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2. Erratum to: Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA

Author

Bousquet, Jean, Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R. E., Somekh, D., Vera-Muñoz, C., Visser, F., Farrell, J., Malva, J., Andersen Ranberg, K., Camuzat, T., Carriazo, A. M., Crooks, G., Gutter, Z., Iaccarino, G., de Keenoy, E. Manuel, Moda, G., Rodriguez-Mañas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M. T., Avolio, F., Bedbrook, A., Białoszewski, A. Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M. F., Catala, A., O’Caoimh, R., Cesari, M., Chavannes, N. H., Correia-Da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W. J., Garcia-Lizana, F., Guérin, O., Hellings, P. W., Haahtela, T., Illario, M., Inzerilli, M. C., Lodrup Carlsen, K. C., Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J. P., Murray, R., Nogues, M., O’Byrne-Maguire, I., Pappa, D., Parent, A. S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A. M., Tsartara, S. I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G. W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I. M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S. H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K. C., Bernard, P. L., Bonini, S., Bousquet, P. J., Branchini, B., Brightling, C. E., Bruguière, V., Bunu, C., Bush, A., Caimmi, D. P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K. H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K. F., D’Angelantonio, M., de Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D. J., Costa, E., Coste, O., Coupet, A. -L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S. E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougère, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioğlu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Héve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S. L., Just, J., Jutel, M., Kaidashev, I. P., Kaitov, M., Kalayci, O., Kalyoncu, A. F., Keijser, W., Kerstjens, H., Knezović, J., Kowalski, M., Koppelman, G. H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Maggio, M., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinarić, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Mösges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N. K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T. A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J. C., Robine, J. M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H. J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Siciliano, P., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Tsartara, S. I., Valero, A. L., Valovirta, E., van Ganse, E., van Hage, M., van den Berge, M., Vandenplas, O., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wickman, M., Wilson, N., Yiallouros, P. K., Žagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., and de Oliveira-Alves, B.

Published
2023
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3. Comprehensive assessment of the long-term safety of pirfenidone in patients with idiopathic pulmonary fibrosis

Author

King, Talmadge, Valeyre, D, Albera, C, Bradford, WZ, Costabel, U, King, TE, Leff, JA, Noble, PW, Sahn, SA, and du, RM

Abstract

Background and objective: Pirfenidone is an oral antifibrotic agent that is approved in several countries for the treatment of idiopathic pulmonary fibrosis (IPF). We performed a comprehensive analysis of safety across four clinical trials evaluating pirfe

Published
2014

5. Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA

Author

Bousquet, Jean, Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R. E., Somekh, D., Vera-Muñoz, C., Visser, F., Farrell, J., Malva, J., Andersen Ranberg, K., Camuzat, T., Carriazo, A. M., Crooks, G., Gutter, Z., Iaccarino, G., de Keenoy, E. Manuel, Moda, G., Rodriguez-Mañas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M. T., Avolio, F., Bedbrook, A., Białoszewski, A. Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M. F., Catala, A., O’Caoimh, R., Cesari, M., Chavannes, N. H., Correia-Da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W. J., Garcia-Lizana, F., Guérin, O., Hellings, P. W., Haahtela, T., Illario, M., Inzerilli, M. C., Lodrup Carlsen, K. C., Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J. P., Murray, R., Nogues, M., O’Byrne-Maguire, I., Pappa, D., Parent, A. S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A. M., Tsartara, S. I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G. W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I. M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S. H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K. C., Bernard, P. L., Bonini, S., Bousquet, P. J., Branchini, B., Brightling, C. E., Bruguière, V., Bunu, C., Bush, A., Caimmi, D. P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K. H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K. F., D’Angelantonio, M., de Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D. J., Costa, E., Coste, O., Coupet, A. -L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S. E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougère, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioğlu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Héve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S. L., Just, J., Jutel, M., Kaidashev, I. P., Kaitov, M., Kalayci, O., Kalyoncu, A. F., Keijser, W., Kerstjens, H., Knezović, J., Kowalski, M., Koppelman, G. H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Maggio, M., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinarić, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Mösges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N. K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T. A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J. C., Robine, J. M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H. J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Siciliano, P., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Tsartara, S. I., Valero, A. L., Valovirta, E., van Ganse, E., van Hage, M., van den Berge, M., Vandenplas, O., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wickman, M., Wilson, N., Yiallouros, P. K., Žagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., and de Oliveira-Alves, B.

Published
2017
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7. Clinical course of IPF in Italian patients during 12 months of observation: results from the FIBRONET observational study

Author

Poletti, V, Vancheri, C, Albera, C, Harari, S, Pesci, A, Metella, R, Campolo, B, Crespi, G, Rizzoli, S, Tomassetti, S, Rottoli, P, Bocchino, M, Stanziola, A, Luppi, F, Sebastiani, A, Lacedonia, D, Vitulo, P, Tavanti, L, Vianello, A, Saetta, M, Marinari, S, Pirina, P, Valente, S, Oggionni, T, Gasparini, S, Poletti V., Vancheri C., Albera C., Harari S., Pesci A., Metella R. R., Campolo B., Crespi G., Rizzoli S., Tomassetti S., Rottoli P., Bocchino M., Stanziola A. A., Luppi F., Sebastiani A., Lacedonia D., Vitulo P., Tavanti L., Vianello A., Saetta M., Marinari S., Pirina P., Valente S., Oggionni T., Gasparini S., Poletti, V, Vancheri, C, Albera, C, Harari, S, Pesci, A, Metella, R, Campolo, B, Crespi, G, Rizzoli, S, Tomassetti, S, Rottoli, P, Bocchino, M, Stanziola, A, Luppi, F, Sebastiani, A, Lacedonia, D, Vitulo, P, Tavanti, L, Vianello, A, Saetta, M, Marinari, S, Pirina, P, Valente, S, Oggionni, T, Gasparini, S, Poletti V., Vancheri C., Albera C., Harari S., Pesci A., Metella R. R., Campolo B., Crespi G., Rizzoli S., Tomassetti S., Rottoli P., Bocchino M., Stanziola A. A., Luppi F., Sebastiani A., Lacedonia D., Vitulo P., Tavanti L., Vianello A., Saetta M., Marinari S., Pirina P., Valente S., Oggionni T., and Gasparini S.

Abstract

Background: FIBRONET was an observational, multicentre, prospective cohort study investigating the baseline characteristics, clinical course of disease and use of antifibrotic treatment in Italian patients with idiopathic pulmonary fibrosis (IPF). Methods: Patients aged ≥ 40 years diagnosed with IPF within the previous 3 months at 20 Italian centres were consecutively enrolled and followed up for 12 months, with evaluations at 3, 6, 9 and 12 months. The primary objective was to describe the clinical course of IPF over 12 months of follow-up, including changes in lung function measured by % predicted forced vital capacity (FVC% predicted). Results: 209 patients (82.3% male, mean age 69.54 ± 7.43 years) were enrolled. Mean FVC% predicted was relatively preserved at baseline (80.01%). The mean time between IPF diagnosis and initiation of antifibrotic therapy was 6.38 weeks; 72.3% of patients received antifibrotic therapy within the first 3 months of follow-up, and 83.9% within 12 months of follow-up. Mean FVC% predicted was 80.0% at baseline and 82.2% at 12 months, and 47.4% of patients remained stable (i.e. had no disease progression) in terms of FVC% predicted during the study. Conclusions: FIBRONET is the first prospective, real-life, observational study of patients with IPF in Italy. The short time between diagnosis and initiation of antifibrotic therapy, and the stable lung function between baseline and 12 months, suggest that early diagnosis and prompt initiation of antifibrotic therapy may preserve lung function in patients with IPF. Trial registration: NCT02803580

Published
2021

10. Clinical course of IPF in Italian patients during 12 months of observation: results from the FIBRONET observational study

Author

Poletti V., Vancheri C., Albera C., Harari S., Pesci A., Metella R. R., Campolo B., Crespi G., Rizzoli S., Tomassetti S., Rottoli P., Bocchino M., Stanziola A. A., Luppi F., Sebastiani A., Lacedonia D., Vitulo P., Tavanti L., Vianello A., Saetta M., Marinari S., Pirina P., Valente S., Oggionni T., Gasparini S., Poletti, V, Vancheri, C, Albera, C, Harari, S, Pesci, A, Metella, R, Campolo, B, Crespi, G, Rizzoli, S, Tomassetti, S, Rottoli, P, Bocchino, M, Stanziola, A, Luppi, F, Sebastiani, A, Lacedonia, D, Vitulo, P, Tavanti, L, Vianello, A, Saetta, M, Marinari, S, Pirina, P, Valente, S, Oggionni, T, Gasparini, S, Poletti, V., Vancheri, C., Albera, C., Harari, S., Pesci, A., Metella, R. R., Campolo, B., Crespi, G., Rizzoli, S., Tomassetti, S., Rottoli, P., Bocchino, M., Stanziola, A. A., Luppi, F., Sebastiani, A., Lacedonia, D., Vitulo, P., Tavanti, L., Vianello, A., Saetta, M., Marinari, S., Pirina, P., Valente, S., Oggionni, T., and Gasparini, S.

