searched and screened from various databases. Relevant data were then extracted, tabulated, and analyzed using Meta-DiSc 1.4 software. Results Sensitivity and specificity rates were 90% to 100% and 80% to 95%, respectively. The area under the receiver operating characteristic curve was at 0.9729, indicating that serum analysis via FTIR spectroscopy can accurately discriminate between healthy individuals and patients with breast cancer. Conclusion Overall, FTIR spectroscopy for breast cancer diagnosis using serum specimens shows promising results. However, further studies are still needed to validate these claims. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Pks+ Escherichia Coli More Prevalent in Benign than Malignant Colorectal Tumors

Author

Tolentino, Carmina Villariba, primary, Cariño, Ana Maria, additional, Notarte, Kin Israel, additional, Macaranas, Imee, additional, Fellizar, Allan, additional, Tomas, Rock Christian, additional, Angeles, Lara Mae, additional, Abanilla, Lorenzo, additional, Lim, Antonio, additional, Aguilar, Ma. Kristina Carmela, additional, and Albano, Pia Marie, additional

Published
2021
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22. pks+ Escherichia coli more prevalent in benign than malignant colorectal tumors

Author

Villariba-Tolentino, Carmina, primary, Cariño, Ana Maria, additional, Notarte, Kin Israel, additional, Macaranas, Imee, additional, Fellizar, Allan, additional, Tomas, Rock Christian, additional, Angeles, Lara Mae, additional, Abanilla, Lorenzo, additional, Lim, Antonio, additional, Aguilar, Ma. Kristina Carmela, additional, and Albano, Pia Marie, additional

Published
2021
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29. pks+Escherichia coli more prevalent in benign than malignant colorectal tumors.

Author

Villariba-Tolentino, Carmina, Cariño, Ana Maria, Notarte, Kin Israel, Macaranas, Imee, Fellizar, Allan, Tomas, Rock Christian, Angeles, Lara Mae, Abanilla, Lorenzo, Lim, Antonio, Aguilar, Ma. Kristina Carmela, and Albano, Pia Marie

Abstract

Background: Some E. coli strains that synthesize the toxin colibactin within the 54-kb pks island are being implicated in colorectal cancer (CRC) development. Here, the prevalence of pks+E. coli in malignant and benign colorectal tumors obtained from selected Filipino patients was compared to determine the association of pks+E. coli with CRC in this population. Methods and results: A realtime qPCR protocol was developed to quantify uidA, clbB, clbN, and clbA genes in formalin fixed paraffin embedded colorectal tissues. The number of malignant tumors (44/62; 71%) positive for the uidA gene was not significantly different (p = 0.3428) from benign (38/62; 61%) tumors. Significantly higher number of benign samples (p < 0.05) were positive for all three colibactin genes (clbB, clbN, and clbA) compared with malignant samples. There was also higher prevalence of pks+E. coli among older females and in tissue samples taken from the rectum. Conclusion: Hence, pks+E. coli may not be associated with CRC development among Filipinos. [ABSTRACT FROM AUTHOR]

Published
2021
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32. Low prevalence of human papillomavirus in head and neck squamous cell carcinoma in the northwest region of the Philippines

Author

Albano, Pia Marie, primary, Holzinger, Dana, additional, Salvador, Christianne, additional, Orosa, Jose, additional, Racelis, Sheryl, additional, Leaño, Modesty, additional, Sanchez, Danilo, additional, Angeles, Lara Mae, additional, Halec, Gordana, additional, Schmitt, Markus, additional, Ramos, John Donnie, additional, and Pawlita, Michael, additional

Published
2017
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35. Immunogenicity of a Fap2 peptide mimotope of <italic>Fusobacterium nucleatum</italic> and its potential use in the diagnosis of colorectal cancer.

Author

Guevarra, Leonardo A., Afable, Andrea Claudine F., Belza, Patricia Joyce O., Dy, Karen Joy S., Lee, Scott Justin Q., Sy-Ortin, Teresa T., and Albano, Pia Marie S. P.

Subjects
BLOOD testing, ANIMAL experimentation, COLON tumors, ENZYME-linked immunosorbent assay, GRAM-negative bacteria, IMMUNOGENETICS, RABBITS, RECTUM tumors
Abstract

Background: The role of Fusobacterium nucleatum Fap2 protein in the development of colorectal cancer has recently been explained. Fap2, when bound to the human inhibitory receptor, TIGIT, inhibits the cytotoxic activity of natural killer (NK) cells against cancer cells, thus, allowing proliferation of the latter eventually leading to tumor growth. The aim of the study was to identify the immunogenicity of a peptide mimotope of the Fap2 protein and to determine the reactivity of colorectal cancer patients’ sera against the mimotope. Methods: Immunogenic epitope of the Fap2 protein of F. nucleatum was selected using the B-cell epitope prediction of the Immune Epitope Database and Analysis Resource (IEDB). The immunogenicity of the synthetic peptide mimotope of the Fap2 protein was determined in animal models and reactivity of colorectal cancer patients’ sera against the mimotope was done by indirect ELISA. Results: Results show that the selected peptide mimotope, with sequence TELAYKHYFGT, of the outer membrane protein Fap2 of F. nucleatum is immunogenic. Increase in the absorbance readings of peptide-immunized rabbit sera was observed starting Week 1 which was sustained up to Week 10 in the indirect ELISA performed. Colorectal cancer cases (n = 37) were all reactive in an ELISA-based analysis using the mimotope as the capture antigen. Conclusions: In this study, we identified an immunogenic epitope of the Fap2 protein of the Fusobacterium nucleatum. We demonstrated the reactivity of serum of histopathologically confirmed CRC patients in a peptide-capture indirect ELISA which may serve as proof of concept for the development of CRC diagnostics. [ABSTRACT FROM AUTHOR]

Published
2018
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36. A Meta-Analysis on the Association of Colibactin-Producing pks+ Escherichia coli with the Development of Colorectal Cancer.

Author

Gaab ME, Lozano PO, Ibañez D, Manese KD, Riego FM, Tiongco RE, and Albano PM

Subjects
Humans, Escherichia coli, Peptides, Polyketides, Colorectal Neoplasms epidemiology
Abstract

Objective: Previous studies on the association between pks+Escherichia coli and colorectal cancer (CRC) demonstrated conflicting results. Hence, we performed a meta-analysis to obtain more precise estimates., Methods: Related literature was obtained from PubMed, ScienceDirect, Google Scholar, and Cochrane Library. Data were then extracted, summarized, and subjected to analysis using Review Manager 5.4 by computing for the pooled odds ratios at the 95% confidence interval., Results: Overall analysis showed that individuals carrying pks+E coli had a greater risk of developing CRC. Subgroup analysis further showed that individuals from Western countries carrying pks+E coli and individuals with pks+E coli in their tissue samples had increased risk of developing CRC., Conclusion: Results of this meta-analysis suggest that individuals with pks+E coli have a greater risk of developing CRC. However, more studies are needed to confirm our claims., (© The Author(s) 2022. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2023
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