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One of the risks of distraction osteogenesis-based techniques is the development of vascular complications, such as pseudoaneurysms associated with the osteotomies performed or the fixation elements of the external fixator used in the procedure.Pseudoaneurysm are formed when the tunica adventitia of the artery is injured, resulting in a gradual and persistent blood extravasation into the surrounding tissues that is encapsulated and connected to the arterial lumen.This report describes a rare case of a late-presentation pseudoaneurysm in the anterior tibial artery resulting from a tibial lengthening procedure aimed at addressing a leg length discrepancy in a 57-year-old female with severe peripheral neuropathy resulting from long-standing poorly controlled diabetes mellitus. We describe the diagnostic process, the treatment options and confirm how the shape of the bony callus can be a reliable indicator of this pathology, as has already been described in the literature.

Abstract Background There has been a rise in endometrial cancer (EC) incidence leading to increased mortality. To counter this trend, improving the stratification of post-surgery recurrence risk and anticipating disease relapse and treatment resistance is essential. Liquid biopsy analyses offer a promising tool for these clinical challenges, though the best strategy for applying them in EC must be defined. This study was designed to determine the value of cfDNA/ctDNA monitoring in improving the clinical management of patients with localized and recurrent disease. Methods Plasma samples and uterine aspirates (UA) from 198 EC patients were collected at surgery and over time. The genetic landscape of UAs was characterized using targeted sequencing. Total cfDNA was analyzed for ctDNA presence based on the UA mutational profile. Results High cfDNA levels and detectable ctDNA at baseline correlated with poor prognosis for DFS (p-value

Abstract Background Pregnancy-associated breast cancer (PABC) is a rare entity whose prognosis has previously been studied and is subject to controversy. Methods Survival of patients with PABC diagnosed between 2009 and 2021 with breast cancer during pregnancy or until 1 year after childbirth was compared with non-pregnant patients with breast cancer from the same period at La Paz University Hospital. Cox proportional hazards regression was used to compare disease-free (DFS) and overall (OS) survival between the groups, adjusting for grade and pathologic stage. Results Among the 89 included patients with breast cancer, 34 were diagnosed during pregnancy, and 55 were not pregnant. The pregnant patients were more likely to have grade 3 tumors (61.3% vs 37%, p = 0.023) and an advanced stage (pathologic stage III-IV: 44.1% vs 17.6%, p = 0.008). Median follow-up was 47 months for the pregnant group and 46 months for the control group. After adjustments for tumor grade and pathologic stage, OS was comparable between the groups (HR 2.03; 95% CI 0.61 to 6.79; P = 0.25). Conclusions The outcome of women diagnosed with PABC is comparable to young non-pregnant controls. However, it should be taken into account that PABC has a more aggressive phenotype.

CD36 is a type 2 cell surface scavenger receptor expressed in various tissues. In macrophages, CD36 recognizes oxidized low-density lipoprotein (ox-LDL), which promotes the formation of foam cells, the first step toward an atherosclerotic arterial lesion. CD36 possesses a variety of posttranslational modifications, among them N-glycosylation and O-GlcNAc modification. Some of the roles of these modifications on CD36 are known, such as N-linked glycosylation, which provides proper folding and trafficking to the plasma membrane in the human embryonic kidney. This study aimed to determine whether variations in the availability of UDP-GlcNAc could impact Rab-5-mediated endocytic trafficking and, therefore, the cellular localization of CD36. These preliminary results suggest that the availability of the substrate UDP-GlcNAc, modulated in response to treatment with Thiamet G (TMG), OSMI-1 (O-GlcNAcylation enzymes modulators) or Azaserine (HBP modulator), influences the localization of CD36 in J774 macrophages, and the endocytic trafficking as evidenced by the regulatory protein Rab-5, between the plasma membrane and the cytoplasm.

The fluidity of gender along with sexual fluidity and flexibility indicate that sexual attraction may exist and vary within a spectrum or a flux changing during the life. On the other hand, scientists distinguished two understandings of the ‘self’, the self as “Me” and the self as “I”. “Me” corresponds to the self as an object of experience, while “I” reflects the self as a subject of experience. The phenomenology of human sexuality provides a trans-disciplinary basis where we can create a synthesis of the various perspectival approaches to the subject. We suggested a ‘Sexual-Self’ model, comprised from the ‘Sexual-Me” component, corresponding to ‘Gender Identity’, and the ‘Sexual-I’ component, corresponding to ‘Sexuality’ - including ‘Sexual Preference and Orientation’. We also suggested different scientific concepts and domains that can help understanding the existence and the processes of ‘Sexual-Self’ throughout the life.

Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP). Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events. Risk of renal toxicity with each treatment was evaluated separately. Results: We included 631 IE episodes caused by MSSA treated with cloxacillin and/or cefazolin. Antibiotic treatment was cloxacillin, cefazolin, or both in 537 (85%), 57 (9%), and 37 (6%) episodes, respectively. Patients treated with cefazolin had significantly higher rates of comorbidities (median Charlson Index 7, P

Abstract Background The SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) pandemic changed the distribution of healthcare resources, leading in many cases to the suspension of all non-essential treatments and procedures and representing a challenge for medical professionals. The objective of this study was to evaluate whether clinical protocols in gynecologic oncology care were modified as a result of the pandemic and to assess surgeons’ perceptions regarding the management of gynecologic cancers". Methods Data were collected through an anonymous and voluntary survey sent via email to healthcare professionals in the field of gynecologic oncology in Spain. Results A total of 75 gynecologic oncologists completed the online survey. Of these, 93.2% (69) reported working in public hospitals and 62.5% (45) in tertiary care hospitals. 97.3% (71) were affiliated with hospitals treating patients infected with SARS-CoV-2. 85.1% (63) of the respondents expressed concern about the SARS-CoV-2 pandemic and 52.1% (38) indicated that the pandemic impacted the diagnostic and therapeutic quality of care for oncology patients. SARS-CoV-2 nasopharyngeal swab PCR (Polymerase Chain Reaction) testing was always performed before surgical interventions by 97.3% (71), being considered a best practice in triage by 94.4% (68). 87.5% (63) reported no change in the type of surgical approach during the pandemic. 62.5% (45) experienced limitations in accessing special personal protective equipment for SARS-CoV-2. An impact on the follow-up of patients with gynecologic cancers due to the pandemic was reported by 70.4% (50). Conclusions Most of the Spanish gynecologic oncologists who responded to our survey reported that the SARS-CoV-2 pandemic had affected their clinical practice. The primary measures implemented were an increase in telemedicine, restricting outpatient visits to high-risk or symptomatic patients and the use of SARS-CoV-2 screening prior to surgery. No major changes in the surgical approach or management of the treatment of ovarian, endometrial or cervical cancer during the pandemic were reported.

