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131 results on '"Alessandrini, Gabriele"'

1. Kirsten Rat Sarcoma Virus Mutations Effect On Tumor Doubling Time And Prognosis Of Solid Dominant Stage I Lung Adenocarcinoma

Author

Tajè, Riccardo, Ambrogi, Vincenzo, Tacconi, Federico, Gallina, Filippo Tommaso, Alessandrini, Gabriele, Forcella, Daniele, Buglioni, Simonetta, Visca, Paolo, Patirelis, Alexandro, Cecere, Fabiana Letizia, Melis, Enrico, Vidiri, Antonello, Sperduti, Isabella, Cappuzzo, Federico, Novello, Silvia, Caterino, Mauro, and Facciolo, Francesco

Published
2025
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3. A PIK3CA-mutant breast cancer metastatic patient-derived organoid approach to evaluate alpelisib treatment for multiple secondary lesions

Author

Donzelli, Sara, Cioce, Mario, Sacconi, Andrea, Zanconato, Francesca, Daralioti, Theodora, Goeman, Frauke, Orlandi, Giulia, Di Martino, Simona, Fazio, Vito Michele, Alessandrini, Gabriele, Telera, Stefano, Carosi, Mariantonia, Ciliberto, Gennaro, Botti, Claudio, Strano, Sabrina, Piccolo, Stefano, and Blandino, Giovanni

Published
2022
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4. Thymic Neoplasm

Author

Marino, Mirella, Facciolo, Francesco, Shen, Yan, Alessandrini, Gabriele, Girard, Nicolas, Giordano, Antonio, Series Editor, Franco, Renato, editor, and Zito Marino, Federica, editor

Published
2018
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5. Analysis of predictive factors of unforeseen nodal metastases in resected clinical stage I NSCLC

Author

Gallina, Filippo Tommaso, primary, Marinelli, Daniele, additional, Tajè, Riccardo, additional, Forcella, Daniele, additional, Alessandrini, Gabriele, additional, Cecere, Fabiana Letizia, additional, Fusco, Francesca, additional, Visca, Paolo, additional, Sperduti, Isabella, additional, Ambrogi, Vincenzo, additional, Cappuzzo, Federico, additional, Melis, Enrico, additional, and Facciolo, Francesco, additional

Published
2023
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6. LINC00174 is a novel prognostic factor in thymic epithelial tumors involved in cell migration and lipid metabolism

Author

Tito, Claudia, Ganci, Federica, Sacconi, Andrea, Masciarelli, Silvia, Fontemaggi, Giulia, Pulito, Claudio, Gallo, Enzo, Laquintana, Valentina, Iaiza, Alessia, De Angelis, Luciana, Benedetti, Anna, Cacciotti, Jessica, Miglietta, Selenia, Bellenghi, Maria, Carè, Alessandra, Fatica, Alessandro, Diso, Daniele, Anile, Marco, Petrozza, Vincenzo, Facciolo, Francesco, Alessandrini, Gabriele, Pescarmona, Edoardo, Venuta, Federico, Marino, Mirella, Blandino, Giovanni, and Fazi, Francesco

Published
2020
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7. Prognostic Score of Long-Term Survival After Surgery for Malignant Pleural Mesothelioma: A Multicenter Analysis

Author

Leuzzi, Giovanni, Rea, Federico, Spaggiari, Lorenzo, Marulli, Giuseppe, Sperduti, Isabella, Alessandrini, Gabriele, Casiraghi, Monica, Bovolato, Pietro, Pariscenti, Gianluca, Alloisio, Marco, Infante, Maurizio, Pagan, Vittore, Fontana, Paolo, Oliaro, Alberto, Ruffini, Enrico, Ratto, Giovanni Battista, Leoncini, Giacomo, Sacco, Rocco, Mucilli, Felice, and Facciolo, Francesco

Published
2015
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9. Thymic epithelial tumors express vascular endothelial growth factors and their receptors as potential targets of antiangiogenic therapy: A tissue micro array-based multicenter study

