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1. Addendum to consensus opinion from International Deep Endometriosis Analysis (IDEA) group: sonographic evaluation of the parametrium.

Author

Guerriero, S., Condous, G., Rolla, M., Hudelist, G., Ferrero, S., Alcazar, J. L., Ajossa, S., Bafort, C., Van Schoubroeck, D., Bourne, T., Van den Bosch, T., Singh, S. S., Abrao, M. S., Szabó, G., Testa, A. C., Di Giovanni, A., Fischerova, D., Tomassetti, C., and Timmerman, D.

Subjects
ENDOMETRIOSIS, ULTRASONIC imaging, GYNECOLOGY, OBSTETRICS, DIAGNOSIS
Abstract

Preoperative sonographic staging in patients with suspected parametrial endometriosis is essential to plan surgical intervention and anticipate the need for a multidisciplinary approach, and thus optimize surgical outcome. The results of a recent meta‐analysis suggest that there is a need to define more accurately the ultrasonographic criteria for parametrial involvement in endometriosis. This addendum to the International Deep Endometriosis Analysis (IDEA) consensus highlights the sonographic characteristics of the parametrium and identifies ultrasound techniques to diagnose deep endometriosis in this area. © 2023 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Non‐invasive imaging techniques for diagnosis of pelvic deep endometriosis and endometriosis classification systems: an International Consensus Statement.

Author

Condous, G., Gerges, B., Thomassin‐Naggara, I., Becker, C., Tomassetti, C., Krentel, H., van Herendael, B. J., Malzoni, M., Abrao, M. S., Saridogan, E., Keckstein, J., Hudelist, G., Aas‐Eng, K., Alcazar, J. L., Bafort, C., Bazot, M., Bielen, D., Bokor, A., Bourne, T., and Carmona, F.

Subjects
PELVIC pain, ENDOMETRIOSIS, HUMAN reproduction, HUMAN embryology, DIAGNOSIS, MEDICAL needs assessment
Abstract

The International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) and International Deep Endometriosis Analysis (IDEA) group, the European Endometriosis League (EEL), the European Society for Gynaecological Endoscopy (ESGE), the European Society of Human Reproduction and Embryology (ESHRE), the International Society for Gynecologic Endoscopy (ISGE), the American Association of Gynecologic Laparoscopists (AAGL) and the European Society of Urogenital Radiology (ESUR) elected an international, multidisciplinary panel of gynecological surgeons, sonographers and radiologists, including a steering committee, which searched the literature for relevant articles in order to review the literature and provide evidence‐based and clinically relevant statements on the use of imaging techniques for non‐invasive diagnosis and classification of pelvic deep endometriosis. Preliminary statements were drafted based on review of the relevant literature. Following two rounds of revisions and voting orchestrated by chairs of the participating societies, consensus statements were finalized. A final version of the document was then resubmitted to the society chairs for approval. Twenty statements were drafted, of which 14 reached strong and three moderate agreement after the first voting round. The remaining three statements were discussed by all members of the steering committee and society chairs and rephrased, followed by an additional round of voting. At the conclusion of the process, 14 statements had strong and five statements moderate agreement, with one statement left in equipoise. This consensus work aims to guide clinicians involved in treating women with suspected endometriosis during patient assessment, counseling and planning of surgical treatment strategies. © 2024 The Authors. Published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology, by Universa Press, by The International Society for Gynecologic Endoscopy, by Oxford University Press on behalf of European Society of Human Reproduction and Embryology, by Elsevier Inc. on behalf of American Association of Gynecologic Laparoscopists and by Elsevier B.V. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Addendum to the consensus opinion from the International Deep Endometriosis Analysis (IDEA) group: sonographic evaluation of the parametrium

Author

Stefano, G., primary, Condous, G., additional, Rolla, M., additional, Hudelist, G., additional, Ferrero, S., additional, Alcazar, J. L., additional, Ajossa, S., additional, Bafort, C., additional, Van Schoubroeck, D., additional, Bourne, T., additional, Van den Bosch, T., additional, Singh, S. S., additional, Abrao, M. S., additional, Szabó, G., additional, Testa, A. C., additional, Di Giovanni, A., additional, Fischerova, D., additional, Tomassetti, C., additional, and Timmerman, D., additional

Published
2023
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6. SUCCOR study. An international european cohort observational study comparing minimally invasive surgery versus open abdominal radical hysterectomy in patients with stage IB1 (FIGO 2009, <4 cm) cervical cancer operated in 2013-2014

Author

Chiva, L, Zanagnolo, V, Kucukmetin, A, Chakalova, G, Raspagliesi, F, Narducci, F, Toptas, T, Meydanli, M, Fagotti, A, Cibula, D, Wydra, D, Póka, R, Jach, R, Tavares, M, Tamussino, K, Haidopoulos, D, Ponce, J, Berlev, I, Roldán, F, Domingo, S, Zapardiel, I, Goncalves, E, Malzoni, M, Arencibia, O, Kukk, K, Haller, H, Vorgias, G, Ghezzi, F, Guyon, F, Herrero, S, Haesen, J, Feron, J G, Minguez, J, Chacon, E, Vazquez, D, Castellanos, T, Arevalo, J, Calvo, Martin N, and Alcazar, J L