Subjects
Male, Vital capacity, medicine.medical_specialty, Time Factors, Nintedanib, Vital Capacity, Idiopathic pulmonary fibrosis, Disease, Pirfenidone, 03 medical and health sciences, chemistry.chemical_compound, FEV1/FVC ratio, 0302 clinical medicine, Internal medicine, medicine, Humans, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Observational, Aged, lcsh:RC705-779, Idiopathic pulmonary fibrosi, business.industry, Research, Anti-Inflammatory Agents, Non-Steroidal, Antifibrotic therapy, lcsh:Diseases of the respiratory system, respiratory system, medicine.disease, Prognosis, Lung function, respiratory tract diseases, 030228 respiratory system, chemistry, Italy, Real-world, Disease Progression, Observational study, Female, business, medicine.drug, Follow-Up Studies
Abstract

Background FIBRONET was an observational, multicentre, prospective cohort study investigating the baseline characteristics, clinical course of disease and use of antifibrotic treatment in Italian patients with idiopathic pulmonary fibrosis (IPF). Methods Patients aged ≥ 40 years diagnosed with IPF within the previous 3 months at 20 Italian centres were consecutively enrolled and followed up for 12 months, with evaluations at 3, 6, 9 and 12 months. The primary objective was to describe the clinical course of IPF over 12 months of follow-up, including changes in lung function measured by % predicted forced vital capacity (FVC% predicted). Results 209 patients (82.3% male, mean age 69.54 ± 7.43 years) were enrolled. Mean FVC% predicted was relatively preserved at baseline (80.01%). The mean time between IPF diagnosis and initiation of antifibrotic therapy was 6.38 weeks; 72.3% of patients received antifibrotic therapy within the first 3 months of follow-up, and 83.9% within 12 months of follow-up. Mean FVC% predicted was 80.0% at baseline and 82.2% at 12 months, and 47.4% of patients remained stable (i.e. had no disease progression) in terms of FVC% predicted during the study. Conclusions FIBRONET is the first prospective, real-life, observational study of patients with IPF in Italy. The short time between diagnosis and initiation of antifibrotic therapy, and the stable lung function between baseline and 12 months, suggest that early diagnosis and prompt initiation of antifibrotic therapy may preserve lung function in patients with IPF. Trial registration: NCT02803580

Published
2021

12. Pamrevlumab, an anti-connective tissue growth factor therapy, for idiopathic pulmonary fibrosis (PRAISE): a phase 2, randomised, double-blind, placebo-controlled trial

Author

Richeldi, Luca, Fernandez Perez, E. R., Costabel, U., Albera, C., Lederer, D. J., Flaherty, K. R., Ettinger, N., Perez, R., Scholand, M. B., Goldin, J., Peony Yu, K. -H., Neff, T., Porter, S., Zhong, M., Gorina, E., Kouchakji, E., Raghu, G., Richeldi L. (ORCID:0000-0001-8594-1448), Richeldi, Luca, Fernandez Perez, E. R., Costabel, U., Albera, C., Lederer, D. J., Flaherty, K. R., Ettinger, N., Perez, R., Scholand, M. B., Goldin, J., Peony Yu, K. -H., Neff, T., Porter, S., Zhong, M., Gorina, E., Kouchakji, E., Raghu, G., and Richeldi L. (ORCID:0000-0001-8594-1448)

Abstract

Background: Connective tissue growth factor (CTGF) is a secreted glycoprotein that has a central role in the process of fibrosis. This study was designed to assess the safety, tolerability, and efficacy of pamrevlumab (FG-3019), a fully recombinant human monoclonal antibody against CTGF, in idiopathic pulmonary fibrosis. The aim was to establish whether pamrevlumab could slow, stop, or reverse progression of idiopathic pulmonary fibrosis. Methods: The phase 2, randomised, double-blind, placebo-controlled PRAISE trial was done at 39 medical centres in seven countries (Australia, Bulgaria, Canada, India, New Zealand, South Africa, and the USA). Patients with idiopathic pulmonary fibrosis and percentage of predicted forced vital capacity (FVC) of 55% or greater were enrolled and randomly assigned (1:1) by use of interactive responsive technology to intravenous infusion of pamrevlumab 30 mg/kg or placebo every 3 weeks over 48 weeks (16 infusions). The primary efficacy outcome was change from baseline in percentage of predicted FVC at week 48. Disease progression (defined as a decline from baseline in percentage of predicted FVC of ≥10%, or death) at week 48 was a key secondary efficacy outcome. All patients in the pamrevlumab group received at least one dose of the study drug and were analysed for safety. Two patients in the placebo group were excluded from the intention-to-treat population for the efficacy analyses because of enrolment error. This trial is registered with ClinicalTrials.gov, NCT01890265. Findings: Between Aug 17, 2013, and July 21, 2017, 103 patients were randomly assigned (50 to pamrevlumab and 53 to placebo). Pamrevlumab reduced the decline in percentage of predicted FVC by 60·3% at week 48 (mean change from baseline −2·9% with pamrevlumab vs −7·2% with placebo; between-group difference 4·3% [95% CI 0·4–8·3]; p=0·033). The proportion of patients with disease progression was lower in the pamrevlumab group than in the placebo group at week 48 (10·0% vs

Published
2020

13. Hot of the breath: Mortality as a primary end-point in IPF treatment trials: the best is the enemy of the good

Author

Wells, Athol U, Behr, Juergen, Costabel, Ulrich, Cottin, Vincent, Poletti, Venerino, Richeldi, Luca, Albera, C, Ancochea, J, Antoniou, KM, Bonella, F, Bonniaud, P, Bouros, D, Bresser, P, Cordier, JF, Crestani, B, Domagala-Kulawik, J, Drent, M, Egan, JJ, Geiser, T, Grunewald, J, Grutters, J, Gudmundsson, G, Guenther, A, Harari, S, Harrison, NK, Hirani, N, Hodgson, U, Kahler, CM, Keane, MP, Kiter, G, Kneussl, M, Maher, TM, Mogulkoc, N, Muller-Quernheim, J, Neurohr, C, Nunes, H, Parfrey, H, Peros-Golubicic, T, Polychronopoulos, V, Prevot, G, Renzoni, ER, Robalo Cordeiro, C, Saltini, C, Skold, M, Spagnolo, P, Thomeer, M, Tomasseti, S, Valeyre, D, Vancheri, C, Wallaert, B, Wuyts, W, and Xaubet, A

Published
2012
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15. Italian Cystic Fibrosis Registry (ICFR). Report 2015-2016

Author

Giordani, B., Amato, A., Majo, F., Ferrari, G., Quattrucci, S., Minicucci, L., Padoan, R., Floridia, G., Salvatore, D., Carnovale, V., Puppo Fornaro, G., Taruscio, D., Salvatore, M., Albera, C, Amato, A, Angiolillo, A, Baldo, E, Battistini, F, Bena, C, Bernardi, Mg, Bertasi, S, Bignamini, E, Bisogno, A, Braggion, C, Cannata, L, Carnicella, A, Carnovale, V, Ciciretti, Ma, Cipolli, M, Cirilli, N, Colombo, C, Cucchiara, S, Di Sabatino, M, Di Stefano, E, Fabrizi, B, Ferrari, G, Ficili, F, Floridia, G, Francalanci, M, Gagliardini, R, Giordani, B, Iansa, P, Laezza, C, Leonardi, S, Lucanto, Mc, Lucidi, V, Macchiaroli, Am, Magazzù, G, Majo, F, Manca, A, Maschio, M, Mascotto, D, Mencarini, V, Minicucci, L, Moretti, P, Negri, A, Padoan, R, Palladino, N, Pintani, E, Pisano, G, Pisi, G, Pizzamiglio, G, Quattrucci, S, Raia, V, Ratclif, L, Ros, M, Rotolo, N, Salvatore, D, Salvatore, M, Spaggiari, C, Taruscio, D, Tonelli, T, Tuccio, G, Vassanelli, C, Vitullo, P, and Zavataro L, .

Published
2019

17. The prognostic role of Gender-Age-Physiology system in idiopathic pulmonary fibrosis patients treated with pirfenidone

Author

Harari, S, Caminati, A, Confalonieri, M, Poletti, V, Vancheri, C, Pesci, A, Rogliani, P, Luppi, F, Agostini, C, Rottoli, P, Sanduzzi Zamparelli, A, Sebastiani, A, Della Porta, R, Salton, F, Messore, B, Tomassetti, S, Rosso, R, Biffi, A, Puxeddu, E, Cerri, S, Cinetto, F, Refini, R, Bocchino, M, Di Michele, L, Specchia, C, Albera, C, Harari, Sergio, Caminati, Antonella, Confalonieri, Marco, Poletti, Venerino, Vancheri, Carlo, Pesci, Alberto, Rogliani, Paola, Luppi, Fabrizio, Agostini, Carlo, Rottoli, Paola, Sanduzzi Zamparelli, Alessandro, Sebastiani, Alfredo, Della Porta, Rossana, Salton, Francesco, Messore, Barbara, Tomassetti, Sara, Rosso, Roberta, Biffi, Alice, Puxeddu, Ermanno, Cerri, Stefania, Cinetto, Francesco, Refini, Rosa Metella, Bocchino, Marialuisa, Di Michele, Loreta, Specchia, Claudia, Albera, Carlo, Harari, S, Caminati, A, Confalonieri, M, Poletti, V, Vancheri, C, Pesci, A, Rogliani, P, Luppi, F, Agostini, C, Rottoli, P, Sanduzzi Zamparelli, A, Sebastiani, A, Della Porta, R, Salton, F, Messore, B, Tomassetti, S, Rosso, R, Biffi, A, Puxeddu, E, Cerri, S, Cinetto, F, Refini, R, Bocchino, M, Di Michele, L, Specchia, C, Albera, C, Harari, Sergio, Caminati, Antonella, Confalonieri, Marco, Poletti, Venerino, Vancheri, Carlo, Pesci, Alberto, Rogliani, Paola, Luppi, Fabrizio, Agostini, Carlo, Rottoli, Paola, Sanduzzi Zamparelli, Alessandro, Sebastiani, Alfredo, Della Porta, Rossana, Salton, Francesco, Messore, Barbara, Tomassetti, Sara, Rosso, Roberta, Biffi, Alice, Puxeddu, Ermanno, Cerri, Stefania, Cinetto, Francesco, Refini, Rosa Metella, Bocchino, Marialuisa, Di Michele, Loreta, Specchia, Claudia, and Albera, Carlo

