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1. SARS-CoV-2-related bat viruses evade human intrinsic immunity but lack efficient transmission capacity

Author

Peña-Hernández, Mario A., Alfajaro, Mia Madel, Filler, Renata B., Moriyama, Miyu, Keeler, Emma L., Ranglin, Zara E., Kong, Yong, Mao, Tianyang, Menasche, Bridget L., Mankowski, Madeleine C., Zhao, Zhe, Vogels, Chantal B. F., Hahn, Anne M., Kalinich, Chaney C., Zhang, Shuo, Huston, Nicholas, Wan, Han, Araujo-Tavares, Rafael, Lindenbach, Brett D., Homer, Robert, Pyle, Anna Marie, Martinez, David R., Grubaugh, Nathan D., Israelow, Benjamin, Iwasaki, Akiko, and Wilen, Craig B.

Published
2024
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2. The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression.

Author

Wei, Jin, Alfajaro, Mia, Cai, Wesley, Graziano, Vincent, Strine, Madison, Filler, Renata, Biering, Scott, Sarnik, Sylvia, Patel, Sonam, Menasche, Bridget, Compton, Susan, Konermann, Silvana, Hsu, Patrick, Orchard, Robert, Yan, Qin, and Wilen, Craig

Subjects
Animals, Humans, Mice, Angiotensin-Converting Enzyme 2, COVID-19, Dipeptidyl Peptidase 4, Histone Demethylases, Middle East Respiratory Syndrome Coronavirus, Receptors, Virus, SARS-CoV-2
Abstract

Identification of host determinants of coronavirus infection informs mechanisms of pathogenesis and may provide novel therapeutic targets. Here, we demonstrate that the histone demethylase KDM6A promotes infection of diverse coronaviruses, including SARS-CoV, SARS-CoV-2, MERS-CoV and mouse hepatitis virus (MHV) in a demethylase activity-independent manner. Mechanistic studies reveal that KDM6A promotes viral entry by regulating expression of multiple coronavirus receptors, including ACE2, DPP4 and Ceacam1. Importantly, the TPR domain of KDM6A is required for recruitment of the histone methyltransferase KMT2D and histone deacetylase p300. Together this KDM6A-KMT2D-p300 complex localizes to the proximal and distal enhancers of ACE2 and regulates receptor expression. Notably, small molecule inhibition of p300 catalytic activity abrogates ACE2 and DPP4 expression and confers resistance to all major SARS-CoV-2 variants and MERS-CoV in primary human airway and intestinal epithelial cells. These data highlight the role for KDM6A-KMT2D-p300 complex activities in conferring diverse coronaviruses susceptibility and reveal a potential pan-coronavirus therapeutic target to combat current and emerging coronaviruses. One Sentence Summary: The KDM6A/KMT2D/EP300 axis promotes expression of multiple viral receptors and represents a potential drug target for diverse coronaviruses.

Published
2023

3. DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner

Author

Strine, Madison S, Cai, Wesley L, Wei, Jin, Alfajaro, Mia Madel, Filler, Renata B, Biering, Scott B, Sarnik, Sylvia, Chow, Ryan D, Patil, Ajinkya, Cervantes, Kasey S, Collings, Clayton K, DeWeirdt, Peter C, Hanna, Ruth E, Schofield, Kevin, Hulme, Christopher, Konermann, Silvana, Doench, John G, Hsu, Patrick D, Kadoch, Cigall, Yan, Qin, and Wilen, Craig B