Purpose The surgical management of deep infiltrative endometriosis (DE) involving the rectum remains a challenge. The objective of this study was to assess the outcomes from a single tertiary center over a decade with an emphasis on the role of a protective loop ileostomy (PI). Methods A retrospective review of outcomes for 168 patients managed between 2008 and 2018 is presented including 57 rectal shaves, 23 discoid excisions, and 88 segmental rectal resections. Results The nodule size (mean±standard deviation) in the segmental resection group was 32.7±11.2 mm, 23.4±10.5 mm for discoid excision, and 18.8±6.0 mm for rectal shaves. A PI was performed in 19 elective cases (11.3%) usually for an ultra-low anastomosis

This work aimed to evaluate the growth of two species of microgreens (mizuna and pak choi), using agro-industrial compost as growing media in two different mixes versus one hundred percent peat, under two different LED illumination spectra (LED 1 and LED 2) in a 14 h photoperiod. The experiment was carried-out for two times. Biomass yield, glucosinolates, and phenolic compounds, and nitrate (NO3−) content were analysed in leaf tissues. In both species, the highest fresh and dry biomass production was in compost:peat (50:50%) and LED 2 (Blue/Red/Far Red). In general, compost had a greater influence on nitrate content than light, but in the microgreen pak choi, the anthocyanin content was inhibited by the compost treatment. In the other hand both LED illumination had a positive effect on mizuna for glucosinolates and anthocyanins, and LED 2 also showed a positive effect on pak choi for anthocyanin. Therefore, the use of agri-food compost: peat (50:50%) with LED 2 (blue/red) lighting treatment to obtain microgreens in indoor crops is a plausible technology that provides nutritionally and phytochemically rich crops.

Se presenta la intervención en el caso de un adolescente de 15 años con trastorno depresivo mayor leve. El objetivo fue analizar los efectos de un tratamiento basado en la terapia racional emotivo conductual, activación conductual y estrategias para la mejora de la interacción padre-hijo, con el propósito de reducir sintomatología depresiva. La evaluación se realizó mediante el Inventario de Depresión de Beck (BDI-II), Inventario de Ansiedad de Beck (BAI) y el Test de Creencias Irracionales de Ellis. Los resultados indicaron una disminución de la sintomatología depresiva y un aumento de respuestas incompatibles con el comportamiento depresivo.

El conjunto arqueológico de San Esteban se localiza en el actual centro urbano de la ciudad de Murcia. Se trata de un amplio espacio de origen andalusí que formaba parte del antiguo arrabal de la Arrixaca, un barrio extramuros que parece conformarse durante el siglo XI y que constituyó una parte importante de la ciudad medieval de Murcia. El proyecto de investigación realizado entre los años 2018 y 2020 en el conjunto arqueológico de San Esteban, bajo el convenio firmado entre la Universidad de Murcia y el Ayuntamiento de Murcia, conllevó una serie de campañas de excavación arqueológica en diferentes puntos de este enclave. Se intervino en cuatro sectores que se mostraban especialmente relevantes desde el punto de vista funcional y de la articulación urbana de este entramado: los edificios conocidos como “Recinto I” y “Recinto II”, el “oratorio” y la maqbara. El proyecto fue concebido desde una perspectiva interdisciplinar, jugando un papel clave la incorporación de nuevas tecnologías en el proceso de documentación de la excavación. La metodología llevada a cabo se basó en los procedimientos fotogramétricos de alta precisión y de seguimiento diacrónico de la intervención arqueológica, teniendo como objetivo la elaboración de un registro gráfico que afectaba tanto al plano bidimensional (2D) como al tridimensional (3D). Para su correcta elaboración se combinó el uso de vehículos aéreos no tripulados (UAV por sus siglas en ingles) y de instrumental topográfico. Como resultado, este registro permitió confeccionar toda una serie de planimetrías vectoriales, ortomosaicos y recursos 3D de cara a su posterior análisis y de divulgación arquitectónica y material de los elementos arqueológicos intervenidos. Este trabajo desarrolla los procedimientos metodológicos llevados a cabo, una serie de propuestas de análisis y los resultados obtenidos en el marco de aplicación de las nuevas tecnologías en el campo de la arqueología.

Introduction: The identification of chemical compounds that interfere with SARS-CoV-2 replication continues to be a priority in several academic and pharmaceutical laboratories. Computational tools and approaches have the power to integrate, process and analyze multiple data in a short time. However, these initiatives may yield unrealistic results if the applied models are not inferred from reliable data and the resulting predictions are not confirmed by experimental evidence.Methods: We undertook a drug discovery campaign against the essential major protease (MPro) from SARS-CoV-2, which relied on an in silico search strategy –performed in a large and diverse chemolibrary– complemented by experimental validation. The computational method comprises a recently reported ligand-based approach developed upon refinement/learning cycles, and structure-based approximations. Search models were applied to both retrospective (in silico) and prospective (experimentally confirmed) screening.Results: The first generation of ligand-based models were fed by data, which to a great extent, had not been published in peer-reviewed articles. The first screening campaign performed with 188 compounds (46 in silico hits and 100 analogues, and 40 unrelated compounds: flavonols and pyrazoles) yielded three hits against MPro (IC50 ≤ 25 μM): two analogues of in silico hits (one glycoside and one benzo-thiazol) and one flavonol. A second generation of ligand-based models was developed based on this negative information and newly published peer-reviewed data for MPro inhibitors. This led to 43 new hit candidates belonging to different chemical families. From 45 compounds (28 in silico hits and 17 related analogues) tested in the second screening campaign, eight inhibited MPro with IC50 = 0.12–20 μM and five of them also impaired the proliferation of SARS-CoV-2 in Vero cells (EC50 7–45 μM).Discussion: Our study provides an example of a virtuous loop between computational and experimental approaches applied to target-focused drug discovery against a major and global pathogen, reaffirming the well-known “garbage in, garbage out” machine learning principle.

