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49 results on '"Alessandri, Elisa"'

2. Nonthyroidal illness syndrome (NTIS) in severe COVID-19 patients: role of T3 on the Na/K pump gene expression and on hydroelectrolytic equilibrium

Author

Sciacchitano, Salvatore, Capalbo, Carlo, Napoli, Christian, Negro, Andrea, De Biase, Luciano, Marcolongo, Adriano, Anibaldi, Paolo, Salvati, Valentina, Petrella, Lea, Merlo, Luca, Alampi, Daniela, Alessandri, Elisa, Loffredo, Chiara, Ulivieri, Alessandra, Lavra, Luca, Magi, Fiorenza, Morgante, Alessandra, Salehi, Leila B., De Vitis, Claudia, Mancini, Rita, Coluzzi, Flaminia, and Rocco, Monica

Published
2021
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4. Opioid Use and Gut Dysbiosis in Cancer Pain Patients.

Author

Coluzzi, Flaminia, Scerpa, Maria Sole, Loffredo, Chiara, Borro, Marina, Pergolizzi, Joseph V., LeQuang, Jo Ann, Alessandri, Elisa, Simmaco, Maurizio, and Rocco, Monica

Subjects
DYSBIOSIS, CANCER patients, GUT microbiome, PAIN tolerance, CANCER pain
Abstract

Opioids are commonly used for the management of severe chronic cancer pain. Their well-known pharmacological effects on the gastrointestinal system, particularly opioid-induced constipation (OIC), are the most common limiting factors in the optimization of analgesia, and have led to the wide use of laxatives and/or peripherally acting mu-opioid receptor antagonists (PAMORAs). A growing interest has been recently recorded in the possible effects of opioid treatment on the gut microbiota. Preclinical and clinical data, as presented in this review, showed that alterations of the gut microbiota play a role in modulating opioid-mediated analgesia and tolerability, including constipation. Moreover, due to the bidirectional crosstalk between gut bacteria and the central nervous system, gut dysbiosis may be crucial in modulating opioid reward and addictive behavior. The microbiota may also modulate pain regulation and tolerance, by activating microglial cells and inducing the release of inflammatory cytokines and chemokines, which sustain neuroinflammation. In the subset of cancer patients, the clinical meaning of opioid-induced gut dysbiosis, particularly its possible interference with the efficacy of chemotherapy and immunotherapy, is still unclear. Gut dysbiosis could be a new target for treatment in cancer patients. Restoring the physiological amount of specific gut bacteria may represent a promising therapeutic option for managing gastrointestinal symptoms and optimizing analgesia for cancer patients using opioids. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Association between esophageal motor disorders and pulmonary involvement in patients affected by systemic sclerosis: a retrospective study

Author

Marten Canavesio, Ylenia, primary, Pasta, Andrea, additional, Calabrese, Francesco, additional, Alessandri, Elisa, additional, Cutolo, Maurizio, additional, Paolino, Sabrina, additional, Pizzorni, Carmen, additional, Sulli, Alberto, additional, Savarino, Vincenzo, additional, Giannini, Edoardo Giovanni, additional, Zentilin, Patrizia, additional, Bodini, Giorgia, additional, Furnari, Manuele, additional, Savarino, Edoardo, additional, and Marabotto, Elisa, additional

Published
2023
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8. Adult-onset Still’s disease: an Italian multicentre retrospective observational study of manifestations and treatments in 245 patients

Author

Sfriso, Paolo, Priori, Roberta, Valesini, Guido, Rossi, Silvia, Montecucco, Carlo Maurizio, D’Ascanio, Anna, Carli, Linda, Bombardieri, Stefano, LaSelva, Gaetana, Iannone, Florenzo, Lapadula, Giovanni, Alivernini, Stefano, Ferraccioli, Gianfranco, Colaci, Michele, Ferri, Clodoveo, Iacono, Daniela, Valentini, Gabriele, Costa, Luisa, Scarpa, Raffaele, LoMonaco, Andrea, Bagnari, Valentina, Govoni, Marcello, Piazza, Ilaria, Adami, Silvano, Ciccia, Francesco, Triolo, Giovanni, Alessandri, Elisa, Cutolo, Maurizio, Cantarini, Luca, Galeazzi, Mauro, Ruscitti, Piero, Giacomelli, Roberto, Caso, Francesco, Galozzi, Paola, and Punzi, Leonardo

Published
2016
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10. Bioelectrical Impedance Analysis (BIA) to measure alterations on hydroelectrolytic equilibrium of peripheral cells in COVID-19 patients with nonthyroidal illness syndrome (NTIS)

Author

Sciacchitano, Salvatore, primary, Capalbo, Carlo, additional, Salvati, Valentina, additional, Alampi, Daniela, additional, Alessandri, Elisa, additional, Loffredo, Chiara, additional, Vitis, Claudia De, additional, Mancini, Rita, additional, Coluzzi, Flaminia, additional, and Rocco, Monica, additional

Published
2022
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13. Vitamin D and Lung Outcomes in Elderly COVID-19 Patients

Author

Sulli, Alberto, primary, Gotelli, Emanuele, additional, Casabella, Andrea, additional, Paolino, Sabrina, additional, Pizzorni, Carmen, additional, Alessandri, Elisa, additional, Grosso, Marco, additional, Ferone, Diego, additional, Smith, Vanessa, additional, and Cutolo, Maurizio, additional

Published
2021
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15. Lower urinary tract symptoms in systemic sclerosis: a detailed investigation

Author

Pacini, Greta, primary, Paolino, Sabrina, primary, C. Trombetta, Amelia, primary, Goegan, Federica, primary, Pizzorni, Carmen, primary, Alessandri, Elisa, primary, Patanè, Massimo, primary, Gotelli, Emanuele, primary, Ferrari, Giorgia, primary, Cattelan, Francesco, primary, Ghio, Massimo, primary, Casabella, Andrea, primary, Smith, Vanessa, primary, and Cutolo, Maurizio, primary

Published
2019
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18. THU0348 IDENTIFICATION OF CIRCULATING CELLS WITH AN HYBRID M1/M2 MACROPHAGE PHENOTYPE IN SYSTEMIC SCLEROSIS PATIENTS AND CORRELATIONS WITH SELECTED CLINICAL ASPECTS

Author

Soldano, Stefano, primary, Trombetta, Amelia Chiara, additional, Contini, Paola, additional, Pacini, Greta, additional, Tomatis, Veronica, additional, Montagna, Paola, additional, Patanè, Massimo, additional, Alessandri, Elisa, additional, Goegan, Federica, additional, Smith, Vanessa, additional, and Cutolo, Maurizio, additional

Published
2019
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21. FRI0341 LOWER URINARY TRACT SYMPTOMS PREVALENCE IN SYSTEMIC SCLEROSIS PATIENTS: RESULTS FROM A COMPREHENSIVE ANALYSIS

Author

Pacini, Greta, primary, Trombetta, Amelia Chiara, additional, Goegan, Federica, additional, Paolino, Sabrina, additional, Pizzorni, Carmen, additional, Alessandri, Elisa, additional, Patanè, Massimo, additional, Gotelli, Emanuele, additional, Ferrari, Giorgia, additional, Cattelan, Francesco, additional, Ghio, Massimo, additional, Casabella, Andrea, additional, Smith, Vanessa, additional, and Cutolo, Maurizio, additional

