14 results on '"Alina Suciu"'
Search Results
2. Sewage sludge for sustainable agriculture: contaminants’ contents and potential use as fertilizer
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Lucrezia Lamastra, Nicoleta Alina Suciu, and Marco Trevisan
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Sewage sludge ,Sustainability ,Risk quotient ,Soil fertilizer ,Agriculture - Abstract
Abstract Background Sewage sludge, the inevitable byproduct of municipal wastewater-treatment plant operation, is a key issue in many countries due to its increasing volume and the impacts associated with its disposal. According to the report of European Commission published in 2010, 39% of sewage sludge produced in the European Union is recycled into agriculture. Management options require extensive waste characterization, since many of them may contain compounds, which could be harmful to the ecosystem, such as heavy metals, organic pollutants, etc. The present study aims to show the results of 2 years’ sampling of sewage sludge—based on 130 samples collected from 35 wastewater-treatment plants situated in the North of Italy—and to assess its suitability as soil fertilizer regarding contents of nonylphenol (NP), nonylphenolethoxylates (NPnEOs), and phthalates (DEHP). Results An effective analytic method for organic pollutants detection in the sewage sludge has been developed, showing an excellent repeatability and recoveries. Ecotoxicological risk assessment was evaluated using risk quotients (RQs) for sludge-amended soil. Most of the analyzed samples do not contain NP, NPnEOs, and DEHP at levels higher than the limit established by the draft-working document of the European Commission on Sludge. The assessment using RQs reports that NP and NPnEOs never give values higher than 1, and for DEHP the obtained RQs exceed the value of 1 just three times. Data obtained were compared to the data from other European and Asiatic countries, showing a huge variability for all the compounds considered. Conclusions Based on the obtained results, it appears that the proposed EU limits for the selected substances on sewage sludge intended to be used as soil fertilizer in agriculture are sufficiently conservative to avoid negative effects on soil fauna.
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- 2018
- Full Text
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3. Malnutrition and non-compliance to nutritional recommendations in patients with cirrhosis are associated with a lower survival
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Alexandra Epure, Horia Stefanescu, Nicolae Crisan, Alina Suciu, Rares Craciun, Dana Crisan, Emil Mois, Andreea Fodor, and Bogdan Procopet
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medicine.medical_specialty ,Percentile ,Multivariate analysis ,Cirrhosis ,Survival ,Observational Study ,Decompensated cirrhosis ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,Medicine ,Subjective global assessment ,In patient ,Creatinine ,Hepatology ,business.industry ,Mortality rate ,Malnutrition ,medicine.disease ,Protein intake ,chemistry ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,business - Abstract
BACKGROUND Malnutrition is frequently encountered in patients with cirrhosis and appears to significantly impact their prognosis. While evaluating the burden of malnutrition in cirrhosis is gathering momentum, as suggested by multiple recently published reports, there is still a persistent scarcity of solid data in the field, especially with regards to the role of nutritional interventions. AIM To assess the prevalence of malnutrition in patients with advanced cirrhosis and to evaluate its impact on survival. METHODS One hundred and one consecutive patients with advanced cirrhosis were screened for malnutrition using the Subjective Global Assessment (SGA) criteria and the mid-arm circumference (MAC). Malnutrition was defined as SGA class B and C and MAC < 10th percentile. All patients were interviewed regarding their food intake using an adapted questionnaire. Subsequently, total energy intake was calculated and further subdivided in main nutrients. The data were then compared to the available recommendations at the time of analysis to assess adherence. RESULTS 54/79 patients (68.4%) in the decompensated group had malnutrition, while only 3/22 patients (13.6%) were malnourished in the compensated group. After a median follow-up time of 27 mo (0-53), the overall mortality was 70%. Survival was significantly lower among patients with malnutrition. The mortality rates were 50% at 1 year and 63% at 2 years for the patients with malnutrition, compared to 21% at 1 year and 30% at 2 years for patients without malnutrition (P = 0.01). On multivariate analysis, the factors independently associated with mortality were age, creatinine level and adherence to the protein intake recommendations. The mortality was lower in patients with the appropriate protein intake: 8% at 1 year and 28% at 2 years in the adherent group, compared to 47% at 1 year and 56% at 2 years in the non-adherent group. CONCLUSION The prevalence of malnutrition is high among patients with advanced cirrhosis and might be related in part to a low adherence to nutritional recommendations, especially with regards to protein intake.