Abstract

Introduction: Gender, age, physiology (GAP) system have proven to be an easy tool for predicting disease stages and survival in idiopathic pulmonary fibrosis (IPF) patients. Objective: To validate mortality risk as determined by the GAP system in a real-life multicentre IPF population treated with pirfenidone. Methods: The study included patients who received pirfenidone for at least 6 months. The GAP calculator and the GAP index were determined. The primary outcome was all-cause mortality. The prognostic accuracy of the GAP system was evaluated with respect to calibration and discrimination. Results and Conclusion: Sixty-eight IPF patients were enrolled in the study. The median follow-up was 2.4 years (range 0.1-7.4 years). A total of 22 deaths as first event (32%) and of 10 lung transplantation (15%) were recorded. The cumulative incidence of mortality at 1, 2 and 3 years was 10.4%, 22.4% and 38.4%, respectively. The differences between the predicted and observed mortality were not significant for the GAP index while the observed mortality become comparable to that predicted by the GAP calculator only in the third year of follow-up. The C-index for the GAP index was 0.74 (95% CI 0.57-0.93) while the C-statistic value for the GAP calculator was 0.77 (95% CI 0.59-0.95)

Published
2019

18. Pirfenidone in real life: A retrospective observational multicentre study in Italian patients with idiopathic pulmonary fibrosis

Author

Vancheri, C, Sebastiani, A, Tomassetti, S, Pesci, A, Rogliani, P, Tavanti, L, Luppi, F, Harari, S, Rottoli, P, Ghirardini, A, Kirchgaessler, K, Albera, C, Vancheri, Carlo, Sebastiani, Alfredo, Tomassetti, Sara, Pesci, Alberto, Rogliani, Paola, Tavanti, Laura, Luppi, Fabrizio, Harari, Sergio, Rottoli, Paola, Ghirardini, Alessandra, Kirchgaessler, Klaus-Uwe, Albera, Carlo, Vancheri, C, Sebastiani, A, Tomassetti, S, Pesci, A, Rogliani, P, Tavanti, L, Luppi, F, Harari, S, Rottoli, P, Ghirardini, A, Kirchgaessler, K, Albera, C, Vancheri, Carlo, Sebastiani, Alfredo, Tomassetti, Sara, Pesci, Alberto, Rogliani, Paola, Tavanti, Laura, Luppi, Fabrizio, Harari, Sergio, Rottoli, Paola, Ghirardini, Alessandra, Kirchgaessler, Klaus-Uwe, and Albera, Carlo

Abstract

Rationale: Real-world data on pirfenidone treatment of patients with idiopathic pulmonary fibrosis (IPF) are limited. This study assessed the effectiveness of pirfenidone in a large real-life Italian IPF cohort. Methods: IRENE was an observational, retrospective study of patients with IPF treated with pirfenidone in routine clinical practice (18 centres). At Month 6, a mandatory re-evaluation of forced vital capacity (FVC) decline (absolute change < 10%) was required to continue pirfenidone. The primary effectiveness outcomes were absolute change from baseline in FVC and the percentage of patients with ≥ 10% absolute decline in % predicted FVC at Month 12. Safety was described by adverse event (AE) occurrence. Prespecified subgroups included sex, age, presence/absence of emphysema, usual interstitial pneumonia (UIP) pattern on high-resolution computed tomography, and baseline lung function. Results: The study included 379 patients (mean age, 67.6 years; 78.1% male). Mean change from baseline in FVC and the percentage of patients with ≥ 10% absolute decline in % predicted FVC at Month 12 were −81.8 mL (SD, 419.6 mL; P = 0.002) and 16.0% (95% CI, 12.2–20.9%), respectively. Disease progression was similar across prespecified subgroups, including patients with definite vs possible UIP. Overall, 211 AEs occurred in 149 patients (39.3%), with serious AEs in 31 patients (8.2%) and 9 discontinuations due to AEs. Skin and gastrointestinal AEs were most frequent. Fifteen patients (4.0%) died. Conclusions: The decline in FVC and the safety profile observed in this real-world IPF cohort were consistent with the findings of the Phase III pirfenidone trials.

Published
2019

20. Malattie infiltrative diffuse del polmone

Author

Albera, C, Cerri, S, Luppi, F, Richeldi, L, Rogliani, P, Spagnolo, P, Clini, EM, Pelaia, G, Albera, C, Cerri, S, Luppi, F, Richeldi, L, Rogliani, P, and Spagnolo, P

Subjects
Malattie infiltrative diffuse del polmone
Abstract

Le pneumopatie infiltative diffuse (PID) o interstiziopatie polmonari rappresentano un ampio ed eterogeneo gruppo di patologie, alcune a esclusivo interessamento polmonare, altre in cui il polmone è solo uno degli organi colpiti. Le PID possono insorgere in modo acuto, subacuto o cronico, o avere un decorso subclinico e indolente. Inoltre, mentre alcune di esse possono regredire (con o senza terapia), altre, quali la fibrosi polmonare idiopatica, progrediscono in modo inesorabile, anche se alcuni farmaci ad azione antifibrotica sono in grado di rallentarne la progressione.

Published
2017

21. Italian Cystic Fibrosis Registry. Report 2011-2014

Author

Barbara, Giordani, Annalisa, Amato, Fabio, Majo, Gianluca, Ferrari, Serena, Quattrucci, Laura, Minicucci, Rita, Padoan, Giovanna, Floridia, Gianna Puppo Fornaro, Domenica, Taruscio, Marco, Salvatore, Gruppo di lavoro RIFC, Albera, C, Amato, A, Angiolillo, A, Assael, Bm, Baldo, E, Battistini, F, Bena, C, Bernardi, Mg, Bertasi, S, Bignamini, E, Bisogno, A, Braggion, C, Cannata, L, Carnicella, A, Carnovale, V, Ciciretti, Ma, Cirilli, N, Collura, M, Colombo, C, Cucchiara, S, Di Sabatino, M, Di Stefano, E, Ferrari, G, Ficili, F, Floridia, G, Francalanci, M, Gagliardini, R, Giordani, B, Iansa, P, Laezza, C, La Rosa, M, Leonardi, S, Lucanto, Mc, Lucidi, V, Macchiaroli, Am, Magazzù, G, Majo, F, Manca, A, Mascotto, D, Mencarini, V, Minicucci, L, Moretti, P, Negri, A, Padoan, R, Palladino, N, Pintani, E, Pisano, G, Pisi, G, Pizzamiglio, G, Poli, F, Quattrucci, S, Raia, V, Ratclif, L, Ros, M, Rotolo, N, Salvatore, D, Salvatore, M, Spaggiari, C, Taruscio, D, Tonelli, T, Tuccio, G, and Zavataro, L.

Subjects
Registry, Cystic Fibrosis, Italy, Cystic Fibrosis, Registry, Italy
Published
2018

22. The Diagnosis of Interstitial Lung Disease: Comparison Between HRTC Appearance and Histological Pattern

Author

Verri, G., primary, Guerrera, F., additional, Lyberis, P., additional, Solidoro, P., additional, Costardi, L., additional, Mercante, L., additional, Limerutti, G., additional, Delsedime, L., additional, Mangiapia, M., additional, Bardessono, M.M., additional, Mattei, A., additional, Filosso, P.L., additional, Ruffini, E., additional, and Albera, C., additional

Published
2019
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24. Structured reporting for fibrosing lung disease: a model shared by radiologist and pulmonologist