Author

Lattanzio, Rossano, La Sorda, Rossana, Facciolo, Francesco, Sioletic, Stefano, Lauriola, Libero, Martucci, Robert, Gallo, Enzo, Palmieri, Giovannella, Evoli, Amelia, Alessandrini, Gabriele, Ruco, Luigi, Rendina, Erino Angelo, Truini, Mauro, Chiarle, Roberto, Barreca, Antonella, Pich, Achille, Ascani, Stefano, Remotti, Daniele, Tunesi, Gianni, Granone, Pierluigi, Ratto, Giovanni Battista, Puma, Francesco, Pescarmona, Edoardo, Piantelli, Mauro, Marino, Mirella, Carlini, Sandro, Cerasoli, Virna, Corzani, Felicita, Melis, Enrico, Filippetti, Massimo, Canalini, Paola, Palestro, Giorgio, Lalle, Maurizio, Ruffini, Enrico, Ceribelli, Anna, and Rinaldi, Massimo

Published
2014
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10. Extrapleural Pneumonectomy for Malignant Mesothelioma: An Italian Multicenter Retrospective Study

Author

Spaggiari, Lorenzo, Marulli, Giuseppe, Bovolato, Pietro, Alloisio, Marco, Pagan, Vittore, Oliaro, Alberto, Ratto, Giovanni Battista, Facciolo, Francesco, Sacco, Rocco, Brambilla, Daniela, Maisonneuve, Patrick, Mucilli, Felice, Alessandrini, Gabriele, Leoncini, Giacomo, Ruffini, Enrico, Fontana, Paolo, Infante, Maurizio, Pariscenti, Gian Luca, Casiraghi, Monica, and Rea, Federico

Published
2014
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11. Prognostic Impact of Node-Spreading Pattern in Surgically Treated Small-Cell Lung Cancer: A Multicentric Analysis

Author

Leuzzi, Giovanni, Lococo, Filippo, Alessandrini, Gabriele, Sperduti, Isabella, Spaggiari, Lorenzo, Venuta, Federico, and Rendina, Erino A.

Abstract

Author(s): Giovanni Leuzzi [sup.1] , Filippo Lococo [sup.2] , Gabriele Alessandrini [sup.3] , Isabella Sperduti [sup.4] , Lorenzo Spaggiari [sup.5] , Federico Venuta [sup.6] , Erino A. Rendina [sup.7] , [...], Objective Although surgery in selected small-cell lung cancer (SCLC) patients has been proposed as a part of multimodality therapy, so far, the prognostic impact of node-spreading pattern has not been fully elucidated. To investigate this issue, a retrospective analysis was performed. Methods From 01/1996 to 12/2012, clinico-pathological, surgical, and oncological features were retrospectively reviewed in a multicentric cohort of 154 surgically treated SCLC patients. A multivariate Cox proportional hazard model was developed using stepwise regression, in order to identify independent outcome predictors. Overall (OS), cancer-specific (CSS), and Relapse-free survival (RFS) were calculated by Kaplan-Meier method. Results Overall, median OS, CSS, and RFS were 29 (95 % CI 18-39), 48 (95 % CI 19-78), and 22 (95 % CI 17-27) months, respectively. Lymphadenectomy was performed in 140 (90.9 %) patients (median number of harvested nodes: 11.5). Sixty-seven (47.9 %) pN0-cases experienced the best long-term survival (CSS: 71, RFS: 62 months; p < 0.0001). Among node-positive patients, no prognostic differences were found between pN1 and pN2 involvement (CSS: 22 vs. 15, and RFS: 14 vs. 10 months, respectively; p = 0.99). By splitting node-positive SCLC according to concurrent N1-invasion, N0N2-patients showed a worse CSS compared to those cases with combined N1N2-involvement (N0N2: 8 months vs. N1N2: 22 months; p = 0.04). On the other hand, the number of metastatic stations (p = 0.80) and the specific node-level (p = 0.85) did not affect CSS. At multivariate analysis, pN+ (HR: 3.05, 95 % CI 1.21-7.67, p = 0.02) and ratio between metastatic and resected lymph-nodes (RL, HR: 1.02, 95 % CI 1.00-1.04, p = 0.03) were independent predictors of CSS. Moreover, node-positive patients (HR: 3.60, 95 % CI 1.95-6.63, p < 0.0001) with tumor size [greater than or equal to]5 cm (HR: 1.85, 95 % CI 0.88-3.88, p = 0.10) experienced a worse RFS. Conclusions In selected surgically treated SCLC, the long-term survival may be stratified according to the node-spreading pattern.