Using a combination of molecular, genetic, functional and behavioural tools, this study describes the impact of brain synthesized estrogen in inhibitory neuronal function, network oscillations and hippocampal dependent memory.

Our aim was to study the advantages, complications and obstetrical outcomes of laparoscopic myomectomy (LM) compared with abdominal myomectomy (AM). We conducted a retrospective cohort study at La Paz University Hospital that included LMs and AMs performed between 2012 and 2018, analyzing 254 myomectomies (142 AMs [55.7%] and 112 LMs [43.9%]). The mean number of fibroids was 1.8 ± 1.5 and 3 ± 2.9 for the LM and AM groups, respectively (p

Solar radiation and the incorporation of compost into soil is a practice for disinfecting soil that could have some other effects on spinach cultivation. The quality of spinach leaves after two types of soil disinfection, non-amended soil (NAS) and compost-amended soil (CAS), was compared in order to find biomarkers of both types of disinfection. These practices did not show significant differences in nutrient composition (N-P-K) compared to the control soil (CS). However, the amount of harmful nutrients such as NO2− was significantly lower in CAS (65.74 mg kg−1 FW) and NAS (49.99 mg kg−1 FW) than in CS (114.39 mg kg−1 FW). In addition, NO3− levels did not exceed the EU-recommended limit (−1 FW). Both types of disinfected soils produced higher concentrations of total phenols and more individual flavonoids in spinach leaves than the control. Combined chemometric analysis of the HRAMS data showed different clustering depending on the type of disinfection (NAS and CAS). Fifteen metabolite compounds could be identified, seven of which are beneficial for health and were more abundant in spinach grown in CAS compared to that grown in NAS or CS. Such beneficial metabolites measured with non-target analysis as markers of CAS-grown spinach. However, more studies are necessary in order to determine the differences between the metabolites of spinach grown in NAS or CAS.

ObjectiveAssess the surgeons' workload during deep endometriosis surgery after ureteral ICGDesignProspective, consecutive, comparative, single-center studyPopulation41 patients enrolled to deep endometriosis surgery with ureteral ICG from January 2019 to July 2021 at La Paz University HospitalMethodsPatients were divided into 2 groups: patients operated during the learning curve of ureteral ICG instillation and patients operated after the technique was implemented and routinely performed. After surgery, the SURG-TLX form was completed by the surgeons. We evaluated whether a workload reduction occurred.Main outcomes measuresSurgeon's workload was measured using the SURG-TLX form, obtaining the total workload and 6 different dimensions (distractions, temporal demands, task complexity, mental demands, situational stress and physical demands)ResultsA significant positive correlation was found between surgical complexity and situational stress (p = 0.04). Mental demands (p = 0.021), physical demands (p = 0.03), and total workload (p = 0.025) were significantly lower when the technique was routinely performed. The mental demand, physical demands, and total workload perceived by the surgeons at the beginning of the implementation was higher (68 [39–72], 27 [11–46.5], 229 [163–240], respectively) than in the latter ones (40 [9–63], 11.5 [0–32.8], 152 [133.3–213.8], respectively). Distractions appeared to be higher in the latter surgeries (8.5 [0–27.8]) than in the first surgeries (0 [0–7]; p = 0.057).ConclusionsUreter ICG instillation prior to DE surgery significantly reduces the mental and physical demands and total workload of the surgeons in DE surgeries after overcoming the learning curve. Distractions appear to increase as surgical stress decreases.

Resumen Introducción: el síndrome del túnel carpiano es de importante repercusión en el ámbito laboral, debido a su alta prevalencia, reconociéndose recientemente como enfermedad profesional. Tras la cirugía de liberación del nervio, es de interés valorar los parámetros que repercuten en el retorno al trabajo. Objetivos: revisar la literatura existente relativa al estado funcional de trabajadores previo a ser intervenidos quirúrgicamente por síndrome del túnel carpiano, y su reincorporación laboral analizando los factores de mayor influencia sobre ésta. Material y métodos: revisión sistemática de artículos publicados entre 2009-2019 en bases de datos, escogiéndose los artículos en base a criterios de inclusión y exclusión que abarcaban factores con repercusión en la vuelta al trabajo tras una cirugía del síndrome del túnel carpiano. Resultados: se seleccionan 13 estudios observacionales, excluyéndose 1 metaanálisis, 9 revisiones sistemáticas, 20 ensayos clínicos y 1 opinión de expertos. Se analizan en mayor medida factores como el tiempo de retorno, tipo de cirugía empleada, compensación económica y sintomatología. Conclusión: se sugiere una evidencia limitada en la asociación entre los factores analizados y el retraso en el retorno a la actividad profesional. La evaluación posterior al tipo de cirugía empleada muestra la compensación económica como el parámetro de mayor predominancia.

El duelo es un proceso normal ante la pérdida de una persona significativa. Debido a diversos factores los síntomas implicados en el proceso pueden intensificarse y perdurar de tal manera que interfieren significativamente en la vida de los dolientes, generando así un duelo complicado. El objetivo del estudio fue evaluar una intervención cognitivo-conductual dirigido a mejorar el afrontamiento emocional y la disminución de síntomas depresivos y ansiosos de una paciente de 32 años con trastorno de duelo complejo persistente. Para esto, se utilizó un diseño de caso de caso único, que incluyó un programa de intervención adaptado a 16 sesiones. Se aplicaron escalas estandarizadas antes y después del tratamiento. Los resultados indicaron una disminución de la sintomatología depresiva y ansiosa, un aumento del afrontamiento emocional y una disminución de conductas de evitación asociadas con la muerte y en el malestar reactivo a la muerte.

