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1. Comparison among populations with severe and intermediate alpha1-antitrypsin deficiency and chronic obstructive pulmonary disease.

Author

PILONI, Davide, OTTAVIANI, Stefania, SADERI, Laura, CORDA, Luciano, BADERNA, Paolo, BARZON, Valentina, BALDERACCHI, Alice M., SEEBACHER, Christine, BALBI, Bruno, ALBICINI, Federica, CORINO, Alessandra, MENNITTI, Maria C., TIRELLI, Claudio, SPREAFICO, Fabio, BOSIO, Matteo, MARIANI, Francesca, SOTGIU, Giovanni, CORSICO, Angelo G., and FERRAROTTI, Ilaria

Published
2024
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3. Comparison among populations with severe and intermediate alpha1-antitrypsin deficiency and chronic obstructive pulmonary disease

Author

PILONI, Davide, primary, OTTAVIANI, Stefania, additional, SADERI, Laura, additional, CORDA, Luciano, additional, BADERNA, Paolo, additional, BARZON, Valentina, additional, BALDERACCHI, Alice M., additional, SEEBACHER, Christine, additional, BALBI, Bruno, additional, ALBICINI, Federica, additional, CORINO, Alessandra, additional, MENNITTI, Maria C., additional, TIRELLI, Claudio, additional, SPREAFICO, Fabio, additional, BOSIO, Matteo, additional, MARIANI, Francesca, additional, SOTGIU, Giovanni, additional, CORSICO, Angelo G., additional, and FERRAROTTI, Ilaria, additional

Published
2023
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4. Inhaled corticosteroids and risk of osteoporosis in late-middle-aged subjects: a multicenter European cohort study

Author

GROSSO, Amelia, primary, CERVERI, Isa, additional, CAZZOLETTI, Lucia, additional, ZANOLIN, Maria E., additional, MATTIOLI, Veronica, additional, PILONI, Davide, additional, GINI, Erica, additional, ALBICINI, Federica, additional, RONZONI, Vanessa, additional, JARVIS, Debbie, additional, JANSON, Christer, additional, and CORSICO, Angelo G., additional

Published
2023
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5. Sub-lingual administration of a polyvalent mechanical bacterial lysate (PMBL) in patients with moderate, severe, or very severe chronic obstructive pulmonary disease (COPD) according to the GOLD spirometric classification: A multicentre, double-blind, randomised, controlled, phase IV study (AIACE study: Advanced Immunological Approach in COPD Exacerbation)

Author

Garelli, Valentina, Bagnasco, Diego, Colombo, Barbara, Lagasio, Chiara, Segreti, Andrea, Basili, M.C., Dodaj, Meridiana, Alessandrini, Arnaldo, Maggi, Sara, Rossi, Marinella, Bighiani, Marco, Rocca, Sabrina, Cardaci, Vittorio, Pedicelli, Ilaria, Mattei, Francesca, Censori, Marta, Dall'Armi, Valentina, Appodia, Massimiliano, Lapenna, Luisa Maria, Bisceglia, Michela, Centanni, Stefano, Barlassina, Roberta, Verga, Massimo, Corsico, Angelo, Grosso, Amelia, Gini, Erica, Albicini, Federica, Di Vincenzo, Eti Maria Giulia, Agnesi, Marta Ernesta, D'Amato, Gennaro, Salzillo, Antonello, Piccolo, Amedeo, Damonte, Claudio, Miragoli, Barbara, Passera, Alberto, Roveda, Paolo, La Vecchia, Giuseppe, Mercuri, Maria, Scala, Alberto, Ferliga, Mauro, Gardenghi, Giovanni Gardini, Taranto, Luigi, Meriggi, Antonio, Gatto, Elena, Noschese, Paolo, Magro, Gaetano, Pesci, Alberto, Tana, Francesco, Paolini, Valentina, Stefani, Italo, Trigiani, Marco, Maffini, Milena, Contini, Pamela, Braido, Fulvio, Melioli, Giovanni, Cazzola, Mario, Fabbri, Leonardo, Blasi, Francesco, Moretta, Lorenzo, and Canonica, Giorgio Walter

Published
2015
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11. COVID-19 epidemic in a Respiratory Diseases Unit: predictor ranking and mining