Published
2017
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13. Deconvolution of malignant pleural effusions immune landscape unravels a novel macrophage signature associated with worse clinical outcome in lung adenocarcinoma patients

Author

Bruschini, Sara, primary, Pallocca, Matteo, additional, Sperandio, Eleonora, additional, D’Ambrosio, Lorenzo, additional, Ascenzi, Francesca, additional, De Vitis, Claudia, additional, Salvati, Valentina, additional, Esposito, Antonella, additional, Di Martino, Simona, additional, De Nicola, Francesca, additional, Paolini, Francesca, additional, Fattore, Luigi, additional, Alessandrini, Gabriele, additional, Facciolo, Francesco, additional, Foddai, Maria Laura, additional, Bassi, Massimiliano, additional, Venuta, Federico, additional, D’Ascanio, Michela, additional, Ricci, Alberto, additional, D’ Andrilli, Antonio, additional, Napoli, Christian, additional, Aurisicchio, Luigi, additional, Fanciulli, Maurizio, additional, Rendina, Erino Angelo, additional, Ciliberto, Gennaro, additional, and Mancini, Rita, additional

Published
2022
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15. A novel clinical prognostic score incorporating the number of resected lymph-nodes to predict recurrence and survival in non-small-cell lung cancer

Author

Bria, Emilio, Milella, Michele, Sperduti, Isabella, Alessandrini, Gabriele, Visca, Paolo, Corzani, Felicita, Giannarelli, Diana, Cerasoli, Virna, Cuppone, Federica, Cecere, Fabiana Letizia, Marchetti, Antonio, Sacco, Rocco, Mucilli, Felice, Malatesta, Sara, Guetti, Luigi, Vitale, Luca, Ceribelli, Anna, Rinaldi, Massimo, Terzoli, Edmondo, Cognetti, Francesco, and Facciolo, Francesco

Published
2009
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20. Thymic Epithelial Tumors as a Model of Networking: Development of a Synergistic Strategy for Clinical and Translational Research Purposes

Author

Melis, Enrico, primary, Gallo, Enzo, additional, di Martino, Simona, additional, Gallina, Filippo Tommaso, additional, Laquintana, Valentina, additional, Casini, Beatrice, additional, Visca, Paolo, additional, Ganci, Federica, additional, Alessandrini, Gabriele, additional, Caterino, Mauro, additional, Cecere, Fabiana Letizia, additional, Mandoj, Chiara, additional, Papadantonakis, Arianna, additional, De Bello, Nicoletta, additional, Lattanzio, Rossano, additional, Palmieri, Giovannella, additional, Garassino, Marina Chiara, additional, Girard, Nicolas, additional, Conti, Laura, additional, Blandino, Giovanni, additional, Fazi, Francesco, additional, Facciolo, Francesco, additional, Pescarmona, Edoardo, additional, Ciliberto, Gennaro, additional, and Marino, Mirella, additional

Published
2020
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21. Additional file 1: of Erratum to: Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer

Author

Prodosmo, Andrea, Buffone, Amelia, Mattioni, Manlio, Barnabei, Agnese, Persichetti, Agnese, Leo, Aurora De, Appetecchia, Marialuisa, Nicolussi, Arianna, Coppa, Anna, Sciacchitano, Salvatore, Giordano, Carolina, Pinnarò, Paola, Sanguineti, Giuseppe, Strigari, Lidia, Alessandrini, Gabriele, Facciolo, Francesco, Cosimelli, Maurizio, Grazi, Gian, Corrado, Giacomo, Vizza, Enrico, Giannini, Giuseppe, and Soddu, Silvia

Abstract

Characteristics of ATM variants. (DOCX 16 kb)

Published
2019
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22. Determination of SGK1 mRNA in non-small cell lung cancer samples underlines high expression in squamous cell carcinomas

Author

Abbruzzese Claudia, Mattarocci Stefano, Pizzuti Laura, Mileo Anna M, Visca Paolo, Antoniani Barbara, Alessandrini Gabriele, Facciolo Francesco, Amato Rosario, D'Antona Lucia, Rinaldi Massimo, Felsani Armando, Perrotti Nicola, and Paggi Marco G