Objetivo: Analizar el autocuidado, la regulación emocional y el burnout en psicólogos clínicos que hayan brindado atención en servicios de salud mental durante la pandemia del COVID-19 y desarrollar un modelo de regresión lineal, para conocer las variables predictoras y la influencia de dichas variables en la problemática estudiada. Métodos: Se llevó a cabo un estudio transversal, cuantitativo aplicando la Escala de Conductas de Autocuidado para Psicólogos Clínicos, el Cuestionario de Regulación Emocional y el Inventario de Burnout de Maslach. Resultados: La mayoría de los participantes tienen conductas de autocuidado, un nivel medio de regulación emocional y puntuaciones bajas en agotamiento emocional y despersonalización. Las correlaciones entre las variables medidas se ajustaron a tres modelos de regresión lineal simple para el análisis y predicción de la regulación emocional, el autocuidado y el burnout. Conclusiones: Se encontró que el conocer las implicaciones de riesgos laborales en psicólogos clínicos tiene relevancia en los ámbitos de salud pública integral y el considerar el bienestar de estos profesionales es importante para garantizar el desarrollo efectivo de su trabajo para brindar atención a la salud mental de la sociedad.

Objetivo. Identificar los niveles de síntomas de ansiedad y desesperanza, así como, las estrategias de afrontamiento durante la pandemia de COVID-19 en usuarios de servicios de atención psicológica en línea. Método. Se utilizó un diseño de tipo transversal predictivo, con una muestra de 78 personas voluntarias. Se aplicó la Escala de estrategias de afrontamiento frente a riesgos extremos, Inventario de Ansiedad de Beck (BAI) y la Escala de Desesperanza de Beck (BHS). Resultados. Al existir un alto nivel de ansiedad en las personas participantes, se tiende a manifestar mayor nivel de indefensión y de conductas de afrontamiento orientadas hacia la evitación y de naturaleza pasiva.

En los últimos dos años el mundo ha vivido una pandemia por la COVID-19. A consecuencia de esta han ocurrido pérdidas de vidas humanas inesperadas, en condiciones de aislamiento. La enfermedad y la muerte sin la presencia de la familia se hace una experiencia bastante dolorosa que, sumado a la no celebración de los ritos tradicionales, complejizan el duelo. Si las experiencias de dolor y sufrimiento no se realizan en forma adecuada y oportuna, pueden afectar la salud mental. Se presenta un estudio de caso realizado en México, de una doliente femenina, adulta media de 41 años de edad, maestra de primaria. Refirió que hace un mes y medio falleció su esposo, con quien tenía una relación muy cercana e íntima, con buena comunicación, una muerte repentina por la COVID-19 y otras complicaciones. No se realizó velatorio, ni hubo oportunidad de despedida. La paciente comentó sentirse angustiada, triste, con dificultades para concentrarse, sensación de vacío y soledad, preocupada por su vida futura y la de sus hijos. Presenta náuseas y constantes dolores de cabeza. Se mostró impaciente y nerviosa, pero cooperadora con la entrevista. Se diagnostica duelo no complicado en fase aguda. Se realiza intervención cognitivo-conductual, en 12 sesiones de psicoterapia. Posterior al tratamiento se aplicaron nuevamente los instrumentos de evaluación, obteniéndose algunas modificaciones tanto en pensamientos y creencias, así como en la sintomatología presentada inicialmente. El modelo de intervención cognitivo conductual se puede valorar como un método de impacto positivo, resultando de utilidad para el logro del bienestar y salud del doliente.

Ovarian cancer (OC) is a life-threatening tumor and the deadliest among gynecological cancers in developed countries. First line treatment with a carboplatin/paclitaxel regime is initially effective in the majority of patients, but most advanced OC will recur and develop drug resistance. Therefore, the identification of alternative therapies is needed. In this study, we employed a panel of high-grade serous ovarian cancer (HGSOC) cell lines, in monolayer and three-dimensional cell cultures. We evaluated the effects of a novel tubulin-binding agent, plocabulin, on proliferation, cell cycle, migration and invasion. We have also tested combinations of plocabulin with several drugs currently used in OC in clinical practice. Our results show a potent antitumor activity of plocabulin, inhibiting proliferation, disrupting microtubule network, and decreasing their migration and invasion capabilities. We did not observe any synergistic combination of plocabulin with cisplatin, doxorubicin, gemcitabine or trabectedin. In conclusion, plocabulin has a potent antitumoral effect in HGSOC cell lines that warrants further clinical investigation.

Anti-Müllerian hormone (AMH) and antral follicular count (AFC) decrease in women with ovarian endometrioma (OMA) and in vitro fertilization (IVF). In addition, these parameters drop even further when women with OMA undergo surgery. In this study, the primary aim was to compare the reproductive variables in IVF-treated women with and without endometriosis. The secondary aim was to explore if the reproductive variables were modified by endometrioma surgery. In this retrospective study, 244 women undergoing IVF were enrolled at the Hospital Universitario La Paz (Madrid, Spain). Women were categorized as OMA not surgically treated (OMA; n = 124), OMA with surgery (OMA + S; n = 55), and women with infertility issues not related to OMA (control; n = 65). Demographic and clinical variables, including age, body mass index (BMI), and reproductive (AMH, AFC, number of extracted oocytes, and transferred embryos) and obstetrical data (biochemical pregnancy and fetal heart rate at 6 weeks) were collected. Adjusted logistic regression models were built to evaluate reproductive and pregnancy outcomes. The models showed that women with OMA (with and without surgery) had significantly decreased levels of AMH and AFC and numbers of cycles and C + D embryos. Women with OMA + S had similar rates of pregnancy to women in the control group. However, women with OMA had lower biochemical pregnancy than controls (aOR = 0.08 [0.01; 0.50]; p-value = 0.025). OMA surgery seems to improve pregnancy outcomes, at least until 6 weeks of gestation. However, it is important to counsel the patients about surgery expectations due to the fact that endometrioma itself reduces the quality of oocytes.

Con el objetivo de identificar los sistemas de armas utilizados en el sudoeste bonaerense durante el Holoceno se analiza la variabilidad de puntas de proyectil recuperadas en nueve sitios arqueológicos. Sobre la base de variables métricas se realizó la segmentación del conjunto en grupos mediante el análisis estadístico, descriptivo e inferencial, aplicando métodos univariados y multivariados. La relación entre largo, ancho y espesor permitió identificar cuatro grupos estadísticos y, a partir de los mismos, proponer la presencia de diferentes sistemas de armas. El relevamiento de las diferentes morfologías de limbos y bases posibilitó reconocer siete tipos morfológicos. El análisis tecno-tipológico permitió reconocer las distintas técnicas de formatización empleadas, la presencia de mantenimiento y las diferentes materias primas utilizadas para su confección.