Published
2019
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7. Benign descriptors and ADNEX in two‐step strategy to estimate risk of malignancy in ovarian tumors: retrospective validation in IOTA5 multicenter cohort

Author

Landolfo, C., primary, Bourne, T., additional, Froyman, W., additional, Van Calster, B., additional, Ceusters, J., additional, Testa, A. C., additional, Wynants, L., additional, Sladkevicius, P., additional, Van Holsbeke, C., additional, Domali, E., additional, Fruscio, R., additional, Epstein, E., additional, Franchi, D., additional, Kudla, M. J., additional, Chiappa, V., additional, Alcazar, J. L., additional, Leone, F. P. G., additional, Buonomo, F., additional, Coccia, M. E., additional, Guerriero, S., additional, Deo, N., additional, Jokubkiene, L., additional, Savelli, L., additional, Fischerova, D., additional, Czekierdowski, A., additional, Kaijser, J., additional, Coosemans, A., additional, Scambia, G., additional, Vergote, I., additional, Timmerman, D., additional, and Valentin, L., additional

Published
2023
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8. SUCCOR Nodes: May Sentinel Node Biopsy Determine the Need for Adjuvant Treatment?

Author

Berasaluce Gómez A., Martín-Calvo N., Boria F., Manzour N., Chacón E., Bizzarri N., Chiva L., Martinez A., Quesada A., Kucukmetin A., Vázquez A., Mandic A., Casajuana A., Kavallaris A., Fagotti A., Perrone A., Ferrero A., Lekuona A., Uppin A., Stepanyan A., Chiofalo B., Morillas B., Tauste C., Andrade C., Mom C., Brucker C., Sarac C. P., Vázquez-Vicente D., Cibula D., Querleu D., Erasun D., Kaidarova D., Tsolakidis D., Haidopoulos D., Golub D., Bonci E. A., Aksahin E., Gonçalves E., Moratalla E., Karaman E., Myriokefalitaki E., Ghezzi F., Narducci F., Roldan F., Raspagliesi F., Goffin F., Grandjean F., Guyon F., Demirkiran F., Fiol G., Chakalova G., Mancebo G., Vorgias G., Gebauer G., Meili G., Hernandez-Cortes G., Bogani G., Cordeiro G., Vujić G., Mendinhos G., Trum H., Bonsang-Kitzis H., Haller H., Vergote I., Zapardiel I., Aluloski I., Berlev I., Pete I., Kalogiannidis I., Kotsopoulos I., Yezhova I., Díez J., Feron J. G., Scharf J. P., Beltman J., Haesen J., Ponce J., Cea J., Mínguez J. Á., García J., Arévalo-Serrano J., Gilabert J., Alcazar J. L., Kukk K., Galaal K., Cárdenas L., Pirtea L., Mereu L., Anchora L. P., Dostalek L., Klasa L., PakižImre M., Undurraga M., Jedryka M., Bernardino M., Alonso-Espias M., Martín-Salamanca M. B., Cuadra M., Tavares M., Malzoni M., Fruscio R., Berasaluce Gómez, A, Martín-Calvo, N, Boria, F, Manzour, N, Chacón, E, Bizzarri, N, Chiva, L, Martinez, A, Quesada, A, Kucukmetin, A, Vázquez, A, Mandic, A, Casajuana, A, Kavallaris, A, Fagotti, A, Perrone, A, Ferrero, A, Lekuona, A, Uppin, A, Stepanyan, A, Chiofalo, B, Morillas, B, Tauste, C, Andrade, C, Mom, C, Brucker, C, Sarac, C, Vázquez-Vicente, D, Cibula, D, Querleu, D, Erasun, D, Kaidarova, D, Tsolakidis, D, Haidopoulos, D, Golub, D, Bonci, E, Aksahin, E, Gonçalves, E, Moratalla, E, Karaman, E, Myriokefalitaki, E, Ghezzi, F, Narducci, F, Roldan, F, Raspagliesi, F, Goffin, F, Grandjean, F, Guyon, F, Demirkiran, F, Fiol, G, Chakalova, G, Mancebo, G, Vorgias, G, Gebauer, G, Meili, G, Hernandez-Cortes, G, Bogani, G, Cordeiro, G, Vujić, G, Mendinhos, G, Trum, H, Bonsang-Kitzis, H, Haller, H, Vergote, I, Zapardiel, I, Aluloski, I, Berlev, I, Pete, I, Kalogiannidis, I, Kotsopoulos, I, Yezhova, I, Díez, J, Feron, J, Scharf, J, Beltman, J, Haesen, J, Ponce, J, Cea, J, Mínguez, J, García, J, Arévalo-Serrano, J, Gilabert, J, Alcazar, J, Kukk, K, Galaal, K, Cárdenas, L, Pirtea, L, Mereu, L, Anchora, L, Dostalek, L, Klasa, L, Pakižimre, M, Undurraga, M, Jedryka, M, Bernardino, M, Alonso-Espias, M, Martín-Salamanca, M, Cuadra, M, Tavares, M, Malzoni, M, and Fruscio, R

