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In 2022, many monkeypox (MPX) outbreaks have been documented in countries where MPX was not endemic. It spread all around the world, especially in European Union and United States. While MPX is classically considered to be transmitted through close contact with lesions, the hypothesis of sexual transmission has been proposed. This study considered a total of 49 patients suspected for MPX that were also tested for other sexually transmitted infections (STIs), including Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, and Trichomonas vaginalis. The data from coinfected patients suggested that MPXV and STIs might share the same route of inoculum, corroborating the hypothesis of possible sexual transmission for the emerging poxvirus. And like any other STI, MPX should be considered without stigmatization.

We identified the first case in Italy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 variant, using whole-genome sequencing in an Italian subject traveling from Mozambique. Specific mutation profiles deserve further investigations to clarify potential effects on vaccination efficacy. This case highlights the crucial role of rapid and continuous surveillance of SARS-CoV-2 variant circulation.

Background The increasing age of global populations highlights the urgent need to understand the biological underpinnings of ageing. To this end, inhibition of the insulin/insulin-like signalling (IIS) pathway can extend healthy lifespan in diverse animal species, but with trade-offs including delayed development. It is possible that distinct cell types underlie effects on development and ageing; cell-type-specific strategies could therefore potentially avoid negative trade-offs when targeting diseases of ageing, including prevalent neurodegenerative diseases. The highly conserved diversity of neuronal and non-neuronal (glial) cell types in the Drosophila nervous system makes it an attractive system to address this possibility. We have thus investigated whether IIS in distinct glial cell populations differentially modulates development and lifespan in Drosophila. Results We report here that glia-specific IIS inhibition, using several genetic means, delays development while extending healthy lifespan. The effects on lifespan can be recapitulated by adult-onset IIS inhibition, whereas developmental IIS inhibition is dispensable for modulation of lifespan. Notably, the effects we observe on both lifespan and development act through the PI3K branch of the IIS pathway and are dependent on the transcription factor FOXO. Finally, IIS inhibition in several glial subtypes can delay development without extending lifespan, whereas the same manipulations in astrocyte-like glia alone are sufficient to extend lifespan without altering developmental timing. Conclusions These findings reveal a role for distinct glial subpopulations in the organism-wide modulation of development and lifespan, with IIS in astrocyte-like glia contributing to lifespan modulation but not to developmental timing. Our results enable a more complete picture of the cell-type-specific effects of the IIS network, a pathway whose evolutionary conservation in humans make it tractable for therapeutic interventions. Our findings therefore underscore the necessity for cell-type-specific strategies to optimise interventions for the diseases of ageing.

Structural inequality is a framework that examines conditions in which groups of people experience unequal opportunities in terms of roles, rights and decision-making compared to others. This research sought to examine whether students from refugee backgrounds faced structural inequalities in their access to higher education. Data regarding the participation of refugee students in higher education between 2011 and 2014 was obtained from the Australian Department of Education and Training. This data was compared with sector averages and those of students from formal equity backgrounds to establish possible structural impediments to university study. Students from refugee backgrounds were found to face both horizontal and vertical inequalities in their access to higher education, as do other equity groups. The experience of refugee students appears to have unique features, however, including gender, age, type of institution accessed and potentially field of study. These barriers may be addressed to some extent by university outreach and support programmes, but more will be required to facilitate full participation in higher education by these students.

A diluted 3% w/w hydrogen peroxide solution acidified to pH 2 5 by adding citric acid inactivated SARS-CoV-2 virus by more than 4 orders of magnitude in 5 min After a contact time of 15 min, no viral replication was detected Aqueous solutions of sodium percarbonate inactivated coronavirus by >3 log10 diminution in 15 min Conversely, H2O2 solutions with no additives displayed a scarce virucidal activity (1 1 log10 diminution in 5 min), confirming that a pH-modifying ingredient is necessary to have a H2O2-based disinfectant active against the novel coronavirus © 2021 American Chemical Society

An Italian male with no link to China SARS-CoV-2 epidemic presented at Emergency Room with severe respiratory impairment. The RT-PCR on 20th February, 2020, nasopharyngeal swab revealed SARS-CoV-2 infection, confirmed with viral culture and sequencing. This was the first identified autochthonous SARS-CoV-2 transmission in Italy, that unveiled global pathogen diffusion.