Objetivo: Realizar la validación inicial de la estructura de la Escala de Conciliación Vida-Trabajo en mujeres insertas en el mercado laboral del noreste de México. Método: Se utilizó un diseño cuantitativo de corte explicativo. El muestreo fue intencional, 554 mujeres mayores de 18 años y que desempeñan actividades laborales remuneradas. El instrumento contó con 35 reactivos organizados en ocho dimensiones: desarrollo personal, vida familiar, vida social, cuidado personal, alimentación, actividad física, satisfacción e interferencia. Resultados: Se obtuvo la consistencia interna y el análisis factorial exploratorio (AFE) y confirmatorio (AFC). Se logró una reducción de ocho a seis dimensiones y de 35 a 25 reactivos. Una vez obtenidos estos valores, la escala tiene una adecuada estructura interna (GFI=0,867, RMSEA= 0,063) es válida y confiable (?=0,874) para evaluar el nivel de conciliación vida-familia de mujeres que se desempeñan en diferentes sectores laborales. Conclusiones: La gratificación, interferencia, pareja y crianza, cuidado de la salud, responsabilidades en el hogar y tiempo libre son dimensiones de la ECVT que permiten identificar la estructura de la conciliación desde la perspectiva de las mujeres trabajadoras.

El estudio histórico del funduq en al-Andalus muestra que estos edificios, utilizados como almacén y posada, fueron un espacio habitual de las ciudades andalusíes. Sin embargo, su caracterización arqueológica es más reciente y continúa en marcha con el estudio y revisión de los restos arqueológicos que pueden interpretarse como funduq. En el presente artículo exponemos los restos arqueológicos de la ciudad de Murcia que han sido interpretados como fanādiq (pl. de funduq) o edificios públicos, o restos que podrían ser interpretados como tal a los que no se les atribuyó una funcionalidad concreta. A partir del análisis de los restos arqueológicos de estos edificios, de las características generales de los fanādiq, determinadas a partir de la información que han proporcionado otras excavaciones arqueológicas de la península ibérica, y del estudio del urbanismo de la ciudad de Murcia, planteamos una propuesta de interpretación o reinterpretación de los casos de estudio murcianos.

ObjectiveTo evaluate the role of sentinel lymph node biopsy (SLNB) to avoid staging lymphadenectomies by detecting nodal metastasis in intermediate- and high-risk endometrial cancer (EC).MethodsA single institutional retrospective study was performed including all patients with intermediate- and high-risk EC who underwent surgical nodal staging between January 2012 and December 2019. Patients with disseminated disease detected on imaging techniques or at the time of surgery were excluded. Patients were evaluable if they underwent nodal staging with SLNB and pelvic (PLD) and paraaortic (PALD) lymph node dissection. We analyzed the accuracy of the sentinel lymph node technique. Only patients with at least one sentinel lymph node (SLN) detected were included in the sensitivity and negative predictive value (NPV) analyses. The tracers used were technetium 99m, blue dye, and indocyanine green.ResultsEighty-eight patients presented intermediate- and high-risk EC (51 patients and 37 patients respectively) and underwent SLNB with consecutive PLD and PALD. The median (range) number of sentinel nodes retrieved was 2.9 (0–11). The global detection rate of SLN was 96.6% with a bilateral detection of 80.7% when considering all tracers used. However, when combination of indocyanine green and technetium was used the bilateral detection rate was 90.3%. Nodal metastases were detected in 17 (19.3%) cases, 8 (47%) of them corresponded to low volume metastasis (LVM), 7 (87.5%) of them diagnosed at ultrastaging pathologic exam. Finally, we obtained a sensitivity of 90%, a NPV of 97.5%, and a false negative rate (FNR) of 10% in the intermediate-risk EC compared to sensitivity of 85.7%, NPV of 96.6%, and FNR of 14.3% in the high-risk EC group. The only patient with isolated paraaortic nodal metastasis was found at the high-risk group, 1.1%.ConclusionsAccording to our results, full lymphadenectomy could be avoided by performing SLNB in patients with intermediate-risk EC because the only false negative case detected was at the beginning of ICG learning curve. For high-risk EC patients we did not find enough evidence to support the systematic avoidance of staging full lymph node dissection. Nevertheless, SLNB should be performed in all cases of EC as it improves LVM diagnosis substantially.

Protein tyrosine phosphatase 1B (PTP1B) dephosphorylates phosphotyrosine residues and is an important regulator of several signaling pathways, such as insulin, leptin, and the ErbB signaling network, among others. Therefore, this enzyme is considered an attractive target to design new drugs against type 2 diabetes, obesity, and cancer. To date, a wide variety of PTP1B inhibitors that have been developed by experimental and computational approaches. In this review, we summarize the achievements with respect to PTP1B inhibitors discovered by applying computer-assisted drug design methodologies (virtual screening, molecular docking, pharmacophore modeling, and quantitative structure–activity relationships (QSAR)) as the principal strategy, in cooperation with experimental approaches, covering articles published from the beginning of the century until the time this review was submitted, with a focus on studies conducted with the aim of discovering new drugs against type 2 diabetes. This review encourages the use of computational techniques and includes helpful information that increases the knowledge generated to date about PTP1B inhibition, with a positive impact on the route toward obtaining a new drug against type 2 diabetes with PTP1B as a molecular target.