Subjects
cervical cancer
Abstract

Background: The SUCCOR cohort was developed to analyse the overall and disease-free survival at 5 years in women with FIGO 2009 stage IB1 cervical cancer. The aim of this study was to compare the use of adjuvant therapy in these women, depending on the method used to diagnose lymphatic node metastasis. Patients and Methods: We used data from the SUCCOR cohort, which collected information from 1049 women with FIGO 2009 stage IB1 cervical cancer who were operated on between January 2013 and December 2014 in Europe. We calculated the adjusted proportion of women who received adjuvant therapy depending on the lymph node diagnosis method and compared disease free and overall survival using Cox proportional-hazards regression models. Inverse probability weighting was used to adjust for baseline potential confounders. Results: The adjusted proportion of women who received adjuvant therapy was 33.8% in the sentinel node biopsy + lymphadenectomy (SNB+LA) group and 44.7% in the LA group (p = 0.02), although the proportion of positive nodal status was similar (p = 0.30). That difference was greater in women with negative nodal status and positive Sedlis criteria (difference 31.2%, p = 0.01). Here, those who underwent a SNB+LA had an increased risk of relapse [hazard ratio (HR) 2.49, 95% confidence interval (CI) 0.98–6.33, p = 0.056] and risk of death (HR 3.49, 95% CI 1.04–11.7, p = 0.042) compared with those who underwent LA. Conclusions: Women in this study were less likely to receive adjuvant therapy if their nodal invasion was determined using SNB+LA compared with LA. These results suggest a lack of therapeutic measures available when a negative result is obtained by SNB+LA, which may have an impact on the risk of recurrence and survival.

Published
2023

11. Prospective geographical and temporal validation of three published mathematical models to calculate risk of endometrial malignancy in patients with postmenopausal bleeding.

Author

Heremans, R., Van den Bosch, T., Sladkevicius, P., Pascual, M. A., Alcazar, J. L., Timmerman, D., and Valentin, L.

Subjects
UTERINE hemorrhage, ENDOMETRIAL hyperplasia, MATHEMATICAL models, HEMORRHAGE, DOPPLER ultrasonography, PATIENT selection
Abstract

3 Sladkevicius P, Opolskiene G, Valentin L. Prospective temporal validation of mathematical models to calculate risk of endometrial malignancy in patients with postmenopausal bleeding. Endometrial thickness as measured with transvaginal ultrasound is commonly used to estimate the risk of endometrial malignancy in women with postmenopausal bleeding. [Extracted from the article]

Published
2023
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13. Systematic approach to sonographic evaluation of the pelvis in women with suspected endometriosis, including terms, definitions and measurements: a consensus opinion from the International Deep Endometriosis Analysis (IDEA) group

Author

Guerriero, S., Condous, G., van den Bosch, T., Valentin, L., Leone, F. P. G., Van Schoubroeck, D., Exacoustos, C., Installé, A. J. F., Martins, W. P., Abrao, M. S., Hudelist, G., Bazot, M., Alcazar, J. L., Gonçalves, M. O., Pascual, M. A., Ajossa, S., Savelli, L., Dunham, R., Reid, S., Menakaya, U., Bourne, T., Ferrero, S., Leon, M., Bignardi, T., Holland, T., Jurkovic, D., Benacerraf, B., Osuga, Y., Somigliana, E., and Timmerman, D.

Published
2016
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17. Typical ultrasound features of various endometrial pathologies described using International Endometrial Tumor Analysis (IETA) terminology in women with abnormal uterine bleeding

Author

Van den Bosch, T. Verbakel, J. Y. Valentin, L. Wynants, L. and De Cock, B. Pascual, M. A. Leone, F. P. G. Sladkevicius, P. Alcazar, J. L. Votino, A. Fruscio, R. Lanzani, C. and Van Holsbeke, C. Rossi, A. Jokubkiene, L. Kudla, M. and Jakab, A. Domali, E. Epstein, E. Van Pachterbeke, C. and Bourne, T. Van Calster, B. Timmerman, D.

Abstract

Objective: To describe the ultrasound features of different endometrial and other intracavitary pathologies inpre- and postmenopausal women presenting with abnormal uterine bleeding, using the International Endometrial Tumor Analysis (IETA) terminology. Methods: This was a prospective observational multicenter study of consecutive women presenting with abnormal uterine bleeding. Unenhanced sonography with color Doppler and fluid-instillation sonography were performed. Endometrial sampling was performed according to each center’s local protocol. The histological endpoints were cancer, atypical endometrial hyperplasia/endometrioid intraepithelial neoplasia (EIN), endometrial atrophy, proliferative or secretory endometrium, endometrial hyperplasia without atypia, endometrial polyp, intracavitary leiomyoma and other. For fluid-instillation sonography, the histological endpoints were endometrial polyp, intracavitary leiomyoma and cancer. For each histological endpoint, we report typical ultrasound features using the IETA terminology. Results: The database consisted of 2856 consecutive women presenting with abnormal uterine bleeding. Unenhanced sonography with color Doppler was performed in all cases and fluid-instillation sonography in 1857. In 2216 women, endometrial histology was available, and these comprised the study population. Median age was 49 years (range, 19-92 years), median parity was 2 (range, 0-10) and median body mass index was 24.9 kg/m(2) (range, 16.0-72.1 kg/m(2) ). Of the study population, 843 (38.0%) women were postmenopausal. Endometrial polyps were diagnosed in 751 (33.9%) women, intracavitary leiomyomas in 223 (10.1%) and endometrial cancer in 137 (6.2%). None (0% (95% CI, 0.0-5.5%)) of the 66 women with endometrial thickness < 3 mm had endometrial cancer or atypical hyperplasia/EIN. Endometrial cancer or atypical hyperplasia/EIN was found in three of 283 (1.1% (95% CI, 0.4-3.1%)) endometria with a three-layer pattern, in three of 459 (0.7% (95% CI, 0.2-1.9%)) endometria with a linear endometrial midline and in five of 337 (1.5% (95% CI, 0.6-3.4%)) cases with a single vessel without branching on unenhanced ultrasound. Conclusions: The typical ultrasound features of endometrial cancer, polyps, hyperplasia and atrophy and intracavitary leiomyomas, are described using the IETA terminology. The detection of some easy-to-assess IETA features (i.e. endometrial thickness < 3 mm, three-layer pattern, linear midline and single vessel without branching) makes endometrial cancer unlikely. Copyright (C) 2020 ISUOG. Published by John Wiley & Sons Ltd.