Published
2019
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23. THU0053 APREMILAST INHIBITS THE TGFî’1 MEDIATED TRANSITION OF CULTURED HUMAN SKIN FIBROBLASTS INTO PROFIBROTIC MYOFIBROBLASTS: IN VITRO STUDY

Author

Cutolo, Maurizio, primary, Montagna, Paola, additional, Martinelli, Giulia, additional, Tardito, Samuele, additional, Corallo, Claudio, additional, Giordano, Nicola, additional, Cozzani, Emanuele, additional, Pizzorni, Carmen, additional, Paolino, Sabrina, additional, Patanè, Massimo, additional, Sulli, Alberto, additional, Alessandri, Elisa, additional, Smith, Vanessa, additional, and Soldano, Stefano, additional

Published
2019
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24. THU0347 TESTING THE IN VITRO EFFECTS OF NINTEDANIB ON CIRCULATING FIBROCYTES AND RESIDENT SKIN FIBROBLASTS FROM THE SAME SYSTEMIC SCLEROSIS PATIENTS: PRELIMINARY RESULTS

Author

Cutolo, Maurizio, primary, Contini, Paola, additional, Martinelli, Giulia, additional, Montagna, Paola, additional, Tardito, Samuele, additional, Paolino, Sabrina, additional, Patanè, Massimo, additional, Pizzorni, Carmen, additional, Alessandri, Elisa, additional, Tomatis, Veronica, additional, Smith, Vanessa, additional, and Soldano, Stefano, additional

Published
2019
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31. Lower urinary tract symptoms in systemic sclerosis: a detailed investigation.

Author

Pacini, Greta, Paolino, Sabrina, Trombetta, Amelia C., Goegan, Federica, Pizzorni, Carmen, Alessandri, Elisa, Patanè, Massimo, Gotelli, Emanuele, Ferrari, Giorgia, Cattelan, Francesco, Ghio, Massimo, Casabella, Andrea, Smith, Vanessa, and Cutolo, Maurizio

Subjects
CONFIDENCE intervals, CYCLOSPORINE, METHOTREXATE, QUALITY of life, QUESTIONNAIRES, RNA, SELF-evaluation, SYSTEMIC scleroderma, TRANSFERASES, URINARY incontinence, URINARY tract infections, COMORBIDITY, DISEASE prevalence, SARCOPENIA, OVERACTIVE bladder, DESCRIPTIVE statistics, CALCINOSIS, ODDS ratio, SYMPTOMS
Abstract

Objectives Urinary tract involvement is a seldom-reported manifestation of SSc that could compromise patients' quality of life. This study compares lower urinary tract symptoms (LUTS) in SSc patients and in healthy subjects and their association with clinical and diagnostic parameters. Methods LUTS were assessed through self-reported questionnaires in 42 SSc patients and 50 matched healthy subjects. Statistical analyses were performed to explore LUTS in the two populations and their association with SSc variables, including nailfold videocapillaroscopy patterns, SSc-related antibodies and DXA parameters. Results SSc patients showed significantly higher prevalence and severity of urinary incontinence (UI) and overactive bladder (OAB) than healthy controls (P < 0.005, P < 0.01). SSc was a strong predictor of LUTS, independent of demographic data, comorbidities and treatments (odds ratio 5.57, 95% CI 1.64–18.88). In SSc patients OAB positively correlated with sarcopenia (P < 0.001), and both OAB and UI significantly correlated with reduced BMD (P < 0.05, P = 0.001). UI positively correlated with Scl70 antibodies (P < 0.05) and ciclosporin treatment (P = 0.001) and negatively with RNA polymerase III antibodies (P < 0.05); OAB positively correlated with calcinosis (P < 0.005) and negatively with methotrexate treatment (P < 0.05). Nailfold videocapillaroscopy 'active' and 'late' patterns were predominant among SSc patients presenting urinary symptoms, although no statistical correlation was found. Conclusion For the first time urinary tract involvement was found to be significantly higher in SSc patients than in healthy matched controls. In addition, sarcopenia, bone damage and calcinosis appeared significantly correlated with LUTS, suggesting a possible interplay. [ABSTRACT FROM AUTHOR]

Published
2020
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35. Utilization of Small Changes in Serum Creatinine with Clinical Risk Factors to Assess the Risk of AKI in Critically lll Adults

Author

Cruz, Dinna N., primary, Ferrer-Nadal, Asunción, additional, Piccinni, Pasquale, additional, Goldstein, Stuart L., additional, Chawla, Lakhmir S., additional, Alessandri, Elisa, additional, Belluomo Anello, Clara, additional, Bohannon, Will, additional, Bove, Tiziana, additional, Brienza, Nicola, additional, Carlini, Mauro, additional, Forfori, Francesco, additional, Garzotto, Francesco, additional, Gramaticopolo, Silvia, additional, Iannuzzi, Michele, additional, Montini, Luca, additional, Pelaia, Paolo, additional, and Ronco, Claudio, additional

Published
2014
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36. Risk factors for acute kidney injury in critically ill patients receiving high intravenous doses of colistin methanesulfonate and/or other nephrotoxic antibiotics: a retrospective cohort study

Author

Rocco, Monica, Montini, Luca, Alessandri, Elisa, Venditti, Mario, Laderchi, Amalia, De Pascale, Gennaro, Raponi, Giammarco, Vitale, Michela, Pietropaoli, Paolo, Antonelli, Massimo, Montini, Luca (ORCID:0000-0003-4602-5134), De Pascale, Gennaro (ORCID:0000-0002-8255-0676), Antonelli, Massimo (ORCID:0000-0003-3007-1670), Rocco, Monica, Montini, Luca, Alessandri, Elisa, Venditti, Mario, Laderchi, Amalia, De Pascale, Gennaro, Raponi, Giammarco, Vitale, Michela, Pietropaoli, Paolo, Antonelli, Massimo, Montini, Luca (ORCID:0000-0003-4602-5134), De Pascale, Gennaro (ORCID:0000-0002-8255-0676), and Antonelli, Massimo (ORCID:0000-0003-3007-1670)

