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22 results on '"Alessi, Iside"'

2. Short and Long-Term Toxicity in Pediatric Cancer Treatment: Central Nervous System Damage

Author

Alessi, Iside, primary, Caroleo, Anna Maria, additional, de Palma, Luca, additional, Mastronuzzi, Angela, additional, Pro, Stefano, additional, Colafati, Giovanna Stefania, additional, Boni, Alessandra, additional, Della Vecchia, Nicoletta, additional, Velardi, Margherita, additional, Evangelisti, Melania, additional, Carboni, Alessia, additional, Carai, Andrea, additional, Vinti, Luciana, additional, Valeriani, Massimiliano, additional, Reale, Antonino, additional, Parisi, Pasquale, additional, and Raucci, Umberto, additional

Published
2022
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3. Long‐term response to crizotinib in a 17‐year‐old boy with treatment‐naïve ALK‐positive non‐small‐cell lung cancer

Author

Megaro, Giacomina, primary, Miele, Evelina, additional, Spinelli, Gian Paolo, additional, Alessi, Iside, additional, Del Baldo, Giada, additional, Cozza, Raffaele, additional, Russo, Ida, additional, De Pasquale, Maria Debora, additional, Cefalo, Maria Giuseppina, additional, Tomà, Paolo, additional, Carai, Andrea, additional, Di Ruscio, Valentina, additional, De Ioris, Maria Antonietta, additional, and Mastronuzzi, Angela, additional

Published
2022
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4. Peripheral Nervous System Involvement in Non-Primary Pediatric Cancer: From Neurotoxicity to Possible Etiologies

Author

Pro, Stefano, primary, Vinti, Luciana, additional, Boni, Alessandra, additional, Mastronuzzi, Angela, additional, Scilipoti, Martina, additional, Velardi, Margherita, additional, Caroleo, Anna Maria, additional, Farina, Elisa, additional, Badolato, Fausto, additional, Alessi, Iside, additional, Di Nardo, Giovanni, additional, Carai, Andrea, additional, Valeriani, Massimiliano, additional, Reale, Antonino, additional, Parisi, Pasquale, additional, and Raucci, Umberto, additional

Published
2021
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6. Expansion of the clinical and molecular spectrum of an XPD ‐related disorder linked to biallelic mutations inERCC2gene

Author

Agolini, Emanuele, primary, Botta, Elena, additional, Lodi, Mariachiara, additional, Digilio, Maria Cristina, additional, Rinelli, Martina, additional, Bellacchio, Emanuele, additional, Alesi, Viola, additional, Nardo, Tiziana, additional, Zambruno, Giovanna, additional, Orioli, Donata, additional, Alessi, Iside, additional, Boccuto, Luigi, additional, Rossi, Sabrina, additional, Carai, Andrea, additional, Colafati, Giovanna Stefania, additional, Cacchione, Antonella, additional, Dallapiccola, Bruno, additional, Novelli, Antonio, additional, and Mastronuzzi, Angela, additional

Published
2021
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7. Molecular Characterization of Medulloblastoma in a Patient with Neurofibromatosis Type 1: Case Report and Literature Review

Author

Ranalli, Marco, primary, Boni, Alessandra, additional, Caroleo, Anna Maria, additional, Del Baldo, Giada, additional, Rinelli, Martina, additional, Agolini, Emanuele, additional, Rossi, Sabrina, additional, Miele, Evelina, additional, Colafati, Giovanna Stefania, additional, Boccuto, Luigi, additional, Alessi, Iside, additional, De Ioris, Maria Antonietta, additional, Cacchione, Antonella, additional, Capolino, Rossella, additional, Carai, Andrea, additional, Vennarini, Sabina, additional, and Mastronuzzi, Angela, additional

Published
2021
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9. Medulloblastoma Associated with Down Syndrome: From a Rare Event Leading to a Pathogenic Hypothesis

Author

Boni, Alessandra, primary, Ranalli, Marco, additional, Del Baldo, Giada, additional, Carta, Roberto, additional, Lodi, Mariachiara, additional, Agolini, Emanuele, additional, Rinelli, Martina, additional, Valentini, Diletta, additional, Rossi, Sabrina, additional, Alesi, Viola, additional, Cacchione, Antonella, additional, Miele, Evelina, additional, Alessi, Iside, additional, Caroleo, Anna Maria, additional, Colafati, Giovanna Stefania, additional, De Ioris, Maria Antonietta, additional, Boccuto, Luigi, additional, Balducci, Mario, additional, Carai, Andrea, additional, and Mastronuzzi, Angela, additional