Published
2021

20. Typical ultrasound features of various endometrial pathologies described using International Endometrial Tumor Analysis ( IETA ) terminology in women with abnormal uterine bleeding

Author

Van Den Bosch, T., primary, Verbakel, J. Y., additional, Valentin, L., additional, Wynants, L., additional, De Cock, B., additional, Pascual, M. A., additional, Leone, F. P. G., additional, Sladkevicius, P., additional, Alcazar, J. L., additional, Votino, A., additional, Fruscio, R., additional, Lanzani, C., additional, Van Holsbeke, C., additional, Rossi, A., additional, Jokubkiene, L., additional, Kudla, M., additional, Jakab, A., additional, Domali, E., additional, Epstein, E., additional, Van Pachterbeke, C., additional, Bourne, T., additional, Van Calster, B., additional, and Timmerman, D., additional

Published
2021
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21. Imaging in gynecological disease: ultrasound features of malignant ovarian yolk sac tumors (endodermal sinus tumors)

Author

Anfelter, P, Testa, A, Chiappa, V, Froyman, W, Fruscio, R, Guerriero, S, Alcazar, J L, Mascillini, F, Pascual, M A, Sibal, M, Savelli, L, Zannoni, G F, Timmerman, D, Epstein, E, Anfelter, P, Testa, A, Chiappa, V, Froyman, W, Fruscio, R, Guerriero, S, Alcazar, J, Mascillini, F, Pascual, M, Sibal, M, Savelli, L, Zannoni, G, Timmerman, D, and Epstein, E

Subjects
ultrasound feature, malignant germ cell tumor, endodermal sinus tumor, yolk sac tumor
Abstract

Objectives To describe the clinical and sonographic characteristics of malignant ovarian yolk sac tumors. Methods In this retrospective multicenter‐study we included 21 patients with a histological diagnosis of ovarian yolk sac tumor where still images and/or videoclips were available. Ten patients collected from the IOTA‐studies, had undergone a standardized preoperative ultrasound examination by an experienced ultrasound examiner between 1999 and 2016. The remaining eleven were identified through medical files, where images were retrieved from local image work stations and PACs systems. All tumors were described using IOTA terminology. The collected images and video clips were used for additional characterization by two observers. Results All cases were pure yolk sac tumors except for one, that was a mixed tumor (80% yolk sac tumor and 20% embryonic carcinoma). Median age at diagnosis was 25 (Interquartile range, IQR 19.5‐30.5) years. Seventy‐six percent (16/21) were FIGO stage I‐II when diagnosed. 58% (11/19) women felt pain during examination and one patient presented with ovarian torsion. Median S‐AFP level was 4755 μg/L (IQR, 1071 ‐ 25303) and CA‐125 126 kU/L (IQR, 35‐227). On ultrasound assessment 95% (20/21) of tumors were unilateral. The median of the maximal tumor diameter was 157 mm (IQR 107‐181), and the largest solid component 110 mm (IQR 66‐159). Tumors were classified either as multilocular‐solid (10/21, 48%), or as solid (11/21, 52%). Papillary projections were found in 10% (2/21) of the cases. Most tumors (20/21, 95%) were well vascularized (color score 3‐4) and none of the tumors had acoustic shadowing. Malignancy was suspected in all cases except for the patient with torsion, which presented with a color score of 1 and was classified as probably benign. Image and video clip quality was considered as adequate in 18/21 cases. Reviewing the images and videoclips we found that all tumors contained both solid components and cystic spaces, and that 89% (16/18) of the tumors had an irregular, still fine‐textured, and slightly hyperechoic solid tissue, giving them a characteristic appearance. Conclusion Malignant ovarian yolk sac tumors are often detected at an early stage, in young women usually in the second or third decade of life, presenting with pain and markedly elevated S‐AFP. On ultrasound yolk sac tumors are mostly unilateral, large, multilocular‐solid or solid, with fine‐textured slightly hyperechoic solid tissue, and rich vascularization.