Subjects
Biodefense, Emerging Infectious Diseases, Pneumonia & Influenza, Pneumonia, Infectious Diseases, Prevention, Vaccine Related, Genetics, Lung, Aetiology, 2.1 Biological and endogenous factors, Underpinning research, 1.1 Normal biological development and functioning, Infection, Good Health and Well Being, Animals, Humans, Angiotensin-Converting Enzyme 2, COVID-19, Dipeptidyl Peptidase 4, Middle East Respiratory Syndrome Coronavirus, SARS-CoV-2, Severe acute respiratory syndrome-related coronavirus, Virus Internalization, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Identifying host genes essential for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has the potential to reveal novel drug targets and further our understanding of Coronavirus Disease 2019 (COVID-19). We previously performed a genome-wide CRISPR/Cas9 screen to identify proviral host factors for highly pathogenic human coronaviruses. Few host factors were required by diverse coronaviruses across multiple cell types, but DYRK1A was one such exception. Although its role in coronavirus infection was previously undescribed, DYRK1A encodes Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A and is known to regulate cell proliferation and neuronal development. Here, we demonstrate that DYRK1A regulates ACE2 and DPP4 transcription independent of its catalytic kinase function to support SARS-CoV, SARS-CoV-2, and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) entry. We show that DYRK1A promotes DNA accessibility at the ACE2 promoter and a putative distal enhancer, facilitating transcription and gene expression. Finally, we validate that the proviral activity of DYRK1A is conserved across species using cells of nonhuman primate and human origin. In summary, we report that DYRK1A is a novel regulator of ACE2 and DPP4 expression that may dictate susceptibility to multiple highly pathogenic human coronaviruses.

Published
2023

4. Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection

Author

Biering, Scott B, Sarnik, Sylvia A, Wang, Eleanor, Zengel, James R, Leist, Sarah R, Schäfer, Alexandra, Sathyan, Varun, Hawkins, Padraig, Okuda, Kenichi, Tau, Cyrus, Jangid, Aditya R, Duffy, Connor V, Wei, Jin, Gilmore, Rodney C, Alfajaro, Mia Madel, Strine, Madison S, Nguyenla, Xammy, Van Dis, Erik, Catamura, Carmelle, Yamashiro, Livia H, Belk, Julia A, Begeman, Adam, Stark, Jessica C, Shon, D Judy, Fox, Douglas M, Ezzatpour, Shahrzad, Huang, Emily, Olegario, Nico, Rustagi, Arjun, Volmer, Allison S, Livraghi-Butrico, Alessandra, Wehri, Eddie, Behringer, Richard R, Cheon, Dong-Joo, Schaletzky, Julia, Aguilar, Hector C, Puschnik, Andreas S, Button, Brian, Pinsky, Benjamin A, Blish, Catherine A, Baric, Ralph S, O’Neal, Wanda K, Bertozzi, Carolyn R, Wilen, Craig B, Boucher, Richard C, Carette, Jan E, Stanley, Sarah A, Harris, Eva, Konermann, Silvana, and Hsu, Patrick D

Subjects
Acute Respiratory Distress Syndrome, Clinical Research, Infectious Diseases, Pneumonia & Influenza, Rare Diseases, Biodefense, Lung, Vaccine Related, Pneumonia, Prevention, Emerging Infectious Diseases, Genetics, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, Aetiology, Respiratory, Infection, Good Health and Well Being, Animals, COVID-19, Clustered Regularly Interspaced Short Palindromic Repeats, Epigenesis, Genetic, Humans, Mice, Mucins, SARS-CoV-2, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of symptoms in infected individuals, from mild respiratory illness to acute respiratory distress syndrome. A systematic understanding of host factors influencing viral infection is critical to elucidate SARS-CoV-2-host interactions and the progression of Coronavirus disease 2019 (COVID-19). Here, we conducted genome-wide CRISPR knockout and activation screens in human lung epithelial cells with endogenous expression of the SARS-CoV-2 entry factors ACE2 and TMPRSS2. We uncovered proviral and antiviral factors across highly interconnected host pathways, including clathrin transport, inflammatory signaling, cell-cycle regulation, and transcriptional and epigenetic regulation. We further identified mucins, a family of high molecular weight glycoproteins, as a prominent viral restriction network that inhibits SARS-CoV-2 infection in vitro and in murine models. These mucins also inhibit infection of diverse respiratory viruses. This functional landscape of SARS-CoV-2 host factors provides a physiologically relevant starting point for new host-directed therapeutics and highlights airway mucins as a host defense mechanism.

