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Your search keyword '"Alexander Moiroux-Sahraoui"' showing total 4 results
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4 results on '"Alexander Moiroux-Sahraoui"'

1. Myocardial effects of angiotensin II compared to norepinephrine in an animal model of septic shock

Author

Bruno Garcia, Fuhong Su, Laurence Dewachter, Raphaël Favory, Amina Khaldi, Alexander Moiroux-Sahraoui, Filippo Annoni, Francisco Vasques-Nóvoa, Estela Rocha-Oliveira, Roberto Roncon-Albuquerque, Geraldine Hubesch, Hassane Njimi, Jean-Louis Vincent, Fabio S. Taccone, Jacques Creteur, and Antoine Herpain

Subjects
Septic shock, Septic cardiomyopathy, Vasopressors, Inflammation, Renin-angiotensin system, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background Angiotensin II is one of the vasopressors available for use in septic shock. However, its effects on the septic myocardium remain unclear. The aim of the study was to compare the effects of angiotensin II and norepinephrine on cardiac function and myocardial oxygen consumption, inflammation and injury in experimental septic shock. Methods This randomized, open-label, controlled study was performed in 20 anesthetized and mechanically ventilated pigs. Septic shock was induced by fecal peritonitis in 16 animals, and four pigs served as shams. Resuscitation with fluids, antimicrobial therapy and abdominal drainage was initiated one hour after the onset of septic shock. Septic pigs were randomly allocated to receive one of the two drugs to maintain mean arterial pressure between 65 and 75 mmHg for 8 h. Results There were no differences in MAP, cardiac output, heart rate, fluid balance or tissue perfusion indices in the two treatment groups but myocardial oxygen consumption was greater in the norepinephrine-treated animals. Myocardial mRNA expression of interleukin-6, interleukin-6 receptor, interleukin-1 alpha, and interleukin-1 beta was higher in the norepinephrine than in the angiotensin II group. Conclusions In septic shock, angiotensin II administration is associated with a similar level of cardiovascular resuscitation and less myocardial oxygen consumption, and inflammation compared to norepinephrine.

Published
2022
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3. Aortic valve repair using pericardial patch standardized with external ring annuloplasty

Author

Pichoy Danial, Alexander Moiroux-Sahraoui, Mathieu Debauchez, Jean-Luc Monin, Alain Berrebi, Nathanael Shraer, and Emmanuel Lansac

Subjects
Cohort Studies, Reoperation, Pulmonary and Respiratory Medicine, Treatment Outcome, Aortic Valve, Aortic Valve Insufficiency, Humans, Surgery, General Medicine, Cardiology and Cardiovascular Medicine, Cardiac Valve Annuloplasty, Aged
Abstract

OBJECTIVES This study was undertaken to analyse outcomes of aortic valve repair using additional material and compare the results to those of cusp repair without the use of the pericardial patch. METHODS All consecutive patients aged over 16 who underwent aortic valve repair with external ring annuloplasty for isolated aortic insufficiency, aortic insufficiency and tubular aortic aneurysm or aortic root aneurysm between May 2003 and November 2019 were included in a cohort study. Data were collected and analysed from the AVIATOR registry (AorticValve repair InternATiOnal Registry). Propensity score framework analysis (inverse probability of treatment weighting) was used to compare outcomes of the groups while controlling for confounders. RESULTS During the 16-year study period, 618 patients underwent aortic valve repair. Eight-year survival rate was 92% in the patch group and 90.2% in the no patch group without significant differences [P = 0.957 inverse probability of treatment weighting (IPTW) weighted]. Early valve-related reoperation was more frequent in the patch group as compared to the no patch group (6% vs 1%, P < 0.001 IPTW weighted), the freedom from aortic valve-related reintervention and from structural valve deterioration at 8 years was not significantly different between the patch and no patch groups (93.7% vs 94%, P = 0.968 IPTW weighted; and 99.3% vs 96.7%, P = 0.964 IPTW weighted). CONCLUSIONS Although a higher rate of early reintervention was observed, aortic valve repair using the pericardial patch, in a standardized approach using external annuloplasty, with effective coaptation height of at least 9 mm, was not associated with an increase in mid-term aortic valve-related reoperation or structural valve deterioration as compared to valve repair without the pericardial patch.

Published
2022

4. Left Hemiclamshell Approach for Posterior Aortic Arch Aneurysm

Author

Pierre Demondion, Pascal Leprince, Alexander Moiroux-Sahraoui, Service de Chirurgie cardiaque et thoracique [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université - Faculté de Médecine (SU FM), and Sorbonne Université (SU)

Subjects
Aortic arch, medicine.medical_specialty, aortic arch aneurysm, [SDV]Life Sciences [q-bio], Dissection (medical), 030204 cardiovascular system & hematology, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, medicine.artery, medicine, Radiology, Nuclear Medicine and imaging, hemiclamshell, Surgical approach, business.industry, Extracorporeal circulation, Aortic arch aneurysm, medicine.disease, Surgery, ductus arteriosus, Descending aorta, Cerebral flow, cardiovascular system, How I Do It, Cardiology and Cardiovascular Medicine, business
Abstract

The anatomical situation of posterior aortic arch aneurysms is a surgical challenge. The surgical approach should not only guarantee a safe dissection of the supra-aortic trunks and the descending aorta but also allow the cannulation for extracorporeal circulation. Indeed, protecting the cerebral flow is essential. Another challenge is to preserve both the phrenic and recurrent nerves while sparing chest wall muscles. A hemiclamshell approach for posterior aortic arch aneurysm seems to be a good compromise regarding these requirements.

Published
2021

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