Published
2020

22. Imaging in gynecological disease (19): clinical and ultrasound features of extragastrointestinal stromal tumors ( eGIST )

Author

Ambrosio, M., primary, Testa, A. C., additional, Moro, F., additional, Franchi, D., additional, Scifo, M. C., additional, Rams, N., additional, Epstein, E., additional, Alcazar, J. L., additional, Hidalgo, J. J., additional, Van Holsbeke, C., additional, Burgetova, A., additional, Dundr, P., additional, Cibula, D., additional, and Fischerova, D., additional

Published
2020
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28. Ultrasound‐based risk model for preoperative prediction of lymph‐node metastases in women with endometrial cancer: model‐development study

Author

Eriksson, L. S. E., primary, Epstein, E., additional, Testa, A. C., additional, Fischerova, D., additional, Valentin, L., additional, Sladkevicius, P., additional, Franchi, D., additional, Frühauf, F., additional, Fruscio, R., additional, Haak, L. A., additional, Opolskiene, G., additional, Mascilini, F., additional, Alcazar, J. L., additional, Van Holsbeke, C., additional, Chiappa, V., additional, Bourne, T., additional, Lindqvist, P. G., additional, Van Calster, B., additional, Timmerman, D., additional, Verbakel, J. Y., additional, Van den Bosch, T., additional, and Wynants, L., additional

Published
2020
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29. Imaging in gynecological disease (17): ultrasound features of malignant ovarian yolk sac tumors (endodermal sinus tumors)

Author

Anfelter, P., primary, Testa, A., additional, Chiappa, V., additional, Froyman, W., additional, Fruscio, R., additional, Guerriero, S., additional, Alcazar, J. L., additional, Mascillini, F., additional, Pascual, M. A., additional, Sibal, M., additional, Savelli, L., additional, Zannoni, G. F., additional, Timmerman, D., additional, and Epstein, E., additional

Published
2020
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30. Congenital Uterine Malformation by Experts (CUME): diagnostic criteria for T‐shaped uterus

Author

Ludwin, A., primary, Coelho Neto, M. A., additional, Ludwin, I., additional, Nastri, C. O., additional, Costa, W., additional, Acién, M., additional, Alcazar, J. L., additional, Benacerraf, B., additional, Condous, G., additional, DeCherney, A., additional, De Wilde, R.‐L., additional, Diamond, M. P., additional, Emanuel, M. H., additional, Guerriero, S., additional, Hurd, W., additional, Levine, D., additional, Lindheim, S., additional, Pellicer, A., additional, Petraglia, F., additional, Saridogan, E., additional, and Martins, W. P., additional

Published
2020
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32. Validation of ultrasound strategies to assess tumor extension and to predict high‐risk endometrial cancer in women from the prospective IETA (International Endometrial Tumor Analysis)‐4 cohort

Author

Verbakel, J. Y., primary, Mascilini, F., additional, Wynants, L., additional, Fischerova, D., additional, Testa, A. C., additional, Franchi, D., additional, Frühauf, F., additional, Cibula, D., additional, Lindqvist, P. G., additional, Fruscio, R., additional, Haak, L. A., additional, Opolskiene, G., additional, Alcazar, J. L., additional, Mais, V., additional, Carlson, J. W., additional, Sladkevicius, P., additional, Timmerman, D., additional, Valentin, L., additional, Bosch, T. Van Den, additional, and Epstein, E., additional

Published
2019
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33. Imaging in gynecological disease (15): clinical and ultrasound characteristics of uterine sarcoma

Author

Ludovisi, M., primary, Moro, F., additional, Pasciuto, T., additional, Di Noi, S., additional, Giunchi, S., additional, Savelli, L., additional, Pascual, M. A., additional, Sladkevicius, P., additional, Alcazar, J. L., additional, Franchi, D., additional, Mancari, R., additional, Moruzzi, M. C., additional, Jurkovic, D., additional, Chiappa, V., additional, Guerriero, S., additional, Exacoustos, C., additional, Epstein, E., additional, Frühauf, F., additional, Fischerova, D., additional, Fruscio, R., additional, Ciccarone, F., additional, Zannoni, G. F., additional, Scambia, G., additional, Valentin, L., additional, and Testa, A. C., additional

Published
2019
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35. Imaging of gynecological disease: clinical and ultrasound characteristics of uterine sarcomas

Author

Ludovisi, Manuela, Moro, Francesca, Pasciuto, Tina, Di Noi, Silvia, Giunchi, S, Savelli, L, Pascual, M A, Sladkevicius, P, Alcazar, J L, Franchi, D, Mancari, R, Moruzzi, M C, Jurkovic, D, Chiappa, V, Guerriero, S, Exacoustos, C, Epstein, E, Frühauf, P, Fischerova, D, Fruscio, R, Ciccarone, F, Zannoni, Gian Franco, Scambia, Giovanni, Valentin, L, and Testa, Antonia Carla

Subjects
endometrial stromal, leiomyosarcoma, pattern recognition, sarcoma, ultrasonography, Settore MED/40 - GINECOLOGIA E OSTETRICIA
Published
2019

36. Learning curve for ultrasonographic diagnosis of deep infiltrating endometriosis using structured offline training program

Author

Guerriero, S., primary, Pascual, M. A., additional, Ajossa, S., additional, Rodriguez, I., additional, Zajicek, M., additional, Rolla, M., additional, Rams Llop, N., additional, Yulzari, V., additional, Bardin, R., additional, Buonomo, F., additional, Comparetto, O., additional, Perniciano, M., additional, Saba, L., additional, Mais, V., additional, and Alcazar, J. L., additional

Published
2019
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37. Validation of ultrasound strategies to assess tumor extension and to predict high-risk endometrial cancer in women from the prospective IETA (International Endometrial Tumor Analysis)-4 cohort.