Published
2022

5. Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection

Author

Wei, Jin, Patil, Ajinkya, Collings, Clayton K., Alfajaro, Mia Madel, Liang, Yu, Cai, Wesley L., Strine, Madison S., Filler, Renata B., DeWeirdt, Peter C., Hanna, Ruth E., Menasche, Bridget L., Ökten, Arya, Peña-Hernández, Mario A., Klein, Jon, McNamara, Andrew, Rosales, Romel, McGovern, Briana L., Luis Rodriguez, M., García-Sastre, Adolfo, White, Kris M., Qin, Yiren, Doench, John G., Yan, Qin, Iwasaki, Akiko, Zwaka, Thomas P., Qi, Jun, Kadoch, Cigall, and Wilen, Craig B.

Published
2023
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9. Human iPSC-Based Model of COPD to Investigate Disease Mechanisms, Predict SARS-COV-2 Outcome, and Test Preventive Immunotherapy

Author

Dagher, Rania, primary, Moldobaeva, Aigul, additional, Gubbins, Elise, additional, Clark, Sydney, additional, Madel Alfajaro, Mia, additional, Wilen, Craig B, additional, Hawkins, Finn, additional, Qu, Xiaotao, additional, Chien Chiang, Chia, additional, Li, Yang, additional, Clarke, Lori, additional, Ikeda, Yasuhiro, additional, Brown, Charles, additional, Kolbeck, Roland, additional, Ma, Qin, additional, Rojas, Mauricio, additional, Koff, Jonathan L, additional, and Ghaedi, Mahboobe, additional

Published
2024
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11. Intestinal tuft cell immune privilege enables norovirus persistence.

Author

Strine, Madison S., Fagerberg, Eric, Darcy, Patrick W., Barrón, Gabriel M., Filler, Renata B., Alfajaro, Mia Madel, D'Angelo-Gavrish, Nicole, Wang, Fang, Graziano, Vincent R., Menasché, Bridget L., Damo, Martina, Wang, Ya-Ting, Howitt, Michael R., Lee, Sanghyun, Joshi, Nikhil S., Mucida, Daniel, and Wilen, Craig B.

Subjects
NOROVIRUSES, T cell receptors, T cells, INTESTINES, NOROVIRUS diseases, SURGICAL site infections
Abstract

The persistent murine norovirus strain MNVCR6 is a model for human norovirus and enteric viral persistence. MNVCR6 causes chronic infection by directly infecting intestinal tuft cells, rare chemosensory epithelial cells. Although MNVCR6 induces functional MNV-specific CD8+ T cells, these lymphocytes fail to clear infection. To examine how tuft cells promote immune escape, we interrogated tuft cell interactions with CD8+ T cells by adoptively transferring JEDI (just EGFP death inducing) CD8+ T cells into Gfi1b-GFP tuft cell reporter mice. Unexpectedly, some intestinal tuft cells partially resisted JEDI CD8+ T cell–mediated killing—unlike Lgr5+ intestinal stem cells and extraintestinal tuft cells—despite seemingly normal antigen presentation. When targeting intestinal tuft cells, JEDI CD8+ T cells predominantly adopted a T resident memory phenotype with decreased effector and cytotoxic capacity, enabling tuft cell survival. JEDI CD8+ T cells neither cleared nor prevented MNVCR6 infection in the colon, the site of viral persistence, despite targeting a virus-independent antigen. Ultimately, we show that intestinal tuft cells are relatively resistant to CD8+ T cells independent of norovirus infection, representing an immune-privileged niche that can be leveraged by enteric microbes. Editor's summary: Norovirus is a major cause of acute foodborne illness that can also lead to persistent infections. Specialized chemosensory epithelial cells called tuft cells are the target cell for murine norovirus, but how chronic infections are established remains unclear. Using mice with CD8+ T cells bearing a fluorescent protein-specific T cell receptor, Strine et al. found that intestinal tuft cells are intrinsically resistant to CD8+ T cell–mediated killing compared with other gut epithelial cells. Tuft cell–mediated immune evasion from CD8+ T cells enabled norovirus persistence in the colon. These findings indicate that intestinal tuft cells represent an immune-privileged niche that is intrinsically resistant to T cell responses. —Claire Olingy [ABSTRACT FROM AUTHOR]