Author

Stella, Giulia M., primary, Piloni, Davide, additional, Accordino, Giulia, additional, Grosso, Amelia, additional, Albicini, Federica, additional, Gini, Erica, additional, Mancinelli, Silvia, additional, Della Zoppa, Matteo, additional, Marchelli, Andrea P. G., additional, Bortolotto, Chandra, additional, and Corsico, Angelo G., additional

Published
2021
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13. Inhaled Corticosteroids and Risk of Osteoporosis in Late-Middle Age Subjects: A Multicenter European Cohort Study

Author

Grosso, Amelia, primary, Piloni, Davide, additional, Zanolin, Maria Elisabetta, additional, Cazzoletti, Lucia, additional, Mattioli, Veronica, additional, Gini, Erica, additional, Albicini, Federica, additional, Ronzoni, Vanessa, additional, Cerveri, Isa, additional, Corsico, Angelo Guido, additional, Jarvis, Debbie, additional, and Janson, Christer, additional

Published
2020
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14. Characterization of asthma and COPD overlap: a single center study

Author

Grosso, Amelia, primary, Piloni, Davide, additional, Gini, Erica, additional, Albicini, Federica, additional, Balderacchi, Alice Maria, additional, Di Domenica, Rita, additional, Accordino, Giulia, additional, Coretti, Manuela, additional, Saracino, Laura, additional, Ronzoni, Vanessa, additional, and Corsico, Angelo Guido, additional

Published
2020
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15. Comparison between population with severe (ZZ) and intermediate (MZ) alpha1-antitrypsin deficiency and established COPD

Author

Piloni, Davide, primary, Mennitti, Maria Chiara, additional, Corda, Luciano, additional, Baderna, Paolo, additional, Ottaviani, Stefania, additional, Balderacchi, Alice Maria, additional, Barzon, Valentina, additional, Tirelli, Claudio, additional, Albicini, Federica, additional, Spreafico, Fabio, additional, Saderi, Laura, additional, Sotgiu, Giovanni, additional, Ferrarotti, Ilaria, additional, and Corsico, Angelo Guido, additional

Published
2019
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16. Persistent exercise limitation after successful pulmonary endoarterectomy: frequency and determinants

Author

Di Domenica, Rita, primary, Corsico, Angelo Guido, additional, D'Armini, Andrea Maria, additional, Conio, Valentina, additional, Grosso, Amelia, additional, Gini, Erica, additional, Albicini, Federica, additional, Pin, Maurizio, additional, Sciortino, Antonio, additional, Ghio, Stefano, additional, Klersy, Catherine, additional, and Cerveri, Isa, additional

Published
2018
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17. Use of inhaled corticosteroids and the risk of osteoporosis: an international cohort study

Author

Grosso, Amelia, primary, Cazzoletti, Lucia, additional, Albicini, Federica, additional, Gini, Erica, additional, Zanolin, Elisabetta, additional, Ronzoni, Vanessa, additional, Conio, Valentina, additional, Di Domenica, Rita, additional, Corsico, Angelo Guido, additional, Jarvis, Debbie, additional, Janson, Christer, additional, and Cerveri, Isa, additional

Published
2018
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20. Epidemiological and clinical features of non tuberculous mycobacteria infection (NTM) in a five-year single centre experience

Author

Conio, Valentina, primary, Piloni, Davide, additional, Cascina, Alessandro, additional, Galasso, Thomas, additional, Fusar Poli, Barbara, additional, Cemmi, Francesca, additional, Grosso, Amelia, additional, Gini, Erica, additional, Albicini, Federica, additional, Meloni, Federica, additional, and Corsico, Angelo Guido, additional

Published
2016
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21. The change of asthma course during pregnancy

Author

Corsico, Angelo Guido, primary, Locatelli, Francesca, additional, Cazzoletti, Lucia, additional, Grosso, Amelia, additional, Albicini, Federica, additional, Ronzoni, Vanessa, additional, Di Vincenzo, Eti Maria Giulia, additional, Piloni, Davide, additional, Cerveri, Isa, additional, and De Marco, Roberto, additional

Published
2015
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22. Sub-lingual administration of a polyvalent mechanical bacterial lysate (PMBL) in patients with moderate, severe, or very severe chronic obstructive pulmonary disease (COPD) according to the GOLD spirometric classification: A multicentre, double-blind, randomised, controlled, phase IV study (AIACE study: Advanced Immunological Approach in COPD Exacerbation)