Author

Verbakel, J. Y., Mascilini, F., Wynants, L., Fischerova, D., Testa, A. C., Franchi, D., Frühauf, F., Cibula, D., Lindqvist, P. G., Fruscio, R., Haak, L. A., Opolskiene, G., Alcazar, J. L., Mais, V., Carlson, J. W., Sladkevicius, P., Timmerman, D., Valentin, L., Bosch, T. Van Den, and Epstein, E.

Subjects
ENDOMETRIAL cancer, ENDOMETRIAL tumors, TUMORS, PREDICTION models, MATHEMATICAL models, DOPPLER ultrasonography, RESEARCH, RESEARCH evaluation, ULTRASONIC imaging, CANCER invasiveness, RESEARCH methodology, EVALUATION research, BURDEN of care, TUMOR classification, COMPARATIVE studies, RESEARCH funding, SENSITIVITY & specificity (Statistics), LONGITUDINAL method
Abstract

Objectives: To compare the performance of ultrasound measurements and subjective ultrasound assessment (SA) in detecting deep myometrial invasion (MI) and cervical stromal invasion (CSI) in women with endometrial cancer, overall and according to whether they had low- or high-grade disease separately, and to validate published measurement cut-offs and prediction models to identify MI, CSI and high-risk disease (Grade-3 endometrioid or non-endometrioid cancer and/or deep MI and/or CSI).Methods: The study comprised 1538 patients with endometrial cancer from the International Endometrial Tumor Analysis (IETA)-4 prospective multicenter study, who underwent standardized expert transvaginal ultrasound examination. SA and ultrasound measurements were used to predict deep MI and CSI. We assessed the diagnostic accuracy of the tumor/uterine anteroposterior (AP) diameter ratio for detecting deep MI and that of the distance from the lower margin of the tumor to the outer cervical os (Dist-OCO) for detecting CSI. We also validated two two-step strategies for the prediction of high-risk cancer; in the first step, biopsy-confirmed Grade-3 endometrioid or mucinous or non-endometrioid cancers were classified as high-risk cancer, while the second step encompassed the application of a mathematical model to classify the remaining tumors. The 'subjective prediction model' included biopsy grade (Grade 1 vs Grade 2) and subjective assessment of deep MI or CSI (presence or absence) as variables, while the 'objective prediction model' included biopsy grade (Grade 1 vs Grade 2) and minimal tumor-free margin. The predictive performance of the two two-step strategies was compared with that of simply classifying patients as high risk if either deep MI or CSI was suspected based on SA or if biopsy showed Grade-3 endometrioid or mucinous or non-endometrioid histotype (i.e. combining SA with biopsy grade). Histological assessment from hysterectomy was considered the reference standard.Results: In 1275 patients with measurable lesions, the sensitivity and specificity of SA for detecting deep MI was 70% and 80%, respectively, in patients with a Grade-1 or -2 endometrioid or mucinous tumor vs 76% and 64% in patients with a Grade-3 endometrioid or mucinous or a non-endometrioid tumor. The corresponding values for the detection of CSI were 51% and 94% vs 50% and 91%. Tumor AP diameter and tumor/uterine AP diameter ratio showed the best performance for predicting deep MI (area under the receiver-operating characteristics curve (AUC) of 0.76 and 0.77, respectively), and Dist-OCO had the best performance for predicting CSI (AUC, 0.72). The proportion of patients classified correctly as having high-risk cancer was 80% when simply combining SA with biopsy grade vs 80% and 74% when using the subjective and objective two-step strategies, respectively. The subjective and objective models had an AUC of 0.76 and 0.75, respectively, when applied to Grade-1 and -2 endometrioid tumors.Conclusions: In the hands of experienced ultrasound examiners, SA was superior to ultrasound measurements for the prediction of deep MI and CSI of endometrial cancer, especially in patients with a Grade-1 or -2 tumor. The mathematical models for the prediction of high-risk cancer performed as expected. The best strategies for predicting high-risk endometrial cancer were combining SA with biopsy grade and the subjective two-step strategy, both having an accuracy of 80%. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd. [ABSTRACT FROM AUTHOR]

Published
2020
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38. Ultrasound characteristics of endometrial cancer as defined by International Endometrial Tumor Analysis (IETA) consensus nomenclature: prospective multicenter study

Author

Epstein, E., primary, Fischerova, D., additional, Valentin, L., additional, Testa, A. C., additional, Franchi, D., additional, Sladkevicius, P., additional, Frühauf, F., additional, Lindqvist, P. G., additional, Mascilini, F., additional, Fruscio, R., additional, Haak, L. A., additional, Opolskiene, G., additional, Pascual, M. A., additional, Alcazar, J. L., additional, Chiappa, V., additional, Guerriero, S., additional, Carlson, J. W., additional, Van Holsbeke, C., additional, Giuseppe Leone, F. P., additional, De Moor, B., additional, Bourne, T., additional, van Calster, B., additional, Installe, A., additional, Timmerman, D., additional, Verbakel, J. Y., additional, and Van den Bosch, T., additional

Published
2018
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42. Reply

Author

Guerriero, S., primary, Saba, L., additional, and Alcazar, J. L., additional

Published
2013
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43. Posters * Endometriosis, Endometrium and Implantation