Subjects
SGK1, NSCLC, mRNA, quantitative PCR, archival samples, retrospective analysis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Lung cancer represents the most frequent cause of death for cancer. In non-small cell lung cancer (NSCLC), which accounts for the vast majority of this disease, only early detection and treatment, when possible, may significantly affect patient's prognosis. An important role in NSCLC malignancy is attributed to the signal transduction pathways involving PI3Kinase, with consequent activation of the AKT family factors. The serum and glucocorticoid kinase (SGK) factors, which share high structural and functional homologies with the AKT factors, are a family of ubiquitously expressed serine/threonine kinases under the control of cellular stress and hormones. SGK1 is the most represented SGK member. Methods By means of immunohistochemistry and quantitative real-time PCR, we determined SGK1 protein and mRNA expression in a cohort of 66 formalin-fixed, paraffin-embedded NSCLC surgical samples. All samples belonged to patients with a well-documented clinical history. Results mRNA expression was significantly higher in squamous cell carcinomas, and correlated with several clinical prognostic indicators, being elevated in high-grade tumors and in tumors with bigger size and worse clinical stage. No correlation was found between SGK1 protein expression and these clinical parameters. Conclusions This explorative analysis of SGK1 expression in NSCLC samples highlights the potential role of this factor in NSCLC patients' prognosis. Moreover, the higher expression in the squamous cell carcinoma subtype opens new therapeutic possibilities in this NSCLC subtype by designing specific kinase inhibitors.

Published
2012
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23. CytoMatrix for a reliable and simple characterization of lung cancer stem cells from malignant pleural effusions

Author

Bruschini, Sara, primary, di Martino, Simona, additional, Pisanu, Maria Elena, additional, Fattore, Luigi, additional, De Vitis, Claudia, additional, Laquintana, Valentina, additional, Buglioni, Simonetta, additional, Tabbì, Eugenio, additional, Cerri, Andrea, additional, Visca, Paolo, additional, Alessandrini, Gabriele, additional, Facciolo, Francesco, additional, Napoli, Christian, additional, Trombetta, Marcella, additional, Santoro, Antonio, additional, Crescenzi, Anna, additional, Ciliberto, Gennaro, additional, and Mancini, Rita, additional

Published
2019
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26. BCL-XL overexpression promotes tumor progression-associated properties article

Author

Trisciuoglio, Daniela, Tupone, Maria Grazia, Desideri, Marianna, Di Martile, Marta, Gabellini, Chiara, Buglioni, Simonetta, Pallocca, Matteo, Alessandrini, Gabriele, D'Aguanno, Simona, and Del Bufalo, Donatella

Subjects
Cancer Research, Skin Neoplasms, Immunology, Nude, bcl-X Protein, alpha Subunit, Small Interfering, Cell Line, Cellular and Molecular Neuroscience, Mice, Cell Movement, Animals, Humans, Melanoma, Neovascularization, Cell Proliferation, Pathologic, Neoplastic, Tumor, Cell Biology, Brain Neoplasms, Cell Line, Tumor, Disease Progression, Female, Glioblastoma, Hypoxia-Inducible Factor 1, alpha Subunit, Mice, Nude, Nanog Homeobox Protein, Neoplastic Stem Cells, Neovascularization, Pathologic, Octamer Transcription Factor-3, RNA, Small Interfering, SOXB1 Transcription Factors, Signal Transduction, Thiazolidines, Xenograft Model Antitumor Assays, Gene Expression Regulation, Neoplastic, Gene Expression Regulation, RNA, Hypoxia-Inducible Factor 1
Published
2017

27. Abstract 933: Bcl-xL overexpression promotes tumor aggressiveness

Author

Tupone, Maria Grazia, primary, Trisciuoglio, Daniela, additional, Desideri, Marianna, additional, Martile, Marta Di, additional, Gabellini, Chiara, additional, Buglioni, Simonetta, additional, Salvo, Laura De, additional, Alessandrini, Gabriele, additional, D'Aguanno, Simona, additional, and Bufalo, Donatella Del, additional

Published
2017
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28. CytoMatrix for a reliable and simple characterization of lung cancer stem cells from malignant pleural effusions.