Abstract

INTRODUCTION: Use of colistin methanesulfonate (CMS) was abandoned in the 1970s because of excessive nephrotoxicity, but it has been reintroduced as a last-resort treatment for extensively drug-resistant infections caused by gram-negative bacteria (Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumonia). We conducted a retrospective cohort study to evaluate risk factors for new-onset acute kidney injury (AKI) in critically ill patients receiving high intravenous doses of colistin methanesulfonate and/or other nephrotoxic antibiotics. METHODS: The cohort consisted of 279 adults admitted to two general ICUs in teaching hospitals between 1 April 2009 and 30 June 2011 with 1) no evidence on admission of acute or chronic kidney disease; and 2) treatment for more than seven days with CMS and/or other nephrotoxic antimicrobials (NAs, that is, aminoglycosides, glycopeptides). Logistic regression analysis was used to identify risk factors associated with this outcome. RESULTS: The 279 cases that met the inclusion criteria included 147 patients treated with CMS, alone (n = 90) or with NAs (n = 57), and 132 treated with NAs alone. The 111 (40%) who developed AKI were significantly older and had significantly higher Simplified Acute Physiology Score II (SAPS II) scores than those who did not develop AKI, but rates of hypertension, diabetes mellitus and congestive heart failure were similar in the two groups. The final logistic regression model showed that in the 147 patients who received CMS alone or with NAs, onset of AKI during the ICU stay was associated with septic shock and with SAPS II scores ≥43. Similar results were obtained in the 222 patients treated with CMS alone or NAs alone. CONCLUSIONS: In severely ill ICU patients without pre-existing renal disease who receive CMS high-dose for more than seven days, CMS therapy does not appear to be a risk factor for this outcome. Instead, the development of AKI was strongly correlated with the presence of septic

Published
2013

38. Risk factors for acute kidney injury in critically ill patients receiving high intravenous doses of colistin methanesulfonate and/or other nephrotoxic antibiotics: a retrospective cohort study

Author

Rocco, Monica, primary, Montini, Luca, additional, Alessandri, Elisa, additional, Venditti, Mario, additional, Laderchi, Amalia, additional, De Gennaro, Pascale, additional, Raponi, Giammarco, additional, Vitale, Michela, additional, Pietropaoli, Paolo, additional, and Antonelli, Massimo, additional

Published
2013
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40. RIFLE-Based Data Collection/Management System Applied to a Prospective Cohort Multicenter Italian Study on the Epidemiology of Acute Kidney Injury in the Intensive Care Unit.

Author

Garzotto, Francesco, Piccinni, Pasquale, Cruz, Dinna, Gramaticopolo, Silvia, Dal Santo, Marzia, Aneloni, Giovanni, Jeong Chul Kim, Rocco, Monica, Alessandri, Elisa, Giunta, Francesco, Michetti, Vincenzo, Iannuzzi, Michele, Belluomo Anello, Clara, Brienza, Nicola, Carlini, Mauro, Pelaia, Paolo, Gabbanelli, Vincenzo, and Ronco, Claudio

Abstract

The epidemiology of acute kidney injury (AKI) has been difficult to explore in the past, due to different definitions across various studies. Nevertheless, this is a very important topic today in light of the high morbidity and mortality of critically ill patients presenting renal dysfunction during their stay in the intensive care unit (ICU). The case mix has changed over the years, and AKI is a common problem in critically ill patients often requiring renal replacement therapy (RRT). The RIFLE and AKIN initiatives have provided a unifying definition for AKI, making possible large retrospective studies in different countries. The present study aims at validating a unified web-based data collection and data management tool based on the most recent AKI definition/classification system. The interactive database is designed to elucidate the epidemiology of AKI in a critically ill population. As a test, we performed a prospective observational multicenter study designed to prospectively evaluate all incident admissions in ten ICUs in Italy and the relevant epidemiology of AKI. Thus, a simple user-friendly web-based data collection tool was created with the scope to serve for this study and to facilitate future multicenter collaborative efforts. We enrolled 601 consecutive incident patients into the study; 25 patients with end-stage renal disease were excluded, leaving 576 patients for analysis. The median age was 66 (IQR 53-76) years, 59.4% were male, while median Simplified Acute Physiology Score II and Acute Physiology and Chronic Health Evaluation II scores were 43 (IQR 35-54) and 18 (IQR 13-24), respectively. The most common diagnostic categories for ICU admission were: respiratory (27.4%), followed by neurologic (17%), trauma (14.4%), and cardiovascular (12.1%). Crude ICU and hospital mortality were 21.7% and median ICU length of stay was 5 (IQR 3-14) days. Of 576 patients, 246 patients (42.7%) had AKI within 24 h of ICU admission, while 133 developed new AKI later during their ICU stay. RIFLE-initial class was Risk in 205 patients (54.1%), Injury in 99 (26.1%) and Failure in 75 (19.8%). Progression of AKI to a worse RIFLE class was seen in 114 patients (30.8% of AKI patients). AKI patients were older, with higher frequency of common risk factors. 116 AKI patients (30.6%) fulfilled criteria for sepsis during their ICU stay, compared to 33 (16.7%) of non-AKI patients (p < 0.001). 48 patients (8.3%) were treated with RRT in the ICU. Patients were started on RRT a median of 2 (IQR 0-6) days after ICU admission. AKI patients were started on RRT a median of 1 (IQR 0-4) day after fulfilling criteria for AKI. Median duration of RRT was 5 (IQR 2-10) days. AKI patients had a higher crude ICU mortality (28.8 vs. 8.1%, non-AKI; p < 0.001) and longer ICU length of stay (median 7 vs. 3 days, non-AKI; p < 0.001). Crude ICU mortality and ICU length of stay increased with greater severity of AKI. 225 (59.4% of AKI patients) had complete recovery of renal function, with a serum creatinine at time of ICU discharge which was ≤120% of baseline; an additional 51 AKI patients (13.5%) had partial renal recovery, while 103 (27.2%) had not recovered renal function at the time of death or ICU discharge. The study supports the use of RIFLE as an optimal classification system to stage AKI severity. AKI is indeed a deadly complication for ICU patients, where the level of severity is correlated with mortality and length of stay. The tool developed for data collection was user-friendly and easy to implement. Some of its features, including a RIFLE class alert system, may help the treating physician to systematically collect AKI data in the ICU and possibly may guide specific decisions on the institution of RRT. Copyright © 2011 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2011
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41. Solute removal during continuous renal replacement therapy in critically ill patients: convection versus diffusion

Author

Ricci, Zaccaria, Ronco, Claudio, Bachetoni, Alessandra, D'amico, Giuseppe, Rossi, Stefano, Alessandri, Elisa, Rocco, Monica, and Pietropaoli, Paolo

Abstract

Introduction The best modality, for continuous renal replacement therapy (CRRT) is currently uncertain and it is poorly understood how transport of different solutes, whether convective or diffusive, changes over time.Methods We conducted a prospective cross over study in a cohort of critically ill patients, comparing small (urea and creatinine) and middle (β2 microglobulin) molecular weight solute clearance, filter lifespan and membrane performance over a period of 72 hours, during 15 continuous veno-venous dialysis (CVVHD) and 15 continuous veno-venous hemofiltration (CVVH)sessions. Both modalities were administered based on a prescription of 35 ml/kg/h and using polyacrylonitrile filters.Results Median filter lifespan was significantly longer during CVVHD (37 hours, interquartile range (IQR) 19.5 to 72.5) than CVVH (19 hours, IQR 12.5 to 28) (p = 0.03). Median urea time weighted average (TWA) clearances were not significantly different during CVVH (31.6 ml/minute, IQR 23.2 to 38.9) and CVVHD (35.7 ml/minute, IQR 30.1 to 41.5) (p = 0.213). Similar results were found for creatinine: 38.1 ml/minute, IQR 28.5 to 39, and 35.6 ml/minute, IQR 26 to 43 (p = 0.917), respectively. Median β2m TWA clearance was higher during convective (16.3 ml/minute, IQR 10.9 to 23) than diffusive (6.27 ml/minute, IQR 1.6 to 14.9) therapy; nonetheless this difference did not reach statistical significance (p = 0.055). Median TWA adsorptive clearance of β2m appeared to have scarce impact on overall solute removal (0.012 ml/minute, IQR -0.09 to 0.1, during hemofiltration versus -0.016 ml/minute, IQR -0.08 to 0.1 during dialysis; p = 0.79). Analysis of clearance modification over time did not show significant modifications of urea, creatinine and β2m clearance in the first 48 hours during both treatments. In the CVVHD group, the only significant difference was found for β2m between 72 hours and baseline clearance.Conclusion Polyacrylonitrile filters during continuous hemofiltration and continuous hemodialysis delivered at 35 ml/kg/h are comparable in little and middle size solute removal. CVVHD appears to warrant longer CRRT sessions. The capacity of both modalities for removing such molecules is maintained up to 48 hours.