Published
2021
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11. Upfront treatment with mTOR inhibitor everolimus in pediatric low‐grade gliomas: A single‐center experience

Author

Cacchione, Antonella, primary, Lodi, Mariachiara, additional, Carai, Andrea, additional, Miele, Evelina, additional, Tartaglia, Marco, additional, Megaro, Giacomina, additional, Del Baldo, Giada, additional, Alessi, Iside, additional, Colafati, Giovanna Stefania, additional, Carboni, Alessia, additional, Boccuto, Luigi, additional, Diomedi Camassei, Francesca, additional, Catanzaro, Giuseppina, additional, Po, Agnese, additional, Ferretti, Elisabetta, additional, Pedace, Lucia, additional, Pizzi, Simone, additional, Folgiero, Valentina, additional, Pezzullo, Marco, additional, Corsetti, Tiziana, additional, Secco, Domitilla Elena, additional, Cefalo, Maria Giuseppina, additional, Locatelli, Franco, additional, and Mastronuzzi, Angela, additional

Published
2020
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14. Role of DNA Methylation Profile in Diagnosing Astroblastoma: A Case Report and Literature Review

Author

Petruzzellis, Giuseppe, primary, Alessi, Iside, additional, Colafati, Giovanna Stefania, additional, Diomedi-Camassei, Francesca, additional, Ciolfi, Andrea, additional, Pedace, Lucia, additional, Cacchione, Antonella, additional, Carai, Andrea, additional, Tartaglia, Marco, additional, Mastronuzzi, Angela, additional, and Miele, Evelina, additional

Published
2019
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15. Vemurafenib Treatment of Pleomorphic Xanthoastrocytoma in a Child With Down Syndrome

Author

Petruzzellis, Giuseppe, primary, Valentini, Diletta, additional, del Bufalo, Francesca, additional, Ceglie, Giulia, additional, Carai, Andrea, additional, Colafati, Giovanna Stefania, additional, Agolini, Emanuele, additional, Diomedi-Camassei, Francesca, additional, Corsetti, Tiziana, additional, Alessi, Iside, additional, Mastronuzzi, Angela, additional, Locatelli, Franco, additional, and Cacchione, Antonella, additional

Published
2019
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17. Upfront treatment with mTOR inhibitor everolimus in pediatric low-grade gliomas: A single-center experience.

Author

Cacchione, Antonella, Lodi, Mariachiara, Carai, Andrea, Miele, Evelina, Tartaglia, Marco, Megaro, Giacomina, Baldo, Giada Del, Alessi, Iside, Colafati, Giovanna Stefania, Carboni, Alessia, Boccuto, Luigi, Camassei, Francesca Diomedi, Catanzaro, Giuseppina, Po, Agnese, Ferretti, Elisabetta, Pedace, Lucia, Pizzi, Simone, Folgiero, Valentina, Pezzullo, Marco, and Corsetti, Tiziana

Subjects
EVEROLIMUS, BRAIN tumors, MTOR inhibitors, MITOGEN-activated protein kinases, GLIOMAS, MAGNETIC resonance imaging, CHILDREN'S hospitals
Abstract

Pediatric low-grade gliomas (pLGGs) are the most frequent brain tumor in children. Adjuvant treatment, consisting in chemotherapy and radiotherapy, is often necessary if a complete surgical resection cannot be obtained. Traditional treatment approaches result in a significant long-term morbidity, with a detrimental impact on quality of life. Dysregulation of the mitogen-activated protein kinase (MAPK) pathway is the molecular hallmark of pLGGs and hyperactivation of the downstream mammalian target of rapamycin (mTOR) pathway is frequently observed. We report clinical and radiological results of front-line treatment with everolimus in 10 consecutive patients diagnosed with m-TOR positive pLGGs at the Bambino Gesù Children's Hospital in Rome, Italy. Median duration of treatment was 19 months (range from 13-60). Brain magnetic resonance imaging showed stable disease in 7 patients, partial response in 1 and disease progression in 2. Therapy-related adverse events were always reversible after dose reduction or temporary treatment interruption. To the best of our knowledge, this is the first report of everolimus treatment for chemo- and radiotherapy-naïve children with pLGG. Our results provide preliminary support, despite low sample size, for the use of everolimus as target therapy in pLGG showing lack of progression with a manageable toxicity profile [ABSTRACT FROM AUTHOR]

Published
2021
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18. BRAF V600E Inhibitor (Vemurafenib) for BRAF V600E Mutated Low Grade Gliomas