Author

Bruschini, Sara, di Martino, Simona, Pisanu, Maria Elena, Fattore, Luigi, De Vitis, Claudia, Laquintana, Valentina, Buglioni, Simonetta, Tabbì, Eugenio, Cerri, Andrea, Visca, Paolo, Alessandrini, Gabriele, Facciolo, Francesco, Napoli, Christian, Trombetta, Marcella, Santoro, Antonio, Crescenzi, Anna, Ciliberto, Gennaro, and Mancini, Rita

Subjects
CANCER stem cells, PLEURAL effusions, LUNG cancer, CANCER cell culture, NON-small-cell lung carcinoma, CANCER cells
Abstract

Cancer stem cells (CSCs) are a subpopulation with the properties of extensive self‐renewal, capability to generate differentiated cancer cells and resistance to therapies. We have previously shown that malignant pleural effusions (MPEs) from patients with non‐small‐cell lung cancer (NSCLC) represent a valuable source of cancer cells that can be grown as three‐dimensional (3D) spheroids enriched for stem‐like features, which depend on the activation of the Yes‐associated protein‐transcriptional coactivator with PDZ‐binding motif (YAP‐TAZ)/Wnt‐βcatenin/stearoyl‐CoA desaturase 1 (SCD1) axis. Here, we describe a novel support, called CytoMatrix, for the characterization of limited amounts of cancer cells isolated from MPEs of patients with NSCLC. Our results show that this synthetic matrix allows an easy and fast characterization of several epithelial cellular markers. The use of CytoMatrix to study CSCs subpopulation confirms that SCD1 protein expression is enhanced in 3D spheroids when compared with 2D adherent cell cultures. YAP/TAZ nuclear‐cytoplasmic distribution analysed by CytoMatrix in 3D spheroids is highly heterogeneous and faithfully reproduces what is observed in tumour biopsies. Our results confirm and extend the robustness of our workflow for the isolation and phenotypic characterization of primary cancer cells derived from the lung MPEs and underscore the role of SCD1. [ABSTRACT FROM AUTHOR]

Published
2020
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29. AB014. OS03.04. Thymic epithelial tumors phenotype relies on MIR-145-5p epigenetic regulation

Author

Bellissimo, Teresa, primary, Ganci, Federica, additional, Sacconi, Andrea, additional, Tito, Claudia, additional, Gallo, Enzo, additional, De Angelis, Luciana, additional, Masciarelli, Silvia, additional, Diso, Daniele, additional, Anile, Marco, additional, Petrozza, Vincenzo, additional, Giangaspero, Felice, additional, Pescarmona, Edoardo, additional, Facciolo, Francesco, additional, Alessandrini, Gabriele, additional, Venuta, Federico, additional, Blandino, Giovanni, additional, Marino, Mirella, additional, and Fazi, Francesco, additional

Published
2017
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30. AB044. PS02.08: Surgery for TET in the era of translational research: towards a workflow model incorporating the biobank

Author

Alessandrini, Gabriele, primary, Marino, Mirella, additional, Cigliana, Giovanni, additional, Mandoj, Chiara, additional, Di Martino, Simona, additional, Baselice, Simona, additional, Gallo, Enzo, additional, Merola, Roberta, additional, Antenucci, Anna, additional, Antoniani, Barbara, additional, De Bello, Nicoletta, additional, Palmieri, Giovannella, additional, Pescarmona, Edoardo, additional, Conti, Laura, additional, Facciolo, Francesco, additional, and Ciliberto, Gennaro, additional

Published
2017
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31. Erratum to: Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer

Author

Prodosmo, Andrea, primary, Buffone, Amelia, additional, Mattioni, Manlio, additional, Barnabei, Agnese, additional, Persichetti, Agnese, additional, De Leo, Aurora, additional, Appetecchia, Marialuisa, additional, Nicolussi, Arianna, additional, Coppa, Anna, additional, Sciacchitano, Salvatore, additional, Giordano, Carolina, additional, Pinnarò, Paola, additional, Sanguineti, Giuseppe, additional, Strigari, Lidia, additional, Alessandrini, Gabriele, additional, Facciolo, Francesco, additional, Cosimelli, Maurizio, additional, Grazi, Gian Luca, additional, Corrado, Giacomo, additional, Vizza, Enrico, additional, Giannini, Giuseppe, additional, and Soddu, Silvia, additional

Published
2016
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32. Prognostic Impact of Node-Spreading Pattern in Surgically Treated Small-Cell Lung Cancer: A Multicentric Analysis