Published
2006

42. Interactions between microbiota, diet/nutrients and immune/ inflammatory response in rheumatic diseases: focus on rheumatoid arthritis.

Author

Paolino, Sabrina, Pacini, Greta, Patanè, Massimo, Alessandri, Elisa, Cattelan, Francesco, Goegan, Federica, Pizzorni, Carmen, Gotelli, Emanuele, and Cutolo, Maurizio

Subjects
*RHEUMATISM, *RHEUMATOID arthritis, *MEDITERRANEAN diet, *DIET, *HUMAN microbiota
Abstract

Rheumatic and musculoskeletal diseases (RMDs) are chronic systemic immune/inflammatory conditions characterized by the interaction between gene predisposition, autoimmunity and environmental factors. A growing scientific interest has focused on the role of diet in RMDs, suggesting its significant contribution to the pathogenesis and prognosis of these diseases. It is now clear that diet can directly modulate the immune response by providing a wide range of nutrients, which interfere with multiple pathways at both the gastro-intestinal and systemic level. Moreover, diet critically shapes the human gut microbiota, which is recognized to have a central role in the modulation of the immune response and in RMD pathogenesis. We hereby provide an in-depth analysis on the role of the microbiota in RMDs and on nutritional intervention as an integral part of a multidisciplinary approach. Particular attention will be given to the Mediterranean diet, as the only diet proven to support substantial benefits in RMD management. [ABSTRACT FROM AUTHOR]

Published
2019
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43. Racial differences in systemic sclerosis disease presentation: A European Scleroderma Trials and Research group study