Published
2024
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12. Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53

Author

Lee, Jonathan D, primary, Menasche, Bridget L, additional, Mavrikaki, Maria, additional, Uyemura, Madison M, additional, Hong, Su Min, additional, Kozlova, Nina, additional, Wei, Jin, additional, Alfajaro, Mia Madel, additional, Filler, Renata, additional, Muller, Arne, additional, Saxena, Tanvi, additional, Posey, Ryan R, additional, Cheung, Priscilla, additional, Muranen, Taru, additional, Heng, Jan, additional, Paulo, Joao A, additional, Wilen, Craig B, additional, and Slack, Frank J, additional

Published
2023
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13. Murine Norovirus: Additional Protocols for Basic and Antiviral Studies

Author

Wobus, Christiane E., primary, Peiper, Amy M., additional, McSweeney, Alice M., additional, Young, Vivienne L., additional, Chaika, Maryna, additional, Lane, Miranda Sophie, additional, Lingemann, Marit, additional, Deerain, Joshua M., additional, Strine, Madison S., additional, Alfajaro, Mia Madel, additional, Helm, Emily W., additional, Karst, Stephanie M., additional, Mackenzie, Jason M., additional, Taube, Stefan, additional, Ward, Vernon K., additional, and Wilen, Craig B., additional

Published
2023
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19. Kinase-independent activity of DYRK1A promotes viral entry of highly pathogenic human coronaviruses

Author

Strine, Madison S., primary, Cai, Wesley L., additional, Wei, Jin, additional, Alfajaro, Mia Madel, additional, Filler, Renata B., additional, Biering, Scott B., additional, Sarnik, Sylvia, additional, Patil, Ajinkya, additional, Cervantes, Kasey S., additional, Collings, Clayton K., additional, DeWeirdt, Peter C., additional, Hanna, Ruth E., additional, Schofield, Kevin, additional, Hulme, Christopher, additional, Konermann, Silvana, additional, Doench, John G., additional, Hsu, Patrick D., additional, Kadoch, Cigall, additional, Yan, Qin, additional, and Wilen, Craig B., additional

Published
2022
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26. High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells

Author

Chen, Jennifer S., primary, Chow, Ryan D., additional, Song, Eric, additional, Mao, Tianyang, additional, Israelow, Benjamin, additional, Kamath, Kathy, additional, Bozekowski, Joel, additional, Haynes, Winston A., additional, Filler, Renata B., additional, Menasche, Bridget L., additional, Wei, Jin, additional, Alfajaro, Mia Madel, additional, Song, Wenzhi, additional, Peng, Lei, additional, Carter, Lauren, additional, Weinstein, Jason S., additional, Gowthaman, Uthaman, additional, Chen, Sidi, additional, Craft, Joe, additional, Shon, John C., additional, Iwasaki, Akiko, additional, Wilen, Craig B., additional, and Eisenbarth, Stephanie C., additional

Published
2022
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32. High-affinity, neutralizing antibodies to SARS-CoV-2 can be made in the absence of T follicular helper cells

Author

Chen, Jennifer S., primary, Chow, Ryan D., additional, Song, Eric, additional, Mao, Tianyang, additional, Israelow, Benjamin, additional, Kamath, Kathy, additional, Bozekowski, Joel, additional, Haynes, Winston A., additional, Filler, Renata B., additional, Menasche, Bridget L., additional, Wei, Jin, additional, Alfajaro, Mia Madel, additional, Song, Wenzhi, additional, Peng, Lei, additional, Carter, Lauren, additional, Weinstein, Jason S., additional, Gowthaman, Uthaman, additional, Chen, Sidi, additional, Craft, Joe, additional, Shon, John C., additional, Iwasaki, Akiko, additional, Wilen, Craig B., additional, and Eisenbarth, Stephanie C., additional