Objective: To evaluate a telephone support programme for mothers who breastfeed for the first 6 months. Methods: A randomised unmasked clinical trial was conducted in 5 urban Primary Care centres that included mothers with healthy newborns who were breastfeeding exclusively (EBF) or partially (PBF). The control group received the usual care. The intervention group also received telephone support for breastfeeding on a weekly basis for the first 2 months and then every 2 weeks until the sixth month. The type of breastfeeding was recorded in the usual check-up visit (1, 2, 4 and 6 months). Results: The study included 193 patients in the intervention group, and 187 in a control group. The greatest increase in the percentage of EBF was observed at 6 months: 21.4% in the control group compared to 30.1% in the intervention group. However, in the adjusted odds ratios analysis, confidence intervals did not show statistical significance. The odds ratio at 1 month, 2 months, 4 months, and 6 months for EBF were 1.45 (0.91–2.31), 1.35 (0.87–2.08), 1.21 (0.80–1.81), and 1.58 (0.99–2.53), respectively. The odds ratio in the same age groups for any type of breastfeeding (EBF + PBF) were 1.65 (0.39–7.00), 2.08 (0.94–4.61), 1.37 (0.79–2.38), and 1.60 (0.98–2.61), respectively. Conclusions: Telephone intervention was not effective enough to generalise it. Resumen: Objetivo: Evaluar un programa de apoyo telefónico a madres que dan lactancia materna los 6 primeros meses. Métodos: Ensayo clínico aleatorizado no enmascarado. Colaboraron 5 centros de salud de medio urbano. Se incluyeron madres con recién nacidos sanos que tomaban lactancia materna exclusiva (LME) o parcial (LMP). El grupo control recibió la atención habitual. El grupo intervención recibió además apoyo telefónico semanal los 2 primeros meses y quincenal hasta el sexto mes. Se valoró el tipo de lactancia en las revisiones habituales (1, 2, 4 y 6 meses). Resultados: Grupo intervención n = 193, grupo control n = 187. La mayor diferencia en porcentaje de LME se apreció a los 6 meses: 21,4% de grupo control frente al 30,1% del grupo intervención. No obstante, en el análisis ajustado de las odds ratio los intervalos de confianza no mostraron significación estadística. Las odds ratio al mes, 2 meses, 4 meses y 6 meses para LME fueron respectivamente: 1,45 (0,91-2,31); 1,35 (0,87-2,08); 1,21 (0,80-1,81) y 1,58 (0,99-2,53). Las odds ratio en los mismos cortes para cualquier tipo de lactancia materna (LME+LMP) fueron: 1,65 (0,39-7,00); 2,08 (0,94-4,61); 1,37 (0,79-2,38) y 1,60 (0,98-2,61). Conclusiones: La intervención telefónica no fue suficientemente efectiva como para generalizarla.

Resumen: Objetivo: Evaluar un programa de apoyo telefónico a madres que dan lactancia materna los 6 primeros meses. Métodos: Ensayo clínico aleatorizado no enmascarado. Colaboraron 5 centros de salud de medio urbano. Se incluyeron madres con recién nacidos sanos que tomaban lactancia materna exclusiva (LME) o parcial (LMP). El grupo control recibió la atención habitual. El grupo intervención recibió además apoyo telefónico semanal los 2 primeros meses y quincenal hasta el sexto mes. Se valoró el tipo de lactancia en las revisiones habituales (1, 2, 4 y 6 meses). Resultados: Grupo intervención n = 193, grupo control n = 187. La mayor diferencia en porcentaje de LME se apreció a los 6 meses: 21,4% de grupo control frente al 30,1% del grupo intervención. No obstante, en el análisis ajustado de las odds ratio los intervalos de confianza no mostraron significación estadística. Las odds ratio al mes, 2 meses, 4 meses y 6 meses para LME fueron respectivamente: 1,45 (0,91-2,31); 1,35 (0,87-2,08); 1,21 (0,80-1,81) y 1,58 (0,99-2,53). Las odds ratio en los mismos cortes para cualquier tipo de lactancia materna (LME+LMP) fueron: 1,65 (0,39-7,00); 2,08 (0,94-4,61); 1,37 (0,79-2,38) y 1,60 (0,98-2,61). Conclusiones: La intervención telefónica no fue suficientemente efectiva como para generalizarla. Abstract: Objective: To evaluate a telephone support programme for mothers who breastfeed for the first 6 months. Methods: A randomised unmasked clinical trial was conducted in 5 urban Primary Care centres that included mothers with healthy newborns who were breastfeeding exclusively (EBF) or partially (PBF). The control group received the usual care. The intervention group also received telephone support for breastfeeding on a weekly basis for the first 2 months and then every 2 weeks until the sixth month. The type of breastfeeding was recorded in the usual check-up visit (1, 2, 4 and 6 months). Results: The study included 193 patients in the intervention group, and 187 in a control group. The greatest increase in the percentage of EBF was observed at 6 months: 21.4% in the control group compared to 30.1% in the intervention group. However, in the adjusted odds ratios analysis, confidence intervals did not show statistical significance. The odds ratio at 1 month, 2 months, 4 months, and 6 months for EBF were 1.45 (0.91-2.31), 1.35 (0.87-2.08), 1.21 (0.80-1.81), and 1.58 (0.99-2.53), respectively. The odds ratio in the same age groups for any type of breastfeeding (EBF + PBF) were 1.65 (0.39-7.00), 2.08 (0.94-4.61), 1.37 (0.79-2.38), and 1.60 (0.98-2.61), respectively. Conclusions: Telephone intervention was not effective enough to generalise it.

We report synthesis, characterization, biological evaluation, and molecular-docking studies of 18 thieno[2,3-b]pyridines with a phenylacetamide moiety at position 2, which is disubstituted with F, Cl, Br, or I at position 4, and with electron-withdrawing and electron-donating groups (-CN, -NO2, -CF3, and -CH3) at position 2, to study how the electronic properties of the substituents affected the FOXM1-inhibitory activity. Among compounds 1–18, only those bearing a -CN (regardless of the halogen) decreased FOXM1 expression in a triple-negative breast cancer cell line (MDA-MB-231), as shown by Western blotting. However, only compounds 6 and 16 decreased the relative expression of FOXM1 to a level lower than 50%, and hence, we determined their anti-proliferative activity (IC50) in MDA-MB-231 cells using the MTT assay, which was comparable to that observed with FDI-6, in contrast to compound 1, which was inactive according to both Western blot and MTT assays. We employed molecular docking to calculate the binding interactions of compounds 1–18 in the FOXM1 DNA-binding site. The results suggest a key role for residues Val296 and Leu289 in this binding. Furthermore, we used molecular electrostatic potential maps showing the effects of different substituents on the overall electron density.

The objective of this study is to validate the internal structure of the School Violence Evaluation Questionnaire in Children and Primary in a sample of northeastern Mexico. It is a quantitative and transversal study. A total of 733 children were included, of which 49.8% are men, 50.2% women, through intentional sampling, obtained from 78 basic education institutions in the city of Saltillo, Coahuila, Mexico. The average age was 12 years. The results confirmed a factorial structure of three dimensions that measure situations witnessed, lived and carried out. The instrument was reduced to 27 indicators of these dimensions, conserving the reliability obtained in previous studies. The contribution of the study is validation of the internal structure of the evaluation tool that allows the identification of school bullying and perceived damage and its characteristics, avoiding mainly the underestimation and normalization of violence.