Author

Braido, Fulvio, primary, Melioli, Giovanni, additional, Cazzola, Mario, additional, Fabbri, Leonardo, additional, Blasi, Francesco, additional, Moretta, Lorenzo, additional, Canonica, Giorgio Walter, additional, Garelli, Valentina, additional, Bagnasco, Diego, additional, Colombo, Barbara, additional, Lagasio, Chiara, additional, Segreti, Andrea, additional, Basili, M.C., additional, Dodaj, Meridiana, additional, Alessandrini, Arnaldo, additional, Maggi, Sara, additional, Rossi, Marinella, additional, Bighiani, Marco, additional, Rocca, Sabrina, additional, Cardaci, Vittorio, additional, Pedicelli, Ilaria, additional, Mattei, Francesca, additional, Censori, Marta, additional, Dall'Armi, Valentina, additional, Appodia, Massimiliano, additional, Lapenna, Luisa Maria, additional, Bisceglia, Michela, additional, Centanni, Stefano, additional, Barlassina, Roberta, additional, Verga, Massimo, additional, Corsico, Angelo, additional, Grosso, Amelia, additional, Gini, Erica, additional, Albicini, Federica, additional, Di Vincenzo, Eti Maria Giulia, additional, Agnesi, Marta Ernesta, additional, D'Amato, Gennaro, additional, Salzillo, Antonello, additional, Piccolo, Amedeo, additional, Damonte, Claudio, additional, Miragoli, Barbara, additional, Passera, Alberto, additional, Roveda, Paolo, additional, La Vecchia, Giuseppe, additional, Mercuri, Maria, additional, Scala, Alberto, additional, Ferliga, Mauro, additional, Gardenghi, Giovanni Gardini, additional, Taranto, Luigi, additional, Meriggi, Antonio, additional, Gatto, Elena, additional, Noschese, Paolo, additional, Magro, Gaetano, additional, Pesci, Alberto, additional, Tana, Francesco, additional, Paolini, Valentina, additional, Stefani, Italo, additional, Trigiani, Marco, additional, Maffini, Milena, additional, and Contini, Pamela, additional

Published
2015
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23. Il coinvolgimento polmonare nei pazienti affetti da sindrome di Marfan

Author

Mennitti, Maria Chiara, Viscardi, Arianna, Corsico, Angelo Guido, Albicini, Federica, Grosso, Amelia, Gini, Erica, Mazzetta, Andrea, and Arbustini, Eloisa

Abstract

Il coinvolgimento polmonare non è considerato una delle principali caratteristiche della sindrome di Marfan. Grazie ai sostanziali progressi nei trattamenti, l’aspettativa di vita di questi pazienti è migliorata determinando cambiamenti nei differenti organi. L’obiettivo è quello di valutare il coinvolgimento polmonare in tutti i pazienti valutando l’esame clinico e i test di funzionalità polmonare. La storia clinica, la spirometria, la capacità diffusiva furono stati valutati nei 64 pazienti. Nessuno dei pazienti riportava sintomi respiratori cronici. Il 14% ha riportato un precedente pneumotorace e 3 blebs. Il 45% aveva moderate o severe anormalità della gabbia toracica. Il 23% ha subito interventi cardiotoracici. Due dei 19 pazienti che hanno eseguito la TC torace risultavano avere l’enfisema; 7 avevano blebs. Solo il 37% dei pazienti aveva un pattern di funzionalità polmonare normale; il 19% mostrava un pattern restrittivo e il 44% un pattern ostruttivo o una diminuzione isolata della DLCO o un’isolata iperinflazione. In assenza di precoci sintomi respiratori, anormalità della funzione polmonare dovrebbero essere individuate. I nostri risultati supportano l’importanza della determinazione dei volumi polmonari per identificare i pazienti in cui è importante un’attenta valutazione della TC torace., Bollettino della Società Medico Chirurgica di Pavia, Vol 126, N° 2 (2013)

Published
2013
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26. The Rapid FEV1Decline in Chronic Obstructive Pulmonary Disease Is Associated with Predominant Emphysema: A Longitudinal Study

Author

Cerveri, Isa, primary, Corsico, Angelo G., additional, Grosso, Amelia, additional, Albicini, Federica, additional, Ronzoni, Vanessa, additional, Tripon, Bianca, additional, Imberti, Federica, additional, Galasso, Thomas, additional, Klersy, Catherine, additional, Luisetti, Maurizio, additional, and Pistolesi, Massimo, additional

Published
2012
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27. The Rapid FEV1 Decline in Chronic Obstructive Pulmonary Disease Is Associated with Predominant Emphysema: A Longitudinal Study.