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- 2020
4. Functional bowel disorders with diarrhoea: Clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility
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Edoardo Savarino, Fabiana Zingone, Brigida Barberio, Giovanni Marasco, Filiz Akyuz, Hale Akpinar, Oana Barboi, Giorgia Bodini, Serhat Bor, Giuseppe Chiarioni, Gheorghe Cristian, Maura Corsetti, Antonio Di Sabatino, Anca Mirela Dimitriu, Vasile Drug, Dan L. Dumitrascu, Alexander C. Ford, Goran Hauser, Radislav Nakov, Nisha Patel, Daniel Pohl, Cătălin Sfarti, Jordi Serra, Magnus Simrén, Alina Suciu, Jan Tack, Murat Toruner, Julian Walters, Cesare Cremon, and Giovanni Barbara
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Diarrhea ,FDr ,IBS-D ,abdominal pain ,clinical practice guidelines ,diarrhea ,functional bowel disorders ,functional diarrhea ,irritable bowel syndrome ,Bile Acids and Salts ,Gastrointestinal Agents ,Humans ,Gastroenterology ,Irritable Bowel Syndrome ,INTESTINAL BACTERIAL OVERGROWTH ,GASTROINTESTINAL DISORDERS ,BILE-ACID MALABSORPTION ,DOUBLE-BLIND ,FECAL INCONTINENCE ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine ,GLUTEN-FREE DIET ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina ,Science & Technology ,Gastroenterology & Hepatology ,LACTOSE-MALABSORPTION ,CELIAC-DISEASE ,Oncology ,CAPSULE ENDOSCOPY ,ROME III ,Life Sciences & Biomedicine - Abstract
Irritable bowel syndrome with diarrhoea (IBS-D) and functional diarrhoea (FDr) are the two major functional bowel disorders characterized by diarrhoea. In spite of their high prevalence, IBS-D and FDr are associated with major uncertainties, especially regarding their optimal diagnostic work-up and management. A Delphi consensus was performed with experts from 10 European countries who conducted a literature summary and voting process on 31 statements. Quality of evidence was evaluated using the grading of recommendations, assessment, development, and evaluation criteria. Consensus (defined as >80% agreement) was reached for all the statements. The panel agreed with the potential overlapping of IBS-D and FDr. In terms of diagnosis, the consensus supports a symptom-based approach also with the exclusion of alarm symptoms, recommending the evaluation of full blood count, C-reactive protein, serology for coeliac disease, and faecal calprotectin, and consideration of diagnosing bile acid diarrhoea. Colonoscopy with random biopsies in both the right and left colon is recommended in patients older than 50 years and in presence of alarm features. Regarding treatment, a strong consensus was achieved for the use of a diet low fermentable oligo-, di-, monosaccharides and polyols, gut-directed psychological therapies, rifaximin, loperamide, and eluxadoline. A weak or conditional recommendation was achieved for antispasmodics, probiotics, tryciclic antidepressants, bile acid sequestrants, 5-hydroxytryptamine-3 antagonists (i.e. alosetron, ondansetron, or ramosetron). A multinational group of European experts summarized the current state of consensus on the definition, diagnosis, and management of IBS-D and FDr. ispartof: UNITED EUROPEAN GASTROENTEROLOGY JOURNAL vol:10 issue:6 pages:556-584 ispartof: location:England status: published
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- 2022
5. Cd content in phosphate fertilizer: Which potential risk for the environment and human health?
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Nicoleta Alina Suciu, Romano De Vivo, Niccolò Rizzati, and Ettore Capri
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Heavy metals ,Environmental contamination ,Settore AGR/13 - CHIMICA AGRARIA ,Health, Toxicology and Mutagenesis ,Sustainable agriculture ,Public Health, Environmental and Occupational Health ,Environmental Chemistry ,Cadmium ,Human health exposure - Published