Author

Del Bufalo, Francesca, primary, Ceglie, Giulia, additional, Cacchione, Antonella, additional, Alessi, Iside, additional, Colafati, Giovanna Stefania, additional, Carai, Andrea, additional, Diomedi-Camassei, Francesca, additional, De Billy, Emmanuel, additional, Agolini, Emanuele, additional, Mastronuzzi, Angela, additional, and Locatelli, Franco, additional

Published
2018
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19. The prognostic role of KRAS and BRAF in patients undergoing surgical resection of colorectal cancer liver metastasis: a systematic review and meta-analysis

Author

PASSIGLIA, Francesco, GALVANO, Antonio, RIZZO, Sergio, LISTI', Angela, Barraco, Nadia, INSALACO, Lavinia, BRONTE, Enrico, ALESSI, Iside, GUARINI, Aurelia Ada, TERRUSO, Lidia, CASTELLANA, Luisa, Perez, Alessandro, Massihnia, Daniela, DI PIAZZA, Florinda, CALO', Valentina, CASTIGLIA, Marta, BAZAN, Viviana, RUSSO, Antonio, Passiglia, F, Galvano, A, Rizzo, S, Listì, A, Barraco, N, Insalaco, L, Bronte, E, Alessi, I, Guarini, A, Terruso, L, Castellana, L, Perez, A, Massihnia, D, Di Piazza, F, Calò, V, Castiglia, M, Bazan, V, and Russo, A

Subjects
Settore MED/06 - Oncologia Medica, KRAS, BRAF, prognostic, colorectal cancer, liver metastasis, meta-analysis
Abstract

Background: Clinical trials investigated the potential role of both KRAS and BRAF mutations, as prognostic biomarkers, in colorectal cancer (CRC) patients who underwent surgical treatment of liver metastasis (CLM), showing conflicting results. This meta-analysis aims to review all the studies reporting survival outcomes (recurrence free survival (RFS), and/or overall survival (OS)) of patients undergoing resection of CLM, stratified according to KRAS and/or BRAF mutation status. Materials and Methods: Data from all published studies reporting survival outcomes (RFS and/or OS) of CRC patients who received resection of CLM, stratified by KRAS and/or BRAF mutation status were collected by searching in PubMed, Cochrane Library, American Society of Clinical Oncology and European Society of Medical Oncology meeting proceedings. Pooled hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated for both the OS and/or RFS. Results: Seven eligible trials (1403 patients) were included. Pooled analysis showed that KRAS mutations predicted a significant worse both RFS (HR: 1.65; 95% CI: 1.23 – 2.21) and OS (HR: 1.86; 95% CI: 1.51 – 2.30) in patients who underwent surgical resection of CLM. BRAF mutations were also associated with a significant worse OS (HR: 3.90; 95% CI: 1.96 – 7.73) in this subgroup of patients. Conclusion: This meta-analysis suggests both KRAS and BRAF mutations as negative prognostic biomarkers associated with worse survival outcomes in patients undergoing hepatic resection of CLM. Such evidences support the introduction of new treatment decision models, taking into account the tumor molecular profile in order to individualize both systemic and loco-regional treatment strategies.

Published
2016

20. THE ROLE OF HUMAN HEAT SHOCK PROTEINS IN CARCINOGENESIS.

Author

Lena, Adriana, Federico, Manuela, Alessi, Iside, and Di Naro, Simona

Subjects
HEAT shock proteins, CARCINOGENESIS, PROTEINS, COLON cancer, TUMOR treatment
Abstract

Recently, the interest towards the role of heat shock proteins (HSPs) in carcinogenesis has been steadily increasing. Indeed, it seems that these proteins contribute to the development of some cancers, including colorectal cancer, that can now be considered "chaperonopathies" by mistake". The specific roles of the different HSPs, in particular Hsp60 and Hsp10, during carcinogenesis are still unclear. However, a number of studies suggest that they could be useful tools for the diagnosis, staging, prognosis and treatment of many tumors. [ABSTRACT FROM AUTHOR]

Published
2011
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21. COLORECTAL CANCER WITH LIVER METASTASIS AND TREATMENT WITH ANTIANGIOGENIC DRUGS.

Author

Alessi, Iside, Di Naro, Federica, Lena, Adriana, Federico, Manuela, and Gristina, Valerio

Subjects
*COLON cancer treatment, *LIVER metastasis
Abstract

The article presents an abstract of an article about the use of anti-angiogenic drugs for the treatment of colorectal cancer with liver metastasis.

Published
2012

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