Author

Sverzellati, N, Odone, A, Silva, M, Polverosi, R, Florio, C, Cardinale, L, Cortese, G, Addonisio, G, Zompatori, M, Dalpiaz, G, Piciucchi, S, Larici, A, Agostini, C, Albera, C, Attinà, D, Battista, G, Bertelli, E, Bertorelli, G, Bnà, C, Bonifazi, M, Bonomo, L, Borghesi, A, Calandriello, L, Caminati, A, Capannelli, D, Cerri, S, Ciccarese, F, Colombi, D, Confalonieri, M, Del Ciello, A, della Casa, G, Dore, R, Falaschi, F, Farchione, A, Feragalli, B, Franchi, P, Gavelli, G, Harari, S, Luppi, F, Maggi, F, Mazzei, M, Mereu, M, Milanese, G, Palmucci, S, Patea, R, Pesci, A, Piolanti, M, Poletti, V, Rea, G, Richeldi, L, Rogliani, P, Romei, C, Rottoli, P, Sanduzzi-Zamparelli, A, Sebastiani, A, Sergiacomi, G, Soardi, G, Spaggiari, L, Spagnolo, P, Tomassetti, S, Trisolini, R, Valentini, A, Vancheri, C, Vespro, V, Volterrani, L, Sverzellati, Nicola, Odone, Anna, Silva, Mario, Polverosi, Roberta, Florio, Carlo, Cardinale, Luciano, Cortese, Giancarlo, Addonisio, Giancarlo, Zompatori, Maurizio, Dalpiaz, Giorgia, Piciucchi, Sara, Larici, Anna Rita, Agostini, Carlo, Albera, Carlo, Attinà, Domenico, Battista, Giuseppe, Bertelli, Elena, Bertorelli, Giuseppina, Bnà, Claudio, Bonifazi, Martina, Bonomo, Lorenzo, Borghesi, Andrea, Calandriello, Lucio, Caminati, Antonella, Capannelli, Diana, Cerri, Stefania, Ciccarese, Federica, Colombi, Davide, Confalonieri, Marco, Del Ciello, Annaemilia, della Casa, Giovanni, Dore, Roberto, Falaschi, Fabio, Farchione, Alessandra, Feragalli, Beatrice, Franchi, Paola, Gavelli, Giampaolo, Harari, Sergio, Luppi, Fabrizio, Maggi, Fabio, Mazzei, Maria Antonietta, Mereu, Manuela, Milanese, Gianluca, Palmucci, Stefano, Patea, Rosa Lucia, Pesci, Alberto, Piolanti, Marco, Poletti, Venerino, Rea, Gaetano, Richeldi, Luca, Rogliani, Paola, Romei, Chiara, Rottoli, Paola, Sanduzzi-Zamparelli, Alessandro, Sebastiani, Alfredo, Sergiacomi, Gianluigi, Soardi, Gian Alberto, Spaggiari, Lucia, Spagnolo, Paolo, Tomassetti, Sara, Trisolini, Rocco, Valentini, Adele, Vancheri, Carlo, Vespro, Valentina, Volterrani, Luca, Sverzellati, N, Odone, A, Silva, M, Polverosi, R, Florio, C, Cardinale, L, Cortese, G, Addonisio, G, Zompatori, M, Dalpiaz, G, Piciucchi, S, Larici, A, Agostini, C, Albera, C, Attinà, D, Battista, G, Bertelli, E, Bertorelli, G, Bnà, C, Bonifazi, M, Bonomo, L, Borghesi, A, Calandriello, L, Caminati, A, Capannelli, D, Cerri, S, Ciccarese, F, Colombi, D, Confalonieri, M, Del Ciello, A, della Casa, G, Dore, R, Falaschi, F, Farchione, A, Feragalli, B, Franchi, P, Gavelli, G, Harari, S, Luppi, F, Maggi, F, Mazzei, M, Mereu, M, Milanese, G, Palmucci, S, Patea, R, Pesci, A, Piolanti, M, Poletti, V, Rea, G, Richeldi, L, Rogliani, P, Romei, C, Rottoli, P, Sanduzzi-Zamparelli, A, Sebastiani, A, Sergiacomi, G, Soardi, G, Spaggiari, L, Spagnolo, P, Tomassetti, S, Trisolini, R, Valentini, A, Vancheri, C, Vespro, V, Volterrani, L, Sverzellati, Nicola, Odone, Anna, Silva, Mario, Polverosi, Roberta, Florio, Carlo, Cardinale, Luciano, Cortese, Giancarlo, Addonisio, Giancarlo, Zompatori, Maurizio, Dalpiaz, Giorgia, Piciucchi, Sara, Larici, Anna Rita, Agostini, Carlo, Albera, Carlo, Attinà, Domenico, Battista, Giuseppe, Bertelli, Elena, Bertorelli, Giuseppina, Bnà, Claudio, Bonifazi, Martina, Bonomo, Lorenzo, Borghesi, Andrea, Calandriello, Lucio, Caminati, Antonella, Capannelli, Diana, Cerri, Stefania, Ciccarese, Federica, Colombi, Davide, Confalonieri, Marco, Del Ciello, Annaemilia, della Casa, Giovanni, Dore, Roberto, Falaschi, Fabio, Farchione, Alessandra, Feragalli, Beatrice, Franchi, Paola, Gavelli, Giampaolo, Harari, Sergio, Luppi, Fabrizio, Maggi, Fabio, Mazzei, Maria Antonietta, Mereu, Manuela, Milanese, Gianluca, Palmucci, Stefano, Patea, Rosa Lucia, Pesci, Alberto, Piolanti, Marco, Poletti, Venerino, Rea, Gaetano, Richeldi, Luca, Rogliani, Paola, Romei, Chiara, Rottoli, Paola, Sanduzzi-Zamparelli, Alessandro, Sebastiani, Alfredo, Sergiacomi, Gianluigi, Soardi, Gian Alberto, Spaggiari, Lucia, Spagnolo, Paolo, Tomassetti, Sara, Trisolini, Rocco, Valentini, Adele, Vancheri, Carlo, Vespro, Valentina, and Volterrani, Luca

Abstract

Objectives: To apply the Delphi exercise with iterative involvement of radiologists and pulmonologists with the aim of defining a structured reporting template for high-resolution computed tomography (HRCT) of patients with fibrosing lung disease (FLD). Methods: The writing committee selected the HRCT criteria—the Delphi items—for rating from both radiology panelists (RP) and pulmonology panelists (PP). The Delphi items were first rated by RPs as “essential”, “optional”, or “not relevant”. The items rated “essential” by < 80% of the RP were selected for the PP rating. The format of reporting was rated by both RP and PP. Results: A total of 42 RPs and 12 PPs participated to the survey. In both Delphi round 1 and 2, 10/27 (37.7%) items were rated “essential” by more than 80% of RP. The remaining 17/27 (63.3%) items were rated by the PP in round 3, with 2/17 items (11.7%) rated “essential” by the PP. PP proposed additional items for conclusion domain, which were rated by RPs in the fourth round. Poor consensus was observed for the format of reporting. Conclusions: This study provides a template for structured report of FLD that features essential items as agreed by expert thoracic radiologists and pulmonologists

Published
2018

25. The AIPO-SIMeR document on idiopathic pulmonary fibrosis

Author

Tomassetti, S, Albera, C, Aronne, D, Confalonieri, M, Harari, S, Luisetti, M, Poletti, V, Richeldi, L, Rottoli, P, Saltini, C, Vancheri, C, Vitulo, P, Pesci, A, Tomassetti S., Albera C., Aronne D., Confalonieri M., Harari S., Luisetti M., Poletti V., Richeldi L., Rottoli P., Saltini C., Vancheri C., Vitulo P., Pesci A., Tomassetti, S, Albera, C, Aronne, D, Confalonieri, M, Harari, S, Luisetti, M, Poletti, V, Richeldi, L, Rottoli, P, Saltini, C, Vancheri, C, Vitulo, P, Pesci, A, Tomassetti S., Albera C., Aronne D., Confalonieri M., Harari S., Luisetti M., Poletti V., Richeldi L., Rottoli P., Saltini C., Vancheri C., Vitulo P., and Pesci A.

Published
2015

26. Clinical course of IPF in Italian patients during 12 months of observation: results from the FIBRONET observational study.

Author

Poletti, V., Vancheri, C., Albera, C., Harari, S., Pesci, A., Metella, R. R., Campolo, B., Crespi, G., Rizzoli, S., the FIBRONET study group, Tomassetti, S., Rottoli, P., Bocchino, M., Stanziola, A. A., Luppi, F., Sebastiani, A., Lacedonia, D., Vitulo, P., Tavanti, L., and Vianello, A.

Subjects
IDIOPATHIC pulmonary fibrosis, SCIENTIFIC observation, DISEASE progression, RESEARCH, NONSTEROIDAL anti-inflammatory agents, TIME, RESEARCH methodology, RESPIRATORY measurements, PROGNOSIS, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, LONGITUDINAL method
Abstract

Background: FIBRONET was an observational, multicentre, prospective cohort study investigating the baseline characteristics, clinical course of disease and use of antifibrotic treatment in Italian patients with idiopathic pulmonary fibrosis (IPF).Methods: Patients aged ≥ 40 years diagnosed with IPF within the previous 3 months at 20 Italian centres were consecutively enrolled and followed up for 12 months, with evaluations at 3, 6, 9 and 12 months. The primary objective was to describe the clinical course of IPF over 12 months of follow-up, including changes in lung function measured by % predicted forced vital capacity (FVC% predicted).Results: 209 patients (82.3% male, mean age 69.54 ± 7.43 years) were enrolled. Mean FVC% predicted was relatively preserved at baseline (80.01%). The mean time between IPF diagnosis and initiation of antifibrotic therapy was 6.38 weeks; 72.3% of patients received antifibrotic therapy within the first 3 months of follow-up, and 83.9% within 12 months of follow-up. Mean FVC% predicted was 80.0% at baseline and 82.2% at 12 months, and 47.4% of patients remained stable (i.e. had no disease progression) in terms of FVC% predicted during the study.Conclusions: FIBRONET is the first prospective, real-life, observational study of patients with IPF in Italy. The short time between diagnosis and initiation of antifibrotic therapy, and the stable lung function between baseline and 12 months, suggest that early diagnosis and prompt initiation of antifibrotic therapy may preserve lung function in patients with IPF.Trial Registration: NCT02803580. [ABSTRACT FROM AUTHOR]

Published
2021
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27. Supplementary Material for: An Open-Label Study of the Long-Term Safety of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis (RECAP)

Author

Costabel, U., Albera, C., Lancaster, L.H., Lin, C.-Y., Hormel, P., Hulter, H.N., and Noble, P.W.