Author

Jaeger, Veronika K, Tikly, Mohammed, Dong, Xu, Siegert, Elise, Hachulla, Eric, Airò, Paolo, Valentini, Gabriele, Matucci Cerinic, Marco, Distler, Oliver, Cozzi, Franco, Carreira, Patricia, Allanore, Yannick, Müller-Ladner, Ulf, Ananieva, Lidia P, Balbir-Gurman, Alexandra, Distler, Jörg H W, Czirják, Laszlo, Mengtao, Li, Henes, Jörg, Jimenez, Sergio A, Smith, Vanessa, Damjanov, Nemanja, Denton, Christopher P, Delgaldo, Francesco, Saketkoo, Lesley Ann, Walker, Ulrich, A, Randone, Sb, Bannert, B, Iannone, F, Maurer, B, Jordan, S, Dobrota, R, Becker, M, Mihai, C, Becvarare, R, Tomčík, M, Bielecka, Ok, Gindzienska-Sieskiewicz, E, Karaszewska, K, Cutolo, M, Pizzorni, C, Paolino, S, Sulli, A, Ruaro, B, Alessandri, E, Riccardi, A, Giacco, V, Messitini, V, Irace, R, Kedor, C, Casteleyn, V, Hilger, J, Hoeppner, J, Rednic, S, Szabo, I, Petcu, A, Avouac, J, Camelia, F, Desbas, C, Vlachoyiannopoulos, P, Montecucco, C, Caporali, R, Cavagna, L, Stork, J, Inanc, M, Joven, Be, Novak, S, Anic, F, Varju, C, Minier, T, Chizzolini, C, Allai, D, Kucharz, Ej, Kotulska, A, Kopec-Medrek, M, Widuchowska, M, Dolnicar, As, Coleiro, B, Gabrielli, A, Manfredi, L, Benfaremo, D, Ferrarini, A, Bancel, Df, Hij, A, Lansiaux, P, Lazzaroni, Mg, Hesselstrand, R, Wuttge, D, Andréasson, R, Martinovic, D, Bozic, I, Radic, M, Braun-Moscovici, Y, Monaco, Al, Furini, F, Hunzelmann, N, Moinzadeh, P, Pellerito, R, Caimmi, C, Bertoldo, E, Morovic-Vergles, J, Culo, Im, Pecher, Ac, Santamaria, Vo, Heitmann, S, Codagnone, M, Pflugfelder, J, Krasowska, D, Michalska-Jakubus, M, Seidel, M, Hasler, P, Kretschmar, S, Kohm, M, Bajocchi, G, Salvador, Mj, Silva, Japd, Stamenkovic, B, Stankovic, A, Selmi, Cf, Santis, M, Ceribelli, A, Garzanova, L, Koneva, O, Starovoytova, M, Herrick, A, Puppo, F, Negrini, S, Murdaca, G, Engelhart, M, Szücs, G, Szamosi, S, de la Puente, C, Grande, Cs, Villanueva, Mjg, Midtvedt, Sø, Hoffmann-Vold, Am, Launay, D, Sobanski, V, Riccieri, V, Vasile, M, Ionescu, Rm, Opris, D, Sha, A, Woods, A, Gheorghiu, Am, Bojinca, M, Sunderkötter, C, Ehrchen, J, Ingegnoli, F, Mouthon, L, Dunogue, B, Chaigne, B, Legendre, P, Cantatore, Fp, Corrado, A, Ullman, S, Iversen, L, von Mühlen CA, Pozzi, Mr, Eyerich, K, Lauffer, F, Wiland, P, Szmyrka-Kaczmarek, M, Sokolik, R, Morgiel, E, Madej, M, Vanthuyne, M, Frédéric, H, Alegre-Sancho, Jj, Aringer, M, Herrmann, K, Günther, C, Westhovens, R, Langhe, E, Lenaerts, J, Anic, B, Baresic, M, Mayer, M, Üprus, M, Otsa, K, Yavuz, S, Granel, B, Radominski, Sc, De, C, Müller, S, Azevedo, Vf, Mendoza, F, Busquets, J, Popa, S, Agachi, S, Zenone, T, Pileckyte, M, Stebbings, S, Mathieu, A, Vacca, A, Sampaio-Barros, Pd, Stamp, L, Solanki, K, Silva, C, Schollum, J, Barns-Graham, H, Veale, D, O'Rourke, M, Loyo, E, Tineo, C, Paulino, G, Mohamed, Waaa, Rosato, E, Gigante, A, Oksel, F, Yargucu, F, Tanaseanu, Cm, Popescu, M, Dumitrascu, A, Tiglea, I, Foti, R, Visalli, E, Benenati, A, Amato, G, Ancuta, C, Villiger, P, Adler, S, Fröhlich, J, Kayser, C, Eduardo, Al, Fathi, N, Alii, S, Ahmed, M, Hasaneen, S, Hakeem, Ee, de la PG, Lefebvre, P, Martin, Jjg, Sibilia, J, Chatelus, E, Gottenberg, Je, Chifflot, H, Litinsky, I, Galdo, Fd, Abignano, G, Eng, S, Seskute, G, Butrimiene, I, Rugiene, R, Karpec, D, Pascal, M, Kerzberg, E, Bianchi, W, Bianchi, Bv, Bianchi, Dv, Barcellos, Y, Castellví, I, Millan, M, Limonta, M, Rimar, D, Rosner, I, Slobodin, G, Couto, M, Spertini, F, Ribi, C, Buss, G, Marcoccia, A, Bondanini, F, Ciani, A, Kahl, S, Hsu, Vm, Martin, T, Poindron, V, Meghit, K, Moiseev, S, Novikov, P, Chung, L, Kolstad, K, Stark, M, Schmeiser, T, Thiele, A, Majewski, D, Zdrojewski, Z, Zaneta, S, Wierzba, K, Martínez-Barrio, J, López-Longo, Fj, Bernardino, V, Moraes-Fontes, Mf, Rodrigues, Ac, Riemekasten, G, Sommerlatte, S, Jendreck, S, Arnold, S, Levy, Y, Rezus, E, Cardoneanu, A, Burlui, Am, Pamuk, On, Puttini, Ps, Talotta, R, Bongiovanni, S, Poormoghim, H, Andalib, E, Almasi, S, Kötter, I, Krusche, M, Cuomo, G, Danzo, F, Masini, F, Gaches, F, Michaud, M, Cartos, F, Belloli, L, Casu, C, Sfikakis, P, Tektonidou, M, Furst, D, Feldman, Gr, Ramazan, Am, Nurmambet, E, Miroto, A, Suta, C, Andronache, I, Huizinga, Twj, de Vries-Bouwstra, J., Chizzolini, Carlo, Jaeger, Veronika K, Tikly, Mohammed, Xu, Dong, Siegert, Elise, Hachulla, Eric, Airò, Paolo, Valentini, Gabriele, Matucci Cerinic, Marco, Distler, Oliver, Cozzi, Franco, Carreira, Patricia, Allanore, Yannick, Müller-Ladner, Ulf, Ananieva, Lidia P, Balbir-Gurman, Alexandra, Distler, Jörg H W, Czirják, Laszlo, Li, Mengtao, Henes, Jörg, Jimenez, Sergio A, Smith, Vanessa, Damjanov, Nemanja, Denton, Christopher P, Delgaldo, Francesco, Saketkoo, Lesley Ann, Walker, Ulrich A, University of Zurich, Cerinic, Marco Matucci, Walker Ulrich, A, Randone, Silvia Bellando, Bannert, Bettina, Iannone, Florenzoaa, Maurer, Brittaab, Jordan, Suzanaab, Dobrota, Rucsandraab, Becker, Mikeab, Mihai, Carinaa, Becvarare, Radima, Tomcik, Michala, Bielecka, Otylia Kowala, Gindzienska-Sieskiewicz, Ewaa, Karaszewska, Katarzynaa, Cutolo, Maurizioa, Pizzorni, Carmena, Paolino, Sabrinaae, Sulli, Albertoa, Ruaro, Barbara, Alessandri, Elisa, Riccardi, Antonella, Giacco, Veronica, Messitini, Valentina, Irace, Rosaria, Kedor, Claudia, Casteleyn, Vincent, Hilger, Julia, Hoeppner, Jakob, Rednic, Simona, Szabo, Iulia, Petcu, Ana, Avouac, Jérome, Camelia, Frantz, Desbas, Carole, Vlachoyiannopoulos, Panayioti, Montecucco, Carlo Maurizio, Caporali, Roberto, Cavagna, Lorenzo, Stork, Jiri, Inanc, Murat, Joven, Beatriz E., Novak, Srdan, Anic, Felina, Varju, Cecilia, Minier, Tunde, Allai, Daniela, Kucharz, Eugene J., Kotulska, Anna, Kopec-Medrek, Magdalena, Widuchowska, Malgorzata, Dolnicar, Alenka Sipek, Coleiro, Bernard, Gabrielli, Armando, Manfredi, Lucia, Benfaremo, Devi, Ferrarini, Alessia, Bancel, Dominique Farge, Hij, Adrian, Lazzaroni, Maria Grazia, Hesselstrand, Roger, Wuttge, Dirk, Andréasson, Kristofer, Martinovic, Duska, Bozic, Ivona, Radic, Mislav, Braun-Moscovici, Yolanda, Monaco, Andrea Lo, Furini, Federica, Hunzelmann, Nicola, Moinzadeh, Pia, Pellerito, Raffaele, Caimmi, Cristian, Bertoldo, Eugenia, Morovic-Vergles, Jadranka, Culo, Ivana Melanie, Pecher, Ann-Christian, Santamaria, Vera Ortiz, Heitmann, Stefan, Codagnone, Medeleine, Pflugfelder, Johanne, Krasowska, Dorota, Michalska-Jakubus, Malgorzata, Seidel, Matthia, Hasler, Paul, Kretschmar, Samuel, Kohm, Michaela, Bajocchi, Gianluigi, Salvador, Maria João, Da Silva, JoséAntonio Pereira, Stamenkovic, Bojana, Stankovic, Aleksandra, Selmi, Carlo Francesco, De Santis, Maria, Ceribelli, Angela, Garzanova, Ludmila, Koneva, Olga, Starovoytova, Maya, Herrick, Ariane, Puppo, Francesco, Negrini, Simone, Murdaca, Giuseppe, Engelhart, Merete, Szücs, Gabriela, Szamosi, Szilvia, De La Puente, Carlo, Grande, Cristina Sobrino, Villanueva, Maria Jesus Garcia, Midtve, Øyvindbw, Hoffmann-Vold, Anna-Mariabw, Launay, Davidbx, Sobanski, Vincentbx, Riccieri, Valeriaby, Vasile, Massimilianoby, Stefantoni, Katia, Ionescu, Ruxandra Maria, Opris, Daniela, Sha, Ami, Woods, Adrianne, Gheorghiu, Ana Maria, Bojinca, Mihai, Sunderkötter, Cord, Ehrchen, Jan, Ingegnoli, Francesca, Mouthon, Luc, Dunogue, Bertrand, Chaigne, Benjamin, Legendre, Paul, Cantatore, Francesco Paolo, Corrado, Ada, Ullman, Susanne, Iversen, Line, Von Mühlen, Carlos Alberto, Pozzi, Maria Rosa, Eyerich, Kilian, Lauffer, Felix, Wiland, Piotr, Szmyrka-Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Madej, Marta, Vanthuyne, Marie, Frédéric, Houssiau, Alegre-Sancho, Juan Jose, Aringer, Martin, Herrmann, Kristine, Günther, Claudia, Westhovens, Rene, De Langhe, Ellen, Lenaerts, Jan, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Üprus, Maria, Otsa, Kati, Yavuz, Sule, Granel, Brigitte, Radominski, Sebastião Cezar, De Souza Müller, Carolina, Feijóazevedo, Valderílio, Mendoza, Fabian, Busquets, Joanna, Popa, Sergei, Agachi, Svetlana, Zenone, Thierry, Pileckyte, Margarita, Stebbings, Simon, Jordan, Sarah, Mathieu, Alessandro, Vacca, Alessandra, Sampaio-Barros, Percival D., Stamp, Lisa, Solanki, Kamal, Silva, Cherumi, Schollum, Joanne, Barns-Graham, Helen, Veale, Dougla, O'Rourke, Marie, Loyo, Esthela, Tineo, Carmen, Paulino, Glenny, Mohamed, Walid Ahmed Abdel Atty, Rosato, Edoardo, Gigante, Antonietta, Oksel, Fahrettin, Yargucu, Figen, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Dumitrascu, Alina, Tiglea, Isabela, Foti, Rosario, Visalli, Elisa, Benenati, Alessia, Amato, Giorgio, Ancuta, Codrina, Villiger, Peter, Adler, Sabine, Fröhlich, Johanne, Kayser, Cristiane, Eduardo, Andrade Lui, Fathi, Nihal, Alii, Safa, Ahmed, Marrow, Hasaneen, Samar, El Hakeem, Eman, De La Peña Lefebvre, Paloma García, Martin, Jorge Juan Gonzalez, Sibilia, Jean, Chatelus, Emmanuel, Gottenberg, Jacques Eric, Chifflot, Hélène, Litinsky, Ira, Del Galdo, Francesco, Abignano, Giuseppina, Eng, Sookho, Seskute, Goda, Butrimiene, Irena, Rugiene, Rita, Karpec, Diana, Pascal, Melanie, Kerzberg, Eduardo, Bianchi, Washington, Bianchi, Breno Valdetaro, Bianchi, Dante Valdetaro, Barcellos, Yeda, Castellví, Ivan, Millan, Milena, Limonta, Massimiliano, Rimar, Doron, Rosner, Itzhak, Slobodin, Gleb, Couto, Maura, Spertini, Françoi, Ribi, Camillo, Buss, Guillaume, Marcoccia, Antonella, Bondanini, Francesco, Ciani, Aldo, Kahl, Sarah, Hsu, Vivien M., Martin, Thierry, Poindron, Vincent, Meghit, Kilifa, Moiseev, Sergey, Novikov, Pavel, Chung, Lori, Kolstad, Kathleen, Stark, Marianna, Schmeiser, Tim, Thiele, Astrid, Majewski, Dominik, Zdrojewski, Zbigniew, Zaneta, Smolenska, Wierzba, Karol, Martínez-Barrio, Julia, López-Longo, Francisco Javier, Bernardino, Vera, Moraes-Fontes, Maria Francisca, Rodrigues, Ana Catarina, Riemekasten, Gabriela, Sommerlatte, Sabine, Jendreck, Sebastian, Arnold, Sabrina, Levy, Yair, Rezus, Elena, Cardoneanu, Anca, Burlui, Alexandra Maria, Pamuk, Omer Nuri, Puttini, Piercarlo Sarzi, Talotta, Rossella, Bongiovanni, Sara, Poormoghim, Hadi, Andalib, Elham, Almasi, Simin, Kötter, Ina, Krusche, Matrin, Cuomo, Giovanna, Danzo, Fiammetta, Masini, Francesco, Gaches, Franci, Michaud, Martin, Cartos, Florian, Belloli, Laura, Casu, Cinzia, Sfikakis, Petro, Tektonidou, Maria, Furst, Daniel, Feldman, Gary R., Ramazan, Ana-Maria, Nurmambet, Emel, Miroto, Amalia, Suta, Cristina, Andronache, Iulia, Huizinga, Tom W. J., De Vries-Bouwstra, Jeska, and Walker, Ulrich A.

