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19 results on '"Alesina, Pier F."'

3. Development of an ontology for laparoscopic transabdominal adrenalectomy via a comprehensive modified Delphi survey and its validation on a multicentric pilot data set for surgical training and future video analysis with machine learning algorithms.

Author

Seeliger, Barbara, Di Lorenzo, Sofia, Alesina, Pier F, Brunaud, Laurent, Chiapponi, Costanza, De Crea, Carmela, Donatini, Gianluca, Iacobone, Maurizio, Makay, Özer, Mihai, Radu, Mogl, Martina T, Mutter, Didier, Padoy, Nicolas, Palazzo, Fausto, Vidal, Oscar, Pennestrí, Francesco, Marescaux, Jacques, Vix, Michel, and Raffaelli, Marco

Subjects
MACHINE learning, ADRENALECTOMY, OPERATIVE surgery, LAPAROSCOPIC surgery, ONTOLOGY
Abstract

Lay Summary: Surgical technique is essential to ensure safe minimally invasive adrenalectomy. Due to the relative rarity of adrenal surgery, it is challenging to ensure adequate exposure in surgical training. Surgical video analysis supports auto-evaluation, expert assessment and could be a target for automatization. The developed ontology was validated by a European expert consensus and is applicable across the surgical techniques encountered in all participating centres, with an exemplary demonstration in bi-centric recordings. Standardization of adrenalectomy video analysis may foster surgical training and enable machine learning training for automated safety alerts. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Automatic detection of normal and neoplastic adrenal tissue in computed tomography

Author

Seeliger, Barbara, Meyer, Adrien, Alesina, Pier F., Walz, Martin K., Padoy, Nicolas, Mutter, Didier, Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), and Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Published
2022

15. Welche Rolle spielt die ergänzende Computertomographie bei negativer präoperativer Lokalisationsdiagnostik des primären Hyperparathyreoidismus?

Author

Seeliger, Barbara, Alesina, Pier F., and Walz, Martin K.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die präoperative Lokalisation eines Nebenschilddrüsenadenoms ist essenziell für die fokussierte Parathyreoidektomie bei primärem Hyperparathyreoidismus (pHPT). Wenn die Lokalisationsdiagnostik mittels Ultraschall und Sesta-MIBI-Szintigraphie negativ ausfällt, ist[for full text, please go to the a.m. URL], 131. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2014
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16. Laparoskopische Leberresektion: Der neue Standard in der Chirurgie?

Author

Heuer, Matthias, Alesina, Pier F., Hinrichs, Jakob, Hofmeister, Sebastian, Meier, Beate, and Walz, Martin K.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Seit Einführung der minimal-invasiven Chirurgie wird deren Anwendung bei Leberresektionen kontrovers diskutiert. Dabei wurde die Bedeutung der laparoskopischen Leberchirurgie innerhalb eines großen Kollektivs bisher nur unzureichend untersucht. In dieser Studie berichten wir über[for full text, please go to the a.m. URL], 130. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2013

17. Local Recurrence in the Neck and Survival After Thyroidectomy for Metastatic Renal Cell Carcinoma

Author

Iesalnieks, Igors, primary, Machens, Andreas, additional, Bures, Claudia, additional, Krenz, Detlef, additional, Winter, Hauke, additional, Vorländer, Christian, additional, Bareck, Evelyne, additional, Alesina, Pier F., additional, Musholt, Thomas, additional, Steinmüller, Thomas, additional, Anthuber, Matthias, additional, Goretzki, Peter, additional, Trupka, Arnold, additional, Mayr, Max, additional, Weber, Theresia, additional, Schlitt, Hans J., additional, Dralle, Henning, additional, Hermann, Michael, additional, and Agha, Ayman, additional

Published
2014
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18. Comprehensive Re-Sequencing of Adrenal Aldosterone Producing Lesions Reveal Three Somatic Mutations near the KCNJ5 Potassium Channel Selectivity Filter

