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1. P53 status, and G2/M cell cycle arrest, are determining factors in cell-death induction mediated by ELF-EMF in glioblastoma

Author

Romina Mehdizadeh, Alireza Madjid Ansari, Flora Forouzesh, Fatemeh Shahriari, Seyed Peyman Shariatpanahi, Ali Salaritabar, and Mohammad Amin Javidi

Subjects
Medicine, Science
Abstract

Abstract The average survival of patients with glioblastoma is 12–15 months. Therefore, finding a new treatment method is important, especially in cases that show resistance to treatment. Extremely low-frequency electromagnetic fields (ELF-EMF) have characteristics and capabilities that can be proposed as a new cancer treatment method with low side effects. This research examines the antitumor effect of ELF-EMF on U87 and U251 glioblastoma cell lines. Flowcytometry determined the viability/apoptosis and distribution of cells in different phases of the cell cycle. The size of cells was assessed by TEM. Important cell cycle regulation genes mRNA expression levels were investigated by real-time PCR. ELF-EMF induced apoptosis in U87cells much more than U251 (15% against 2.43%) and increased G2/M cell population in U87 (2.56%, p value

Published
2023
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2. Contributors

Author

Hale G. Ağalar, Francesca Aiello, Marjan Ajami, J. Alfredo Martínez, Abdul-musawwir Alli-Oluwafuyi, Celso Alves, Marco G. Alves, Harish C. Andola, Anna Blázovics, Giuseppe Annunziata, Sandro Argüelles, Munuswamy Arumugam, Maria S. Atanassova, Everaldo Attard, Henrietta Attard, Ilaria Avanzato, Amit Bahukhandi, Letricia Barbosa-Pereira, Luigi Barrea, Davide Barreca, Sweta Bawari, Bellocco Ersilia, Simona Belviso, Tarun Belwal, Susana Bernardino, Indra D. Bhatt, Md. M. Billah, Arti Bisht, Kapil Bisht, Mohammed Bule, David F. Carrageta, Ma. A. Correa-Murrieta, Paola Cruz-Flores, Giuseppe D’Antona, Behrad Darvish, Andréa Cardoso de Aquino, Gabriela Servín de la Mora-López, Dirce Fernandes de Melo, Luciana de Siqueira Oliveira, Kasi Pandima Devi, Hari Prasad Devkota, Tânia R. Dias, Ayman EL-Meghawry EL-Kenawy, Éva Sárdi, Tiziana Falco, Farhan Farid, Ammad A. Farooqi, Mohammad Hosein Farzaei, Antoni Femenia, Marta Fernández-Galilea, Pere Ferriol, Silvana Ficarra, Maria E. Figueira, Rafaela Freitas, Erika Freitas Mota, María José Frutos, Antonio Galtieri, Shashidhar M. Ghatnur, Jolius Gimbun, Lalit Giri, Neuza Felix Gomes-Rochette, Sandra Gonçalves, Jalaj Kumar Gour, Farzaneh Hadjiakhoondi, Marziyeh Hajialyani, Abdulraheem Haleemat, Snur M.A. Hassan, Md. B. Hosen, Ana E. Huerta, Samineh Jafari, Arvind Jantwal, Bhasker Joshi, Charu Joshi, Gökçe Şeker Karatoprak, Dharambir Kashyap, Pushpa Kewlani, Fazlullah Khan, Haroon Khan, Khaoula Khwaldia, Traudi Klein, Esra Köngül, Laganà Giuseppina, Mariarosaria Leporini, Monica R. Loizzo, Jaime López-Cervantes, Filippo Maggi, Azadeh Manayi, Ramar Manikandan, Leila Larisa Medeiros Marques, null Marya, João Carlos Palazzo de Mello, Selvaraj Miltonprabu, Rafael Minjares-Fuentes, Ahmed Mohmed Mohamed Mohamed, Hala Mahmoud Ahmed Mohammed, María J. Moreno-Aliaga, Seyed Mohammad Nabavi, Abdulrazaq B. Nafiu, Rozita Naseri, Massimo Negro, Kamal Niaz, Marjan Nikan, Sundaramoorthy Niranjana Sri, Diana Célia Sousa Nunes-Pinheiro, Ibrahim S. Olalekan, Pedro F. Oliveira, Hosam-Eldin Hussein Osman, Veena Pande, Sook Fun Pang, Ravi Pathak, Pooja Patni, Rui Pedrosa, Francisca Pérez-Llamas, Aliye A. Perk, Susete Pinteus, Samuel Pinya, Pedro L. Prieto-Hontoria, Muhammad Z. Qureshi, Mohammad T. Rahman, Ranbeer S. Rawal, João Reboleira, Laura Rincón-Frutos, Anabela Romano, Luísa C. Roseiro, Domingo Ruiz-Cano, Annamaria Russo, Gian Luigi Russo, Uteuliyev Y. Sabitaliyevich, Archana N. Sah, Katrin Sak, Ali Salaritabar, Branka Salopek-Sondi, Dunja Šamec, Bilqees Sameem, Reyna G. Sánchez-Duarte, Dalia I. Sánchez-Machado, Carlos Santos, Tahir Shah, Ruchika Sharma, Subrata Shaw, Ovais Sideeq, Joana Silva, Branca M. Silva, Ana Sanches Silva, Manoj Kumar Singh, Smeriglio Antonella, Krishnapura Srinivasan, Ipek Suntar, Antoni Sureda, Renu Suyal, Sobia Tabassum, Mohd. Tariq, Idolo Tedesco, Silvia Tejada, Ester Tellone, Maria C. Tenuta, Devesh Tewari, Shinny Thakur, Raman Thiagarajan, Trombetta Domenico, Hardeep Singh Tuli, Rosa Tundis, Sashi Upadhayay, Estefanía Valero-Cases, Mirele da Silveira Vasconcelos, Roya Vazirijavid, Niaz Wali, Yiu To Yeung, Mashitah M. Yusoff, Salvador Zamora, and Tokmurziyeva G. Zhenisovna