En el presente documento se explora la experiencia formativa universitaria en relación con la formación de sentidos acerca de la sustentabilidad, a partir de considerar las prácticas, relaciones e interacciones que los sujetos establecen con ellos mismos, con otros sujetos y con el entorno. Situada en el paradigma interpretativo, la investigación se basa en entrevistas semiestructuradas realizadas a estudiantes de la Universidad de Sonora, México. En los resultados se aprecia la formación de sentidos acerca de los contenidos educativos (conocimientos, afectos y conductas) sobre la sustentabilidad; se confirma que en la experiencia universitaria se forman y/o reafirman sentidos que incentivan prácticas de cuidado del medio ambiente natural, social y humano.

Objective: Ileocecal endometriosis is rare. Symptoms range from no symptoms, cramps, vomiting, to acute intestinal obstruction. Our objective was to review our cases, clarify, and resume its most appropriate management focusing on the factors to determine diagnosis. This is a retrospective study by revision of medical charts of all ileal endometriosis cases of our unit from 2006 to 2014. Case Report: Seven cases were found; three (43%) had previous endometriosis laparoscopic diagnosis, four (57%) had partial bowel obstruction episodes, three (43%) had chronic pelvic pain, and one developed acute intestinal obstruction in postoperative ileostomy closure. In three (43%), the diagnosis was made with magnetic resonance imaging (MRI) and double contrast barium enema, in one (14%) only with MRI, and the other three (43%) during surgery. All patients underwent resection of the ileum and evolved favorably. Conclusion: Variability in symptoms hinders diagnosis. The gold standard for diagnosis is MRI, but clinical suspicion optimizes imaging test diagnosis. Segmental resection should be indicated in the majority of the cases.

El profesor crea una práctica propia que se adapta a las características del contexto en el que se ubica, para lograrlo tendrá que considerar su experiencia, sus creencias y conocimientos con relación a la enseñanza. El objetivo en el presente artículo es identificar las teorías expuestas de la acción de las educadoras con relación al desarrollo personal y social en niños preescolares. El tipo de estudio es cualitativo con un diseño de estudio de caso. Se trabajó con tres educadoras de dos jardines de niños de la Ciudad de México. Las estrategias, técnicas y materiales utilizados fueron: escritos y planeación de la educadora, una entrevista semiestructurada. Los resultados obtenidos indicaron que las teorías expuestas de la acción de las educadoras están orientadas a un conjunto de categorías relacionadas: la autonomía, la identidad personal, las relaciones interpersonales y las estrategias de acompañamiento para su desarrollo en los niños. Los hallazgos aportan evidencia empírica alrededor de las teorías de la acción con relación al desarrollo personal y social en la primea infancia, dichos resultados demuestran que las educadoras al ingresar al aula crean, aplican, adaptan y le dan sentido al currículum, lo anterior permite entender la realidad educativa desde adentro.

Objetivo. Analizar la estructura interna de la propuesta de una Escala de Indefensión para Jóvenes (EIJ) en una muestra de la ciudad de Saltillo, Coahuila, México. Método. Se utilizó una metodología cuantitativa de diseño instrumental. Se eligió una muestra incidental de 750 casos, 50.3% hombres y 49.7% mujeres. La edad promedio fue de 21.85. Se utilizó la EIJ, que constó de 47 ítems que miden: afectividad, motivación, cognición y conducta. La confiabilidad fue de .898. Resultados. Se realizó el Análisis Factorial Exploratorio y Confirmatorio. Los índices de ajuste cumplieron con el criterio de buen ajuste. Esta herramienta aporta una forma de medir las variables predictoras de la conducta suicida, las cuales constituyen un problema de salud pública y que, en parte, son predichas por los indicadores de indefensión.

Objective: The aim of the present study was to compare post-operative complications and recurrence of three surgical techniques: segmental resection, discoid excision and nodule shaving. Study design: From January 2014 to December 2017, 143 patients who underwent segmental bowel resections for endometriosis at “La Paz” University Hospital, were enrolled and grouped by different techniques. We compared post-operative complications and recurrence rate in three groups: 76 (53%) patients underwent segmental resection (group I), 20 (14%) patients underwent discoid resection (group II) and 47 (33%) patients underwent rectal shaving (group III).Qualitative data was defined by absolute values and percentages, and quantitative data by mean and standard deviation. Qualitative variables between groups were compared using Chi- squared test. While quantitative data between groups was performed by means of t-test and ANOVA test. For all statistical tests a value of p

El objetivo de este trabajo de investigación es medir el grado de satisfacción de los clientes respecto a la calidad del servicio de los restaurantes PyMES en la ciudad de Saltillo Coahuila. Ofrecer servicio de calidad debe ser una filosofía de trabajo, no un estilo de trabajo. La investigación es de carácter descriptivo y exploratorio con una muestra de 342 personas. Se validó instrumento de 22 ítems. Los resultados arrojan que los clientes sienten que se les brinda un servicio de calidad cuando perciben una apariencia pulcra en los empleados, también cuando existe amplia disposición por responder a sus inquietudes y darles adecuada y pronta solución. Se encontró que el constructo más valorado por los clientes es el referente a la fiabilidad. Abstract The objective of this research work is to measure the degree of customer satisfaction with the quality of service of SME Restaurants in the city of Saltillo Coahuila. Providing quality service should be a work philosophy, not a work style. The research is descriptive and exploratory with a sample of 342 people. 22-item instrument was validated. The results show that customers feel that they are provided with quality service when they perceive a neat appearance in employees, even when there is wide willingness to respond to their concerns and give them adequate and prompt resolution. It was found that the most valued construct by customers is the one related to reliability.

