1. N‐terminal peptide deletion influences immunological and structural features of Blo t 5.
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Silva, Eduardo Santos, Huber, Sara, Alcantara‐Neves, Neuza Maria, Asam, Claudia, Silveira, Elisânia Fontes, Andrade Belitardo, Emília Maria Medeiros, Aglas, Lorenz, Wallner, Michael, Gadermaier, Gabriele, Briza, Peter, Karner, Ingrid, Torres, Rogério Tanan, Alvarez, Juan Ricardo Urrego, Wuenschmann, Sabina, Chapman, Martin, Ferreira, Fatima, and Pinheiro, Carina Silva
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IMMUNOGLOBULIN E , *AMINO acid residues - Abstract
Keywords: allergens and epitopes; IgE; immunotherapy vaccines and mechanisms EN allergens and epitopes IgE immunotherapy vaccines and mechanisms 1503 1507 5 06/01/20 20200601 NES 200601 Studies demonstrated that among the identified I B tropicalis i allergens, Blo t 5 is a major allergen,[[1], [3]] which makes the protein a target for diagnosis and allergen-specific immunotherapy (AIT). Cross-inhibition results showed that rBlo t 5 SB short sb cannot always inhibit the rDer p 5-specific IgE, but rDer p 5 possesses a moderate inhibitory capacity on rBlo t 5 SB short sb -specific IgE binding (Figure S4F). Blomia tropicalis Blo t 5 and Blo t 21 recombinant allergens might confer higher specificity to serodiagnostic assays than whole mite extract. [Extracted from the article]
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- 2020
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