- 2022
6. Terratech ERASMUS+ project tackling the objectives of the Farm to Fork Strategy.
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Pereira, Ruth, Katranas, George, Oliveira, Sofia, Carvalho, Susana, Kosmanis, Theodoros, Féjer, Péter, Cachada, Anabela, Nogueira, Verónica, Fernandes, Tânia, Riel, Andreas, Gatti, Matteo, Alina Suciu, Nicoleta, Bel Pereira, Albert, Jason, Edmunds, Haberl, Christiane, Akbar, Ali, Kalaitzidis, Chariton, Volant, Stephane, Fonseca, Bruno, and Schoinoplokakis, Dimitrios
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- 2022
- Full Text
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7. Upper Gastrointestinal Sensitization And Symptom Generation
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Dan-Lucian Dumitrascu, Stefan-Lucian Popa, and Alina Suciu
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PDS - Postprandial distress syndrome ,medicine.medical_specialty ,Nausea ,Gastrointestinal Diseases ,Review ,NMDA N-methyl-D-aspartate receptor ,Organic disease ,Functional Gastrointestinal Disorders ,Epigastric pain ,Gastroenterology ,Sensitization ,ASICs - Acid-sensing ion channels ,03 medical and health sciences ,0302 clinical medicine ,Bloating ,Quality of life ,Brain-Gut Interaction ,Internal medicine ,medicine ,FGID ,Humans ,Gastrointestinal tract ,CNS - Central nervous system ,business.industry ,TRPV1 - The transient receptor potential vanilloid 1 ,FGID - Functional gastrointestinal disorders ,General Medicine ,GNB3 - G-protein-coupled receptor in the brain-gut axis ,Gastrointestinal Tract ,HPA - Hypothalamic-pituitary-adrenal ,medicine.anatomical_structure ,CNVS - Chronic nausea vomiting syndrome ,PTSD - Posttraumatic stress disorder ,CVS - Cyclic vomiting syndrome ,Vomiting ,CHS - Cannabinoid hyperemesis syndrome ,030211 gastroenterology & hepatology ,medicine.symptom ,Visceral Hypersensitivity ,EPS- Epigastric pain syndrome ,business ,030217 neurology & neurosurgery - Abstract
Functional gastrointestinal disorders (FGIDs) are a highly prevalent group of heterogeneous disorders, and their diagnostic criteria are symptom-based, with the absence of anatomical and biochemical abnormalities of the gastrointestinal tract. Chronic visceral symptoms are common both in patients with an identifiable organic disease but also in FGID patients. Patients suffering from upper gastrointestinal functional disorders typically present with various symptoms such as early satiety, postprandial fullness, bloating, nausea, vomiting, and epigastric pain. Considering their increasing prevalence, difficulties in diagnosis, and low quality of life, FGIDs have become an emerging problem in gastroenterology. We aimed to provide an updated summary of pathways involved in visceral sensitization. We examined the recent literature searching for evidence of the most important studies about the mechanisms underlying gastrointestinal symptom generation and sensitization.
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- 2020
8. Interferon-γ-inducible protein-10 in chronic hepatitis C: Correlations with insulin resistance, histological features & sustained virological response
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Dana, Crisan, Mircea Dan, Grigorescu, Corina, Radu, Alina, Suciu, and Mircea, Grigorescu
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Adult ,Male ,Genotype ,Biopsy ,lcsh:Medicine ,Enzyme-Linked Immunosorbent Assay ,Hepacivirus ,Antiviral Agents ,Interferon-gamma ,insulin resistance ,Ribavirin ,steatosis ,Humans ,IFN-γ-inducible protein-10 ,Aged ,lcsh:R ,Hepatitis C, Chronic ,Middle Aged ,Viral Load ,Fibrosis ,Fibrosis - hepatitis C - insulin resistance - IFN-γ-inducible protein-10 - steatosis - sustained virological response ,Chemokine CXCL10 ,Fatty Liver ,Treatment Outcome ,Liver ,Female ,Original Article ,hepatitis C ,sustained virological response - Abstract
Background & objectives: One of the multiple factors contributing to virological response in chronic hepatitis C (CHC) is interferon-gamma-inducible protein-10 (IP-10). Its level reflects the status of interferon-stimulated genes, which in turn is associated with virological response to antiviral therapy. The aim of this study was to evaluate the role of serum IP-10 levels on sustained virological response (SVR) and the association of this parameter with insulin resistance (IR) and liver histology. Methods: Two hundred and three consecutive biopsy proven CHC patients were included in the study. Serum levels of IP-10 were determined using ELISA method. IR was evaluated by homeostasis model assessment-IR (HOMA-IR). Histological features were assessed invasively by liver biopsy and noninvasively using FibroTest, ActiTest and SteatoTest. Predictive factors for SVR and their interrelations were assessed. Results: A cut-off value for IP-10 of 392 pg/ml was obtained to discriminate between responders and non-responders. SVR was obtained in 107 patients (52.70%). Area under the receiver operating characteristic curve for SVR was 0.875 with a sensitivity of 91.6 per cent, specificity 74.7 per cent, positive predictive value 80.3 per cent and negative predictive value 88.7 per cent. Higher values of IP-10 were associated with increasing stages of fibrosis (P
