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Pharmaceutical active compounds (PACs) are under consideration due to their potential risk to human health and the ecosystem. Researchers are exploring economical and effective wastewater treatment methods to address these issues. Conventional wastewater treatment facilities cannot successfully remove PACs. The co-existence of several PACs and various microalgal species provides an opportunity for microalgae-based bioremediation of PACs. This review paper focuses primarily on antibacterial resistance genes (ARGS), removal of PACs through microalgal systems, essential factors influencing PACs removal, ecotoxicity of microalgae, bioprospecting strategy for microalgae, and challenges and future aspects for microalgae in PACs removal. [ABSTRACT FROM AUTHOR]

Aflatoxins are highly toxic, carcinogenic compounds, widely prevalent worldwide, secreted by various fungal strains especially from genus Aspergillus including Aspergillus parasiticus and Aspergillus flavus. Brown rice having more than 17% moisture contents is considered as favorable substrates for fungal growth causing aflatoxins production. The objective of current study was to examine seasonal and geographical impact on production of aflatoxins including aflatoxin B1 (AFB1), aflatoxin B2 (AFB2), aflatoxin G1 (AFG1) and aflatoxin G2 (AFG2) in different brown rice varieties procured from two districts of Punjab. High Performance Liquid Chromatography (HPLC) equipped with fluorescence detector was used to detect aflatoxins in samples including Super Kernel Basmati Rice (SK), Kainat (KN), and Supri (SP). Among aflatoxins, AFB1 was the most common toxin detected in three varieties of brown rice especially in SK. AFG1 and AFG2 in the present study were not detected. A total of 200 samples were taken out of which 125 samples were positive. Among 125 samples, 100(80%) samples had greater AFB1 content than permissible limit (2 µg/kg). In addition, 94(75%) samples had higher total aflatoxin contents than allowable limit (4 µg/kg). Aflatoxins contents in brown rice were dependent on rice varieties, regions, and months. The highest moisture and aflatoxins contents were observed in SK in the month of March collected from Gujranwala and lowest were observed in SP in the month of May collected from Multan. The seasonal comparison for aflatoxins concentrations in brown rice showed higher aflatoxins levels in the samples collected during the month of March than those procured in other months (November, January and May). Furthermore, a strong correlation between moisture contents and aflatoxins was also observed. The results of current study revealed that moisture management during storage is very significant to control aflatoxins production in brown rice varieties. [ABSTRACT FROM AUTHOR]

There is a tremendous demand on the critical care resources due to the extensive spread of the ongoing coronavirus pandemic and the large number of patients requiring critical care. The efficacy of a device directly influences how long a patient lives since patients are often receiving critical care. Smart infusion pump is a medical device that can drip fluids into the patient's body. This device is considered as one of the most safety-critical medical devices due to the way it functions and the risks it presents. The main objective of this work is to develop an affordable infusion pump usin g embedded technology. The main tactic is to develop equipment that can identify air bubbles in infusion pump tubing since even a little one might obstruct blood flow and result in mortality. This method may provide consumers an accurate result, making it the greatest method for identifying bubbles and saving lives. [ABSTRACT FROM AUTHOR]

The expression of cytochrome P450 isoenzymes (subfamilies) CYP1A, CYP2B, CYP2C, CYP3A and CYP4A in the histologically normal cervix was explored using a panel of polyclonal antibodies. There was variation in the intensity of immunohistochemical reaction between the isoenzymes and between the various components of the cervix. Half the subjects tested were smokers and had increased urinary cotinine levels. Statistical analysis revealed no significant differences between smokers and nonsmokers in the expression of these isoenzymes. The implications of these observations in relation to cervical carcinogenesis are discussed. [ABSTRACT FROM AUTHOR]

