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Background: Despite the growth in use of psychotropics in preschoolers, little information is available about the clinical characteristics of very young children who receive psychotropics. No information, specific to young children, is available about the prescribing practices of physicians with the most extensive training in child psychopharmacology, i.e., child psychiatrists. Objective: The aim of this study was to examine the prevalence and nature of psychotropics prescribed by child psychiatrists to very young children with severe functional impairment secondary to psychiatric pathology, and to examine the clinical context in which these psychotropics were prescribed. Methods: The medical charts of 93 children, who were admitted consecutively to a psychiatric unit and who were less than 7 years old, were retrospectively reviewed. Results: The children (mean age, 5.4 ± 1.1 years) had a high rate of exposure to abuse or trauma (64.5%). Functional impairment, as measured on the Clinical Global Assessment...

We examined the spatial distribution of polycyclic aromatic hydrocarbons (PAH) in Lake Erie, lower Great Lakes. The molecular distribution of parental PAH is combined with their compound- specific carbon isotope signatures to statistically identify three distinctive zones within the lake. Portions of the lake that are immediately adjacent to the major cities of Detroit, Cleveland and Buffalo compose the City Zone, characterized by the highest PAH concentrations and 13C-enriched isotopic compositions. The two other clusters partitioned the lake into a southern sector and a northern sector, with the latter exhibiting the lowest PAH concentrations and the most 13C-depleted isotopic compositions. It appears that PAH are fluvially introduced at the three major cities, and are further transported and redistributed by surface and bottom circulation. This contamination superimposed on a natural background, seen in the northern part of the lake, is probably responsible for the observed distribution pattern.

Electron Paramagnetic Resonance (EPR) Volume 18 highlights major developments in this area reported in 2001 and 2002, with results being set into the context of earlier work and presented as a set of critical yet coherent overviews. The topics covered describe contrasting types of application ranging from biological areas such as EPR studies of free-radical reactions in biology and medically-related systems to experimental developments and applications involving EPR imaging the use of very high fields and time-resolved methods. Critical and up-to-the-minute reviews of advances involving the design of spin-traps advances in spin-labelling paramagnetic centres on solid surfaces exchange-coupled oligomers metalloproteins and radicals in flavoenzymes are also included. As EPR continues to find new applications in virtually all areas of modern science including physics chemistry biology and materials science this series caters not only for experts in the field but also those wishing to gain a general overview of EPR applications in a given area.

Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.