Published
2019
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4. Targeting Hedgehog signaling pathway: Paving the road for cancer therapy

Author

Diana Gulei, Samira Shirooie, Seyed Mohammad Nabavi, Davide Barreca, Ammad Ahmad Farooqi, Ipek Süntar, Ali Salaritabar, Maria Daglia, Behrad Darvish, Seyed Fazel Nabavi, Ilkay Erdogan Orhan, Kasi Pandima Devi, Azadeh Manayi, Antoni Sureda, Ahmad Reza Dehpour, Ioana Berindan-Neagoe, Farzaneh Hadjiakhoondi, Salaritabar, A., Berindan-Neagoe, I., Darvish, B., Hadjiakhoondi, F., Manayi, A., Devi, K. P., Barreca, D., Orhan, I. E., Suntar, I., Farooqi, A. A., Gulei, D., Nabavi, S. F., Sureda, A., Daglia, M., Dehpour, A. R., Nabavi, S. M., and Shirooie, S.

Subjects
0301 basic medicine, Angiogenesis, Cancer therapy, Antineoplastic Agents, Smad Proteins, Hedgehog signaling, Biology, 03 medical and health sciences, 0302 clinical medicine, Transforming Growth Factor beta, Neoplasms, Anticancer Therapy, Embryonic development, Hedgehog signaling, Self-renewal, Animals, Humans, Hedgehog Proteins, Receptors, Platelet-Derived Growth Factor, Molecular Targeted Therapy, Hedgehog, Pharmacology, Receptors, Notch, Anticancer therapy, Hedgehog signaling pathway, Cell biology, Crosstalk (biology), 030104 developmental biology, 030220 oncology & carcinogenesis, Embryonic development, Self-renewal, Stem cell, Signal transduction, Homeostasis, Signal Transduction
Abstract

The Hedgehog pathway is essential for embryonic development but also for tissue and organ homeostasis in adult organisms. Activation of this pathway leads to the expression of target genes involved in proliferation, angiogenesis and stem cell self-renewal. Moreover, abnormal persistence of Hedgehog signaling is directly involved in a wide range of human cancers. Development of novel strategies targeting the Hedgehog pathway has become a subject of increased interest in anticancer therapy. These data are sustained by pre-clinical studies demonstrating that Hedgehog pathway inhibitors could represent an effective strategy against a heterogeneous panel of malignancies. Limited activity in other tumor types could be explained by the existence of crosstalk between the Hedgehog pathway and other signaling pathways that can compensate for its function. This review describes the Hedgehog pathway in detail, with its physiological roles during embryogenesis and adult tissues, and summarizing the preclinical evidence on its inhibition, the crosstalk between Hedgehog and other cancer related pathways and finally the potential therapeutic effects of emerging compounds.