Subjects
Male, Vital capacity, Organ manifestations, systemic sclerosis, Type I, race difference, Systemic scleroderma, Gastroenterology, Scleroderma, immunology, 0302 clinical medicine, Diffusing capacity, middle aged, pulmonary hypertension, Medicine, Pharmacology (medical), 030212 general & internal medicine, organ manifestations, races, skin and connective tissue diseases, Lung, race, pathophysiology, African Continental Ancestry Group, ddc:616, integumentary system, disease course, Hazard ratio, Races, 10051 Rheumatology Clinic and Institute of Physical Medicine, Pulmonary, Middle Aged, Blacks, cohort analysis, Autoantibodie, 3. Good health, Asians, female, priority journal, DNA Topoisomerases, Type I, Black, centromere, Cohort, Hypertension, organ manifestation, Systemic sclerosis, Female, systemic sclerosi, Human, Adult, Asian Continental Ancestry Group, medicine.medical_specialty, Hypertension, Pulmonary, European Continental Ancestry Group, Black People, 610 Medicine & health, complication, Caucasian, White People, Article, lung, 03 medical and health sciences, Black person, Rheumatology, Asian People, forced vital capacity, Internal medicine, geographic distribution, Humans, controlled study, human, DNA topoisomerase, Aged, Autoantibodies, 030203 arthritis & rheumatology, Scleroderma, Systemic, Asian, business.industry, Whites, Systemic, Odds ratio, medicine.disease, Pulmonary hypertension, major clinical study, mortality, clinical feature, business, DNA Topoisomerases, autoantibody
Abstract

Objectives Racial factors play a significant role in SSc. We evaluated differences in SSc presentations between white patients (WP), Asian patients (AP) and black patients (BP) and analysed the effects of geographical locations. Methods SSc characteristics of patients from the EUSTAR cohort were cross-sectionally compared across racial groups using survival and multiple logistic regression analyses. Results The study included 9162 WP, 341 AP and 181 BP. AP developed the first non-RP feature faster than WP but slower than BP. AP were less frequently anti-centromere (ACA; odds ratio (OR) = 0.4, P < 0.001) and more frequently anti-topoisomerase-I autoantibodies (ATA) positive (OR = 1.2, P = 0.068), while BP were less likely to be ACA and ATA positive than were WP [OR(ACA) = 0.3, P < 0.001; OR(ATA) = 0.5, P = 0.020]. AP had less often (OR = 0.7, P = 0.06) and BP more often (OR = 2.7, P < 0.001) diffuse skin involvement than had WP. AP and BP were more likely to have pulmonary hypertension [OR(AP) = 2.6, P < 0.001; OR(BP) = 2.7, P = 0.03 vs WP] and a reduced forced vital capacity [OR(AP) = 2.5, P < 0.001; OR(BP) = 2.4, P < 0.004] than were WP. AP more often had an impaired diffusing capacity of the lung than had BP and WP [OR(AP vs BP) = 1.9, P = 0.038; OR(AP vs WP) = 2.4, P < 0.001]. After RP onset, AP and BP had a higher hazard to die than had WP [hazard ratio (HR) (AP) = 1.6, P = 0.011; HR(BP) = 2.1, P < 0.001]. Conclusion Compared with WP, and mostly independent of geographical location, AP have a faster and earlier disease onset with high prevalences of ATA, pulmonary hypertension and forced vital capacity impairment and higher mortality. BP had the fastest disease onset, a high prevalence of diffuse skin involvement and nominally the highest mortality.