Author

Jiang, Y., primary, Zhao, J., additional, Hua, M., additional, Zhen, X., additional, Yan, G., additional, Hu, Y., additional, Sun, H., additional, Selvaggi, L., additional, Zannoni, G. F., additional, Tagliaferri, V., additional, De Cicco, S., additional, Vellone, V. G., additional, Romualdi, D., additional, Lanzone, A., additional, Guido, M., additional, Fassbender, A., additional, Vodolazkaia, A. V., additional, Bossuyt, X. B., additional, Kyama, M. K., additional, Meuleman, C. M., additional, Peeraer, K. P., additional, Tomassetti, C. T., additional, D'Hooghe, T. M., additional, Lumini, A., additional, Nanni, L., additional, Manna, C., additional, Pappalardo, S., additional, Melin, A., additional, Lundholm, C., additional, Malki, N., additional, Swahn, M. L., additional, Sparen, P., additional, Bergqvist, A., additional, Crescenzi, F., additional, Farrag, A., additional, Sallam, H. N., additional, Zou, L., additional, Ding, G., additional, Zhang, R., additional, Sheng, J., additional, Huang, H., additional, von Kleinsorgen, C., additional, Wilson, T., additional, Thiel-Moder, U., additional, Ebert, A. D., additional, Reinfandt, M., additional, Papadopolous, T., additional, Melo, A. S., additional, Rodrigues, J. K., additional, Dib, L. A., additional, Andrade, A. Z., additional, Donabela, F. C., additional, Ferriani, R. A., additional, Navarro, P. A., additional, Tocci, A., additional, Royo, P., additional, Lucchini, C., additional, Ramos, P., additional, Alcazar, J. L., additional, Habara, T., additional, Terada, S., additional, Yoshioka, N., additional, Hayashi, N., additional, Haouzi, D., additional, Assou, S., additional, Monzo, C., additional, Anahory, T., additional, Dechaud, H., additional, De Vos, J., additional, Hamamah, S., additional, Gonzalez-Ramos, R., additional, Rojas, C., additional, Rocco, J., additional, Poch, A., additional, Sovino, H., additional, Kohen, P., additional, Munoz, A., additional, Devoto, L., additional, Aygen, M. A., additional, Atakul, T., additional, Oner, G., additional, Ozgun, M. T., additional, Sahin, Y., additional, Ozturk, F., additional, Li, R., additional, Qiao, J., additional, Zhylkova, I., additional, Feskov, A., additional, Feskova, I., additional, Somova, O., additional, Chumakova, N., additional, Bontekoe, S., additional, Blake, D., additional, Heineman, M. J., additional, Williams, E. C., additional, Johnson, N. P., additional, Motta, A., additional, Colaci, D., additional, Horton, M., additional, Faut, M., additional, Bisioli, C., additional, Kopcow, L., additional, de Zuniga, I., additional, Wiener-Megnazi, Z., additional, Khaytov, M., additional, Lahav - Baratz, S., additional, Shiloh, H., additional, Koifman, M., additional, Oslander, R., additional, Dirnfeld, M., additional, Sundqvist, J., additional, Andersson, K. L., additional, Scarselli, G., additional, Gemzell-Danielsson, K., additional, Lalitkumar, P. G. L., additional, Tokushige, N., additional, Markham, R., additional, Crossett, B., additional, Ahn, S., additional, Nelaturi, V., additional, Khan, A., additional, Fraser, I. S., additional, Van Vaerenbergh, I., additional, Fatemi, H. M., additional, Blockeel, C., additional, Van Lommel, L., additional, In't Veld, P., additional, Schuit, F., additional, Kolibianakis, E. M., additional, Devroey, P., additional, Bourgain, C., additional, Sugino, N., additional, Tamura, I., additional, Lee, R., additional, Maekawa, R., additional, Gelbaya, T., additional, Gordts, S., additional, D'Hooghe, T. N., additional, Gergolet, M., additional, Nardo, L. G., additional, Yu, H., additional, Wang, H., additional, Lee, C., additional, Soong, Y., additional, Kremenska, Y., additional, Masliy, Y., additional, Goncharova, Y., additional, Kremenskoy, M., additional, Veselovskyy, V., additional, Zukin, V., additional, Sudoma, I., additional, Delgado-Rosas, F., additional, Gomez, R., additional, Tamarit, S., additional, Abad, A., additional, Simon, C., additional, Pellicer, A., additional, Racicot, M., additional, Dean, N. L., additional, Antaki, R., additional, Menard, S., additional, Kadoch, I. J., additional, Garcia-Guzman, R., additional, Cabrera Romero, L., additional, Hernandez, J., additional, Palumbo, A., additional, Marshall, E., additional, Lowry, J., additional, Maybin, J. A., additional, Collins, F., additional, Critchley, H. O. D., additional, Saunders, P. T. K., additional, Chaudhury, K., additional, Jana, S. K., additional, Banerjee, P., additional, Mukherjee, S., additional, Chakravarty, B. N., additional, Allegra, A., additional, Marino, A., additional, Lama, A., additional, Santoro, A., additional, Agueli, C., additional, Mazzola, S., additional, Volpes, A., additional, Delvoux, B., additional, de Graaff, A. A., additional, Kyama, C. M., additional, Dunselman, G. A. J., additional, Romano, A., additional, Caccavo, D., additional, Pellegrino, N. M., additional, Totaro, I., additional, Panzarino, M., additional, Nardelli, C., additional, Depalo, R., additional, Flores, R., additional, Montanana, V., additional, Monzo, A., additional, Polo, P., additional, Garcia-Gimeno, T., additional, Cabo, A., additional, Rubio, J. M., additional, Beets, G. L., additional, van