Malaria remains the most important mosquito‐borne infectious disease worldwide, with 229 million new cases and 409.000 deaths in 2019. The infection is caused by a protozoan parasite which attacks red blood cells by feeding on hemoglobin and transforming it into hemozoin. Despite the WHO recommendation of prompt malaria diagnosis, the quality of microscopy‐based diagnosis is frequently inadequate while rapid diagnostic tests based on antigens are not quantitative and still affected by non‐negligible false negative/positive results. PCR‐based methods are highly performant but still not widely used in endemic areas. Here, a diagnostic tool (TMek), based on the paramagnetic properties of hemozoin nanocrystals in infected red blood cells (i‐RBCs), is reported on. Exploiting the competition between gravity and magnetic forces, i‐RBCs in a whole blood specimen are sorted and electrically detected in a microchip. The amplitude and time evolution of the electrical signal allow for the quantification of i‐RBCs (in the range 10–105 i‐RBC µL−1) and the distinction of the infection stage. A preliminary validation study on 75 patients with clinical suspect of malaria shows on‐field operability, without false negative and a few false positive results. These findings indicate the potential of TMek as a quantitative, stage‐selective, rapid test for malaria., Malaria is caused by the Plasmodium parasite which feeds on hemoglobin and produces paramagnetic hemozoin crystals within red blood cells (RBCs). A quantitative and stage‐selective pan‐malaria diagnostic test is disclosed, based on a simple concept implemented on a microchip: the sorting and electrical detection of infected RBCs, thanks to the competition between magnetic and gravity forces.

Chlamydia trachomatis (Ct) and human papillomavirus (HPV) are the most prevalent sexually transmitted infections throughout the world. Despite the serious complications associated with chronic Ct infections in sexually active women, a screening program is not yet available in Italy. Moreover, HPV/Ct co-infections are also known to occur frequently, increasing the risk of HPV-induced carcinogenesis. The aim of this study was to evaluate the prevalence of Ct infections, the distribution of Ct serovars, and the incidences of Ct/HPV co-infections among women with a recent history of abnormal cervical cytology. Cervical samples were collected from 199 women referred for a gynecological visit following an abnormal Pap test results. All samples were tested for the presence of Ct and HPV DNA using real-time PCR assays, Ct typing of positive samples was performed by PCR&ndash, RFLP (restriction fragment length polymorphism) targeting the ompA gene. A high percentage of these women (12.8% and 21.7% with or without abnormal cytology on &ldquo, retesting&rdquo, respectively) were found to be Ct positive. Serovar F was the most prevalent type in Ct positive women, followed by E and K. Ct/HPV co-infections were detected in 7% (14/199) of enrolled women, with HPV-16, HPV-51, and HPV-52 being most frequently identified in co-infections. This study provides new epidemiological data on the prevalence of Ct and associated HPV infection in women with a recent history of abnormal cervical cytology in Italy, where notification of cases is not mandatory.

Consistency relations of large-scale structures provide exact nonperturbative results for cross-correlations of cosmic fields in the squeezed limit. They only depend on the equivalence principle and the assumption of Gaussian initial conditions, and remain nonzero at equal times for cross-correlations of density fields with velocity or momentum fields, or with the time derivative of density fields. We show how to apply these relations to observational probes that involve the integrated Sachs-Wolfe effect or the kinematic Sunyaev-Zeldovich effect. In the squeezed limit, this allows us to express the three-point cross-correlations, or bispectra, of two galaxy or matter density fields, or weak lensing convergence fields, with the secondary Cosmic Microwave Background (CMB) distortion in terms of products of a linear and a nonlinear power spectrum. In particular, we find that cross-correlations with the integrated Sachs-Wolfe effect show a specific angular dependence. These results could be used to test the equivalence principle and the primordial Gaussianity, or to check the modeling of large-scale structures., 10 pages

We present a class of modified-gravity theories which we call ultra-local models. We add a scalar field, with negligible kinetic terms, to the Einstein-Hilbert action. We also introduce a conformal coupling to matter. This gives rise to a new screening mechanism which is not entirely due to the non-linearity of the scalar field potential or the coupling function but to the absence of the kinetic term. As a result this removes any fifth force between isolated objects in vacuum. The predictions of these models only depend on a single free function, as the potential and the coupling function are degenerate, with an amplitude given by a parameter $\alpha \lesssim 10^{-6}$, whose magnitude springs from requiring a small modification of Newton's potential astrophysically and cosmologically. This singles out a redshift $z_{\alpha} \sim \alpha^{-1/3} \gtrsim 100$ where the fifth force is the greatest. The cosmological background follows the $\Lambda$-CDM history within a $10^{-6}$ accuracy, while cosmological perturbations are significantly enhanced (or damped) on small scales, $k \gtrsim 2 h {\rm Mpc}^{-1}$ at $z=0$. The spherical collapse and the halo mass function are modified in the same manner. We find that the modifications of gravity are greater for galactic or sub-galactic structures. We also present a thermodynamic analysis of the non-linear and inhomogeneous fifth-force regime where we find that the Universe is not made more inhomogeneous before $z_\alpha$ when the fifth force dominates, and does not lead to the existence of clumped matter on extra small scales inside halos for large masses while this possibility exists for masses $M\lesssim 10^{11} M_\odot$ where the phenomenology of ultra-local models would be most different from $\Lambda$-CDM., Comment: 40 pages, 23 figures, updated references