Author

Leuzzi, Giovanni, primary, Lococo, Filippo, additional, Alessandrini, Gabriele, additional, Sperduti, Isabella, additional, Spaggiari, Lorenzo, additional, Venuta, Federico, additional, Rendina, Erino A., additional, Granone, Pierluigi M., additional, Rapicetta, Cristian, additional, Zannini, Piero, additional, Di Rienzo, Gaetano, additional, Nicolosi, Maurizio, additional, and Facciolo, Francesco, additional

Published
2016
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33. Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer

Author

Prodosmo, Andrea, primary, Buffone, Amelia, additional, Mattioni, Manlio, additional, Barnabei, Agnese, additional, Persichetti, Agnese, additional, De Leo, Aurora, additional, Appetecchia, Marialuisa, additional, Nicolussi, Arianna, additional, Coppa, Anna, additional, Sciacchitano, Salvatore, additional, Giordano, Carolina, additional, Pinnarò, Paola, additional, Sanguineti, Giuseppe, additional, Strigari, Lidia, additional, Alessandrini, Gabriele, additional, Facciolo, Francesco, additional, Cosimelli, Maurizio, additional, Grazi, Gian Luca, additional, Corrado, Giacomo, additional, Vizza, Enrico, additional, Giannini, Giuseppe, additional, and Soddu, Silvia, additional

Published
2016
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35. Prognostic Impact of Cytoskeleton Regulatory Protein Human Mena (hmena) Isoforms In Resected, Node-negative, Non-smallcell Lung Cancer: Validation of A Clinic-molecular Prognostic Model

Author

Bria, Emilio, Mottolese, Marcella, Francesca Di Modugno, Alessandrini, Gabriele, Ludovini, Vienna, Antoniani, Barbara, Iapicca, Pierluigi, Ceribelli, Anna, Sidoni, Angelo, Crino, Lucio, Cognetti, Francesco, Facciolo, Francesco, Visca, Paolo, Pilotto, Sara, Tortora, Giampaolo, Sperduti, Isabella, Milella, Michele, and Nistico, Paola

Published
2013

39. Induction Therapy versus Initial Surgery in Advanced Thymic Tumors: Perioperative and Oncological Outcome.

Author

Leuzzi, Giovanni, Alessandrini, Gabriele, Sperduti, Isabella, Forcella, Daniele, Marino, Mirella, Ceribelli, Anna, and Facciolo, Francesco

Subjects
*THYMUS tumors, *THYMOMA, *PERIOPERATIVE care, *POSTOPERATIVE care, *CANCER chemotherapy
Abstract

Background: Despite the intense debate concerningmanagement of advanced thymic tumors, no specific oncological strategies have been yet recommended. We report our 13 years' experience to investigate this issue. Methods: From 01/2001 to 12/2013, the clinical data of 28 patients treated for Masaoka stages III-IV thymic tumors were retrospectively reviewed. Eleven potentially nonresectable patients (Group A) underwent induction chemotherapy plus surgery, while immediate surgery was performed in 17 patients (Group B). The endpoint was to compare the two groups on (1) surgical resectability; (2) postoperative course; (3) disease-free survival; and (4) overall survival. Results: Both groups were comparable in terms of age, gender, clinical stage, clinical tumor size, histology, and adjuvant therapy. Length of surgery was statistically longer in Group A (p = 0.015). Combined surgery and R0 resection was similarly performed in both groups (p = 0.14 and p = 0.99, respectively). The 3-year overall survival was 71.4% for Group A and 93.3% for Group B (p = 0.84). On the other hand, 3-year disease-free survival was 40.5 and 53.7% for Group A and B, respectively (p = 0.67). At multivariate analysis, gender was the strongest predictor for recurrence (hazard ratio = 5.71 [1.22; 26.67], p = 0.03). Conclusion: Our results suggest that induction therapy allows obtaining acceptable clinical responses as well as resectability, survival, and recurrence rates. In selected patients with "clinically resectable" stage III-IV cancers, surgery (as first step of a multimodality therapy) could be a feasible treatment option. [ABSTRACT FROM AUTHOR]

Published
2017
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43. Prognostic impact of alternative splicing-derived hMENA isoforms in resected, node-negative, non-small-cell lung cancer