Author

Åkerström, Tobias, Crona, Joakim, Verdugo, Alberto Delgado, Starker, Lee F., Cupisti, Kenko, Willenberg, Holger S., Knoefel, Wolfram T., Saeger, Wolfgang, Feller, Alfred, Ip, Julian, Soon, Patsy, Anlauf, Martin, Alesina, Pier F., Schmid, Kurt W., Decaussin, Myriam, Levillain, Pierre, Wangberg, Bo, Peix, Jean-Louis, Robinson, Bruce, Zedenius, Jan, Backdahl, Martin, Caramuta, Stefano, Iwen, K. Alexander, Botling, Johan, Stålberg, Peter, Kraimps, Jean-Louis, Dralle, Henning, Hellman, Per, Sidhu, Stan, Westin, Gunnar, Lehnert, Hendrik, Walz, Martin K., Åkerström, Göran, Carling, Tobias, Choi, Murim, Lifton, Richard P., Björklund, Peyman, Åkerström, Tobias, Crona, Joakim, Verdugo, Alberto Delgado, Starker, Lee F., Cupisti, Kenko, Willenberg, Holger S., Knoefel, Wolfram T., Saeger, Wolfgang, Feller, Alfred, Ip, Julian, Soon, Patsy, Anlauf, Martin, Alesina, Pier F., Schmid, Kurt W., Decaussin, Myriam, Levillain, Pierre, Wangberg, Bo, Peix, Jean-Louis, Robinson, Bruce, Zedenius, Jan, Backdahl, Martin, Caramuta, Stefano, Iwen, K. Alexander, Botling, Johan, Stålberg, Peter, Kraimps, Jean-Louis, Dralle, Henning, Hellman, Per, Sidhu, Stan, Westin, Gunnar, Lehnert, Hendrik, Walz, Martin K., Åkerström, Göran, Carling, Tobias, Choi, Murim, Lifton, Richard P., and Björklund, Peyman

Abstract

Background: Aldosterone producing lesions are a common cause of hypertension, but genetic alterations for tumorigenesis have been unclear. Recently, either of two recurrent somatic missense mutations (G151R or L168R) was found in the potassium channel KCNJ5 gene in aldosterone producing adenomas. These mutations alter the channel selectivity filter and result in Na+ conductance and cell depolarization, stimulating aldosterone production and cell proliferation. Because a similar mutation occurs in a Mendelian form of primary aldosteronism, these mutations appear to be sufficient for cell proliferation and aldosterone production. The prevalence and spectrum of KCNJ5 mutations in different entities of adrenocortical lesions remain to be defined. Materials and Methods: The coding region and flanking intronic segments of KCNJ5 were subjected to Sanger DNA sequencing in 351 aldosterone producing lesions, from patients with primary aldosteronism and 130 other adrenocortical lesions. The specimens had been collected from 10 different worldwide referral centers. Results: G151R or L168R somatic mutations were identified in 47% of aldosterone producing adenomas, each with similar frequency. A previously unreported somatic mutation near the selectivity filter, E145Q, was observed twice. Somatic G151R or L168R mutations were also found in 40% of aldosterone producing adenomas associated with marked hyperplasia, but not in specimens with merely unilateral hyperplasia. Mutations were absent in 130 non-aldosterone secreting lesions. KCNJ5 mutations were overrepresented in aldosterone producing adenomas from female compared to male patients (63 vs. 24%). Males with KCNJ5 mutations were significantly younger than those without (45 vs. 54, respectively; p < 0.005) and their APAs with KCNJ5 mutations were larger than those without (27.1 mm vs. 17.1 mm; p < 0.005). Discussion: Either of two somatic KCNJ5 mutations are highly prevalent and specific for aldosterone producing lesions

Published
2012
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19. Comprehensive Re-Sequencing of Adrenal Aldosterone Producing Lesions Reveal Three Somatic Mutations near the KCNJ5 Potassium Channel Selectivity Filter

Author

Åkerström, Tobias, primary, Crona, Joakim, additional, Delgado Verdugo, Alberto, additional, Starker, Lee F., additional, Cupisti, Kenko, additional, Willenberg, Holger S., additional, Knoefel, Wolfram T., additional, Saeger, Wolfgang, additional, Feller, Alfred, additional, Ip, Julian, additional, Soon, Patsy, additional, Anlauf, Martin, additional, Alesina, Pier F., additional, Schmid, Kurt W., additional, Decaussin, Myriam, additional, Levillain, Pierre, additional, Wängberg, Bo, additional, Peix, Jean-Louis, additional, Robinson, Bruce, additional, Zedenius, Jan, additional, Bäckdahl, Martin, additional, Caramuta, Stefano, additional, Iwen, K. Alexander, additional, Botling, Johan, additional, Stålberg, Peter, additional, Kraimps, Jean-Louis, additional, Dralle, Henning, additional, Hellman, Per, additional, Sidhu, Stan, additional, Westin, Gunnar, additional, Lehnert, Hendrik, additional, Walz, Martin K., additional, Åkerström, Göran, additional, Carling, Tobias, additional, Choi, Murim, additional, Lifton, Richard P., additional, and Björklund, Peyman, additional

Published
2012
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