Abstract

Background: RECAP (NCT00662038) was an open-label extension study in patients with idiopathic pulmonary fibrosis (IPF) who completed either the Assessment of Pirfenidone to Confirm Efficacy and Safety in Idiopathic Pulmonary Fibrosis (ASCEND) 016 phase 3 trial or the Clinical Studies Assessing Pirfenidone in Idiopathic Pulmonary Fibrosis: Research of Efficacy and Safety Outcomes (CAPACITY) 004/006 phase 3 trials. Objective: To obtain long-term safety data for pirfenidone in patients with IPF in RECAP. Methods: Of the 1,334 patients who participated in the phase 3 trials, 1,058 entered RECAP. The final analysis from enrollment (September 2008) to June 2015 is presented. Results: Mean (SD) and median (range) pirfenidone exposures in RECAP were 122 (98) weeks and 88 (>0 to 349) weeks, respectively, with a mean daily dose of 2,091.1 mg. Cumulative total exposure was 2,482 patient exposure years (PEY). The treatment-emergent adverse event (TEAE) rate was 701.9 per 100 PEY. The serious TEAE rate was 53.5 per 100 PEY, with the most common serious TEAE being IPF (11.1 per 100 PEY). Of the 231 deaths (9.3 per 100 PEY), the most common cause was IPF (5.4 per 100 PEY). The treatment discontinuation rate due to a TEAE was 17.9 per 100 PEY; discontinuations were due to IPF (7.2 per 100 PEY), pneumonia, respiratory failure, acute respiratory failure, rash (0.5 per 100 PEY each), and nausea (0.4 per 100 PEY). For patients from CAPACITY 004/006 who entered RECAP, the mean change in percent predicted forced vital capacity from RECAP baseline at 180 weeks was -9.6%. Median on-treatment survival from the first pirfenidone dose in RECAP was 77.2 months. Conclusions: RECAP provides long-term follow-up and safety data for pirfenidone that were consistent with the known profile, with no new safety signals observed.

Published
2017
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28. Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA

Author

Bousquet, J. Bewick, M. Cano, A. Eklund, P. Fico, G. Goswami, N. Guldemond, N.A. Henderson, D. Hinkema, M.J. Liotta, G. Mair, A. Molloy, W. Monaco, A. Monsonis-Paya, I. Nizinska, A. Papadopoulos, H. Pavlickova, A. Pecorelli, S. Prados-Torres, A. Roller-Wirnsberger, R.E. Somekh, D. Vera-Muñoz, C. Visser, F. Farrell, J. Malva, J. Andersen Ranberg, K. Camuzat, T. Carriazo, A.M. Crooks, G. Gutter, Z. Iaccarino, G. de Keenoy, E.M. Moda, G. Rodriguez-Mañas, L. Vontetsianos, T. Abreu, C. Alonso, J. Alonso-Bouzon, C. Ankri, J. Arredondo, M.T. Avolio, F. Bedbrook, A. Białoszewski, A.Z. Blain, H. Bourret, R. Cabrera-Umpierrez, M.F. Catala, A. O’Caoimh, R. Cesari, M. Chavannes, N.H. Correia-Da-Sousa, J. Dedeu, T. Ferrando, M. Ferri, M. Fokkens, W.J. Garcia-Lizana, F. Guérin, O. Hellings, P.W. Haahtela, T. Illario, M. Inzerilli, M.C. Lodrup Carlsen, K.C. Kardas, P. Keil, T. Maggio, M. Mendez-Zorrilla, A. Menditto, E. Mercier, J. Michel, J.P. Murray, R. Nogues, M. O’Byrne-Maguire, I. Pappa, D. Parent, A.S. Pastorino, M. Robalo-Cordeiro, C. Samolinski, B. Siciliano, P. Teixeira, A.M. Tsartara, S.I. Valiulis, A. Vandenplas, O. Vasankari, T. Vellas, B. Vollenbroek-Hutten, M. Wickman, M. Yorgancioglu, A. Zuberbier, T. Barbagallo, M. Canonica, G.W. Klimek, L. Maggi, S. Aberer, W. Akdis, C. Adcock, I.M. Agache, I. Albera, C. Alonso-Trujillo, F. Angel Guarcia, M. Annesi-Maesano, I. Apostolo, J. Arshad, S.H. Attalin, V. Avignon, A. Bachert, C. Baroni, I. Bel, E. Benson, M. Bescos, C. Blasi, F. Barbara, C. Bergmann, K.C. Bernard, P.L. Bonini, S. Bousquet, P.J. Branchini, B. Brightling, C.E. Bruguière, V. Bunu, C. Bush, A. Caimmi, D.P. Calderon, M.A. Canovas, G. Cardona, V. Carlsen, K.H. Cesario, A. Chkhartishvili, E. Chiron, R. Chivato, T. Chung, K.F. D’Angelantonio, M. de Carlo, G. Cholley, D. Chorin, F. Combe, B. Compas, B. Costa, D.J. Costa, E. Coste, O. Coupet, A.-L. Crepaldi, G. Custovic, A. Dahl, R. Dahlen, S.E. Demoly, P. Devillier, P. Didier, A. Dinh-Xuan, A.T. Djukanovic, R. Dokic, D. du Toit, G. Dubakiene, R. Dupeyron, A. Emuzyte, R. Fiocchi, A. Wagner, A. Fletcher, M. Fonseca, J. Fougère, B. Gamkrelidze, A. Garces, G. Garcia-Aymeric, J. Garcia-Zapirain, B. Gemicioğlu, B. Gouder, C. Hellquist-Dahl, B. Hermosilla-Gimeno, I. Héve, D. Holland, C. Humbert, M. Hyland, M. Johnston, S.L. Just, J. Jutel, M. Kaidashev, I.P. Kaitov, M. Kalayci, O. Kalyoncu, A.F. Keijser, W. Kerstjens, H. Knezović, J. Kowalski, M. Koppelman, G.H. Kotska, T. Kovac, M. Kull, I. Kuna, P. Kvedariene, V. Lepore, V. Macnee, W. Magnan, A. Majer, I. Manning, P. Marcucci, M. Marti, T. Masoli, M. Melen, E. Miculinic, N. Mihaltan, F. Milenkovic, B. Millot-Keurinck, J. Mlinarić, H. Momas, I. Montefort, S. Morais-Almeida, M. Moreno-Casbas, T. Mösges, R. Mullol, J. Nadif, R. Nalin, M. Navarro-Pardo, E. Nekam, K. Ninot, G. Paccard, D. Pais, S. Palummeri, E. Panzner, P. Papadopoulos, N.K. Papanikolaou, C. Passalacqua, G. Pastor, E. Perrot, M. Plavec, D. Popov, T.A. Postma, D.S. Price, D. Raffort, N. Reuzeau, J.C. Robine, J.M. Rodenas, F. Robusto, F. Roche, N. Romano, A. Romano, V. Rosado-Pinto, J. Roubille, F. Ruiz, F. Ryan, D. Salcedo, T. Schmid-Grendelmeier, P. Schulz, H. Schunemann, H.J. Serrano, E. Sheikh, A. Shields, M. Siafakas, N. Scichilone, N. Siciliano, P. Skrindo, I. Smit, H.A. Sourdet, S. Sousa-Costa, E. Spranger, O. Sooronbaev, T. Sruk, V. Sterk, P.J. Todo-Bom, A. Touchon, J. Tramontano, D. Triggiani, M. Valero, A.L. Valovirta, E. van Ganse, E. van Hage, M. van den Berge, M. Ventura, M.T. Vergara, I. Vezzani, G. Vidal, D. Viegi, G. Wagemann, M. Whalley, B. Wilson, N. Yiallouros, P.K. Žagar, M. Zaidi, A. Zidarn, M. Hoogerwerf, E.J. Usero, J. Zuffada, R. Senn, A. de Oliveira-Alves, B.

Abstract

The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups’ new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases). © 2017, Serdi and Springer-Verlag France.

Published
2017

32. The AIPO-SIMeR document on idiopathic pulmonary fibrosis

Author

Tomassetti S., Albera C., Aronne D., Confalonieri M., Harari S., Luisetti M., Poletti V., Richeldi L., Rottoli P., Saltini C., Vancheri C., Vitulo P., Pesci A., Tomassetti, S, Albera, C, Aronne, D, Confalonieri, M, Harari, S, Luisetti, M, Poletti, V, Richeldi, L, Rottoli, P, Saltini, C, Vancheri, C, Vitulo, P, and Pesci, A

Subjects
respiratory tract disease
Published
2015

37. Building Bridges for Innovation in Ageing : Synergies between Action Groups of the EIP on AHA

Author

Bousquet, J, Bewick, M, Cano, A, Eklund, Patrik, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Ferri, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Murray, R, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, O, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Calderon, M A, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Holland, C, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Price, D, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Shields, M, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Wilson, N, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, de Oliveira-Alves, B, Bousquet, J, Bewick, M, Cano, A, Eklund, Patrik, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Ferri, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Murray, R, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, O, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Calderon, M A, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Holland, C, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Price, D, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Shields, M, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Wilson, N, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, and de Oliveira-Alves, B

Abstract

The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).