Author

Bria, Emilio, primary, Modugno, Francesca Di, additional, Sperduti, Isabella, additional, Iapicca, Pierluigi, additional, Visca, Paolo, additional, Alessandrini, Gabriele, additional, Antoniani, Barbara, additional, Pilotto, Sara, additional, Ludovini, Vienna, additional, Vannucci, Jacopo, additional, Bellezza, Guido, additional, Sidoni, Angelo, additional, Tortora, Giampaolo, additional, Radisky, Derek C., additional, Crinò, Lucio, additional, Cognetti, Francesco, additional, Facciolo, Francesco, additional, Mottolese, Marcella, additional, Milella, Michele, additional, and Nisticò, Paola, additional

Published
2014
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46. hMENA splicing program impacts the clinical outcome of early stage lung cancer patients. How and why?

Author

Visca, Paolo, primary, Spada, Sheila, additional, Di Modugno, Francesca, additional, Bria, Emilio, additional, Sperduti, Isabella, additional, Antoniani, Barbara, additional, Alessandrini, Gabriele, additional, Palermo, Belinda, additional, Ludovini, Vienna, additional, Crinò, Lucio, additional, Facciolo, Francesco, additional, Milella, Michele, additional, Mottolese, Marcella, additional, and Nisticò, Paola, additional

Published
2014
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47. Expert Opinions of the First Italian Consensus Conference on the Management of Malignant Pleural Mesothelioma

Author

Pinto, Carmine, primary, Ardizzoni, Andrea, additional, Betta, Pier Giacomo, additional, Facciolo, Francesco, additional, Tassi, Gianfranco, additional, Tonoli, Sandro, additional, Zompatori, Maurizio, additional, Alessandrini, Gabriele, additional, Magrini, Stefano Maria, additional, Tiseo, Marcello, additional, and Mutri, Vita, additional

Published
2011
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48. P3-211: Number of Surgically Removed Mediastinal Lymph-Nodes (SRMLNs) as prognostic factor for survival in resected early stage non-small-cell lung cancer (NSCLC): a retrospective analysis of a mono-institutional series

Author

Alessandrini, Gabriele, primary, Bria, Emilio, additional, Sperduti, Isabella, additional, Visca, Paolo, additional, Melis, Enrico, additional, Cerasoli, Virna, additional, Ceribelli, Anna, additional, Terzoli, Edmondo, additional, Cognetti, Francesco, additional, and Facciolo, Francesco, additional

Published
2007
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49. Intracellular presence of insulin and its phosphorylated receptor in non-small cell lung cancer.

Author

MATTAROCCI, STEFANO, ABBRUZZESE, CLAUDIA, MILEO, ANNA M., VISCA, PAOLO, ANTONIANI, BARBARA, ALESSANDRINI, GABRIELE, FACCIOLO, FRANCESCO, FELSANI, ARMANDO, RADULESCU, RAZVAN T., and PAGGI, MARCO G.

Subjects
INSULIN, CELL differentiation, LUNG cancer, ADENOMA, TUMORS
Abstract

Insulin has been known for a long time to influence the growth and differentiation of normal and transformed cells. In order to delineate the role of insulin specifically in non-small cell lung cancer (NSCLC), we have now searched by immunohistochemistry (IHC) for the presence of insulin in NSCLC samples. Among the 112 samples we studied, 30 were found to contain insulin, which was detected in the form of intracytoplasmic granula. Moreover, its expression significantly correlated with (a) the morphological/histopathological subtype of NSCLC, being more frequent in adenocarcinomas; (b) the grade of tumor differentiation, displaying an increase in low-grade carcinomas; (c) tumor size, occurring predominantly in smaller tumors; (d) the presence of phosphorylated, activated insulin receptor; (e) the median patient age, being present in relatively younger individuals. Furthermore and interestingly, surrounding atypical adenomatous hyperplastic areas and normal alveolar pneumocytes scored insulin-positive in some of the insulin-negative tumors. In addition, PCR exploration for insulin transcripts in some samples positive for immunoreactive insulin was negative, indicating a possibly exogenous origin for the intracellular insulin in our NSCLC cohort. Taken together, our data suggest that an intracellular insulin activity is important for the progression of low-grade human lung adenocarcinomas. J. Cell. Physiol. 221: 766–770, 2009. © 2009 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]

Published
2009
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