Search

Conventional therapy for hypoparathyroidism consisting of active vitamin D and calcium aims to alleviate hypocalcemia but fails to restore normal parathyroid hormone (PTH) physiology. PTH replacement therapy is the ideal physiologic treatment for hypoparathyroidism. The double-blind, placebo-controlled, 26-week, phase 3 PaTHway trial assessed the efficacy and safety of PTH replacement therapy for hypoparathyroidism individuals with the investigational drug TransCon PTH (palopegteriparatide). Participants (n = 84) were randomized 3:1 to once-daily TransCon PTH (initially 18 μg/d) or placebo, both co-administered with conventional therapy. The study drug and conventional therapy were titrated according to a dosing algorithm guided by serum calcium. The composite primary efficacy endpoint was the proportion of participants at week 26 who achieved normal albumin-adjusted serum calcium levels (8.3-10.6 mg/dL), independence from conventional therapy (requiring no active vitamin D and ≤600 mg/d of calcium), and no increase in study drug over 4 weeks before week 26. Other outcomes of interest included health-related quality of life measured by the 36-Item Short Form Survey (SF-36), hypoparathyroidism-related symptoms, functioning, and well-being measured by the Hypoparathyroidism Patient Experience Scale (HPES), and urinary calcium excretion. At week 26, 79% (48/61) of participants treated with TransCon PTH versus 5% (1/21) wiplacebo met the composite primary efficacy endpoint (p

Teacher affective support and student engagement are both fundamental to making the educative process meaningful in distance learning environments. This study assessed the levels of perceived teacher affective support and cognitive and psychological engagements among Science, Technology, Engineering, and Mathematics (STEM) students enrolled in online, modular, and blended distance learning modalities. The study also examined the relationship between the respondents’ perceived teacher affective support and cognitive and psychological engagement. Descriptive research design and correlational method were used in the study. A total of 401 STEM students from a public senior high school in the Santa Cruz district, Province of Laguna participated in the study. Two self-report instruments were used and administered in the study. Results showed that respondents’ perceived teacher affective support was to a very great extent. Cognitive engagement among the respondents was similar to a very great extent, while data showed that participants’ psychological engagement was at a great extent. Pearson’s test of correlation revealed that the respondents’ perceived teacher affective support is significantly correlated to cognitive engagement. Likewise, the study also demonstrated a significant relationship between perceived teacher affective support and psychological engagement. The data indicate that teacher affective behaviors correlate with student engagement in distance learning experiences. The findings of the study may provide a framework for educators and administrators in flexible learning modalities and alternative delivery modes. &nbsp

The purpose of this study is to investigate the influence of Profitability (Net Profit Margin) and Investment Opportunity Set (Price Earning Ratio) to the firm’s value in the oil and gas company listed at Bursa Efek Indonesia (BEI) by the period of 2014-2018. Using purposive sampling techniques, there are 7 companies that being selected that fulfill the criteria for the research sample. The result shows that: 1) Profitabilty has not significant influence to the Price Share, 2) IOS has not significant influence to the Price Share, 3) Profitability has not significant influence to the firm value, 4) IOS has not significant influence to the Firm Value, 5) Price Share has not significant influence to the Firm Value, 6) Price Share can’t mediate the influence of Profitability to the Firm Value, 7)Price Share can’t mediate the influence of IOS to the Firm Value.

Purpose The objectives of the ongoing, Phase 3, open-label extension trial enliGHten are to assess the long-term safety and efficacy of weekly administered long-acting growth hormone lonapegsomatropin in children with growth hormone deficiency. Methods Eligible subjects completing a prior Phase 3 lonapegsomatropin parent trial (heiGHt or fliGHt) were invited to participate. All subjects were treated with lonapegsomatropin. Subjects in the United States switched to the TransCon hGH Auto-Injector when available. Endpoints were long-term safety, annualized height velocity, pharmacodynamics [insulin-like growth factor-1 SD score (SDS) values], and patient- and caregiver-reported assessments of convenience and tolerability. Results Lonapegsomatropin treatment during enliGHten was associated with continued improvements in height SDS through week 104 in treatment-naïve subjects from the heiGHt trial (−2.89 to −1.37 for the lonapegsomatropin group; −3.0 to −1.52 for the daily somatropin group). Height SDS also continued to improve among switch subjects from the fliGHt trial (−1.42 at fliGHt baseline to −0.69 at week 78). After 104 weeks, the average bone age/chronological age ratio for each treatment group was 0.8 (0.1), showing only minimal advancement of bone age relative to chronological age with continued lonapegsomatropin treatment among heiGHt subjects. Fewer local tolerability reactions were reported with the TransCon hGH Auto-Injector compared with syringe/needle. Conclusions Treatment with lonapegsomatropin continued to be safe and well-tolerated, with no new safety signals identified. Children treated with once-weekly lonapegsomatropin showed continued improvement of height SDS through the second year of therapy without excess advancement of bone age.

Metallic enclosures are commonly used to protect electronic circuits against unwanted electromagnetic (EM) interactions. However, these enclosures may be sealed with imperfect mechanical seams or joints. These joints form narrow slots that allow external EM energy to couple into the cavity and then to the internal circuits. This coupled EM energy can severely affect circuit operations, particularly at the cavity resonance frequencies when the cavity has a high Q factor. To model these slots and the corresponding EM coupling, a thin-slot sub-cell model [1] , developed for slots in infinite ground plane and extended to numerical modeling of cavity-backed apertures, was successfully implemented in Sandia’s electromagnetic code EIGER [2] and its next-generation counterpart Gemma [3] . However, this thin-slot model only considers resonances along the length of the slot. At sufficiently high frequencies, the resonances due to the slot depth must also be considered. Currently, slots must be explicitly meshed to capture these depth resonances, which can lead to low-frequency instability (due to electrically small mesh elements). Therefore, a slot sub-cell model that considers resonances in both length and depth is needed to efficiently and accurately capture the slot coupling.