Author

Cerveri, Isa, Corsico, Angelo G., Grosso, Amelia, Albicini, Federica, Ronzoni, Vanessa, Tripon, Bianca, Imberti, Federica, Galasso, Thomas, Klersy, Catherine, Luisetti, Maurizio, and Pistolesi, Massimo

Subjects
OBSTRUCTIVE lung diseases, LONGITUDINAL method, PULMONARY function tests, EARLY medical intervention, SMOKING, HEALTH
Abstract

Background: Early identification of patients with COPD and prone to more rapid decline in lung function is of particular interest from both a prognostic and therapeutic point of view. The aim of this study was to identify the clinical, functional and imaging characteristics associated with the rapid FEV1 decline in COPD. Methods: Between 2001 and 2005, 131 outpatients with moderate COPD in stable condition under maximum inhaled therapy underwent clinical interview, pulmonary function tests and HRCT imaging of the chest and were followed for at least 3 years. Results: Twenty-six percent of patients had emphysema detected visually using HRCT. The FEV1 decline was 42 ± 66 mL/y in the total sample, 88 ± 76 mL/y among rapid decliners and 6 ± 54 mL/y among the other patients. In the univariable analysis, the decline of FEV1 was positively associated with pack-years (p < 0.05), emphysema at HRCT (p < 0.001), RV (p < 0.05), FRC (p < 0.05), FEV1 (p < 0.01) at baseline and with number of hospitalizations per year (p < 0.05) during the follow-up. Using multivariable analysis, the presence of emphysema proved to be an independent prognostic factor of rapid decline (p = 0.001). When emphysema was replaced by RV, the model still remained significant. Conclusions: The rapid decline in lung function may be identified by the presence of emphysema at HRCT or increased RV in patients with a long smoking history. [ABSTRACT FROM AUTHOR]

Published
2013
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28. Comparison between Suspected and Confirmed COVID-19 Respiratory Patients: What Is beyond the PCR Test

Author

Stefania Principe, Amelia Grosso, Alida Benfante, Federica Albicini, Salvatore Battaglia, Erica Gini, Marta Amata, Ilaria Piccionello, Angelo Guido Corsico, Nicola Scichilone, Principe, Stefania, Grosso, Amelia, Benfante, Alida, Albicini, Federica, Battaglia, Salvatore, Gini, Erica, Amata, Marta, Piccionello, Ilaria, Corsico, Angelo Guido, and Scichilone, Nicola

Subjects
COVID-19 diagnosi, COVID-19, PCR test, COVID-19 diagnosis, General Medicine, Settore MED/10 - Malattie Dell'Apparato Respiratorio
Abstract

COVID-19 modified the healthcare system. Nasal-pharyngeal swab (NPS), with real-time reverse transcriptase-polymerase (PCR), is the gold standard for the diagnosis; however, there are difficulties related to the procedure that may postpone it. The study aims to evaluate whether other elements than the PCR-NPS are reliable and confirm the diagnosis of COVID-19. This is a cross-sectional study on data from the Lung Unit of Pavia (confirmed) and at the Emergency Unit of Palermo (suspected). COVID-19 was confirmed by positive NPS, suspected tested negative. We compared clinical, laboratory and radiological variables and performed Logistic regression to estimate which variables increased the risk of COVID-19. The derived ROC-AUCcurve, assessed the accuracy of the model to distinguish between COVID-19 suspected and confirmed. We selected 50 confirmed and 103 suspected cases. High Reactive C-Protein (OR: 1.02; CI95%: 0.11–1.02), suggestive CT-images (OR: 11.43; CI95%: 3.01–43.3), dyspnea (OR: 10.48; CI95%: 2.08–52.7) and respiratory failure (OR: 5.84; CI95%: 1.73–19.75) increased the risk of COVID-19, whereas pleural effusion decreased the risk (OR: 0.15; CI95%: 0.04–0.63). ROC confirmed the discriminative role of these variables between suspected and confirmed COVID-19 (AUC 0.91). Clinical, laboratory and imaging features predict the diagnosis of COVID-19, independently from the NPS result.