Objective: This article shows our experience on sentinel lymph node (SLN) biopsy in early-stage cervical carcinoma since the technique was introduced in our Institution. The main objective is to analyze the detection rate (DR) of metastatic SLNs, identifying prognostic factors for an increased risk of nodal metastases. Our second aim was to compare the accuracy of nodal metastases DR between intraoperative analysis and postoperative ultrastaging. Materials and Methods: Forty-one women with the International Federation of Gynecology and Obstetrics stages IA2-IIA1 who underwent laparoscopic surgical treatment applying the SLN technique, from December 2011 to June 2016, at La Paz University Hospital, were included. The sentinel node was identified using technetium and methylene blue dye or indocyanine green near-infrared fluorescent imaging, analyzed intraoperatively, and compared to deferred ultrastaging. Results: SLN DR was 100%, with a bilaterality rate of 83%. Twelve (26.8%) patients had metastatic nodes, 11 of them (91.7%) detected by SLN technique, of which 9 (81.8%) had only the sentinel node affected. False-negative rate was 2.4% after ultrastaging procedure. Metastatic SLN detection with ultrastaging was 45.5% higher than the intraoperative analysis, 63.6% of which had low tumor burden. The global detection of patients with nodal metastases after SLN technique was 21.9% higher than pelvic lymphadenectomy. Conclusions: Our preliminary results corroborate that SLN biopsy selectively maps metastatic nodes and ultrastaging increases the detection of metastatic SLNs, predominantly due to low tumor burden.

El objetivo de este estudio fue analizar las diferen - cias de la conciliación de los componentes vida y carrera laboral de mujeres trabajadoras de dos es - tados del norte de México, Coahuila y Sonora, con el fin de conocer los contrastes en la distribución y la armonización de las tareas dentro y fuera de casa. Se aplicó una escala para medir la conciliación vida- trabajo a 556 mujeres en ambos estados. Se explo - raron seis dimensiones: gratificación, interferencia, pareja y crianza, cuidado y salud, responsabilidad en el hogar y tiempo libre. Los resultados indican que la muestra de Sonora presenta niveles más altos de conciliación. En general, la incorporación de las mujeres al ámbito laboral les genera gratificaciones personales, sin embargo, esta condición no ha modi - ficado, en lo substancial, la división sexual del tra - bajo, es decir, las mujeres cumplen con sus jornadas de trabajo y continúan en casa con las tareas de cuidado y atención de la familia.

Candidiasis, caused by yeasts of the genus Candida, is the second cause of superficial and mucosal infections and the fourth cause of bloodstream infections. Although some antifungal drugs to treat candidiasis are available, resistant strains to current therapies are emerging. Therefore, the search for new candicidal compounds is certainly a priority. In this regard, a series of indazole and pyrazole derivatives were designed in this work, employing bioisosteric replacement, homologation, and molecular simplification as new anticandidal agents. Compounds were synthesized and evaluated against C. albicans, C. glabrata, and C. tropicalis strains. The series of 3-phenyl-1H-indazole moiety (10a–i) demonstrated to have the best broad anticandidal activity. Particularly, compound 10g, with N,N-diethylcarboxamide substituent, was the most active against C. albicans and both miconazole susceptible and resistant C. glabrata species. Therefore, the 3-phenyl-1H-indazole scaffold represents an opportunity for the development of new anticandidal agents with a new chemotype.

Se identifican los roles y estereotipos de género y su impacto en los comportamientos sexuales de estudiantes universitarios. Se empleó la Teoría Fundamentada como método de interpretación, en particular los procesos de codificación abierta y axial. Para recolectar la información, se recurrió a una entrevista estructurada con preguntas generadoras: ¿cuáles son los comportamientos esperados en los hombres y las mujeres en sus encuentros sexuales? y ¿qué tan de acuerdo estás con estos comportamientos? Concluimos que el comportamiento sexual entre hombres y mujeres guarda diferencias en torno a la socialización de los géneros viajando entre la tradicionalidad de los roles y estereotipos y su transgresión.

El objetivo de este estudio fue analizar las valoraciones sociales de género presentes en las creencias de la población estudiantil universitaria del norte de México, con el fin de conocer los cambios que se van produciendo en relación a este fenómeno. Se aplicó una escala de creencias estereotipadas de género a 1921 estudiantes de ambos sexos de dos universidades públicas del norte de México, localizadas en las ciudades de Hermosillo, Sonora y Saltillo, Coahuila. Se exploraron cinco dimensiones: feminidad/masculinidad, roles de maternidad/paternidad, sexualidad, competencias y capacidades y expresiones de emotividad/ agresividad. Los resultados indican un mayor arraigo a posturas tradicionales en varones y en los estudiantes provenientes de la división académica de ingeniería. En general, los estudiantes de semestres avanzados tienen los mismos prejuicios de género que los de recién ingreso a la institución. Se recomienda transversalizar la perspectiva de género en las instituciones de educación superior a través de programas de sensibilización y capacitación.

Resumen: Este artículo trata de la primera generación de verdaderos nativos digitales en Europa, nacidos en torno al año 2000 y que en la actualidad asisten a los institutos de secundaria. Son diferentes a los de generaciones anteriores debido sobre todo al impacto que la tecnología ha tenido en sus vidas, pero la mayoría sigue sistemas educativos desfasados, diseñados para alumnos del siglo pasado. Muchos profesores intentan adaptarse a la nueva situación incorporando las TIC en sus cursos. La autora analiza el proceso de creación de un telediario, actividad realizada en el marco de un proyecto piloto de uso de los Ipad en los cursos de E/LE. Este proyecto obtuvo el Primer Premio del concurso a la Mejor práctica docente de E/LE basada en las TIC convocado por la Editorial Difusión/Prolinter en 2017, con la colaboración del Instituto Cervantes y el patrocinio de SIELE y FEDELE. Palabras clave: E/LE con Ipads, nativos digitales, enfoque por proyectos, tarea final. Abstract: This article concerns the first generation of true digital natives in Europe, children born in 2000, who, today, attend colleges or secondary schools. They are different to the previous generations due to the important impact of technology on their lives. However, they are compelled to attend schools with an outdated educational system designed for the older generations. Some teachers try to adapt themselves to the new situation by incorporating the ICT. The Spanish teacher at the LFZ therefore analyzes in this article the elaboration process of a newscast, whilst using the school iPads with her students of second year of Spanish. This video was presented at a well-known contest amongst language teachers, where the best teaching practice of Spanish as a foreign language based on the use of ICT is selected, and won the first prize in March 2017. Keywords: S/FL, digital natives, S/FL with Ipads, Task-based language learning.