Lankveld, J. J., additional, Kim, H. Y., additional, Lee, B. S., additional, Cho, S. H., additional, Choi, Y. S., additional, Seo, S. K., additional, Lee, K. E., additional, Yang, H. I., additional, Abubakirov, A., additional, Vacheyshvili, T., additional, Krechetova, L., additional, Ziganshina, M., additional, Demura, T., additional, Nazarenko, T., additional, Fulop, I., additional, Rucz, A., additional, Herczegh, S. Z., additional, Ujvari, A., additional, Takacs, S. Z., additional, Szakonyi, T., additional, Lopez - Muniz, A., additional, Zamora, L., additional, Serra, O., additional, Guix, C., additional, Lopez-Teijon, M., additional, Benadiva, C., additional, Alvarez, J. G., additional, Goudakou, M., additional, Karkanaki, A., additional, Kalogeraki, A., additional, Mataliotakis, I., additional, Kalogiannidis, I., additional, Prapas, I., additional, Hosie, M., additional, Thomson, K. J., additional, Penny, C. B., additional, Penny, C., additional, Hosie, M. J., additional, McKinnon, B., additional, Klaeser, B., additional, Bersinger, N., additional, Mueller, M. D., additional, Horcajadas, J. A., additional, Martinez-Conejero, J. A., additional, Montesinos, M., additional, Morgan, M., additional, Fortuno, S., additional, Yi, K. W., additional, Shin, J. H., additional, Park, H. T., additional, Kim, T., additional, Kim, S. H., additional, Hur, J. Y., additional, Chan, R. W. S., additional, Chan, Y. Y., additional, Ng, E. H. Y., additional, Yeung, W. S. B., additional, Santulli, P., additional, Borghese, B., additional, Chopin, N., additional, Marcellin, L., additional, de Ziegler, D., additional, Chapron, C., additional, Elnashar, A., additional, Badawy, A., additional, Mosbah, A., additional, Tzioras, S., additional, Polyzos, N. P., additional, Messini, C. I., additional, Papanikolaou, E. G., additional, Valachis, A., additional, Patavoukas, E., additional, Mauri, D., additional, Messinis, I. E., additional, Acar, N., additional, Hirota, Y., additional, Tranguch, S., additional, Daikoku, T., additional, Burnum, K. E., additional, Xie, H., additional, Kodama, A., additional, Osuga, Y., additional, Ustunel, I., additional, Friedman, D. B., additional, Caprioli, R. M., additional, Dey, S. K., additional, Mitra, A., additional, Sahu, R., additional, Pal, M., additional, Bhattachrayya, A. K., additional, Bhattachrya, J., additional, Ferrero, S., additional, Remorgida, V., additional, Rollandi, G. A., additional, Biscaldi, E., additional, Cho, S., additional, Arena, E., additional, Morando, A., additional, Tomazevic, T., additional, Ban-Frangez, H., additional, Virant-Klun, I., additional, Verdenik, I., additional, Pozlep, B., additional, Vrtacnik-Bokal, E., additional, Valenzano Menada, M., additional, Morotti, M., additional, Venturini, P. L., additional, Dimitriadis, E., additional, Salamonsen, L. A., additional, Hannan, N., additional, O'Connor, O., additional, Rombauts, L., additional, Stoikos, C., additional, Mahmoudi, M., additional, Shaikh, A., additional, Mousavifar, N., additional, Rastin, M., additional, Baharara, J., additional, Tabasi, N., additional, Takemura, Y., additional, Fujimoto, A., additional, Tsutsumi, R., additional, Ooi, N., additional, Yano, T., additional, Taketani, Y., additional, Panagiotidis, I., additional, Prapas, Y., additional, Zhang, D., additional, Lv, P. P., additional, Ding, G. L., additional, Zhang, R. J., additional, Zou, L. B., additional, Xu, G. F., additional, Gao, H. J., additional, Zhu, Y. M., additional, Sheng, J. Z., additional, Huang, H. F., additional, Labarta, E., additional, Alama, P., additional, and Bosch, E., additional

Published
2010
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45. OC165: Differential diagnosis of the most common benign ovarian cysts using transvaginal ultrasonography: Results of Sardinia-Navarra (Sa.Na.) group

Author

Ajossa, S., primary, Alcazar, J. L., additional, Galvan, R., additional, Laparte, C., additional, Garcia-Manero, M., additional, Lopez-Garcia, G., additional, Angiolucci, M., additional, Gerada, M., additional, Virgilio, B., additional, Pilloni, M., additional, Melis, G. B., additional, and Guerriero, S., additional

Published
2008
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50. OC168: Transvaginal color Doppler in the detection of ovarian cancer in a large study population: Results of sardinia-navarra (Sa.Na.) group

Author

Guerriero, S., primary, Alcazar, J. L., additional, Ajossa, S., additional, Angiolucci, M., additional, Gerada, M., additional, Virgilio, B., additional, Pilloni, M., additional, Galvan, R., additional, Laparte, C., additional, Garcia-Manero, M., additional, Lopez-Garcia, G., additional, and Melis, G. B., additional

Published
2008
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