Published
2022

29. Renal fibrogenesis and platinum compounds in a rat model: a novel Pt (II) complex vs. cisplatin.

Author

Fenoglio C, Albicini F, De Pascali SA, Milanesi G, Fumagalli M, Migoni D, Fanizzi FP, and Bernocchi G

Subjects
Animals, Body Weight drug effects, Female, Kidney pathology, Rats, Rats, Wistar, Cisplatin toxicity, Disease Models, Animal, Fibrosis chemically induced, Kidney drug effects, Micelles, Platinum Compounds toxicity
Abstract

Background/aim: A new platinum compound, (Pt(O,O'-acac)(γ-acac)(DMS)) (PtAcacDMS), has been shown to possess higher cytotoxic activity than cisplatin on several cancer and chemoresistant cell lines. The aim of the present study was to compare the nephrotoxic effects - particularly renal fibrogenesis- of PtAcacDMS and cisplatin in rats after the subcutaneous administration of a single dose (5 mg/Kg b.w., s.c.) of either compound to ten-day-old rats., Materials and Methods: Control and treated rats were killed 1 day (PD11), 7 days (PD17), 21 days (PD31) and 40 days (PD50) after the injection. Kidneys were processed for light and electron microscopy, and platinum determination. Antibodies against E-cadherin (E-cad), vimentin (VIM) and α-smooth muscle actin (αSMA) were used to identify epithelial and mesenchymal cells., Results and Conclusion: Cisplatin produced progressive cortical fibrotic lesions displaying a variable number of VIM-positive tubules and interstitial αSMA-positive cells around. By contrast, PtAcacDMS induced a minimal number of histopathological changes, which declined in the adult samples, while the renal platinum content was generally higher after PtAcacDMS than after cisplatin. The present experimental model was proven suitable to investigate the occurrence of epithelial-mesenchymal transition (EMT) in renal fibrogenesis induced by the platinum-based compounds., (Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)

Published
2015

30. The rapid FEV(1) decline in chronic obstructive pulmonary disease is associated with predominant emphysema: a longitudinal study.

Author

Cerveri I, Corsico AG, Grosso A, Albicini F, Ronzoni V, Tripon B, Imberti F, Galasso T, Klersy C, Luisetti M, and Pistolesi M

Subjects
Aged, Confidence Intervals, Female, Forced Expiratory Volume, Hospitalization, Humans, Longitudinal Studies, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Prognosis, Pulmonary Disease, Chronic Obstructive complications, Pulmonary Emphysema complications, Residual Volume, Risk Factors, Smoking adverse effects, Tomography, X-Ray Computed, Disease Progression, Pulmonary Disease, Chronic Obstructive diagnostic imaging, Pulmonary Disease, Chronic Obstructive physiopathology, Pulmonary Emphysema diagnostic imaging, Pulmonary Emphysema physiopathology
Abstract

Background: Early identification of patients with COPD and prone to more rapid decline in lung function is of particular interest from both a prognostic and therapeutic point of view. The aim of this study was to identify the clinical, functional and imaging characteristics associated with the rapid FEV(1) decline in COPD., Methods: Between 2001 and 2005, 131 outpatients with moderate COPD in stable condition under maximum inhaled therapy underwent clinical interview, pulmonary function tests and HRCT imaging of the chest and were followed for at least 3 years., Results: Twenty-six percent of patients had emphysema detected visually using HRCT. The FEV(1) decline was 42 ± 66 mL/y in the total sample, 88 ± 76 mL/y among rapid decliners and 6 ± 54 mL/y among the other patients. In the univariable analysis, the decline of FEV(1) was positively associated with pack-years (p < 0.05), emphysema at HRCT (p < 0.001), RV (p < 0.05), FRC (p < 0.05), FEV(1) (p < 0.01) at baseline and with number of hospitalizations per year (p < 0.05) during the follow-up. Using multivariable analysis, the presence of emphysema proved to be an independent prognostic factor of rapid decline (p = 0.001). When emphysema was replaced by RV, the model still remained significant., Conclusions: The rapid decline in lung function may be identified by the presence of emphysema at HRCT or increased RV in patients with a long smoking history.

Published
2013
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