Published
2020

44. Correlations between nailfold microangiopathy severity, finger dermal thickness and fingertip blood perfusion in systemic sclerosis patients

Author

Barbara Ruaro, Giuseppe Zampogna, M. Cutolo, Alberto Sulli, Marco A. Cimmino, Carmen Pizzorni, M Gallo, Elisa Alessandri, Sulli, Alberto, Ruaro, Barbara, Alessandri, Elisa, Pizzorni, Carmen, Cimmino, MARCO AMEDEO, Zampogna, Giuseppe, Gallo, Maurizio, and Cutolo, Maurizio

Subjects
Male, Pathology, medicine.medical_specialty, Immunology, Nailfold videocapillaroscopy, Nail, Systemic Sclerosis, Positive correlation, Severity of Illness Index, General Biochemistry, Genetics and Molecular Biology, Microscopic Angioscopy, Scleroderma, Rheumatology, Disease Activity, Ultrasonography, Aged, Dermis, Female, Humans, Laser-Doppler Flowmetry, Microcirculation, Middle Aged, Nails, Regional Blood Flow, Skin, Scleroderma, Systemic, medicine, Immunology and Allergy, Systemic Sclerosi, integumentary system, business.industry, Systemic, Ultrasound, Microangiopathy, Healthy subjects, Laser Doppler velocimetry, medicine.disease, Connective tissue disease, Dermi, Radiology, business, Perfusion, Human
Abstract

The aim of this study was to identify possible correlations between nailfold microangiopathy severity, finger dermal thickness (DT) and fingertip blood perfusion (FBP) in systemic sclerosis (SSc) patients.Fifty-seven SSc patients and 37 healthy subjects were enrolled. All patients were evaluated by nailfold videocapillaroscopy (NVC) to classify and score the severity of microangiopathy. Both modified Rodnan skin score (mRss) and skin high-frequency ultrasound were used to detect finger DT. Laser Doppler flowmetry (LDF) was employed to detect FBP.A positive correlation was found between nailfold microvascular damage severity and both ultrasound-DT (p=0.028) and mRss values (p0.0001). In particular, both ultrasound-DT and mRss were found progressively higher in patients with 'Early', 'Active' or 'Late' NVC pattern of microangiopathy. A negative correlation was observed between nailfold microvascular damage severity and FBP (p0.0001), showing the lowest FBP of the patients with more advanced NVC patterns. A negative correlation was observed between FBP, and both ultrasound-DT (p=0.007) and mRss values (p=0.0002). SSc patients showed a higher ultrasound-DT at the level of the fingers, as well as a lower FBP than healthy subjects (p0.0001).This study demonstrates a relationship between nailfold microangiopathy severity, DT and FBP in SSc patients.

Published
2013
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45. Adult-onset Still's disease: an Italian multicentre retrospective observational study of manifestations and treatments in 245 patients

Author

G. Laselva, Leonardo Punzi, Paola Galozzi, Daniela Iacono, Stefano Bombardieri, Gianfranco Ferraccioli, Clodoveo Ferri, Michele Colaci, Elisa Alessandri, Stefano Alivernini, Luisa Costa, Paolo Sfriso, Linda Carli, Anna d’Ascanio, Mauro Galeazzi, Roberta Priori, Ilaria Piazza, Carlomaurizio Montecucco, Luca Cantarini, Andrea LoMonaco, Silvia Rossi, Roberto Giacomelli, V. Bagnari, Marcello Govoni, Francesco Ciccia, Piero Ruscitti, Florenzo Iannone, Giovanni Triolo, Guido Valesini, Francesco Caso, Gabriele Valentini, Silvano Adami, Raffaele Scarpa, Giovanni Lapadula, Maurizio Cutolo, Sfriso, Paolo, Priori, Roberta, Valesini, Guido, Rossi, Silvia, Montecucco, Carlo Maurizio, D'Ascanio, Anna, Carli, Linda, Bombardieri, Stefano, Laselva, Gaetana, Iannone, Florenzo, Lapadula, Giovanni, Alivernini, Stefano, Ferraccioli, Gianfranco, Colaci, Michele, Ferri, Clodoveo, Iacono, Daniela, Valentini, Gabriele, Costa, Luisa, Scarpa, Raffaele, Lomonaco, Andrea, Bagnari, Valentina, Govoni, Marcello, Piazza, Ilaria, Adami, Silvano, Ciccia, Francesco, Triolo, Giovanni, Alessandri, Elisa, Cutolo, Maurizio, Cantarini, Luca, Galeazzi, Mauro, Ruscitti, Piero, Giacomelli, Roberto, Caso, Francesco, Galozzi, Paola, Punzi, Leonardo, D’Ascanio, Anna, Sfriso, P., Priori, R., Valesini, G., Rossi, S., Montecucco, C., D’Ascanio, A., Carli, L., Bombardieri, S., Laselva, G., Iannone, F., Lapadula, G., Alivernini, S., Ferraccioli, G., Colaci, M., Ferri, C., Iacono, D., Valentini, G., Costa, L., Scarpa, R., Lomonaco, A., Bagnari, V., Govoni, M., Piazza, I., Adami, S., Ciccia, F., Triolo, G., Alessandri, E., Cutolo, M., Cantarini, L., Galeazzi, M., Ruscitti, P., Giacomelli, R., Caso, F., Galozzi, P., and Punzi, L.

Subjects
Male, 0301 basic medicine, Pediatrics, Adult-onset Still's disease, Settore MED/16 - REUMATOLOGIA, Leukocytosis, Clinical presentation, Arthritis, Comorbidity, Disease, Laboratory finding, 0302 clinical medicine, Adrenal Cortex Hormones, Adult-onset Still’s disease, Biologic drugs, Medicine (all), General Medicine, Middle Aged, Rash, Retrospective study, Treatment Outcome, Italy, Laboratory findings, Rheumatology, Antirheumatic Agents, Female, medicine.symptom, Still's Disease, Adult-Onset, Adult, medicine.medical_specialty, Adolescent, Fever, NO, Young Adult, 03 medical and health sciences, Internal medicine, medicine, Humans, Aged, Retrospective Studies, 030203 arthritis & rheumatology, business.industry, Retrospective cohort study, medicine.disease, Neutrophilia, Surgery, 030104 developmental biology, business, Biologic drug
Abstract

Adult-onset Still’s disease (AOSD) is a systemic inflammatory condition of unknown aetiology characterized by typical episodes of spiking fever, evanescent rash, arthralgia, leukocytosis and hyperferritinemia. Given the lack of data in Italian series, we promote a multicentric data collection to characterize the clinical phenotype of Italian patients with AOSD. Data from 245 subjects diagnosed with AOSD were collected by 15 centres between March and May 2013. The diagnosis was made following Yamaguchi’s criteria. Data regarding clinical manifestations, laboratory features, disease course and treatments were reported and compared with those presented in other published series of different ethnicity. The most frequent features were the following: arthritis (93 %), pyrexia (92.6 %), leukocytosis (89 %), negative ANA (90.4 %) and neutrophilia (82 %). As compared to other North American, North European, Middle Eastern and Far Eastern cohorts, Italian data show differences in clinical and laboratory findings. Regarding the treatments, in 21.9 % of cases, corticosteroids and traditional DMARDs have not been able to control the disease while biologics have been shown to be effective in 48 to 58 patients. This retrospective work summarizes the largest Italian multicentre series of AOSD patients and presents clinical and laboratory features that appear to be influenced by the ethnicity of the affected subjects. © 2016, International League of Associations for Rheumatology (ILAR).