Published
2017
Full Text
View/download PDF

38. Building bridges for innovation in ageing:synergies between action groups of the EIP on AHA

Author

Bousquet, Jean, Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M.J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R.E., Somekh, D., Vera-Muñoz, C., Visser, F., Farrell, J., Malva, J., Andersen Ranberg, K., Camuzat, T., Carriazo, A.M., Crooks, G., Gutter, Z., Iaccarino, G., de Keenoy, E. Manuel, Moda, G., Rodriguez-Mañas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M.T., Avolio, F., Bedbrook, A., Białoszewski, A.Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M.F., Catala, A., O’Caoimh, R., Cesari, M., Chavannes, N.H., Correia-da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W.J., Garcia-Lizana, F., Guérin, O., Hellings, P.W., Haahtela, T., Illario, M., Inzerilli, M.C., Lodrup Carlsen, K.C., Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J.P., Murray, R., Nogues, M., O’Byrne-Maguire, I., Pappa, D., Parent, A.S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A.M., Tsartara, S.I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G.W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I.M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S.H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K.C., Bernard, P. L., Bonini, S., Bousquet, P.J., Branchini, B., Brightling, C.E., Bruguière, V., Bunu, C., Bush, A., Caimmi, D.P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K.H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K.F., D’Angelantonio, M., de Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D.J., Costa, E., Coste, O., Coupet, A.L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S.E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A.T., Djukanovic, R., Dokic, D., du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougère, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioğlu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Héve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S.L., Just, J., Jutel, M., Kaidashev, I.P., Khaitov, M., Kalayci, O., Kalyoncu, A.F., Keijser, W., Kerstjens, H., Knezović, J., Kowalski, M., Koppelman, G.H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinarić, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Mösges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N.K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T.A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J.C., Robine, J.M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H.J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Tsartara, S. I., Valero, A. L., Valovirta, E., van Ganse, E., van Hage, M., van Den Berge, M., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wilson, N., Yiallouros, P. K., Žagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., de Oliveira-Alves, B., Bousquet, Jean, Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M.J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R.E., Somekh, D., Vera-Muñoz, C., Visser, F., Farrell, J., Malva, J., Andersen Ranberg, K., Camuzat, T., Carriazo, A.M., Crooks, G., Gutter, Z., Iaccarino, G., de Keenoy, E. Manuel, Moda, G., Rodriguez-Mañas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M.T., Avolio, F., Bedbrook, A., Białoszewski, A.Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M.F., Catala, A., O’Caoimh, R., Cesari, M., Chavannes, N.H., Correia-da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W.J., Garcia-Lizana, F., Guérin, O., Hellings, P.W., Haahtela, T., Illario, M., Inzerilli, M.C., Lodrup Carlsen, K.C., Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J.P., Murray, R., Nogues, M., O’Byrne-Maguire, I., Pappa, D., Parent, A.S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A.M., Tsartara, S.I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G.W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I.M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S.H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K.C., Bernard, P. L., Bonini, S., Bousquet, P.J., Branchini, B., Brightling, C.E., Bruguière, V., Bunu, C., Bush, A., Caimmi, D.P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K.H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K.F., D’Angelantonio, M., de Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D.J., Costa, E., Coste, O., Coupet, A.L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S.E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A.T., Djukanovic, R., Dokic, D., du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougère, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioğlu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Héve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S.L., Just, J., Jutel, M., Kaidashev, I.P., Khaitov, M., Kalayci, O., Kalyoncu, A.F., Keijser, W., Kerstjens, H., Knezović, J., Kowalski, M., Koppelman, G.H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinarić, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Mösges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N.K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T.A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J.C., Robine, J.M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H.J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Tsartara, S. I., Valero, A. L., Valovirta, E., van Ganse, E., van Hage, M., van Den Berge, M., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wilson, N., Yiallouros, P. K., Žagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., and de Oliveira-Alves, B.

Abstract

The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups’ new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).

Published
2017

39. Building Bridges for Innovation in Ageing: Synergies between Action Groups of the EIP on AHA.

Author

UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Bousquet, J, Bewick, M, Cano, A, Eklund, P, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Ferri, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Murray, R, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, Olivier, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Calderon, M A, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Holland, C, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Price, D, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Shields, M, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Vandenplas, O, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Wilson, N, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, de Oliveira-Alves, B, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Bousquet, J, Bewick, M, Cano, A, Eklund, P, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Ferri, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Murray, R, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, Olivier, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Calderon, M A, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Holland, C, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Price, D, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Shields, M, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Vandenplas, O, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Wilson, N, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, and de Oliveira-Alves, B

Abstract

The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).

Published
2017

40. Pirfenidone safety and adverse event management in idiopathic pulmonary fibrosis

Author

Lancaster, L.H. (Lisa H.), de Andrade, J.A. (Joao A.), Zibrak, J.D. (Joseph D.), Padilla, M.L. (Maria L.), Albera, C., Nathan, S.D. (Steven D.), Wijsenbeek-Lourens, M.S. (Marlies), Stauffer, J.L. (John L.), Kirchgaessler, K.-U. (Klaus-Uwe), Costabel, U., Lancaster, L.H. (Lisa H.), de Andrade, J.A. (Joao A.), Zibrak, J.D. (Joseph D.), Padilla, M.L. (Maria L.), Albera, C., Nathan, S.D. (Steven D.), Wijsenbeek-Lourens, M.S. (Marlies), Stauffer, J.L. (John L.), Kirchgaessler, K.-U. (Klaus-Uwe), and Costabel, U.

Abstract

Pirfenidone is one of two approved therapies for the treatment of idiopathic pulmonary fibrosis (IPF). Randomised controlled clinical trials and

Published
2017
Full Text
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41. BUILDING BRIDGES FOR INNOVATION IN AGEING: SYNERGIES BETWEEN ACTION GROUPS OF THE EIP ON AHA

Author

Bousquet, J., Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R. E., Somekh, D., Vera-Munoz, C., Visser, F., Farrell, J., Malva, J., Ranberg, K. Andersen, Camuzat, T., Carriazo, A. M., Crooks, G., Gutter, Z., Iaccarino, G., Manuel De Keenoy, E., Moda, G., Rodriguez-Manas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M. T., Avolio, F., Bedbrook, A., Bialoszewski, A. Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M. F., Catala, A., O'Caoimh, R., Cesari, M., Chavannes, N. H., Correia-Da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W. J., Garcia-Lizana, F., Guerin, O., Hellings, P. W., Haahtela, T., Illario, M., Inzerilli, M. C., Carlsen, K. C. Lodrup, Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J. P., Murray, R., Nogues, M., O'Byrne-Maguire, I., Pappa, D., Parent, A. S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A. M., Tsartara, S. I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G. W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I. M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S. H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K. C., Bernard, P. L., Bonini, S., Bousquet, P. J., Branchini, B., Brightling, C. E., Bruguiere, V., Bunu, C., Bush, A., Caimmi, D. P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K. H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K. F., D'Angelantonio, M., De Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D. J., Costa, E., Coste, O., Coupet, A. -L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S. E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., Du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougere, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioglu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Heve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S. L., Just, J., Jutel, M., Kaidashev, I. P., Khaitov, M., Kalayci, O., Kalyoncu, A. F., Keijser, W., Kerstjens, H., Knezovic, J., Kowalski, M., Koppelman, G. H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinaric, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Moesges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N. K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T. A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J. C., Robine, J. M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H. J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Valero, A. L., Valovirta, E., Van Ganse, E., Van Hage, M., Van den Berge, M., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wilson, N., Yiallouros, P. K., Zagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., De Oliveira-Alves, B., Bousquet, J., Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R. E., Somekh, D., Vera-Munoz, C., Visser, F., Farrell, J., Malva, J., Ranberg, K. Andersen, Camuzat, T., Carriazo, A. M., Crooks, G., Gutter, Z., Iaccarino, G., Manuel De Keenoy, E., Moda, G., Rodriguez-Manas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M. T., Avolio, F., Bedbrook, A., Bialoszewski, A. Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M. F., Catala, A., O'Caoimh, R., Cesari, M., Chavannes, N. H., Correia-Da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W. J., Garcia-Lizana, F., Guerin, O., Hellings, P. W., Haahtela, T., Illario, M., Inzerilli, M. C., Carlsen, K. C. Lodrup, Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J. P., Murray, R., Nogues, M., O'Byrne-Maguire, I., Pappa, D., Parent, A. S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A. M., Tsartara, S. I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G. W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I. M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S. H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K. C., Bernard, P. L., Bonini, S., Bousquet, P. J., Branchini, B., Brightling, C. E., Bruguiere, V., Bunu, C., Bush, A., Caimmi, D. P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K. H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K. F., D'Angelantonio, M., De Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D. J., Costa, E., Coste, O., Coupet, A. -L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S. E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., Du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougere, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioglu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Heve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S. L., Just, J., Jutel, M., Kaidashev, I. P., Khaitov, M., Kalayci, O., Kalyoncu, A. F., Keijser, W., Kerstjens, H., Knezovic, J., Kowalski, M., Koppelman, G. H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinaric, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Moesges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N. K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T. A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J. C., Robine, J. M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H. J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Valero, A. L., Valovirta, E., Van Ganse, E., Van Hage, M., Van den Berge, M., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wilson, N., Yiallouros, P. K., Zagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., and De Oliveira-Alves, B.

Abstract

The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).

Published
2017

42. Building Bridges for Innovation in Ageing:Synergies between Action Groups of the EIP on AHA

Author

Bousquet, J, Bewick, M, Cano, A, Eklund, P, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, O, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, de Oliveira-Alves, B, Holland, Carol Ann, Bousquet, J, Bewick, M, Cano, A, Eklund, P, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, O, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, de Oliveira-Alves, B, and Holland, Carol Ann

Abstract

The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).