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- 2017
9. What's in Metabolomics for Alcoholic Liver Disease?
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Carmen Socaciu, Horia Stefanescu, Dana Crisan, Bogdan Procopet, Alina Suciu, Mircea Grigorescu, Marcel Tantau, and Corina Radu
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0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,Alcoholic liver disease ,Cirrhosis ,Alcoholic hepatitis ,Urine ,Gastroenterology ,Proof of Concept Study ,Severity of Illness Index ,03 medical and health sciences ,Liver disease ,Metabolomics ,Liver Cirrhosis, Alcoholic ,Predictive Value of Tests ,Internal medicine ,Medicine ,Humans ,Liver Diseases, Alcoholic ,Aged ,medicine.diagnostic_test ,business.industry ,Middle Aged ,medicine.disease ,Lipids ,030104 developmental biology ,Liver biopsy ,Case-Control Studies ,Metabolome ,Female ,business ,Risk assessment ,Biomarkers - Abstract
Background & Aims: Current management of alcoholic liver disease (ALD), especially for alcoholic hepatitis (AH) is still driven by liver biopsy. Therefore, the identification of novel and accurate noninvasive biomarkers for the diagnosis and assessment of severity is important. Metabolomics, because it unravels changes closest to the phenotype, may represent the key for novel biomarkers. The aim of this study was to identify and characterize potential metabolomic biomarkers for diagnosis, staging and severity assessment of ALD.Methods: 30 consecutive ALD patients and 10 healthy controls were included in this proof-of-concept crosssectional study. Baseline assessment consisted in evaluation of Maddrey’s Discriminant Function, Model for End-Stage Liver Disease (MELD) and ABIC scores as well as ASH-Test (Fibromax) as a surrogate for the confirmatory diagnosis of AH in suggestive clinical and biologic settings. Additionally, SOP metabolomics and lipidomics were performed from serum samples by liquid chromatography mass-spectrometry analysis.Results: From the 127 and 135 serum/urine candidate metabolites initially identified, only 11/5 metabolites were characteristic for ALD patients. None of them correlated with alcohol intake, and only 5/1 metabolites could differentiate cirrhotic from non-cirrhotic patients. Of those, N-Lauroglycine (NLG) was the best for identifying cirrhosis (100% sensitivity and 90% negative predictive value, NPV) and decatrienoic acid (DTEA) was the best for assessing disease severity (evaluated by ABIC score) with 100% sensitivity and 100% NPV.Conclusion: Due to their high NPV, NLG and DTEA could be used in conjunction in ALD patients to exclude cirrhosis or a severe disease. If further validated, they could become biomarkers for better management and risk assessment in ALD.
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- 2018
10. Noninvasive Assessment of Liver Diseases using 2D Shear Wave Elastography
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Anca Maniu, Cristian Vicas, Alina Suciu, Radu Badea, Nadim Al Hajjar, Ioana Rusu, Monica Lupșor-Platon, Horia Stefanescu, Mirela Gersak, and Radu Urs
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Observer Variation ,Shear wave elastography ,medicine.medical_specialty ,business.industry ,Liver fibrosis ,Liver Diseases ,Ultrasound ,Gastroenterology ,Reproducibility of Results ,Prognosis ,Severity of Illness Index ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Elasticity Imaging Techniques ,0302 clinical medicine ,Liver ,Predictive Value of Tests ,030220 oncology & carcinogenesis ,medicine ,Examination technique ,Humans ,Radiology ,business ,Observer variation - Abstract
There has been great interest in the development of non-invasive techniques for the diagnosis of liver fibrosis in chronic liver diseases, including ultrasound elastographic methods. Some of these methods have already been adequately studied for the non-invasive assessment of diffuse liver diseases. Others, however, such as two-dimensional Shear Wave Elastography (SWE), of more recent appearance, have yet to be validated and some aspects are for the moment incompletely elucidated. This review discusses some of the aspects related to two-dimensional SWE: the examination technique, the examination performance indicators, intra and interobserver agreement and clinical applications. Recommendations for a high-quality examination technique are formulated. Key words: – – – Two-dimensional Shear Wave Elastography. Abbreviations: 2D- SWE: Two-dimensional Shear Wave Elastography; 3D- SWE: Three-dimensional Shear Wave Elastography; AUROC: area under the receiver operating characteristic curves; ARFI Acoustic Radiation Force Impulse Elastography; EFSUMB: European Federation of Societies for Ultrasound in Medicine and Biology; HVPG: hepatic venous pressure gradient; LS: liver stiffness; LR: likelihood ratio; NPV: negative predictive value; PPV: positive predictive value; ROI: region of interest; RT-E: Real Time-Elastography; Se: sensitivity; Sp: specificity; TE: Transient Elastography; US: ultrasound; VM: valid measurement; E: Young’s modulus