Meconium peritonitis is a chemical reaction of peritonium to meconium which occurs due to leakage of meconium into peritoneal cavity as a result of perforation of intestines antinatally which gets subsequently sealed. In the present retrospective study, 39 cases of neonatal peritonitis were studied. Meconium peritonitis was diagnosed if a) abdominal X-ray showed diffuse calcifications (b) abdominal paracentesis showed meconium aspirate and c) leprotomy examination. Twenty (51.3%) out of 39 cases of neonatal peritonitis were found to have meconium peritonitis. These included 14 boys and 6 girls, birth weight ranged from 1500 gms to 3200 gms and mean age of presentation included abdominal distension in 100% cases, H/O not passing meconium in 50% cases, Ascites in 45% cases and vomiting in 40% cases, 30% presented with abdominal mass. Pseudocyst formation on X-ray was seen in 23% cases which was much higher than reported in world literature. Overall mortality in meconium peritonitis was 80%. The incidence of meconium peritonitis in this part of country in much higher than reported in Western and Indian literature. The high incidence may be due to underlying cystic fibrosis because Kashmir has a more homogenous population and consanguinity is very common. A prospective study including sweat chloride testing needs to be undertaken to look into the cause for proportionately higher occurrence of meconium peritonitis in Kashmir with particular reference to cystic fibrosis. [ABSTRACT FROM AUTHOR]

Objective: To study epidemiology including various risk factors incorporated in neonatal necrotizing enterocolitis in Kashmir., Methods: A retrospective hospital based study on 3235 neonates admitted in Neonatal Intensive Care Unit of Sheri-Kashmir Institute, were evaluated. Forty two were diagnosed as cases of Neonatal Necrotizing Enterocolitis on the basis of various clinical and radiological parameters and grouped in 3 stages as per modified Bell's classification. The case records of these 42 babies and 303 of the control group were reviewed for the purported risk factors and recorded on pretested proforma and finally statistically analyzed., Results: Over a period of 10 years, we documented necrotizing enterocolitis in 42 neonates, with an incidence of 1% of all Neonatal Intensive Care Unit admissions and 1% of all live births. Eighty one percent were less than 2000 gms and 76% less than 36 weeks of gestation. Twenty four percent had stage I disease, 33% had stage II, and 43% babies had stage III disease. Multiple risk factors were present in these babies, with significant differences among Necrotizing Enterocolitis and the control group of patients, particularly hypothermia (P < 0.001), respiratory distress (P < 0.05), polycythemia (P < 0.001) acidosis (P < 0.01), sepsis (P < 0.001), enteral feeding and asphyxia (P < 0.001). Of the 59 babies (< 2000 gms) with hypothermia (< 35 degrees C), 39% developed Necrotizing Enterocolitis, compared to 4% babies (11/278), who did not have hypothermia, statistically a significant finding. Mean birth weight and gestational age were lower than in control group (P < 0.05). The age of presentation was 5.2 +/- 4.0 days and majority (81%) presented during first week of life, most severe cases presenting earlier than the mild cases. Severity of Necrotizing Enterocolitis as per modified Bell's classification and mortality was inversely related to birth weight and gestational age. One hundred percent mortality was noted in the babies, with birth weight less than 1000 gms and gestational age less than 28 weeks. The overall mortality was 45%, for stage I, 20%; for stage II, 36% and 67% for stage III. Necrotizing Enterocolitis cases accounted for maximum mortality in Neonatal Intensive Care Unit than in control group (P < 0.001)., Conclusion: Recognition of factors such as prematurity, low birth weight, hypothermia, asphyxia and their timely prevention would help in reducing morbidity and mortality due to Necrotizing Enterocolitis.

This report analyses 1234 patients with CIN and non-condylomatous wart virus infection (NCWVI) managed by CO2 laser ablation in the Regional Department of Gynaecological Oncology, Queen Elizabeth Hospital, Gateshead from 1979 to 1983. Thirty-five patients (3%) were lost to follow-up. Of the 1157 patients currently under review and with at least 1 year of follow-up, 44 (3.8%) were laser treatment failures. This group is analysed and the results compared with other series.