Published
2017

43. Building Bridges for Innovation in Ageing: Synergies between Action Groups of the EIP on AHA

Author

CMM USEQ Facility, Circulatory Health, Child Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Public Health Epidemiologie, Bousquet, J, Bewick, M, Cano, A, Eklund, P, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Ferri, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Murray, R, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, O, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Calderon, M A, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Holland, C, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Price, D, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Shields, M, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Wilson, N, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, de Oliveira-Alves, B, CMM USEQ Facility, Circulatory Health, Child Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Public Health Epidemiologie, Bousquet, J, Bewick, M, Cano, A, Eklund, P, Fico, G, Goswami, N, Guldemond, N A, Henderson, D, Hinkema, M J, Liotta, G, Mair, A, Molloy, W, Monaco, A, Monsonis-Paya, I, Nizinska, A, Papadopoulos, H, Pavlickova, A, Pecorelli, S, Prados-Torres, A, Roller-Wirnsberger, R E, Somekh, D, Vera-Muñoz, C, Visser, F, Farrell, J, Malva, J, Andersen Ranberg, K, Camuzat, T, Carriazo, A M, Crooks, G, Gutter, Z, Iaccarino, G, Manuel de Keenoy, E, Moda, G, Rodriguez-Mañas, L, Vontetsianos, T, Abreu, C, Alonso, J, Alonso-Bouzon, C, Ankri, J, Arredondo, M T, Avolio, F, Bedbrook, A, Białoszewski, A Z, Blain, H, Bourret, R, Cabrera-Umpierrez, M F, Catala, A, O'Caoimh, R, Cesari, M, Chavannes, N H, Correia-da-Sousa, J, Dedeu, T, Ferrando, M, Ferri, M, Fokkens, W J, Garcia-Lizana, F, Guérin, O, Hellings, P W, Haahtela, T, Illario, M, Inzerilli, M C, Lodrup Carlsen, K C, Kardas, P, Keil, T, Maggio, M, Mendez-Zorrilla, A, Menditto, E, Mercier, J, Michel, J P, Murray, R, Nogues, M, O'Byrne-Maguire, I, Pappa, D, Parent, A S, Pastorino, M, Robalo-Cordeiro, C, Samolinski, B, Siciliano, P, Teixeira, A M, Tsartara, S I, Valiulis, A, Vandenplas, O, Vasankari, T, Vellas, B, Vollenbroek-Hutten, M, Wickman, M, Yorgancioglu, A, Zuberbier, T, Barbagallo, M, Canonica, G W, Klimek, L, Maggi, S, Aberer, W, Akdis, C, Adcock, I M, Agache, I, Albera, C, Alonso-Trujillo, F, Angel Guarcia, M, Annesi-Maesano, I, Apostolo, J, Arshad, S H, Attalin, V, Avignon, A, Bachert, C, Baroni, I, Bel, E, Benson, M, Bescos, C, Blasi, F, Barbara, C, Bergmann, K C, Bernard, P L, Bonini, S, Bousquet, P J, Branchini, B, Brightling, C E, Bruguière, V, Bunu, C, Bush, A, Caimmi, D P, Calderon, M A, Canovas, G, Cardona, V, Carlsen, K H, Cesario, A, Chkhartishvili, E, Chiron, R, Chivato, T, Chung, K F, d'Angelantonio, M, De Carlo, G, Cholley, D, Chorin, F, Combe, B, Compas, B, Costa, D J, Costa, E, Coste, O, Coupet, A-L, Crepaldi, G, Custovic, A, Dahl, R, Dahlen, S E, Demoly, P, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Du Toit, G, Dubakiene, R, Dupeyron, A, Emuzyte, R, Fiocchi, A, Wagner, A, Fletcher, M, Fonseca, J, Fougère, B, Gamkrelidze, A, Garces, G, Garcia-Aymeric, J, Garcia-Zapirain, B, Gemicioğlu, B, Gouder, C, Hellquist-Dahl, B, Hermosilla-Gimeno, I, Héve, D, Holland, C, Humbert, M, Hyland, M, Johnston, S L, Just, J, Jutel, M, Kaidashev, I P, Khaitov, M, Kalayci, O, Kalyoncu, A F, Keijser, W, Kerstjens, H, Knezović, J, Kowalski, M, Koppelman, G H, Kotska, T, Kovac, M, Kull, I, Kuna, P, Kvedariene, V, Lepore, V, MacNee, W, Magnan, A, Majer, I, Manning, P, Marcucci, M, Marti, T, Masoli, M, Melen, E, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mlinarić, H, Momas, I, Montefort, S, Morais-Almeida, M, Moreno-Casbas, T, Mösges, R, Mullol, J, Nadif, R, Nalin, M, Navarro-Pardo, E, Nekam, K, Ninot, G, Paccard, D, Pais, S, Palummeri, E, Panzner, P, Papadopoulos, N K, Papanikolaou, C, Passalacqua, G, Pastor, E, Perrot, M, Plavec, D, Popov, T A, Postma, D S, Price, D, Raffort, N, Reuzeau, J C, Robine, J M, Rodenas, F, Robusto, F, Roche, N, Romano, A, Romano, V, Rosado-Pinto, J, Roubille, F, Ruiz, F, Ryan, D, Salcedo, T, Schmid-Grendelmeier, P, Schulz, H, Schunemann, H J, Serrano, E, Sheikh, A, Shields, M, Siafakas, N, Scichilone, N, Skrindo, I, Smit, H A, Sourdet, S, Sousa-Costa, E, Spranger, O, Sooronbaev, T, Sruk, V, Sterk, P J, Todo-Bom, A, Touchon, J, Tramontano, D, Triggiani, M, Valero, A L, Valovirta, E, van Ganse, E, van Hage, M, van den Berge, M, Ventura, M T, Vergara, I, Vezzani, G, Vidal, D, Viegi, G, Wagemann, M, Whalley, B, Wilson, N, Yiallouros, P K, Žagar, M, Zaidi, A, Zidarn, M, Hoogerwerf, E J, Usero, J, Zuffada, R, Senn, A, and de Oliveira-Alves, B

Published
2017

44. Malattie infiltrative diffuse del polmone

Author

Clini, EM, Pelaia, G, Albera, C, Cerri, S, Luppi, F, Richeldi, L, Rogliani, P, Spagnolo, P, Clini, EM, Pelaia, G, Albera, C, Cerri, S, Luppi, F, Richeldi, L, Rogliani, P, and Spagnolo, P

Abstract

Le pneumopatie infiltative diffuse (PID) o interstiziopatie polmonari rappresentano un ampio ed eterogeneo gruppo di patologie, alcune a esclusivo interessamento polmonare, altre in cui il polmone è solo uno degli organi colpiti. Le PID possono insorgere in modo acuto, subacuto o cronico, o avere un decorso subclinico e indolente. Inoltre, mentre alcune di esse possono regredire (con o senza terapia), altre, quali la fibrosi polmonare idiopatica, progrediscono in modo inesorabile, anche se alcuni farmaci ad azione antifibrotica sono in grado di rallentarne la progressione.

Published
2017

45. Antacid therapy in idiopathic pulmonary fibrosis: more questions than answers?

Author

Johannson, K, Strâmbu, I, Ravaglia, C, Grutters, J, Valenzuela, C, Mogulkoc, N, Luppi, F, Richeldi, L, Wells, A, Vancheri, C, Kreuter, M, Albera, C, Antoniou, K, Altinisik, G, Bendstrup, E, Bondue, B, Borie, R, Brown, K, Camus, P, Castillo, D, Collard, H, Cottin, V, Crimi, N, Ferrara, G, Fischer, A, Gauldie, J, Geiser, T, Guenther, A, Hambly, N, Hansell, D, Harari, S, Jones, M, Keane, M, Ley, B, Maher, T, Molina-Molina, M, Palmucci, S, Poletti, V, Prasse, A, Rottoli, P, Spagnolo, P, Sterclova, M, Torrisi, S, Tsitoura, E, Vasakova, M, Walsh, S, Wijsenbeek, M, Wuyts, W, Johannson, Kerri A, Strâmbu, Irina, Ravaglia, Claudia, Grutters, Jan C, Valenzuela, Claudia, Mogulkoc, Nesrin, Luppi, Fabrizio, Richeldi, Luca, Wells, Athol U, Vancheri, Carlo, Kreuter, Michael, Albera, Carlo, Antoniou, Katerina M., Altinisik, Goksel, Bendstrup, Elisabeth, Bondue, Benjamin, Borie, Raphael, Brown, Kevin K., Camus, Philippe, Castillo, Diego, Collard, Harold R., Cottin, Vincent, Crimi, Nunzio, Ferrara, Giovanni, Fischer, Aryeh, Gauldie, Jack, Geiser, Thomas, Guenther, Andreas, Hambly, Nathan, Hansell, David M., Harari, Sergio, Jones, Mark G., Keane, Michael, Ley, Brett, Maher, Toby M., Molina-Molina, Maria, Palmucci, Stefano, Poletti, Venerino, Prasse, Antje, Rottoli, Paola, Spagnolo, Paolo, Sterclova, Martina, Torrisi, Sebastiano, Tsitoura, Eliza, Vasakova, Martina, Walsh, Simon L., Wijsenbeek, Marlies S., Wuyts, Wim A., Johannson, K, Strâmbu, I, Ravaglia, C, Grutters, J, Valenzuela, C, Mogulkoc, N, Luppi, F, Richeldi, L, Wells, A, Vancheri, C, Kreuter, M, Albera, C, Antoniou, K, Altinisik, G, Bendstrup, E, Bondue, B, Borie, R, Brown, K, Camus, P, Castillo, D, Collard, H, Cottin, V, Crimi, N, Ferrara, G, Fischer, A, Gauldie, J, Geiser, T, Guenther, A, Hambly, N, Hansell, D, Harari, S, Jones, M, Keane, M, Ley, B, Maher, T, Molina-Molina, M, Palmucci, S, Poletti, V, Prasse, A, Rottoli, P, Spagnolo, P, Sterclova, M, Torrisi, S, Tsitoura, E, Vasakova, M, Walsh, S, Wijsenbeek, M, Wuyts, W, Johannson, Kerri A, Strâmbu, Irina, Ravaglia, Claudia, Grutters, Jan C, Valenzuela, Claudia, Mogulkoc, Nesrin, Luppi, Fabrizio, Richeldi, Luca, Wells, Athol U, Vancheri, Carlo, Kreuter, Michael, Albera, Carlo, Antoniou, Katerina M., Altinisik, Goksel, Bendstrup, Elisabeth, Bondue, Benjamin, Borie, Raphael, Brown, Kevin K., Camus, Philippe, Castillo, Diego, Collard, Harold R., Cottin, Vincent, Crimi, Nunzio, Ferrara, Giovanni, Fischer, Aryeh, Gauldie, Jack, Geiser, Thomas, Guenther, Andreas, Hambly, Nathan, Hansell, David M., Harari, Sergio, Jones, Mark G., Keane, Michael, Ley, Brett, Maher, Toby M., Molina-Molina, Maria, Palmucci, Stefano, Poletti, Venerino, Prasse, Antje, Rottoli, Paola, Spagnolo, Paolo, Sterclova, Martina, Torrisi, Sebastiano, Tsitoura, Eliza, Vasakova, Martina, Walsh, Simon L., Wijsenbeek, Marlies S., and Wuyts, Wim A.

Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive parenchymal lung disease of complex cause. Gastro-oesophageal reflux (GER) and microaspiration have been proposed as risk factors for the development and progression of IPF, but robust definitive data are few. A recent international guideline conditionally recommended the use of antacid therapy (proton pump inhibitors or histamine-2-receptor antagonists) for patients with IPF, in the absence of oesophageal reflux or symptoms. In this Position Paper, we summarise the literature addressing the association between GER and IPF, and also identify future research priorities that could clarify this issue. We shed light on the process through which the guideline recommendation was achieved and aim to contextualise the recommendation for providers caring for patients with IPF.

Published
2017

46. Pirfenidone safety and adverse event management in idiopathic pulmonary fibrosis

Author

Lancaster, LH, de Andrade, JA, Zibrak, JD, Padilla, ML, Albera, C, Nathan, SD, Wijsenbeek - Lourens, Marlies, Stauffer, JL, Kirchgaessler, K U, Costabel, U, Lancaster, LH, de Andrade, JA, Zibrak, JD, Padilla, ML, Albera, C, Nathan, SD, Wijsenbeek - Lourens, Marlies, Stauffer, JL, Kirchgaessler, K U, and Costabel, U

Published
2017

47. Italian Cystic Fibrosis Register - Report 2010

Author

Amato, A, Ferrigno, L, Salvatore, M, Toccaceli, V, Gruppo di lavoro RIFC/ICFR Working Group, Albera, C, Assael, B, Baldo, E, Battistini, F, Bena, C, Bernardi, M, Bertasi, S, Bignamini, E, Bisogno, A0, Braggion, C1, Cannata, L, Carnicella, A, Carnovale, V, Ciciretti, M, Cirilli, N, Collura, M, Colombo, C, Contoli, B, Cotichini, R, Cristadoro, S, Cucchiara, S, Ferrari, G, Ficili, F, Fogazza, D, Forte, F, Francalanci, M, Gagliardini, R, Iansa, P, Laezza, C, La Rosa, M, Lucidi, V, Magazzù, G, Majo, F, Manca, A, Mascotto, D, Mencarini, V, Minicucci, L, Moretti, P, Padoan, R, Pintani, E, Pisi, G, Pizzamiglio, G, Poli, F, Quattrucci, S, Raia, V, Ratclif, L, Ros, M, Salvatore, D, Seia, M, Spaggiari, C, Stazi, M, Taruscio, D, Tonelli, T, Tuccio, G, and Zavataro, L

Subjects
Registry, Cystic Fibrosis, Italy, Cystic Fibrosis, Registry, Italy
Published
2016

48. Erratum to: Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA

Author

Bousquet, J. Bewick, M. Cano, A. Eklund, P. Fico, G. Goswami, N. Guldemond, N.A. Henderson, D. Hinkema, M.J. Liotta, G. Mair, A. Molloy, W. Monaco, A. Monsonis-Paya, I. Nizinska, A. Papadopoulos, H. Pavlickova, A. Pecorelli, S. Prados-Torres, A. Roller-Wirnsberger, R.E. Somekh, D. Vera-Muñoz, C. Visser, F. Farrell, J. Malva, J. Andersen Ranberg, K. Camuzat, T. Carriazo, A.M. Crooks, G. Gutter, Z. Iaccarino, G. de Keenoy, E.M. Moda, G. Rodriguez-Mañas, L. Vontetsianos, T. Abreu, C. Alonso, J. Alonso-Bouzon, C. Ankri, J. Arredondo, M.T. Avolio, F. Bedbrook, A. Białoszewski, A.Z. Blain, H. Bourret, R. Cabrera-Umpierrez, M.F. Catala, A. O’Caoimh, R. Cesari, M. Chavannes, N.H. Correia-Da-Sousa, J. Dedeu, T. Ferrando, M. Ferri, M. Fokkens, W.J. Garcia-Lizana, F. Guérin, O. Hellings, P.W. Haahtela, T. Illario, M. Inzerilli, M.C. Lodrup Carlsen, K.C. Kardas, P. Keil, T. Maggio, M. Mendez-Zorrilla, A. Menditto, E. Mercier, J. Michel, J.P. Murray, R. Nogues, M. O’Byrne-Maguire, I. Pappa, D. Parent, A.S. Pastorino, M. Robalo-Cordeiro, C. Samolinski, B. Siciliano, P. Teixeira, A.M. Tsartara, S.I. Valiulis, A. Vandenplas, O. Vasankari, T. Vellas, B. Vollenbroek-Hutten, M. Wickman, M. Yorgancioglu, A. Zuberbier, T. Barbagallo, M. Canonica, G.W. Klimek, L. Maggi, S. Aberer, W. Akdis, C. Adcock, I.M. Agache, I. Albera, C. Alonso-Trujillo, F. Angel Guarcia, M. Annesi-Maesano, I. Apostolo, J. Arshad, S.H. Attalin, V. Avignon, A. Bachert, C. Baroni, I. Bel, E. Benson, M. Bescos, C. Blasi, F. Barbara, C. Bergmann, K.C. Bernard, P.L. Bonini, S. Bousquet, P.J. Branchini, B. Brightling, C.E. Bruguière, V. Bunu, C. Bush, A. Caimmi, D.P. Calderon, M.A. Canovas, G. Cardona, V. Carlsen, K.H. Cesario, A. Chkhartishvili, E. Chiron, R. Chivato, T. Chung, K.F. D’Angelantonio, M. de Carlo, G. Cholley, D. Chorin, F. Combe, B. Compas, B. Costa, D.J. Costa, E. Coste, O. Coupet, A.-L. Crepaldi, G. Custovic, A. Dahl, R. Dahlen, S.E. Demoly, P. Devillier, P. Didier, A. Dinh-Xuan, A.T. Djukanovic, R. Dokic, D. du Toit, G. Dubakiene, R. Dupeyron, A. Emuzyte, R. Fiocchi, A. Wagner, A. Fletcher, M. Fonseca, J. Fougère, B. Gamkrelidze, A. Garces, G. Garcia-Aymeric, J. Garcia-Zapirain, B. Gemicioğlu, B. Gouder, C. Hellquist-Dahl, B. Hermosilla-Gimeno, I. Héve, D. Holland, C. Humbert, M. Hyland, M. Johnston, S.L. Just, J. Jutel, M. Kaidashev, I.P. Khaitov, M. Kalayci, O. Kalyoncu, A.F. Keijser, W. Kerstjens, H. Knezović, J. Kowalski, M. Koppelman, G.H. Kotska, T. Kovac, M. Kull, I. Kuna, P. Kvedariene, V. Lepore, V. Macnee, W. Maggio, M. Magnan, A. Majer, I. Manning, P. Marcucci, M. Marti, T. Masoli, M. Melen, E. Miculinic, N. Mihaltan, F. Milenkovic, B. Millot-Keurinck, J. Mlinarić, H. Momas, I. Montefort, S. Morais-Almeida, M. Moreno-Casbas, T. Mösges, R. Mullol, J. Nadif, R. Nalin, M. Navarro-Pardo, E. Nekam, K. Ninot, G. Paccard, D. Pais, S. Palummeri, E. Panzner, P. Papadopoulos, N.K. Papanikolaou, C. Passalacqua, G. Pastor, E. Perrot, M. Plavec, D. Popov, T.A. Postma, D.S. Price, D. Raffort, N. Reuzeau, J.C. Robine, J.M. Rodenas, F. Robusto, F. Roche, N. Romano, A. Romano, V. Rosado-Pinto, J. Roubille, F. Ruiz, F. Ryan, D. Salcedo, T. Schmid-Grendelmeier, P. Schulz, H. Schunemann, H.J. Serrano, E. Sheikh, A. Shields, M. Siafakas, N. Scichilone, N. Siciliano, P. Skrindo, I. Smit, H.A. Sourdet, S. Sousa-Costa, E. Spranger, O. Sooronbaev, T. Sruk, V. Sterk, P.J. Todo-Bom, A. Touchon, J. Tramontano, D. Triggiani, M. Tsartara, S.I. Valero, A.L. Valovirta, E. van Ganse, E. van Hage, M. van Den Berge, M. Vandenplas, O. Ventura, M.T. Vergara, I. Vezzani, G. Vidal, D. Viegi, G. Wagemann, M. Whalley, B. Wickman, M. Wilson, N. Yiallouros, P.K. Žagar, M. Zaidi, A. Zidarn, M. Hoogerwerf, E.J. Usero, J. Zuffada, R. Senn, A. de Oliveira-Alves, B.

Abstract

The authors would like to change and use the correct name of M. Khaitov which is M. Kaitov on this manuscript. The authors have incorrectly used her other name during the finalization of this research. With this, the authors hereby publish the correct author names as presented above. © 2016 Serdi and Springer-Verlag France

Published
2016

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