Published
2019

5. Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review

Author

Antoni Sureda, Leo R. Fitzpatrick, Anupam Bishayee, Seyed Mohammad Nabavi, Farzaneh Hadjiakhoondi, Behrad Darvishi, Ali Salaritabar, Seyed Fazel Nabavi, and Azadeh Manayi

Subjects
0301 basic medicine, colitis, Colon, Anti-Inflammatory Agents, Inflammation, Disease, Review, Bioinformatics, Inflammatory bowel disease, Neuroprotection, ensayos clínicos como asunto, 03 medical and health sciences, 0302 clinical medicine, Intestinal mucosa, Crohn Disease, Gastrointestinal tract, flavonoides, medicine, Adjuvant therapy, Animals, Intestinal Mucosa, Flavonoids, Clinical Trials as Topic, business.industry, resultado del tratamiento, Gastroenterology, food and beverages, Polyphenols, General Medicine, medicine.disease, antiinflamatorios, Ulcerative colitis, Disease Models, Animal, 030104 developmental biology, Treatment Outcome, 030220 oncology & carcinogenesis, mucosa intestinal, enfermedad de Crohn, animales, Colitis, Ulcerative, medicine.symptom, Metabolic syndrome, Antioxidant, business
Abstract

The inflammatory process plays a central role in the development and progression of numerous pathological situations, such as inflammatory bowel disease (IBD), autoimmune and neurodegenerative diseases, metabolic syndrome, and cardiovascular disorders. IBDs involve inflammation of the gastrointestinal area and mainly comprise Crohn's disease (CD) and ulcerative colitis (UC). Both pathological situations usually involve recurring or bloody diarrhea, pain, fatigue and weight loss. There is at present no pharmacological cure for CD or UC. However, surgery may be curative for UC patients. The prescribed treatment aims to ameliorate the symptoms and prevent and/or delay new painful episodes. Flavonoid compounds are a large family of hydroxylated polyphenolic molecules abundant in plants, including vegetables and fruits which are the major dietary sources of these compounds for humans, together with wine and tea. Flavonoids are becoming very popular because they have many health-promoting and disease-preventive effects. Most interest has been directed towards the antioxidant activity of flavonoids, evidencing a remarkable free-radical scavenging capacity. However, accumulating evidence suggests that flavonoids have many other biological properties, including anti-inflammatory, antiviral, anticancer, and neuroprotective activities through different mechanisms of action. The present review analyzes the available data about the different types of flavonoids and their potential effectiveness as adjuvant therapy of IBDs.

Published
2017

6. Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review.

Author

Salaritabar A, Darvishi B, Hadjiakhoondi F, Manayi A, Sureda A, Nabavi SF, Fitzpatrick LR, Nabavi SM, and Bishayee A

Subjects
Animals, Clinical Trials as Topic, Colitis, Ulcerative pathology, Colon drug effects, Colon pathology, Crohn Disease pathology, Disease Models, Animal, Flavonoids pharmacology, Intestinal Mucosa drug effects, Intestinal Mucosa pathology, Treatment Outcome, Anti-Inflammatory Agents therapeutic use, Colitis, Ulcerative drug therapy, Crohn Disease drug therapy, Flavonoids therapeutic use
Abstract

The inflammatory process plays a central role in the development and progression of numerous pathological situations, such as inflammatory bowel disease (IBD), autoimmune and neurodegenerative diseases, metabolic syndrome, and cardiovascular disorders. IBDs involve inflammation of the gastrointestinal area and mainly comprise Crohn's disease (CD) and ulcerative colitis (UC). Both pathological situations usually involve recurring or bloody diarrhea, pain, fatigue and weight loss. There is at present no pharmacological cure for CD or UC. However, surgery may be curative for UC patients. The prescribed treatment aims to ameliorate the symptoms and prevent and/or delay new painful episodes. Flavonoid compounds are a large family of hydroxylated polyphenolic molecules abundant in plants, including vegetables and fruits which are the major dietary sources of these compounds for humans, together with wine and tea. Flavonoids are becoming very popular because they have many health-promoting and disease-preventive effects. Most interest has been directed towards the antioxidant activity of flavonoids, evidencing a remarkable free-radical scavenging capacity. However, accumulating evidence suggests that flavonoids have many other biological properties, including anti-inflammatory, antiviral, anticancer, and neuroprotective activities through different mechanisms of action. The present review analyzes the available data about the different types of flavonoids and their potential effectiveness as adjuvant therapy of IBDs., Competing Interests: Conflict-of-interest statement: The authors declare no conflict of interests for this article.

Published
2017
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