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- 2016
11. Liver stiffness better predicts portal hypertension after HCV eradication
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Roxana Sav, Anca Bugariu, Bogdan Procopet, Crina Grigoras, Oana Stancu, Horia Stefanescu, Zeno Sparchez, Alina Suciu, and Corina Radu
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Male ,medicine.medical_specialty ,Sustained Virologic Response ,Antiviral Agents ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Liver stiffness ,Internal medicine ,Hypertension, Portal ,medicine ,Humans ,Aged ,business.industry ,Hepatitis C, Chronic ,Middle Aged ,Prognosis ,medicine.disease ,Treatment Outcome ,Liver ,030220 oncology & carcinogenesis ,Elasticity Imaging Techniques ,Portal hypertension ,Female ,030211 gastroenterology & hepatology ,business - Published
- 2018
12. Predictions from a very hard liver: The role of liver stiffness in alcoholic hepatitis
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Marcel Tantau, R. Badea, Alina Suciu, Bogdan Procopet, Monica Lupsor-Platon, Adelina Horhat, H. Stefanescu, R. Corina, Daniela Matei, and F. Petra
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medicine.medical_specialty ,Hepatology ,Liver stiffness ,business.industry ,Internal medicine ,medicine ,Alcoholic hepatitis ,business ,medicine.disease ,Gastroenterology ,Hard liver - Published
- 2018
13. Hepatitis C in nonobese nondiabetic patients: Insulin resistance and the metabolic syndrome make a difference
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N. Leach, N. Crisan, Alina Suciu, Dana Crisan, Lucretia Avram, Corina Radu, Horia Stefanescu, and M. Grigorescu
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medicine.medical_specialty ,Hepacivirus ,Article ,03 medical and health sciences ,0302 clinical medicine ,Insulin resistance ,Text mining ,Virology ,Internal medicine ,medicine ,Humans ,Insulin ,Obesity ,Metabolic Syndrome ,Hepatology ,business.industry ,Hepatitis C ,medicine.disease ,Infectious Diseases ,Endocrinology ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Metabolic syndrome ,Insulin Resistance ,business - Abstract
Hepatitis C infection (HCV) and menopause are associated with insulin resistance (IR), and IR accelerates HCV-induced liver disease. The relationship between menopause and IR has not been studied in this population. This study aimed to assess the impact of menopause on IR and metabolic syndrome in HCV. One hundred and three (69 men, 16 premenopausal, 18 postmenopausal women) noncirrhotic, nondiabetic HCV-infected adults underwent IR measurement via steady-state plasma glucose during a 240-min insulin suppression test. Metabolic syndrome was defined by at least three of five standard laboratory/clinical criteria. The patient characteristics were as follows: mean age 48 years, waist circumference 94.4 ± 12.4 cm and 37.9% Caucasian. SSPG was higher in postmenopausal than premenopausal women or men (mean difference 18, 95% CI −41 to 76 and 35, 95% CI −3 to 72 mg/dL; respectively). After adjusting for waist circumference, female gender, nonwhite race and triglycerides were positively associated and high-density lipoprotein negatively associated with steady-state plasma glucose. Compared to men, both pre-(Coef 48, 95% CI 12–84) and postmenopausal women (Coef 49, 95% CI 17–82) had higher steady-state plasma glucose. Compared to premenopausal women, men (OR 2.0, 95% CI 0.38–10.2) and postmenopausal women (OR 2.9, 95% CI 0.46–18.8) had higher odds of metabolic syndrome, but this was statistically nonsignificant. Both liver inflammation (OR 7.9) and nonwhite race (OR 6.9) were associated with metabolic syndrome. We conclude that women are at increased risk for IR in HCV. There may also be an increased risk of metabolic syndrome postmenopause. Along with lifestyle modification and weight loss, women with metabolic abnormalities represent an especially at-risk group warranting HCV treatment to prevent adverse metabolic outcomes.
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- 2016
14. Lyso‐phosphatidylcholine: A potential metabolomic biomarker for alcoholic liver disease?
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Horia Stefanescu, Carmen Socaciu, Alina Suciu, Mircea Grigorescu, Dana Crisan, Florina Romanciuc, Bogdan Procopet, Corina Radu, and Marcel Tantau
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Alcoholic liver disease ,Hepatology ,business.industry ,Pharmacology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Metabolomics ,030220 oncology & carcinogenesis ,Medicine ,Biomarker (medicine) ,030211 gastroenterology & hepatology ,business ,Lyso phosphatidylcholine - Published
- 2016
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