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3. Sialic acid is a critical fetal defense against maternal complement attack

Author

Abeln, Markus, Albers, Iris, Peters-Bernard, Ulrike, Flachsig-Schulz, Kerstin, Kats, Elina, Kispert, Andreas, Tomlinson, Stephen, Gerardy-Schahn, Rita, Munster-Kuhnel, Anja, and Weinhold, Birgit

Subjects
Immune response -- Research, Laboratory rats -- Health aspects, Pregnancy complications -- Risk factors, Sialic acids -- Research, Health care industry
Abstract

The negatively charged sugar sialic acid (Sia) occupies the outermost position in the bulk of cell surface glycans. Lack of sialylated glycans due to genetic ablation of the Sia-activating enzyme CMP-sialic acid synthase (CMAS) resulted in embryonic lethality around day 9.5 post coitum (E9.5) in mice. Developmental failure was caused by complement activation on trophoblasts in [Cmas.sup.-/-] implants and was accompanied by infiltration of maternal neutrophils at the fetal- maternal interface, intrauterine growth restriction, impaired placental development, and a thickened Reichert's membrane. This phenotype, which shared features with complement receptor 1-related protein Y (Crry) depletion, was rescued in E8.5 [Cmas.sup.-/-] mice upon injection of cobra venom factor, resulting in exhaustion of the maternal complement component C3. Here we show that Sia is dispensable for early development of the embryo proper but pivotal for fetal-maternal immune homeostasis during pregnancy, i.e., for protecting the allograft implant against attack by the maternal innate immune system. Finally, embryos devoid of cell surface sialylation suffered from malnutrition due to inadequate placentation as a secondary effect., IntroductionEvery living cell is coated with a dense layer of glycans, the glycocalyx. In mammals, 10 different monosaccharides can be assembled in various linkages, generating an enormous number of glycans, [...]

Published
2019
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4. Supplementary Figure S1 from Proinflammatory Macrophage Activation by the Polysialic Acid-Siglec-16 Axis Is Linked to Increased Survival of Patients with Glioblastoma

Author

Thiesler, Hauke, primary, Gretenkort, Lina, primary, Hoffmeister, Leonie, primary, Albers, Iris, primary, Ohlmeier, Luisa, primary, Röckle, Iris, primary, Verhagen, Andrea, primary, Banan, Rouzbeh, primary, Köpcke, Nora, primary, Krönke, Nicole, primary, Feuerhake, Friedrich, primary, Behling, Felix, primary, Barrantes-Freer, Alonso, primary, Mielke, Dorothee, primary, Rohde, Veit, primary, Hong, Bujung, primary, Varki, Ajit, primary, Schwabe, Kerstin, primary, Krauss, Joachim K., primary, Stadelmann, Christine, primary, Hartmann, Christian, primary, and Hildebrandt, Herbert, primary

Published
2023
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5. Supplementary Methods S1 from Proinflammatory Macrophage Activation by the Polysialic Acid-Siglec-16 Axis Is Linked to Increased Survival of Patients with Glioblastoma

Author

Thiesler, Hauke, primary, Gretenkort, Lina, primary, Hoffmeister, Leonie, primary, Albers, Iris, primary, Ohlmeier, Luisa, primary, Röckle, Iris, primary, Verhagen, Andrea, primary, Banan, Rouzbeh, primary, Köpcke, Nora, primary, Krönke, Nicole, primary, Feuerhake, Friedrich, primary, Behling, Felix, primary, Barrantes-Freer, Alonso, primary, Mielke, Dorothee, primary, Rohde, Veit, primary, Hong, Bujung, primary, Varki, Ajit, primary, Schwabe, Kerstin, primary, Krauss, Joachim K., primary, Stadelmann, Christine, primary, Hartmann, Christian, primary, and Hildebrandt, Herbert, primary

Published
2023
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6. Supplementary Tables S1-S14 from Proinflammatory Macrophage Activation by the Polysialic Acid-Siglec-16 Axis Is Linked to Increased Survival of Patients with Glioblastoma

Author

Thiesler, Hauke, primary, Gretenkort, Lina, primary, Hoffmeister, Leonie, primary, Albers, Iris, primary, Ohlmeier, Luisa, primary, Röckle, Iris, primary, Verhagen, Andrea, primary, Banan, Rouzbeh, primary, Köpcke, Nora, primary, Krönke, Nicole, primary, Feuerhake, Friedrich, primary, Behling, Felix, primary, Barrantes-Freer, Alonso, primary, Mielke, Dorothee, primary, Rohde, Veit, primary, Hong, Bujung, primary, Varki, Ajit, primary, Schwabe, Kerstin, primary, Krauss, Joachim K., primary, Stadelmann, Christine, primary, Hartmann, Christian, primary, and Hildebrandt, Herbert, primary

Published
2023
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7. Proinflammatory Macrophage Activation by the Polysialic Acid-Siglec-16 Axis Is Linked to Increased Survival of Patients with Glioblastoma

Author

Thiesler, Hauke, primary, Gretenkort, Lina, additional, Hoffmeister, Leonie, additional, Albers, Iris, additional, Ohlmeier, Luisa, additional, Röckle, Iris, additional, Verhagen, Andrea, additional, Banan, Rouzbeh, additional, Köpcke, Nora, additional, Krönke, Nicole, additional, Feuerhake, Friedrich, additional, Behling, Felix, additional, Barrantes-Freer, Alonso, additional, Mielke, Dorothee, additional, Rohde, Veit, additional, Hong, Bujung, additional, Varki, Ajit, additional, Schwabe, Kerstin, additional, Krauss, Joachim K., additional, Stadelmann, Christine, additional, Hartmann, Christian, additional, and Hildebrandt, Herbert, additional

Published
2023
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8. Data from Proinflammatory Macrophage Activation by the Polysialic Acid-Siglec-16 Axis Is Linked to Increased Survival of Patients with Glioblastoma

Author

Thiesler, Hauke, primary, Gretenkort, Lina, primary, Hoffmeister, Leonie, primary, Albers, Iris, primary, Ohlmeier, Luisa, primary, Röckle, Iris, primary, Verhagen, Andrea, primary, Banan, Rouzbeh, primary, Köpcke, Nora, primary, Krönke, Nicole, primary, Feuerhake, Friedrich, primary, Behling, Felix, primary, Barrantes-Freer, Alonso, primary, Mielke, Dorothee, primary, Rohde, Veit, primary, Hong, Bujung, primary, Varki, Ajit, primary, Schwabe, Kerstin, primary, Krauss, Joachim K., primary, Stadelmann, Christine, primary, Hartmann, Christian, primary, and Hildebrandt, Herbert, primary

Published
2023
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10. Podocyte-Specific Sialylation-Deficient Mice Serve as a Model for Human FSGS

Author

Niculovic, Kristina M., primary, Blume, Linda, additional, Wedekind, Henri, additional, Kats, Elina, additional, Albers, Iris, additional, Groos, Stephanie, additional, Abeln, Markus, additional, Schmitz, Jessica, additional, Beuke, Esther, additional, Bräsen, Jan H., additional, Melk, Anette, additional, Schiffer, Mario, additional, Weinhold, Birgit, additional, and Münster-Kühnel, Anja K., additional

Published
2019
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