Background: Previously studied risk factors for sports-related concussion in soccer players include sex, age, and player position. However, prior studies were limited in number, they reported conflicting results, and most did not assess initial concussion severity. Purpose/Hypothesis: The purpose of this study was to conduct an in-depth analysis of soccer players across key demographic groups (sex, age, position) for both concussion incidence and severity. It was hypothesized that concussion incidence and severity would be higher among male players, players aged ≥17 years, and goalkeepers. Study Design: Cohort study; Level of evidence, 3. Methods: The authors analyzed baseline and postinjury ImPACT (Immediate Post-Concussion Assessment and Cognitive Testing) scores for athletes aged 12 to 22 years between July 2009 and June 2019. Players were assigned to an age group based on when they had their most recent baseline test. Concussion incidence and concussion severity index were compared using t tests and multivariate logistic regression. Results: For 1189 individuals who reported soccer as their primary sport, 1032 contributed 1754 baseline ImPACT tests (some individuals had multiple baseline tests), whereas 445 individuals were suspected of sustaining a concussion and then referred for a postinjury 1 test. Of these players, 254 (24.6%) had both a baseline and a postinjury test and were analyzed for concussion severity. Linear regression showed that forwards had a lower incidence of ImPACT-proxied concussions than goalkeepers had ( P = .008). Female players had a significantly higher incidence of ImPACT concussions compared with male players (mean, 0.07 [female] vs 0.04 [male] concussions per person-year; P = .05). Players in the ≥17-year age group had a higher incidence of ImPACT concussions than players in the 15- to 16-year age group ( P = .04), although the 15- to 16-year age group had more severe concussions than the ≥17-year age group (mean severity index, 2.91 [age 15-16 years] vs 1.73 [age ≥17 years]; P = .001). Conclusion: Female soccer players experienced a higher incidence of concussion than did male players, and goalkeepers experienced a greater incidence of ImPACT concussions than did forwards. Players of both sexes and all positions in the 15- to 16-year age group showed increased initial concussion severity compared with the ≥17-year age group, despite a lower comparative incidence of ImPACT concussions. Further study is needed to understand whether sex and player position affect concussion severity.

We document the discovery of an active, shallow, seafloor hydrothermal system (known as the Seven Sisters Vent Field) hosted in mafic volcaniclasts at a mid-ocean ridge setting. The vent field is located at the southern part of the Arctic mid-ocean ridge where it lies on top of a flat-topped volcano at ~130 m depth. Up to 200 &deg, C phase-separating fluids vent from summit depressions in the volcano, and from pinnacle-like edifices on top of large hydrothermal mounds. The hydrothermal mineralization at Seven Sisters manifests as a replacement of mafic volcaniclasts, as direct intraclast precipitation from the hydrothermal fluid, and as elemental sulfur deposition within orifices. Barite is ubiquitous, and is sequentially replaced by pyrite, which is the first sulfide to form, followed by Zn-Cu-Pb-Ag bearing sulfides, sulfosalts, and silica. The mineralized rocks at Seven Sisters contain highly anomalous concentrations of &lsquo, epithermal suite&rsquo, elements such as Tl, As, Sb and Hg, with secondary alteration assemblages including silica and dickite. Vent fluids have a pH of ~5 and are Ba and metal depleted. Relatively high dissolved Si (~7.6 mmol/L Si) combined with low (0.2&ndash, 0.4) Fe/Mn suggest high-temperature reactions at ~150 bar. A 13C value of &minus, 5.4&permil, in CO2 dominated fluids denotes magmatic degassing from a relatively undegassed reservoir. Furthermore, low CH4 and H2 (&lt, 0.026 mmol/kg and &lt, 0.009 mmol/kg, respectively) and 3He/4He of ~8.3 R/Racorr support a MORB-like, sediment-free fluid signature from an upper mantle source. Sulfide and secondary alteration mineralogy, fluid and gas chemistry, as well as 34S and 87Sr/86Sr values in barite and pyrite indicate that mineralization at Seven Sisters is sustained by the input of magmatic fluids with minimal seawater contribution. 226Ra/Ba radiometric dating of the barite suggests that this hydrothermal system has been active for at least 4670 &plusmn, 60 yr.

A 2003 high-resolution magnetic survey conducted by the Autonomous Underwater Vehicle ABE over the low-temperature, ultramafic-hosted hydrothermal field Lost City reveals a weak positive magnetic anomaly. This observation is in direct contrast to recent observations of strong positive magnetic anomalies documented over the high-temperature ultramafic-hosted hydrothermal vents fields Rainbow and Ashadze, which indicates that temperature may control the production of magnetization at these sites. The Lost City survey provides a unique opportunity to study a field that is, to date, one of a kind, and is an end member of ultramafic-hosted hydrothermal systems. Our results highlight the key contribution of temperature on magnetite production resulting from serpentinization reactions. Whereas high temperature promotes significant production and partitioning of iron into magnetite, low temperature favors iron partitioning into various alteration phases, resulting in a magnetite-poor rock. Moreover, the distribution of magnetic anomalies confirms results of a previous geological survey indicating the progressive migration of hydrothermal activity upslope. These discoveries contribute to the results of 25 yrs of magnetic exploration of a wide range of hydrothermal sites, from low- to high-temperature and from basalt- to ultramafic-hosted, and thereby validate using high-resolution magnetics as a crucial parameter for locating and characterizing hydrothermal sites hosting unique chemosynthetic-based ecosystems and potentially mineral-rich deposits.