We present exact kinematic consistency relations for cosmological structures that do not vanish at equal times and can thus be measured in surveys. These rely on cross-correlations between the density and velocity, or momentum, fields. Indeed, the uniform transport of small-scale structures by long wavelength modes, which cannot be detected at equal times by looking at density correlations only, gives rise to a shift in the amplitude of the velocity field that could be measured. These consistency relations only rely on the weak equivalence principle and Gaussian initial conditions. They remain valid in the non-linear regime and for biased galaxy fields. They can be used to constrain non-standard cosmological scenarios or the large-scale galaxy bias., 5 pages

Super-chameleon models where all types of matter belong to three secluded sectors, i.e. the dark, supersymmetry breaking and matter sectors, are shown to be dynamically equivalent to ultra-local models of modified gravity. In the dark sector, comprising both dark matter and dark energy, the interaction range between the dark energy field and dark matter is constrained to be extremely short, i.e. shorter than the inverse gravitino mass set by supersymmetry breaking. This realises an extreme version of chameleon screening of the dark energy interaction. On the other hand, the baryonic matter sector decouples from the dark energy in a Damour-Polyakov way. These two mechanisms preclude the existence of any modification of gravity locally in the Solar System due to the presence of the super-chameleon field. On larger scales, the super-chameleon can have effects on the growth of structure and the number of dark matter halos. It can also affect the dynamics of galaxies where the fifth force interaction that it induces can have the same order of magnitude as Newton's interaction., 23 pages, 14 figures. arXiv admin note: text overlap with arXiv:1605.02938

We use the cosmic shear data from the Canada-France-Hawaii Telescope Lensing Survey to place constraints on $f(R)$ and {\it Generalized Dilaton} models of modified gravity. This is highly complimentary to other probes since the constraints mainly come from the non-linear scales: maximal deviations with respects to the General-Relativity + $\Lambda$CDM scenario occurs at $k\sim1 h \mbox{Mpc}^{-1}$. At these scales, it becomes necessary to account for known degeneracies with baryon feedback and massive neutrinos, hence we place constraints jointly on these three physical effects. To achieve this, we formulate these modified gravity theories within a common tomographic parameterization, we compute their impact on the clustering properties relative to a GR universe, and propagate the observed modifications into the weak lensing $\xi_{\pm}$ quantity. Confronted against the cosmic shear data, we reject the $f(R)$ $\{ |f_{R_0}|=10^{-4}, n=1\}$ model with more than 99.9% confidence interval (CI) when assuming a $\Lambda$CDM dark matter only model. In the presence of baryonic feedback processes and massive neutrinos with total mass up to 0.2eV, the model is disfavoured with at least 94% CI in all different combinations studied. Constraints on the $\{ |f_{R_0}|=10^{-4}, n=2\}$ model are weaker, but nevertheless disfavoured with at least 89% CI. We identify several specific combinations of neutrino mass, baryon feedback and $f(R)$ or Dilaton gravity models that are excluded by the current cosmic shear data. Notably, universes with three massless neutrinos and no baryon feedback are strongly disfavoured in all modified gravity scenarios studied. These results indicate that competitive constraints may be achieved with future cosmic shear data., Comment: 13 pages, 7 figures, 2 tables

We investigate the effects of a K-mouflage modification of gravity on the dynamics of clusters of galaxies. We extend the description of K-mouflage to situations where the scalar field responsible for the modification of gravity is coupled to a perfect fluid with pressure. We describe the coupled system at both the background cosmology and cosmological perturbations levels, focusing on cases where the pressure emanates from small-scale nonlinear physics. We derive these properties in both the Einstein and Jordan frames, as these two frames already differ by a few percents at the background level for K-mouflage scenarios, and next compute cluster properties in the Jordan frame that is better suited to these observations. Galaxy clusters are not screened by the K-mouflage mechanism and therefore feel the modification of gravity in a maximal way. This implies that the halo mass function deviates from $\Lambda$-CDM by a factor of order one for masses $M\gtrsim 10^{14} \ h^{-1} M_\odot$. We then consider the hydrostatic equilibrium of gases embedded in galaxy clusters and the consequences of K-mouflage on the X-ray cluster luminosity, the gas temperature, and the Sunyaev-Zel'dovich effect. We find that the cluster temperature function, and more generally number counts, are largely affected by K-mouflage, mainly due to the increased cluster abundance in these models. Other scaling relations such as the mass-temperature and the temperature-luminosity relations are only modified at the percent level due to the constraints on K-mouflage from local Solar System tests., Comment: 34 pages

In this paper we describe the knowledge building process involved in creating The Lab, a technology-enabled 'learning community' of young people with Asperger's Syndrome (AS) and High-Functioning Autism (HFA), and their parents. We use Vygotsky's (1978) cultural-historical approach to analyse social engagement through material, individual, and social interactions and the emergence of a 'third space' (Gutierrez, 1999 & 2008) as a particular kind of 'zone of proximal development' in developing an effective learning environment. We speculate on the centrality of the sensory and perceptual differences of AS and HFA people as contributing to a better understanding of the role of embodied imagination and creativity as essential aspects of their 'difference' and their distinct patterns of social and cultural relations.