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Your search keyword '"Aleliunas, Rika E"' showing total 13 results
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13 results on '"Aleliunas, Rika E"'

3. Maternal folic acid supplementation with vitamin B 12 deficiency during pregnancy and lactation affects the metabolic health of adult female offspring but is dependent on offspring diet

Author

Henderson, Amanda M., primary, Tai, Daven C., additional, Aleliunas, Rika E., additional, Aljaadi, Abeer M., additional, Glier, Melissa B., additional, Xu, Eric E., additional, Miller, Joshua W., additional, Verchere, C. Bruce, additional, Green, Tim J., additional, and Devlin, Angela M., additional

Published
2018
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12. Tissue-specific relationship of S-adenosylhomocysteine with allele-specific H19/Igf2methylation and imprinting in mice with hyperhomocysteinemia

Author

Glier, Melissa B., Ngai, Ying F., Sulistyoningrum, Dian C., Aleliunas, Rika E., Bottiglieri, Teodoro, and Devlin, Angela M.

Abstract

DNA methylation is linked to homocysteine metabolism through the generation of S-adenosylmethionine (AdoMet) and S-Adenosylhomocysteine (AdoHcy). The ratio of AdoMet/AdoHcy is often considered an indicator of tissue methylation capacity. The goal of this study is to determine the relationship of tissue AdoMet and AdoHcy concentrations to allele-specific methylation and expression of genomically imprinted H19/Igf2. Expression of H19/Igf2is regulated by a differentially methylated domain (DMD), with H19paternally imprinted and Igf2maternally imprinted. F1 hybrid C57BL/6J x Castaneous/EiJ(Cast) mice with (+/−), and without (+/+), heterozygous disruption of cystathionine-β-synthase (Cbs) were fed a control diet or a diet (called HH) to induce hyperhomocysteinemia and changes in tissue AdoMet and AdoHcy. F1 Castx Cbs+/− mice fed the HH diet had significantly higher plasma total homocysteine concentrations, higher liver AdoHcy, and lower AdoMet/AdoHcy ratios and this was accompanied by lower liver maternal H19DMD allele methylation, lower liver Igf2mRNA levels, and loss of Igf2maternal imprinting. In contrast, we found no significant differences in AdoMet and AdoHcy in brain between the diet groups but F1 Castx Cbs+/− mice fed the HH diet had higher maternal H19DMD methylation and lower H19mRNA levels in brain. A significant negative relationship between AdoHcy and maternal H19DMD allele methylation was found in liver but not in brain. These findings suggest the relationship of AdoMet and AdoHcy to gene-specific DNA methylation is tissue-specific and that changes in DNA methylation can occur without changes in AdoMet and AdoHcy.

Published
2013
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13. Folic Acid Supplementation of Female Mice, with or without Vitamin B-12, before and during Pregnancy and Lactation Programs Adiposity and Vascular Health in Adult Male Offspring.

Author

Aleliunas RE, Aljaadi AM, Laher I, Glier MB, Green TJ, Murphy M, Miller JW, and Devlin AM

Abstract

Background: The developmental origins of health and disease theory suggest that disturbances in the fetal and early postnatal environment contribute to chronic adulthood diseases, such as type 2 diabetes and cardiovascular disease. Greater adiposity and insulin resistance have been reported in children of women with high erythrocyte folate but poor vitamin B-12 status during pregnancy. The mechanisms underlying this relation are not known., Objective: The objective of this study was to investigate the effects of maternal supplemental folic acid, with or without vitamin B-12, on adiposity, glucose homeostasis, and vascular health in adult male offspring mice., Methods: Female C57BL/6J mice were fed a control diet (M-CON, 2 mg folic acid/kg, 50 μg vitamin B-12/kg) or a folic acid-supplemented diet with [10 mg folic acid/kg, 50 μg vitamin B-12/kg (SFA+B12)] or without [10 mg folic acid/kg, no vitamin B-12 (SFA-B12)] vitamin B-12 for 6 wk before mating and during pregnancy and lactation. The offspring were weaned onto a control diet (16% energy from fat) or a western diet (45% energy from fat) until 23 wk of age. The effects of maternal diet on adiposity, vascular function, and glucose tolerance were assessed in 6 groups of adult male offspring: control diet-fed M-CON, SFA+B12, and SFA-B12 and western diet-fed M-CON, SFA+B12, and SFA-B12., Results: Control and western diet-fed SFA-B12 and SFA+B12 offspring had smaller visceral and subcutaneous adipose tissue than M-CON offspring (P < 0.05). Control SFA-B12 and SFA+B12 offspring had lower serum total adiponectin and vitamin B-12 concentrations and lower NADPH oxidase 2 expression in aorta compared with M-CON offspring (P < 0.05). These effects were not observed in western diet-fed offspring., Conclusions: Folic acid supplementation of female mice before and during pregnancy and lactation, with or without dietary vitamin B-12, affects adult male offspring adiposity, vascular function, and one-carbon metabolism in those fed a control diet but not a western diet., (© 2016 American Society for Nutrition.)

Published
2015
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