Published
2021
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33. Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions

Author

Flynn, Ryan A., primary, Belk, Julia A., additional, Qi, Yanyan, additional, Yasumoto, Yuki, additional, Wei, Jin, additional, Alfajaro, Mia Madel, additional, Shi, Quanming, additional, Mumbach, Maxwell R., additional, Limaye, Aditi, additional, DeWeirdt, Peter C., additional, Schmitz, Cameron O., additional, Parker, Kevin R., additional, Woo, Elizabeth, additional, Chang, Howard Y., additional, Horvath, Tamas L., additional, Carette, Jan E., additional, Bertozzi, Carolyn R., additional, Wilen, Craig B., additional, and Satpathy, Ansuman T., additional

Published
2021
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34. Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes

Author

Ravindra, Neal G., primary, Alfajaro, Mia Madel, additional, Gasque, Victor, additional, Huston, Nicholas C., additional, Wan, Han, additional, Szigeti-Buck, Klara, additional, Yasumoto, Yuki, additional, Greaney, Allison M., additional, Habet, Victoria, additional, Chow, Ryan D., additional, Chen, Jennifer S., additional, Wei, Jin, additional, Filler, Renata B., additional, Wang, Bao, additional, Wang, Guilin, additional, Niklason, Laura E., additional, Montgomery, Ruth R., additional, Eisenbarth, Stephanie C., additional, Chen, Sidi, additional, Williams, Adam, additional, Iwasaki, Akiko, additional, Horvath, Tamas L., additional, Foxman, Ellen F., additional, Pierce, Richard W., additional, Pyle, Anna Marie, additional, van Dijk, David, additional, and Wilen, Craig B., additional

Published
2021
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37. CD300lf Conditional Knockout Mouse Reveals Strain-Specific Cellular Tropism of Murine Norovirus

Author

Graziano, Vincent R., primary, Alfajaro, Mia Madel, additional, Schmitz, Cameron O., additional, Filler, Renata B., additional, Strine, Madison S., additional, Wei, Jin, additional, Hsieh, Leon L., additional, Baldridge, Megan T., additional, Nice, Timothy J., additional, Lee, Sanghyun, additional, Orchard, Robert C., additional, and Wilen, Craig B., additional

Published
2021
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38. Neuroinvasion of SARS-CoV-2 in human and mouse brain

Author

Song, Eric, primary, Zhang, Ce, additional, Israelow, Benjamin, additional, Lu-Culligan, Alice, additional, Prado, Alba Vieites, additional, Skriabine, Sophie, additional, Lu, Peiwen, additional, Weizman, Orr-El, additional, Liu, Feimei, additional, Dai, Yile, additional, Szigeti-Buck, Klara, additional, Yasumoto, Yuki, additional, Wang, Guilin, additional, Castaldi, Christopher, additional, Heltke, Jaime, additional, Ng, Evelyn, additional, Wheeler, John, additional, Alfajaro, Mia Madel, additional, Levavasseur, Etienne, additional, Fontes, Benjamin, additional, Ravindra, Neal G., additional, Van Dijk, David, additional, Mane, Shrikant, additional, Gunel, Murat, additional, Ring, Aaron, additional, Kazmi, Syed A. Jaffar, additional, Zhang, Kai, additional, Wilen, Craig B., additional, Horvath, Tamas L., additional, Plu, Isabelle, additional, Haik, Stephane, additional, Thomas, Jean-Leon, additional, Louvi, Angeliki, additional, Farhadian, Shelli F., additional, Huttner, Anita, additional, Seilhean, Danielle, additional, Renier, Nicolas, additional, Bilguvar, Kaya, additional, and Iwasaki, Akiko, additional

Published
2021
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39. Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection

Author

Wei, Jin, primary, Alfajaro, Mia Madel, additional, DeWeirdt, Peter C., additional, Hanna, Ruth E., additional, Lu-Culligan, William J., additional, Cai, Wesley L., additional, Strine, Madison S., additional, Zhang, Shang-Min, additional, Graziano, Vincent R., additional, Schmitz, Cameron O., additional, Chen, Jennifer S., additional, Mankowski, Madeleine C., additional, Filler, Renata B., additional, Ravindra, Neal G., additional, Gasque, Victor, additional, de Miguel, Fernando J., additional, Patil, Ajinkya, additional, Chen, Huacui, additional, Oguntuyo, Kasopefoluwa Y., additional, Abriola, Laura, additional, Surovtseva, Yulia V., additional, Orchard, Robert C., additional, Lee, Benhur, additional, Lindenbach, Brett D., additional, Politi, Katerina, additional, van Dijk, David, additional, Kadoch, Cigall, additional, Simon, Matthew D., additional, Yan, Qin, additional, Doench, John G., additional, and Wilen, Craig B., additional

Published
2021
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40. Single-cell longitudinal analysis of SARS-CoV-2 infection in human bronchial epithelial cells

Author

Ravindra, Neal G., Alfajaro, Mia Madel, Gasque, Victor, Wei, Jin, Filler, Renata B., Huston, Nicholas C., Wan, Han, Szigeti-Buck, Klara, Wang, Bao, Montgomery, Ruth R., Eisenbarth, Stephanie C., Williams, Adam, Pyle, Anna Marie, Iwasaki, Akiko, Horvath, Tamas L., Foxman, Ellen F., van Dijk, David, and Wilen, Craig B.

Subjects
viruses, skin and connective tissue diseases, Article
Abstract

SARS-CoV-2, the causative agent of COVID-19, has resulted in more than 3,000,000 infections and 200,000 deaths. There are currently no approved drugs or vaccines for the treatment or prevention of COVID-19. Enhanced understanding of SARS-CoV-2 infection and pathogenesis is critical for the development of therapeutics. To reveal insight into viral replication, cell tropism, and host-viral interactions of SARS-CoV-2 we performed single-cell RNA sequencing of experimentally infected human bronchial epithelial cells (HBECs) in air-liquid interface cultures over a time-course. This revealed novel polyadenylated viral transcripts and highlighted ciliated cells as the major target of infection, which we confirmed by electron microscopy. Over the course of infection, cell tropism of SARS-CoV-2 expands to other epithelial cell types including basal and club cells. Infection induces cell intrinsic expression of type I and type III IFNs and IL6 but not IL1. This results in expression of interferon stimulated genes in both infected and bystander cells. Here, we have conducted an in-depth analysis of SARS-CoV-2 infection in HBECs and provide a detailed characterization of genes, cell types, and cell state changes associated with the infection.

Published
2020
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41. Systematic discovery and functional interrogation of SARS-CoV-2 viral RNA-host protein interactions during infection

Author

Flynn, Ryan A., primary, Belk, Julia A., additional, Qi, Yanyan, additional, Yasumoto, Yuki, additional, Schmitz, Cameron O., additional, Mumbach, Maxwell R., additional, Limaye, Aditi, additional, Wei, Jin, additional, Alfajaro, Mia Madel, additional, Parker, Kevin R., additional, Chang, Howard Y., additional, Horvath, Tamas L., additional, Carette, Jan E., additional, Bertozzi, Carolyn, additional, Wilen, Craig B., additional, and Satpathy, Ansuman T., additional

Published
2020
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43. CD300lf conditional knockout mouse reveals strain-specific cellular tropism for murine norovirus

Author

Graziano, Vincent R., primary, Alfajaro, Mia Madel, additional, Schmitz, Cameron O., additional, Filler, Renata B., additional, Strine, Madison S., additional, Wei, Jin, additional, Hsieh, Leon L., additional, Baldridge, Megan T., additional, Nice, Timothy J., additional, Lee, Sanghyun, additional, Orchard, Robert C., additional, and Wilen, Craig B., additional