Published
2016

46. Laser speckle contrast analysis: a new method to evaluate peripheral blood perfusion in systemic sclerosis patients

Author

Elisa Alessandri, Maurizio Cutolo, Barbara Ruaro, Carmen Pizzorni, Alberto Sulli, G. Ferrari, Ruaro, Barbara, Sulli, Alberto, Alessandri, Elisa, Pizzorni, Carmen, Ferrari, Giorgia, and Cutolo, Maurizio

Subjects
Male, Pathology, Perfusion scanning, Pilot Projects, Autoimmune Diseases, Qualitative Research, Systemic Sclerosis, Aged, Female, Fingers, Humans, Laser-Doppler Flowmetry, Lasers, Microscopic Angioscopy, Middle Aged, Perfusion Imaging, Scleroderma, Systemic, Skin, Scleroderma, Immunology and Allergy, Contrast (vision), skin and connective tissue diseases, media_common, integumentary system, Laser Doppler velocimetry, Connective tissue disease, Systemic, Cardiology, Perfusion, Human, medicine.medical_specialty, media_common.quotation_subject, Immunology, Laser, Autoimmune Disease, General Biochemistry, Genetics and Molecular Biology, Speckle pattern, Rheumatology, Internal medicine, medicine, Finger, Pilot Project, Systemic Sclerosi, business.industry, Microangiopathy, medicine.disease, Peripheral blood, business
Abstract

The aim of this pilot study was to assess peripheral blood perfusion (PBP) by a new technique, the laser speckle contrast analysis (LASCA), in systemic sclerosis (SSc) patients showing different patterns of nailfold microangiopathy. Correlations between LASCA and single laser Doppler flowmetry (LDF) analysis were also checked.Sixty-one SSc patients and 61 healthy subjects were enrolled. PBP was evaluated using LASCA and LDF. Scleroderma patterns and microangiopathy evolution score (MES) were assessed by nailfold videocapillaroscopy (NVC).As detected by LASCA and LDF, PBP was lower in SSc patients than in healthy subjects (p0.0001), showing SSc patients with the 'Early', 'Active' or 'Late' NVC pattern a progressively lower PBP (p=0.04 and p=0.002, respectively). There was a negative correlation between PBP and MES values (p=0.006 and p=0.002 for LASCA and LDF, respectively). A positive correlation was detected between LASCA and LDF values, in all subjects (p0.0001). However, LASCA evaluates larger skin areas, is significantly less time consuming, is more accepted by patients and shows lower intra-operator variability than LDF.LASCA detected lower PBP in SSc patients than in healthy subjects, and for the first time, LASCA perfusion values were found correlated with progression of NVC patterns of microangiopathy.

Published
2014

47. Kikuchi-Fujimoto's disease associated with systemic lupus erythematous: difficult case report and literature review

Author

Elisa Alessandri, Alberto Sulli, Barbara Ruaro, G Fraternali-Orcioni, Maurizio Cutolo, Ruaro, Barbara, Sulli, Alberto, Alessandri, Elisa, Fraternali Orcioni, G, and Cutolo, Maurizio

Subjects
Male, medicine.medical_specialty, Pathology, business.industry, Unknown aetiology, Systemic lupus, Disease, Histiocytic necrotizing lymphadenitis, Dermatology, Diagnosis, Differential, Young Adult, Rheumatology, immune system diseases, Young population, Medicine, Humans, Lupus Erythematosus, Systemic, Differential diagnosis, Lymphoproliferative disease, skin and connective tissue diseases, business, Histiocytic Necrotizing Lymphadenitis
Abstract

Kikuchi–Fujimoto’s disease (KFD), or histiocytic necrotizing lymphadenitis, is a benign and self-limiting disease of unknown aetiology. KFD tends to affect a young population under 30 years of age and predominantly females. KFD is a rare pathology and its association with systemic lupus erythematosus (SLE) is not frequent. Herein, we present the case of a male Italian patient with SLE in association with KFD with 5 years of follow-up, where a differential diagnosis from infection or lymphoproliferative disease was problematic.

Published
2013

48. The dichotomy of glucocorticosteroid treatment in immune-inflammatory rheumatic diseases: an evidence-based perspective and insights from clinical practice.

Author

Hysa E, Vojinovic T, Gotelli E, Alessandri E, Pizzorni C, Paolino S, Sulli A, Smith V, and Cutolo M

Abstract

Objectives: Glucocorticosteroids (GCs) are the most used anti-inflammatory and immunosuppressive drugs due to their effectiveness in managing pain and disease modification in many immune-inflammatory rheumatic diseases (IRDs). However, their use is limited because of adverse effects (AEs)., Material and Methods: The authors analyzed recent studies, including randomized controlled trials (RCTs), observational, translational studies and systematic reviews, providing an in-depth viewpoint on the benefits and drawbacks of GC use in rheumatology., Results: Glucocorticosteroids are essential in managing life-threatening autoimmune diseases and a cornerstone in many IRDs given their swift onset of action, necessary in flares. Several RCTs and meta-analyses have demonstrated that when administered over a long time and on a low-dose basis, GC can slow the radiographic progression in early rheumatoid arthritis (RA) patients by at least 50%, satisfying the conventional definition of a disease-modifying anti-rheumatic drug (DMARD). In the context of RA treatment, the use of modified-release prednisone formulations at night may offer the option of respecting circadian rhythms of both inflammatory response and HPA activation, thereby enabling low-dose GC administration to mitigate nocturnal inflammation and prolonged morning fatigue and joint stiffness. Long-term GC use should be individualized based on patient characteristics and minimized due to their potential AEs. Their chronic use, especially at medium/high dosages, might cause irreversible organ damage due to the burden of metabolic systemic effects and increased risk of infections. Many international guidelines recommend tapering/withdrawal of GCs in sustained remission. Treat-to-target (T2T) strategies are critical in setting targets for disease activity and reducing/discontinuing GCs once control is achieved., Conclusions: Glucocorticosteroids' use in treating IRDs should be judicious, focused on minimizing use, tapering and discontinuing treatment, when possible, to improve long-term safety. Glucocorticosteroids remain part of many therapeutic regimens, particularly at low doses, and elderly RA patients, especially with associated chronic comorbidities, may benefit from long-term low-dose GC treatment. A personalized GC therapy is essential for optimal long-term outcomes., Competing Interests: The authors declare no conflict of interest., (Copyright: © 2023 Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie.)

Published
2023
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