Published
2020
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45. Neuroinvasion of SARS-CoV-2 in human and mouse brain

Author

Song, Eric, primary, Zhang, Ce, additional, Israelow, Benjamin, additional, Lu-Culligan, Alice, additional, Prado, Alba Vieites, additional, Skriabine, Sophie, additional, Lu, Peiwen, additional, Weizman, Orr-El, additional, Liu, Feimei, additional, Dai, Yile, additional, Szigeti-Buck, Klara, additional, Yasumoto, Yuki, additional, Wang, Guilin, additional, Castaldi, Christopher, additional, Heltke, Jaime, additional, Ng, Evelyn, additional, Wheeler, John, additional, Alfajaro, Mia Madel, additional, Levavasseur, Etienne, additional, Fontes, Benjamin, additional, Ravindra, Neal G., additional, Van Dijk, David, additional, Mane, Shrikant, additional, Gunel, Murat, additional, Ring, Aaron, additional, Jaffar Kazmi, Syed A., additional, Zhang, Kai, additional, Wilen, Craig B, additional, Horvath, Tamas L., additional, Plu, Isabelle, additional, Haik, Stephane, additional, Thomas, Jean-Leon, additional, Louvi, Angeliki, additional, Farhadian, Shelli F., additional, Huttner, Anita, additional, Seilhean, Danielle, additional, Renier, Nicolas, additional, Bilguvar, Kaya, additional, and Iwasaki, Akiko, additional

Published
2020
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46. Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection

Author

Wei, Jin, primary, Alfajaro, Mia Madel, additional, Hanna, Ruth E., additional, DeWeirdt, Peter C., additional, Strine, Madison S., additional, Lu-Culligan, William J., additional, Zhang, Shang-Min, additional, Graziano, Vincent R., additional, Schmitz, Cameron O., additional, Chen, Jennifer S., additional, Mankowski, Madeleine C., additional, Filler, Renata B., additional, Gasque, Victor, additional, de Miguel, Fernando, additional, Chen, Huacui, additional, Oguntuyo, Kasopefoluwa, additional, Abriola, Laura, additional, Surovtseva, Yulia V., additional, Orchard, Robert C., additional, Lee, Benhur, additional, Lindenbach, Brett, additional, Politi, Katerina, additional, van Dijk, David, additional, Simon, Matthew D., additional, Yan, Qin, additional, Doench, John G., additional, and Wilen, Craig B., additional

Published
2020
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47. Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium

Author

Ravindra, Neal G., primary, Alfajaro, Mia Madel, additional, Gasque, Victor, additional, Habet, Victoria, additional, Wei, Jin, additional, Filler, Renata B., additional, Huston, Nicholas C., additional, Wan, Han, additional, Szigeti-Buck, Klara, additional, Wang, Bao, additional, Wang, Guilin, additional, Montgomery, Ruth R., additional, Eisenbarth, Stephanie C., additional, Williams, Adam, additional, Pyle, Anna Marie, additional, Iwasaki, Akiko, additional, Horvath, Tamas L., additional, Foxman, Ellen F., additional, Pierce, Richard W., additional, van Dijk, David, additional, and Wilen, Craig B., additional

Published
2020
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49. Dual Recognition of Sialic Acid and αGal Epitopes by the VP8* Domains of the Bovine Rotavirus G6P[5] WC3 and of Its Mono-reassortant G4P[5] RotaTeq Vaccine Strains

Author

Alfajaro, Mia Madel, primary, Kim, Ji-Yun, additional, Barbé, Laure, additional, Cho, Eun-Hyo, additional, Park, Jun-Gyu, additional, Soliman, Mahmoud, additional, Baek, Yeong-Bin, additional, Kang, Mun-Il, additional, Kim, Soo Hyun, additional, Kim, Geun-Joong, additional, Park, Sang-Ik, additional, Pendu, Jacques Le, additional, and Cho, Kyoung-Oh, additional

Published
2019
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